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Gene: Pinx1 (PIN2/TERF1 interacting, telomerase inhibitor 1) Rattus norvegicus

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Symbol:

Pinx1

Name:

PIN2/TERF1 interacting, telomerase inhibitor 1

RGD ID:

1566025

Description:

Predicted to enable telomerase RNA binding activity and telomerase inhibitor activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Predicted to act upstream of or within telomere maintenance via telomerase. Predicted to be located in several cellular components, including chromosome; nucleoplasm; and spindle. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC305963; PIN2-interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; RGD1566025; similar to Pin2-interacting protein X1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	42,273,805 - 42,333,047 (+)	NCBI		GRCr8
mRatBN7.2	15	38,097,896 - 38,157,143 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	38,097,886 - 38,157,140 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	39,955,508 - 40,014,259 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	41,106,199 - 41,164,948 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	39,558,617 - 39,617,496 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	47,211,682 - 47,270,343 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	47,211,583 - 47,270,317 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	50,970,703 - 51,029,737 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	43,124,973 - 43,184,374 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	37,779,927 - 37,838,591 (+)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pinx1	Rat	hepatocellular carcinoma	disease_progression	ISO	PINX1 (Homo sapiens)	152977752	associated with Chronic Hepatitis B and DNA:SNP::rs1469557(human)	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pinx1	Rat	Neurodevelopmental Disorders		ISO	PINX1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pinx1	Rat	(+)-schisandrin B	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PINX1 mRNA]	CTD	PMID:31150632
Pinx1	Rat	1,2-dimethylhydrazine	increases expression	ISO	Pinx1 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in increased expression of PINX1 mRNA	CTD	PMID:22206623
Pinx1	Rat	17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of PINX1 mRNA	CTD	PMID:32145629
Pinx1	Rat	17beta-estradiol	increases expression	ISO	PINX1 (Homo sapiens)	6480464	Estradiol results in increased expression of PINX1 mRNA	CTD	PMID:31614463
Pinx1	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	Pinx1 (Mus musculus)	6480464	AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PINX1 mRNA]	CTD	PMID:15034205
Pinx1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of PINX1 mRNA	CTD	PMID:33387578
Pinx1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Pinx1 (Mus musculus)	6480464	Tetrachlorodibenzodioxin results in increased expression of PINX1 mRNA	CTD	PMID:15034205
Pinx1	Rat	arsenous acid	decreases expression	ISO	PINX1 (Homo sapiens)	6480464	Arsenic Trioxide results in decreased expression of PINX1 mRNA	CTD	PMID:22944098
Pinx1	Rat	atrazine	decreases expression	ISO	PINX1 (Homo sapiens)	6480464	Atrazine results in decreased expression of PINX1 mRNA	CTD	PMID:22378314
Pinx1	Rat	benzo[a]pyrene	multiple interactions	ISO	Pinx1 (Mus musculus)	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PINX1 mRNA and AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of PINX1 mRNA]	CTD	PMID:15034205 and PMID:27858113
Pinx1	Rat	benzo[a]pyrene	affects methylation	ISO	PINX1 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of PINX1 intron	CTD	PMID:30157460
Pinx1	Rat	benzo[a]pyrene	increases expression	ISO	Pinx1 (Mus musculus)	6480464	Benzo(a)pyrene results in increased expression of PINX1 mRNA	CTD	PMID:15034205
Pinx1	Rat	benzo[b]fluoranthene	multiple interactions	ISO	Pinx1 (Mus musculus)	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PINX1 mRNA	CTD	PMID:27858113
Pinx1	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of PINX1 mRNA	CTD	PMID:25181051
Pinx1	Rat	bisphenol A	multiple interactions	ISO	PINX1 (Homo sapiens)	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of PINX1 gene	CTD	PMID:31601247
Pinx1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of PINX1 mRNA	CTD	PMID:32145629 and PMID:34947998
Pinx1	Rat	bisphenol F	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	bisphenol F results in decreased expression of PINX1 mRNA	CTD	PMID:38685157
Pinx1	Rat	butanal	increases expression	ISO	PINX1 (Homo sapiens)	6480464	butyraldehyde results in increased expression of PINX1 mRNA	CTD	PMID:26079696
Pinx1	Rat	cadmium dichloride	decreases expression	ISO	PINX1 (Homo sapiens)	6480464	Cadmium Chloride results in decreased expression of PINX1 mRNA	CTD	PMID:38382870
Pinx1	Rat	cadmium dichloride	increases expression	ISO	PINX1 (Homo sapiens)	6480464	Cadmium Chloride results in increased expression of PINX1 mRNA	CTD	PMID:38568856
Pinx1	Rat	caffeine	decreases phosphorylation	ISO	PINX1 (Homo sapiens)	6480464	Caffeine results in decreased phosphorylation of PINX1 protein	CTD	PMID:35688186
Pinx1	Rat	carbon nanotube	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	Nanotubes more ...	CTD	PMID:25554681
Pinx1	Rat	CGP 52608	multiple interactions	ISO	PINX1 (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to PINX1 gene]	CTD	PMID:28238834
