Clk3 (CDC-like kinase 3) - Rat Genome Database

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Gene: Clk3 (CDC-like kinase 3) Rattus norvegicus
Analyze
Symbol: Clk3
Name: CDC-like kinase 3
RGD ID: 621259
Description: Enables protein kinase activity. Predicted to be involved in protein phosphorylation and regulation of RNA splicing. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Predicted to be located in intermediate filament cytoskeleton and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CLK3 (CDC like kinase 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity protein kinase CLK3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,048,121 - 67,063,192 (-)NCBIGRCr8
mRatBN7.2858,152,155 - 58,167,196 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,152,155 - 58,168,181 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,685,282 - 63,698,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,962,856 - 61,976,365 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,827,402 - 59,840,911 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,528,135 - 62,543,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,528,225 - 62,542,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,305,094 - 62,320,487 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,519,196 - 61,532,816 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,538,249 - 61,551,870 (-)NCBI
Celera857,617,880 - 57,631,407 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Clk3RatBardet-Biedl syndrome  ISORGD:7336258554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:28492532
Clk3RatBloom syndrome  ISORGD:7336258554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
Clk3RatBrugada syndrome 8  ISORGD:7336258554872ClinVar Annotator: match by term: Brugada syndrome 8ClinVarPMID:28492532
Clk3Ratcolorectal cancer  ISORGD:7336258554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
Clk3RatPAPA syndrome  ISORGD:7336258554872ClinVar Annotator: match by term: PAPA SYNDROMEClinVarPMID:28492532
Clk3Ratschizophrenia  ISORGD:7336258554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311

1 to 20 of 84 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Clk3Rat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:7336256480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CLK3 mRNACTDPMID:22079256
Clk3Rat(1->4)-beta-D-glucan multiple interactionsISORGD:15536516480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CLK3 mRNACTDPMID:36331819
Clk3Rat1,2-dimethylhydrazine multiple interactionsISORGD:15536516480464Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CLK3 mRNA]CTDPMID:22206623
Clk3Rat1,2-dimethylhydrazine increases expressionISORGD:155365164804641,2-Dimethylhydrazine results in increased expression of CLK3 mRNACTDPMID:22206623
Clk3Rat17alpha-ethynylestradiol multiple interactionsISORGD:15536516480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLK3 mRNACTDPMID:17942748
Clk3Rat17beta-estradiol decreases expressionISORGD:15536516480464Estradiol results in decreased expression of CLK3 mRNACTDPMID:39298647
Clk3Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of CLK3 mRNACTDPMID:35192832
Clk3Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:73362564804642,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CLK3 mRNACTDPMID:19095052
Clk3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:15536516480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLK3 mRNACTDPMID:17942748
Clk3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:15536516480464Tetrachlorodibenzodioxin affects the expression of CLK3 mRNACTDPMID:21570461
Clk3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CLK3 mRNACTDPMID:16960034|PMID:21215274|PMID:33387578
Clk3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:15536516480464Tetrachlorodibenzodioxin results in increased expression of CLK3 mRNACTDPMID:16960034
Clk3Rat2-hydroxypropanoic acid decreases expressionISORGD:7336256480464Lactic Acid results in decreased expression of CLK3 mRNACTDPMID:30851411
