Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cnn3 | Rat | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of CNN3 protein | CTD | PMID:14620880 | Cnn3 | Rat | 1,2-dichloroethane | increases expression | ISO | Cnn3 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of CNN3 mRNA | CTD | PMID:28960355 | Cnn3 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Cnn3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CNN3 mRNA | CTD | PMID:22206623 | Cnn3 | Rat | 1-chloro-2,4-dinitrobenzene | affects binding | ISO | CNN3 (Homo sapiens) | 6480464 | Dinitrochlorobenzene binds to CNN3 protein | CTD | PMID:32991956 | Cnn3 | Rat | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of CNN3 mRNA | CTD | PMID:15576828 and PMID:17557909 | Cnn3 | Rat | 17beta-estradiol | affects expression | ISO | CNN3 (Homo sapiens) | 6480464 | Estradiol affects the expression of CNN3 mRNA | CTD | PMID:22574217 | Cnn3 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:27291303 | Cnn3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CNN3 mRNA | CTD | PMID:16054898 | Cnn3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CNN3 mRNA | CTD | PMID:34747641 | Cnn3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CNN3 mRNA | CTD | PMID:21215274 | Cnn3 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:19954255 | Cnn3 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:19954255 | Cnn3 | Rat | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | Cnn3 (Mus musculus) | 6480464 | 3 more ... | CTD | PMID:19467301 | Cnn3 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CNN3 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of CNN3 mRNA | CTD | PMID:28628672 | Cnn3 | Rat | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of CNN3 mRNA | CTD | PMID:19162173 | Cnn3 | Rat | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of CNN3 mRNA | CTD | PMID:30723492 | Cnn3 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of CNN3 mRNA | CTD | PMID:28628672 | Cnn3 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of CNN3 protein | CTD | PMID:34186270 | Cnn3 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Fenretinide results in increased expression of CNN3 mRNA | CTD | PMID:28973697 | Cnn3 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of CNN3 mRNA | CTD | PMID:24780913 | Cnn3 | Rat | 7,12-dimethyltetraphene | increases expression | EXP | | 6480464 | 9 more ... | CTD | PMID:12376462 | Cnn3 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of CNN3 mRNA | CTD | PMID:28959563 | Cnn3 | Rat | aflatoxin B1 | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of CNN3 mRNA | CTD | PMID:19770486 | Cnn3 | Rat | aflatoxin B1 | decreases methylation | ISO | CNN3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of CNN3 gene | CTD | PMID:27153756 | Cnn3 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CNN3 mRNA | CTD | PMID:16483693 | Cnn3 | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of CNN3 mRNA | CTD | PMID:30779732 | Cnn3 | Rat | antimycin A | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Antimycin A results in increased expression of CNN3 mRNA | CTD | PMID:33512557 | Cnn3 | Rat | benzo[a]pyrene | increases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CNN3 mRNA | CTD | PMID:22228805 and PMID:22610609 | Cnn3 | Rat | benzo[a]pyrene | decreases methylation | ISO | CNN3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of CNN3 promoter | CTD | PMID:27901495 | Cnn3 | Rat | beta-naphthoflavone | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CNN3 mRNA | CTD | PMID:18164116 | Cnn3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CNN3 mRNA and bisphenol A results in increased expression of CNN3 protein | CTD | PMID:22649256 and PMID:25181051 | Cnn3 | Rat | bisphenol A | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of CNN3 protein | CTD | PMID:34186270 | Cnn3 | Rat | bisphenol A | decreases methylation | ISO | CNN3 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of CNN3 gene | CTD | PMID:31601247 | Cnn3 | Rat | bisphenol A | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of CNN3 mRNA | CTD | PMID:33221593 | Cnn3 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of CNN3 mRNA | CTD | PMID:30903817 | Cnn3 | Rat | bisphenol A | affects expression | ISO | CNN3 (Homo sapiens) | 6480464 | bisphenol A affects the expression of CNN3 mRNA | CTD | PMID:30903817 | Cnn3 | Rat | Bisphenol B | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of CNN3 protein | CTD | PMID:34186270 | Cnn3 | Rat | bisphenol F | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CNN3 mRNA | CTD | PMID:28628672 | Cnn3 | Rat | bisphenol F | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of CNN3 protein | CTD | PMID:34186270 | Cnn3 | Rat | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of CNN3 protein | CTD | PMID:28903499 | Cnn3 | Rat | cadmium atom | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Cadmium results in increased expression of CNN3 mRNA | CTD | PMID:24284285 | Cnn3 | Rat | cadmium dichloride | affects expression | EXP | | 6480464 | Cadmium Chloride affects the expression of CNN3 mRNA | CTD | PMID:22110744 | Cnn3 | Rat | cadmium dichloride | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of CNN3 mRNA | CTD | PMID:26472689 | Cnn3 | Rat | caffeine | increases phosphorylation | ISO | CNN3 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of CNN3 protein | CTD | PMID:35688186 | Cnn3 | Rat | captan | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Captan results in decreased expression of CNN3 mRNA | CTD | PMID:31558096 | Cnn3 | Rat | carbamazepine | affects expression | ISO | CNN3 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of CNN3 mRNA | CTD | PMID:25979313 | Cnn3 | Rat | carbon nanotube | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Cnn3 | Rat | chlorpyrifos | increases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of CNN3 mRNA | CTD | PMID:37019170 | Cnn3 | Rat | chromium(6+) | affects expression | ISO | Cnn3 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of CNN3 mRNA | CTD | PMID:28472532 | Cnn3 | Rat | cisplatin | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | Cisplatin inhibits the reaction [Piroxicam results in decreased expression of CNN3 mRNA] | CTD | PMID:21858171 | Cnn3 | Rat | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of CNN3 protein | CTD | PMID:24386269 | Cnn3 | Rat | copper(II) sulfate | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of CNN3 mRNA | CTD | PMID:19549813 | Cnn3 | Rat | CU-O LINKAGE | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | cupric oxide results in increased expression of CNN3 protein | CTD | PMID:25470785 | Cnn3 | Rat | cyclosporin A | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CNN3 mRNA | CTD | PMID:20106945 more ... | Cnn3 | Rat | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of CNN3 mRNA | CTD | PMID:23914054 | Cnn3 | Rat | dexamethasone | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CNN3 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of CNN3 mRNA | CTD | PMID:28628672 | Cnn3 | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of CNN3 mRNA | CTD | PMID:21266533 | Cnn3 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of CNN3 mRNA | CTD | PMID:17379624 | Cnn3 | Rat | dibutyl phthalate | increases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of CNN3 mRNA | CTD | PMID:17361019 and PMID:21266533 | Cnn3 | Rat | dichlorine | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of CNN3 mRNA | CTD | PMID:18636392 | Cnn3 | Rat | diethylstilbestrol | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Diethylstilbestrol results in increased expression of CNN3 mRNA | CTD | PMID:36621641 | Cnn3 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of CNN3 mRNA | CTD | PMID:25152437 | Cnn3 | Rat | elemental selenium | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Selenium results in increased expression of CNN3 mRNA | CTD | PMID:19244175 | Cnn3 | Rat | enzyme inhibitor | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CNN3 protein | CTD | PMID:23301498 | Cnn3 | Rat | epoxiconazole | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of CNN3 mRNA | CTD | PMID:35436446 | Cnn3 | Rat | ethanol | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Ethanol results in decreased expression of CNN3 protein | CTD | PMID:20621659 | Cnn3 | Rat | folic acid | multiple interactions | ISO | Cnn3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CNN3 mRNA | CTD | PMID:22206623 | Cnn3 | Rat | folic acid | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of CNN3 mRNA | CTD | PMID:25629700 | Cnn3 | Rat | folpet | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | folpet results in decreased expression of CNN3 mRNA | CTD | PMID:31558096 | Cnn3 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of CNN3 mRNA | CTD | PMID:33387578 | Cnn3 | Rat | hyaluronic acid | decreases expression | EXP | | 6480464 | Hyaluronic Acid analog results in decreased expression of CNN3 protein | CTD | PMID:23178681 | Cnn3 | Rat | hydrogen peroxide | decreases expression | EXP | | 6480464 | Hydrogen Peroxide results in decreased expression of CNN3 protein | CTD | PMID:23178681 | Cnn3 | Rat | indometacin | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CNN3 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of CNN3 mRNA | CTD | PMID:28628672 | Cnn3 | Rat | iron atom | increases expression | EXP | | 6480464 | Iron deficiency results in increased expression of CNN3 mRNA | CTD | PMID:16629162 | Cnn3 | Rat | iron(0) | increases expression | EXP | | 6480464 | Iron deficiency results in increased expression of CNN3 mRNA | CTD | PMID:16629162 | Cnn3 | Rat | ivermectin | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of CNN3 