Fam229b (family with sequence similarity 229, member B) - Rat Genome Database

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Gene: Fam229b (family with sequence similarity 229, member B) Rattus norvegicus
Analyze
Symbol: Fam229b
Name: family with sequence similarity 229, member B
RGD ID: 2300149
Description: Orthologous to human FAM229B (family with sequence similarity 229 member B); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC100188933; LOC100188933; MGC188102; Uncharacterized protein LOC619208 homolog; UPF0731 protein C6orf225 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,093,492 - 44,106,871 (-)NCBIGRCr8
mRatBN7.22042,538,853 - 42,552,355 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2042,538,868 - 42,552,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2044,287,635 - 44,301,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02043,946,840 - 43,960,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02044,677,464 - 44,690,973 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,207,463 - 44,220,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,207,478 - 44,220,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02045,931,971 - 45,947,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,266,782 - 43,279,959 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2043,255,097 - 43,268,621 (-)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 45 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam229bRat(1->4)-beta-D-glucan multiple interactionsISORGD:16240086480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of FAM229B mRNACTDPMID:36331819
Fam229bRat17beta-estradiol 3-benzoate increases methylationEXP 6480464estradiol 3-benzoate results in increased methylation of FAM229B promoterCTDPMID:27415467
Fam229bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:16240086480464Tetrachlorodibenzodioxin results in increased expression of FAM229B mRNACTDPMID:27913140
Fam229bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of FAM229B mRNACTDPMID:33387578
Fam229bRataflatoxin B1 decreases methylationISORGD:22988366480464Aflatoxin B1 results in decreased methylation of FAM229B geneCTDPMID:27153756
Fam229bRatall-trans-retinoic acid decreases expressionISORGD:22988366480464Tretinoin results in decreased expression of FAM229B mRNACTDPMID:33167477
Fam229bRatarsane multiple interactionsISORGD:22988366480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
Fam229bRatarsenic atom multiple interactionsISORGD:22988366480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
Fam229bRatbenzo[a]pyrene increases methylationISORGD:22988366480464Benzo(a)pyrene results in increased methylation of FAM229B 5' UTRCTDPMID:27901495
Fam229bRatbeta-lapachone decreases expressionISORGD:22988366480464beta-lapachone results in decreased expression of FAM229B mRNACTDPMID:38218311
Fam229bRatbisphenol A affects methylationEXP 6480464bisphenol A affects the methylation of FAM229B promoterCTDPMID:27415467
Fam229bRatbisphenol A decreases methylationISORGD:22988366480464bisphenol A results in decreased methylation of FAM229B geneCTDPMID:31601247
Fam229bRatbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of FAM229B geneCTDPMID:28505145
Fam229bRatcadmium atom multiple interactionsISORGD:22988366480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FAM229B more ...CTDPMID:35301059
Fam229bRatcadmium dichloride multiple interactionsISORGD:22988366480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FAM229B more ...CTDPMID:35301059
Fam229bRatchlordecone decreases expressionISORGD:16240086480464Chlordecone results in decreased expression of FAM229B mRNACTDPMID:29980752
Fam229bRatcyclosporin A decreases expressionISORGD:22988366480464Cyclosporine results in decreased expression of FAM229B mRNACTDPMID:25562108
Fam229bRatdicrotophos decreases expressionISORGD:22988366480464dicrotophos results in decreased expression of FAM229B mRNACTDPMID:28302478
Fam229bRatdiethylstilbestrol decreases expressionISORGD:22988366480464Diethylstilbestrol results in decreased expression of FAM229B mRNACTDPMID:36621641
Fam229bRatfuran increases expressionEXP 6480464furan results in increased expression of FAM229B mRNACTDPMID:25539665|PMID:27387713

1 to 20 of 45 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam229bRatprotein binding enablesISORGD:22988361624291UniProtKB:Q96PF2|UniProtKB:Q9BXA7 PMID:32296183, PMID:32707033RGDPMID:32296183|PMID:32707033