Pinx1	Rat	chrysene	multiple interactions	ISO	Pinx1 (Mus musculus)	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PINX1 mRNA	CTD	PMID:27858113
Pinx1	Rat	cobalt dichloride	decreases expression	ISO	PINX1 (Homo sapiens)	6480464	cobaltous chloride results in decreased expression of PINX1 mRNA	CTD	PMID:19320972
Pinx1	Rat	cocaine	multiple interactions	ISO	Pinx1 (Mus musculus)	6480464	[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PINX1 mRNA	CTD	PMID:18355967
Pinx1	Rat	Cuprizon	decreases expression	EXP		6480464	Cuprizone results in decreased expression of PINX1 mRNA	CTD	PMID:26577399
Pinx1	Rat	cypermethrin	increases expression	ISO	Pinx1 (Mus musculus)	6480464	cypermethrin results in increased expression of PINX1 mRNA	CTD	PMID:21142847
Pinx1	Rat	DDE	increases expression	ISO	PINX1 (Homo sapiens)	6480464	Dichlorodiphenyl Dichloroethylene results in increased expression of PINX1 mRNA	CTD	PMID:38568856
Pinx1	Rat	diarsenic trioxide	decreases expression	ISO	PINX1 (Homo sapiens)	6480464	Arsenic Trioxide results in decreased expression of PINX1 mRNA	CTD	PMID:22944098
Pinx1	Rat	dibutyl phthalate	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	Dibutyl Phthalate results in decreased expression of PINX1 mRNA	CTD	PMID:17361019
Pinx1	Rat	dioxygen	multiple interactions	ISO	Pinx1 (Mus musculus)	6480464	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PINX1 mRNA	CTD	PMID:30529165
Pinx1	Rat	enzyme inhibitor	multiple interactions	ISO	PINX1 (Homo sapiens)	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PINX1 protein	CTD	PMID:23301498
Pinx1	Rat	flutamide	increases expression	EXP		6480464	Flutamide results in increased expression of PINX1 mRNA	CTD	PMID:24136188
Pinx1	Rat	folic acid	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	Folic Acid results in decreased expression of PINX1 mRNA	CTD	PMID:25629700
Pinx1	Rat	FR900359	decreases phosphorylation	ISO	PINX1 (Homo sapiens)	6480464	FR900359 results in decreased phosphorylation of PINX1 protein	CTD	PMID:37730182
Pinx1	Rat	fulvestrant	multiple interactions	ISO	PINX1 (Homo sapiens)	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of PINX1 gene	CTD	PMID:31601247
Pinx1	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of PINX1 mRNA	CTD	PMID:33387578
Pinx1	Rat	hydrogen peroxide	affects expression	ISO	PINX1 (Homo sapiens)	6480464	Hydrogen Peroxide affects the expression of PINX1 mRNA	CTD	PMID:20044591
Pinx1	Rat	methyl methanesulfonate	increases expression	ISO	PINX1 (Homo sapiens)	6480464	Methyl Methanesulfonate results in increased expression of PINX1 mRNA	CTD	PMID:23649840
Pinx1	Rat	N-methyl-N-nitrosourea	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	Methylnitrosourea results in decreased expression of PINX1 mRNA	CTD	PMID:25270620
Pinx1	Rat	ozone	multiple interactions	ISO	Pinx1 (Mus musculus)	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of PINX1 mRNA	CTD	PMID:34911549
Pinx1	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of PINX1 mRNA	CTD	PMID:33387578
Pinx1	Rat	pentanal	increases expression	ISO	PINX1 (Homo sapiens)	6480464	pentanal results in increased expression of PINX1 mRNA	CTD	PMID:26079696
Pinx1	Rat	pirinixic acid	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	pirinixic acid results in decreased expression of PINX1 mRNA	CTD	PMID:23811191
Pinx1	Rat	resveratrol	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	resveratrol results in decreased expression of PINX1 protein	CTD	PMID:25505154
Pinx1	Rat	silicon dioxide	increases expression	ISO	PINX1 (Homo sapiens)	6480464	Silicon Dioxide analog results in increased expression of PINX1 mRNA	CTD	PMID:25895662
Pinx1	Rat	sodium arsenite	decreases expression	ISO	PINX1 (Homo sapiens)	6480464	sodium arsenite results in decreased expression of PINX1 mRNA	CTD	PMID:38568856
Pinx1	Rat	sodium fluoride	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	Sodium Fluoride results in decreased expression of PINX1 mRNA	CTD	PMID:27862939
Pinx1	Rat	tetrachloromethane	increases expression	EXP		6480464	Carbon Tetrachloride results in increased expression of PINX1 mRNA	CTD	PMID:31150632
Pinx1	Rat	tetrachloromethane	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PINX1 mRNA]	CTD	PMID:31150632
Pinx1	Rat	tetraphene	multiple interactions	ISO	Pinx1 (Mus musculus)	6480464	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PINX1 mRNA	CTD	PMID:27858113
Pinx1	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of PINX1 mRNA	CTD	PMID:34492290
Pinx1	Rat	titanium dioxide	decreases expression	ISO	Pinx1 (Mus musculus)	6480464	titanium dioxide results in decreased expression of PINX1 mRNA	CTD	PMID:23557971
Pinx1	Rat	titanium dioxide	increases methylation	ISO	Pinx1 (Mus musculus)	6480464	titanium dioxide results in increased methylation of PINX1 promoter	CTD	PMID:35295148
Pinx1	Rat	valproic acid	increases expression	ISO	PINX1 (Homo sapiens)	6480464	Valproic Acid results in increased expression of PINX1 mRNA	CTD	PMID:23179753 and PMID:28001369
Pinx1	Rat	valproic acid	decreases methylation	ISO	PINX1 (Homo sapiens)	6480464	Valproic Acid results in decreased methylation of PINX1 gene	CTD	PMID:29154799
Pinx1	Rat	valproic acid	affects expression	ISO	PINX1 (Homo sapiens)	6480464	Valproic Acid affects the expression of PINX1 mRNA	CTD	PMID:25979313