protein | CTD | PMID:32959892 | Cnn3 | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of CNN3 mRNA | CTD | PMID:24136188 | Cnn3 | Rat | lipopolysaccharide | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | [NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CNN3 mRNA | CTD | PMID:35877022 | Cnn3 | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CNN3 mRNA | CTD | PMID:18164116 | Cnn3 | Rat | ochratoxin A | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | ochratoxin A results in decreased expression of CNN3 protein | CTD | PMID:19445961 | Cnn3 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CNN3 mRNA | CTD | PMID:25729387 | Cnn3 | Rat | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of CNN3 mRNA | CTD | PMID:18636392 | Cnn3 | Rat | ozone | increases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Ozone results in increased expression of CNN3 mRNA | CTD | PMID:31626304 | Cnn3 | Rat | p-toluidine | increases expression | EXP | | 6480464 | 4-toluidine results in increased expression of CNN3 mRNA | CTD | PMID:27638505 | Cnn3 | Rat | perfluorooctanoic acid | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of CNN3 protein | CTD | PMID:26879310 | Cnn3 | Rat | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of CNN3 mRNA | CTD | PMID:19162173 | Cnn3 | Rat | PhIP | increases expression | EXP | | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of CNN3 mRNA | CTD | PMID:12376462 | Cnn3 | Rat | pirinixic acid | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of CNN3 mRNA | CTD | PMID:17426115 | Cnn3 | Rat | piroxicam | multiple interactions | ISO | CNN3 (Homo sapiens) | 6480464 | Cisplatin inhibits the reaction [Piroxicam results in decreased expression of CNN3 mRNA] | CTD | PMID:21858171 | Cnn3 | Rat | piroxicam | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of CNN3 mRNA | CTD | PMID:21858171 | Cnn3 | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of CNN3 mRNA | CTD | PMID:28374803 | Cnn3 | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of CNN3 protein | CTD | PMID:35544339 | Cnn3 | Rat | rotenone | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Rotenone results in increased expression of CNN3 mRNA | CTD | PMID:33512557 | Cnn3 | Rat | selenium atom | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Selenium results in increased expression of CNN3 mRNA | CTD | PMID:19244175 | Cnn3 | Rat | sodium dichromate | decreases expression | EXP | | 6480464 | sodium bichromate results in decreased expression of CNN3 mRNA | CTD | PMID:22561333 | Cnn3 | Rat | sodium dichromate | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | sodium bichromate results in decreased expression of CNN3 mRNA | CTD | PMID:31558096 | Cnn3 | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of CNN3 mRNA | CTD | PMID:19281266 | Cnn3 | Rat | sulforaphane | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of CNN3 mRNA | CTD | PMID:31838189 | Cnn3 | Rat | sunitinib | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of CNN3 mRNA | CTD | PMID:31533062 | Cnn3 | Rat | tebufenpyrad | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of CNN3 mRNA | CTD | PMID:33512557 | Cnn3 | Rat | temozolomide | increases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of CNN3 mRNA | CTD | PMID:31758290 | Cnn3 | Rat | tetrachloromethane | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of CNN3 mRNA | CTD | PMID:31919559 | Cnn3 | Rat | thapsigargin | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Thapsigargin results in decreased expression of CNN3 mRNA | CTD | PMID:22378314 | Cnn3 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CNN3 mRNA | CTD | PMID:23411599 | Cnn3 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of CNN3 mRNA | CTD | PMID:34492290 | Cnn3 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CNN3 mRNA | CTD | PMID:25729387 | Cnn3 | Rat | trichostatin A | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of CNN3 mRNA | CTD | PMID:24935251 | Cnn3 | Rat | tunicamycin | decreases expression | ISO | CNN3 (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of CNN3 mRNA | CTD | PMID:22378314 | Cnn3 | Rat | valproic acid | decreases methylation | ISO | CNN3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of CNN3 gene | CTD | PMID:29154799 | Cnn3 | Rat | zearalenone | decreases expression | ISO | Cnn3 (Mus musculus) | 6480464 | Zearalenone results in decreased expression of CNN3 protein | CTD | PMID:36252740 | Cnn3 | Rat | zinc atom | decreases expression | EXP | | 6480464 | Zinc results in decreased expression of CNN3 mRNA | CTD | PMID:17074742 | Cnn3 | Rat | zinc sulfate | decreases expression | EXP | | 6480464 | Zinc Sulfate results in decreased expression of CNN3 mRNA | CTD | PMID:17074742 | Cnn3 | Rat | zinc(0) | decreases expression | EXP | | 6480464 | Zinc results in decreased expression of CNN3 mRNA | CTD | PMID:17074742 | |