Clk3Rat3-methylcholanthrene multiple interactionsISORGD:7336256480464Methylcholanthrene promotes the reaction [AHR protein binds to CLK3 promoter]CTDPMID:20348232
Clk3Rat4,4'-diaminodiphenylmethane decreases expressionISORGD:155365164804644,4'-diaminodiphenylmethane results in decreased expression of CLK3 mRNACTDPMID:18648102
Clk3Rat4,4'-sulfonyldiphenol decreases expressionISORGD:15536516480464bisphenol S results in decreased expression of CLK3 mRNACTDPMID:39298647
Clk3Rat4-hydroxynon-2-enal decreases expressionISORGD:73362564804644-hydroxy-2-nonenal results in decreased expression of CLK3 mRNACTDPMID:12419474
Clk3Rat5-iodotubercidin decreases activityISORGD:73362564804645-iodotubercidin results in decreased activity of CLK3 proteinCTDPMID:26953159
Clk3Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of CLK3 mRNACTDPMID:30047161
Clk3Ratacetylsalicylic acid decreases expressionISORGD:7336256480464Aspirin results in decreased expression of CLK3 mRNACTDPMID:15928584

1 to 20 of 84 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Clk3Ratpeptidyl-tyrosine phosphorylation acts_upstream_of_or_withinISORGD:15536511624291 PMID:9307018RGDPMID:9307018
Clk3Ratprotein autophosphorylation acts_upstream_of_or_withinISORGD:15536511624291 PMID:9307018RGDPMID:9307018
Clk3Ratprotein phosphorylation involved_inISORGD:15536511624291 PMID:9307018RGDPMID:9307018
Clk3Ratprotein phosphorylation involved_inISORGD:7336251624291 PMID:9637771RGDPMID:9637771
Clk3Ratregulation of RNA splicing involved_inISSUniProtKB:P497611600115GO_REF:0000024UniProtGO_REF:0000024
Clk3Ratregulation of RNA splicing involved_inIBAPANTHER:PTN002901570|PomBase:SPAC1D4.11c|UniProtKB:P49759|UniProtKB:P49760|UniProtKB:P49761|UniProtKB:Q9HAZ11600115GO_REF:0000033GO_CentralGO_REF:0000033
Clk3Ratregulation of RNA splicing involved_inISORGD:7336251624291 PMID:9637771RGDPMID:9637771
Clk3Ratregulation of RNA splicing involved_inIEAUniProtKB:P49761|ensembl:ENSP000003785051600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Clk3Ratacrosomal vesicle located_inIEAUniProtKB-SubCell:SL-00071600115GO_REF:0000044UniProtGO_REF:0000044
Clk3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Clk3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Clk3Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Clk3Ratintermediate filament cytoskeleton located_inIEAUniProtKB:P49761|ensembl:ENSP000003785051600115GO_REF:0000107EnsemblGO_REF:0000107
Clk3Ratintermediate filament cytoskeleton located_inISORGD:733625|UniProtKB:P49761-11624291 RGDGO_REF:0000052
Clk3Ratnucleoplasm located_inIEAUniProtKB:P49761|ensembl:ENSP000003785051600115GO_REF:0000107EnsemblGO_REF:0000107
Clk3Ratnucleoplasm located_inISORGD:733625|UniProtKB:P49761-11624291 RGDGO_REF:0000052
Clk3Ratnucleus located_inIEAUniProtKB:P49761|ensembl:ENSP000003785051600115GO_REF:0000107EnsemblGO_REF:0000107
Clk3Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Clk3Ratnucleus is_active_inIBAFB:FBgn0265998|MGI:107403|MGI:1098551|MGI:1098669|MGI:1098670|PANTHER:PTN000624720|PomBase:SPAC1D4.11c|SGD:S000003942|UniProtKB:P49760|UniProtKB:P49761|UniProtKB:Q8IL191600115GO_REF:0000033GO_CentralGO_REF:0000033
Clk3Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Clk3Ratnucleus located_inISORGD:7336251624291 PMID:9637771RGDPMID:9637771
Clk3Ratnucleus located_inISORGD:15536511624291 PMID:9307018RGDPMID:9307018
Clk3Ratnucleus located_inISSUniProtKB:P497611600115GO_REF:0000024UniProtGO_REF:0000024
1 to 15 of 15 rows

Molecular Function
1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Clk3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Clk3RatATP binding enablesIEAInterPro:IPR000719|InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Clk3RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Clk3Ratidentical protein binding enablesIEAUniProtKB:P49761|ensembl:ENSP000003785051600115GO_REF:0000107EnsemblGO_REF:0000107
Clk3Ratidentical protein binding enablesISORGD:7336251624291UniProtKB:P49761 PMID:25416956, PMID:32296183RGDPMID:25416956|PMID:32296183
Clk3Ratkinase activity  IDA 727235 RGD 