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pinx1	Rat	mitotic metaphase chromosome alignment	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	mitotic metaphase chromosome alignment	involved_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:19393617	RGD	PMID:19393617
Pinx1	Rat	negative regulation of G2/M transition of mitotic cell cycle	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	negative regulation of G2/M transition of mitotic cell cycle	involved_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:11701125	RGD	PMID:11701125
Pinx1	Rat	negative regulation of protein ubiquitination	involved_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:24415760	RGD	PMID:24415760
Pinx1	Rat	negative regulation of protein ubiquitination	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	negative regulation of telomere maintenance via telomerase	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	negative regulation of telomere maintenance via telomerase	involved_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:11701125 and PMID:21119197	RGD	PMID:11701125 and PMID:21119197
Pinx1	Rat	positive regulation of protein localization to nucleolus	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	positive regulation of protein localization to nucleolus	involved_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:19265708	RGD	PMID:19265708
Pinx1	Rat	protein localization to chromosome, telomeric region	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	protein localization to chromosome, telomeric region	involved_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:22749911	RGD	PMID:22749911
Pinx1	Rat	protein localization to nucleolus	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	protein localization to nucleolus	involved_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:24415760	RGD	PMID:24415760
Pinx1	Rat	regulation of protein stability	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	regulation of protein stability	involved_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:24415760	RGD	PMID:24415760
Pinx1	Rat	telomere maintenance via telomerase	acts_upstream_of_or_within	ISO	PINX1 (Homo sapiens)	1624291	PMID:11701125	RGD	PMID:11701125
Pinx1	Rat	telomere maintenance via telomerase	involved_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pinx1	Rat	chromosome, telomeric region	located_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	chromosome, telomeric region	located_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:11701125 more ...	RGD	PMID:11701125 more ...
Pinx1	Rat	kinetochore	located_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:19393617	RGD	PMID:19393617
Pinx1	Rat	kinetochore	located_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	mitochondrion	located_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	mitochondrion	located_in	ISO	PINX1 (Homo sapiens) and UniProtKB:Q96BK5-1	1624291		RGD	GO_REF:0000052
Pinx1	Rat	nuclear chromosome	located_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:19393617	RGD	PMID:19393617
Pinx1	Rat	nuclear chromosome	located_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	nucleolus	located_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	nucleolus	located_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:11701125 more ...	RGD	PMID:11701125 more ...
Pinx1	Rat	nucleolus	is_active_in	IBA	PANTHER:PTN000567695 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pinx1	Rat	nucleolus	located_in	ISO	PINX1 (Homo sapiens) and UniProtKB:Q96BK5-1	1624291		RGD	GO_REF:0000052
Pinx1	Rat	nucleoplasm	located_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	nucleoplasm	located_in	ISO	PINX1 (Homo sapiens) and UniProtKB:Q96BK5-1	1624291		RGD	GO_REF:0000052
Pinx1	Rat	spindle	located_in	ISO	PINX1 (Homo sapiens)	1624291	PMID:19393617	RGD	PMID:19393617
Pinx1	Rat	spindle	located_in	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pinx1	Rat	protein binding	enables	ISO	PINX1 (Homo sapiens)	1624291	UniProtKB:O14746 more ...	RGD	PMID:11701125 more ...
Pinx1	Rat	protein-containing complex binding	enables	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	protein-containing complex binding	enables	ISO	PINX1 (Homo sapiens)	1624291	ComplexPortal:CPX-152 PMID:18202258	RGD	PMID:18202258
Pinx1	Rat	telomerase inhibitor activity	enables	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	telomerase inhibitor activity	enables	IBA	PANTHER:PTN001139619 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pinx1	Rat	telomerase inhibitor activity	enables	ISO	PINX1 (Homo sapiens)	1624291	PMID:11701125 and PMID:21119197	RGD	PMID:11701125 and PMID:21119197
Pinx1	Rat	telomerase RNA binding	enables	IEA	UniProtKB:Q96BK5 and ensembl:ENSP00000318966	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pinx1	Rat	telomerase RNA binding	enables	ISO	PINX1 (Homo sapiens)	1624291	PMID:15381700	RGD	PMID:15381700