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:15489334  



Fam229b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,093,492 - 44,106,871 (-)NCBIGRCr8
mRatBN7.22042,538,853 - 42,552,355 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2042,538,868 - 42,552,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2044,287,635 - 44,301,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02043,946,840 - 43,960,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02044,677,464 - 44,690,973 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02044,207,463 - 44,220,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2044,207,478 - 44,220,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02045,931,971 - 45,947,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42043,266,782 - 43,279,959 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2043,255,097 - 43,268,621 (-)NCBICelera
Cytogenetic Map20q12NCBI
FAM229B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386112,087,591 - 112,102,790 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6112,087,591 - 112,102,790 (+)EnsemblGRCh38hg38GRCh38
GRCh376112,408,794 - 112,423,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366112,515,367 - 112,530,686 (+)NCBINCBI36Build 36hg18NCBI36
Celera6113,149,981 - 113,165,299 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6109,983,541 - 109,998,854 (+)NCBIHuRef
CHM1_16112,671,010 - 112,686,329 (+)NCBICHM1_1
T2T-CHM13v2.06113,271,009 - 113,286,208 (+)NCBIT2T-CHM13v2.0
Fam229b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391038,994,800 - 39,009,936 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1038,994,800 - 39,009,910 (-)EnsemblGRCm39 Ensembl
GRCm381039,118,804 - 39,133,914 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1039,118,804 - 39,133,914 (-)EnsemblGRCm38mm10GRCm38
MGSCv371038,838,614 - 38,853,701 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361038,808,224 - 38,823,311 (-)NCBIMGSCv36mm8
Celera1040,003,019 - 40,018,124 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1020.14NCBI
Fam229b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555264,469,766 - 4,484,738 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555264,469,766 - 4,484,934 (-)NCBIChiLan1.0ChiLan1.0
FAM229B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25132,103,553 - 132,117,927 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16129,991,763 - 130,006,138 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06109,897,954 - 109,914,304 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16113,973,172 - 113,989,558 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6113,973,172 - 113,989,558 (+)Ensemblpanpan1.1panPan2
FAM229B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11268,514,195 - 68,527,031 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1268,514,303 - 68,527,115 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1268,333,036 - 68,353,188 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01269,396,303 - 69,416,542 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1269,396,419 - 69,409,236 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11268,755,779 - 68,776,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01268,593,289 - 68,613,584 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01268,920,274 - 68,940,474 (+)NCBIUU_Cfam_GSD_1.0
Fam229b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946103,551,167 - 103,566,092 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936679783,329 - 802,838 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936679783,363 - 798,261 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM229B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl178,058,529 - 78,063,272 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1178,048,496 - 78,063,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,717,419 - 87,732,096 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM229B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11361,755,601 - 61,769,048 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1361,755,707 - 61,768,921 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604034,091,212 - 34,104,801 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Fam229b
188 total Variants

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:84
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000036853
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 14 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat

1 to 10 of 14 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 85 84 53 25 53 6 212 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000036853   ⟹   ENSRNOP00000038054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2042,538,868 - 42,552,248 (-)Ensembl
Rnor_6.0 Ensembl2044,207,478 - 44,220,702 (-)Ensembl
RefSeq Acc Id: NM_001134695   ⟹   NP_001128167
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,093,492 - 44,106,871 (-)NCBI
mRatBN7.22042,538,867 - 42,552,248 (-)NCBI
Rnor_6.02044,207,477 - 44,220,702 (-)NCBI
Rnor_5.02045,931,971 - 45,947,772 (-)NCBI
RGSC_v3.42043,266,782 - 43,279,959 (-)RGD
Celera2043,255,097 - 43,268,621 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098352   ⟹   XP_038954280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,093,492 - 44,105,417 (-)NCBI
mRatBN7.22042,538,853 - 42,552,352 (-)NCBI
RefSeq Acc Id: XM_039098356   ⟹   XP_038954284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,093,492 - 44,105,421 (-)NCBI
mRatBN7.22042,538,853 - 42,552,352 (-)NCBI
RefSeq Acc Id: XM_063278904   ⟹   XP_063134974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,093,492 - 44,097,614 (-)NCBI
RefSeq Acc Id: XM_063278905   ⟹   XP_063134975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,093,492 - 44,097,623 (-)NCBI
RefSeq Acc Id: XM_063278906   ⟹   XP_063134976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,093,492 - 44,105,417 (-)NCBI
RefSeq Acc Id: XM_063278907   ⟹   XP_063134977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,094,711 - 44,105,417 (-)NCBI
RefSeq Acc Id: NP_001128167   ⟸   NM_001134695
- UniProtKB: B0BND4 (UniProtKB/Swiss-Prot),   A6KIF1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038054   ⟸   ENSRNOT00000036853
RefSeq Acc Id: XP_038954280   ⟸   XM_039098352
- Peptide Label: isoform X1
- UniProtKB: B0BND4 (UniProtKB/Swiss-Prot),   A6KIF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954284   ⟸   XM_039098356
- Peptide Label: isoform X1
- UniProtKB: B0BND4 (UniProtKB/Swiss-Prot),   A6KIF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134976   ⟸   XM_063278906
- Peptide Label: isoform X1
- UniProtKB: B0BND4 (UniProtKB/Swiss-Prot),   A6KIF1 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-B0BND4-F1-model_v2 AlphaFold B0BND4 1-80 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701648
Promoter ID:EPDNEW_R12172
Type:initiation region
Name:Fam229b_1
Description:family with sequence similarity 229, member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02044,220,725 - 44,220,785EPDNEW


1 to 14 of 14 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-3479 BioCyc
Ensembl Genes ENSRNOG00000024918 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036853 ENTREZGENE
  ENSRNOT00000036853.3 UniProtKB/Swiss-Prot
InterPro FAM229 UniProtKB/Swiss-Prot
KEGG Report rno:100188933 UniProtKB/Swiss-Prot
NCBI Gene 100188933 ENTREZGENE
PANTHER PROTEIN FAM229B UniProtKB/Swiss-Prot
  PTHR35355 UniProtKB/Swiss-Prot
Pfam UPF0731 UniProtKB/Swiss-Prot
PhenoGen Fam229b PhenoGen
RatGTEx ENSRNOG00000024918 RatGTEx
UniProt A6KIF1 ENTREZGENE, UniProtKB/TrEMBL
  B0BND4 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 14 of 14 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-20 Fam229b  family with sequence similarity 229, member B  LOC100188933  hypothetical protein LOC100188933  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-06 LOC100188933  hypothetical protein LOC100188933      Symbol and Name status set to provisional 70820 PROVISIONAL