Clk3Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Clk3Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Clk3Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Clk3Ratprotein binding enablesISORGD:7336251624291UniProtKB:O00560|UniProtKB:O14492-2|UniProtKB:O14978|UniProtKB:O43463|UniProtKB:O75494|UniProtKB:O76064|UniProtKB:P08238|UniProtKB:P09017|UniProtKB:P09629|UniProtKB:P0DJD3|UniProtKB:P10523|UniProtKB:P17509|UniProtKB:P29728|UniProtKB:P29728-2|UniProtKB:P38159|UniProtKB:P49760|UniProtKB:P62258|UniProtKB:P62995|UniProtKB:P78362|UniProtKB:P84103|UniProtKB:Q0VD86|UniProtKB:Q15287|UniProtKB:Q15415|UniProtKB:Q16560-2|UniProtKB:Q5M9Q1|UniProtKB:Q8IWX8|UniProtKB:Q8N2M8|UniProtKB:Q8TAD8|UniProtKB:Q8TBB1|UniProtKB:Q8WTR7|UniProtKB:Q96D03|UniProtKB:Q9BRL6-2|UniProtKB:Q9BSI4|UniProtKB:Q9BUV0|UniProtKB:Q9UBU9|UniProtKB:Q9ULD5|UniProtKB:Q9Y2P0 PMID:16189514, PMID:21044950, PMID:21516116, PMID:22939624, PMID:23455924, PMID:23602568, PMID:25416956, PMID:31515488, PMID:32296183, PMID:32707033, PMID:33961781, PMID:36931259RGDPMID:16189514|PMID:21044950|PMID:21516116|PMID:22939624|PMID:23455924|PMID:23602568|PMID:25416956|PMID:31515488|PMID:32296183|PMID:32707033|PMID:33961781|PMID:36931259
Clk3Ratprotein kinase activity  IDA 727235 RGD 
Clk3Ratprotein kinase activity enablesIEAInterPro:IPR000719|InterPro:IPR0082711600115GO_REF:0000002InterProGO_REF:0000002
Clk3Ratprotein serine kinase activity enablesIEARHEA:179891600115GO_REF:0000116RHEAGO_REF:0000116
Clk3Ratprotein serine/threonine kinase activity enablesISSUniProtKB:O354921600115GO_REF:0000024UniProtGO_REF:0000024
Clk3Ratprotein serine/threonine kinase activity enablesIBAFB:FBgn0265998|MGI:107403|MGI:1098551|MGI:1098669|MGI:1098670|PANTHER:PTN000624720|PomBase:SPAC1D4.11c|SGD:S000003942|UniProtKB:P49759|UniProtKB:P497601600115GO_REF:0000033GO_CentralGO_REF:0000033
Clk3Ratprotein serine/threonine kinase activity enablesISORGD:15536511624291 PMID:9307018RGDPMID:9307018
Clk3Ratprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-07231600115GO_REF:0000043UniProtGO_REF:0000043
Clk3Ratprotein serine/threonine/tyrosine kinase activity enablesIEAEC:2.7.12.11600115GO_REF:0000003UniProtGO_REF:0000003
Clk3Ratprotein tyrosine kinase activity enablesIEAUniProtKB-KW:KW-08291600115GO_REF:0000043UniProtGO_REF:0000043
Clk3Ratprotein tyrosine kinase activity enablesISORGD:15536511624291 PMID:9307018RGDPMID:9307018
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#
Reference Title
Reference Citation
1. cDNA cloning and characterization of rat Clk3, a LAMMER kinase predominately expressed in testis. Becker W, etal., Biochim Biophys Acta 1996 Jun 5;1312(1):63-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
PMID:9307018   PMID:9637771   PMID:19946888   PMID:22658674   PMID:22681889   PMID:25416956   PMID:38438604  



Clk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,048,121 - 67,063,192 (-)NCBIGRCr8
mRatBN7.2858,152,155 - 58,167,196 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,152,155 - 58,168,181 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,685,282 - 63,698,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,962,856 - 61,976,365 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,827,402 - 59,840,911 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,528,135 - 62,543,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,528,225 - 62,542,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,305,094 - 62,320,487 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,519,196 - 61,532,816 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,538,249 - 61,551,870 (-)NCBI
Celera857,617,880 - 57,631,407 (-)NCBICelera
Cytogenetic Map8q24NCBI
CLK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,608,372 - 74,630,201 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,598,500 - 74,645,414 (+)EnsemblGRCh38hg38GRCh38
GRCh371574,900,713 - 74,922,542 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,687,766 - 72,709,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 341572,687,765 - 72,709,511NCBI
Celera1551,850,648 - 51,872,477 (+)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,698,874 - 51,720,703 (+)NCBIHuRef
CHM1_11575,019,166 - 75,040,995 (+)NCBICHM1_1
T2T-CHM13v2.01572,478,273 - 72,500,102 (+)NCBIT2T-CHM13v2.0
Clk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,657,904 - 57,672,397 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,657,907 - 57,673,143 (-)EnsemblGRCm39 Ensembl
GRCm38957,750,621 - 57,766,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,750,624 - 57,765,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv37957,598,518 - 57,613,667 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,548,848 - 57,563,997 (-)NCBIMGSCv36mm8
Celera954,979,934 - 54,995,075 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.47NCBI
Clk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,250,444 - 3,262,920 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,250,169 - 3,262,977 (-)NCBIChiLan1.0ChiLan1.0
CLK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,840,095 - 63,861,949 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,003,680 - 68,025,617 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,550,793 - 53,576,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,181,664 - 73,196,466 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,181,664 - 73,196,148 (+)Ensemblpanpan1.1panPan2
CLK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,706,895 - 37,719,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,706,645 - 37,719,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,640,472 - 37,653,252 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03037,912,348 - 37,925,129 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3037,915,589 - 37,925,202 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,864,932 - 37,877,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03037,890,620 - 37,903,396 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,145,976 - 38,158,756 (+)NCBIUU_Cfam_GSD_1.0
Clk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,752,697 - 115,767,123 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,600,544 - 33,618,378 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,600,909 - 33,615,186 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,895,419 - 58,909,551 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,895,407 - 58,909,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,583,925 - 63,598,457 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,846,970 - 8,862,831 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048132,767,941 - 132,783,228 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478142,251 - 51,765 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478142,251 - 55,105 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Clk3
44 total Variants

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:52
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000068108
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 60 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat

1 to 10 of 60 rows
BE116970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,152,390 - 58,152,626 (+)MAPPERmRatBN7.2
Rnor_6.0862,528,371 - 62,528,606NCBIRnor6.0
Rnor_5.0862,305,330 - 62,305,565UniSTSRnor5.0
RGSC_v3.4861,519,342 - 61,519,577UniSTSRGSC3.4
Celera857,618,026 - 57,618,261UniSTS
RH 3.4 Map8670.1UniSTS
Cytogenetic Map8q24UniSTS
RH136098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,152,848 - 58,153,016 (+)MAPPERmRatBN7.2
Rnor_6.0862,528,829 - 62,528,996NCBIRnor6.0
Rnor_5.0862,305,788 - 62,305,955UniSTSRnor5.0
RGSC_v3.4861,519,800 - 61,519,967UniSTSRGSC3.4
Celera857,618,484 - 57,618,651UniSTS
Cytogenetic Map8q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000068108   ⟹   ENSRNOP00000061691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,152,155 - 58,166,886 (-)Ensembl
Rnor_6.0 Ensembl862,528,225 - 62,541,959 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080071   ⟹   ENSRNOP00000072998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,152,182 - 58,168,181 (-)Ensembl
Rnor_6.0 Ensembl862,528,259 - 62,542,622 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110279   ⟹   ENSRNOP00000097825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,152,246 - 58,166,141 (-)Ensembl
RefSeq Acc Id: NM_134340   ⟹   NP_599167
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,048,123 - 67,061,649 (-)NCBI
mRatBN7.2858,152,245 - 58,165,775 (-)NCBI
Rnor_6.0862,528,225 - 62,541,959 (-)NCBI
Rnor_5.0862,305,094 - 62,320,487 (-)NCBI
RGSC_v3.4861,519,196 - 61,532,816 (-)RGD
Celera857,617,880 - 57,631,407 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243146   ⟹   XP_006243208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,048,121 - 67,063,192 (-)NCBI
mRatBN7.2858,152,155 - 58,167,196 (-)NCBI
Rnor_6.0862,528,135 - 62,543,550 (-)NCBI
Rnor_5.0862,305,094 - 62,320,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080747   ⟹   XP_038936675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,048,121 - 67,062,013 (-)NCBI
mRatBN7.2858,152,155 - 58,165,031 (-)NCBI
RefSeq Acc Id: XM_063264824   ⟹   XP_063120894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,048,121 - 67,062,054 (-)NCBI
RefSeq Acc Id: XM_063264825   ⟹   XP_063120895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,048,121 - 67,062,225 (-)NCBI
RefSeq Acc Id: XM_063264826   ⟹   XP_063120896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,048,121 - 67,061,586 (-)NCBI
RefSeq Acc Id: XM_063264827   ⟹   XP_063120897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8867,048,121 - 67,062,236 (-)NCBI
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_599167   ⟸   NM_134340
- UniProtKB: Q63117 (UniProtKB/Swiss-Prot),   Q6IRK2 (UniProtKB/Swiss-Prot),   A6J4X9 (UniProtKB/TrEMBL),   A0A8I6GM85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243208   ⟸   XM_006243146
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UQV5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072998   ⟸   ENSRNOT00000080071
Ensembl Acc Id: ENSRNOP00000061691   ⟸   ENSRNOT00000068108
RefSeq Acc Id: XP_038936675   ⟸   XM_039080747
- Peptide Label: isoform X2
- UniProtKB: Q63117 (UniProtKB/Swiss-Prot),   Q6IRK2 (UniProtKB/Swiss-Prot),   A6J4X9 (UniProtKB/TrEMBL),   A0A8I6GM85 (UniProtKB/TrEMBL)
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-Q63117-F1-model_v2 AlphaFold Q63117 1-490 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696020
Promoter ID:EPDNEW_R6545
Type:single initiation site
Name:Clk3_2
Description:CDC-like kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6546  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0862,541,919 - 62,541,979EPDNEW
RGD ID:13696027
Promoter ID:EPDNEW_R6546
Type:initiation region
Name:Clk3_1
Description:CDC-like kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6545  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0862,542,583 - 62,542,643EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30294 BioCyc
Ensembl Genes ENSRNOG00000030126 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000068108 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099115 IMAGE-MGC_LOAD
InterPro CLK_kinases UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:171305 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91497 IMAGE-MGC_LOAD
NCBI Gene 171305 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE CLK3 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE DOA-RELATED UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Clk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030126 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6GM85 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QUB6_RAT UniProtKB/TrEMBL
  A0A8L2UQV5 ENTREZGENE, UniProtKB/TrEMBL
  A6J4X7_RAT UniProtKB/TrEMBL
  A6J4X9 ENTREZGENE, UniProtKB/TrEMBL
  A6J4Y0_RAT UniProtKB/TrEMBL
  CLK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IRK2 ENTREZGENE
UniProt Secondary Q6IRK2 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Clk3  CDC-like kinase 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Clk3  CDC-like kinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression mRNA is expressed predominantly in testis 727235