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Association of PINX1 but not TEP1 Polymorphisms with Progression to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection.	Sriprapun M, etal., Asian Pac J Cancer Prev. 2016;17(4):2019-25. doi: 10.7314/apjcp.2016.17.4.2019.

PMID:11701125	PMID:12477932	PMID:15381700	PMID:17624691	PMID:18202258	PMID:19265708	PMID:19393617	PMID:21119197	PMID:22749911	PMID:24415760	PMID:33819185

Pinx1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	42,273,805 - 42,333,047 (+)	NCBI		GRCr8
mRatBN7.2	15	38,097,896 - 38,157,143 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	38,097,886 - 38,157,140 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	39,955,508 - 40,014,259 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	41,106,199 - 41,164,948 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	39,558,617 - 39,617,496 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	47,211,682 - 47,270,343 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	47,211,583 - 47,270,317 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	50,970,703 - 51,029,737 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	43,124,973 - 43,184,374 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	37,779,927 - 37,838,591 (+)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

PINX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	10,764,961 - 10,839,875 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	10,725,399 - 10,839,847 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p14 Ensembl	8	10,764,961 - 10,839,884 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	10,622,471 - 10,697,385 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	10,660,294 - 10,734,709 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	9,750,922 - 9,825,196 (-)	NCBI		Celera
Cytogenetic Map	8	p23.1	NCBI
HuRef	8	9,553,144 - 9,627,372 (-)	NCBI		HuRef
CHM1_1	8	10,688,381 - 10,762,380 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	8,899,172 - 8,974,128 (+)	NCBI		T2T-CHM13v2.0

Pinx1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	64,097,728 - 64,157,311 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	64,097,813 - 64,157,308 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	63,860,277 - 63,919,862 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	63,860,364 - 63,919,859 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	64,479,149 - 64,538,696 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	62,814,474 - 62,873,914 (+)	NCBI		MGSCv36	mm8
Celera	14	61,637,517 - 61,696,912 (+)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	33.34	NCBI

Pinx1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	52,284,166 - 52,362,206 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	52,284,378 - 52,361,924 (-)	NCBI	ChiLan1.0	ChiLan1.0

PINX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	27,220,919 - 27,297,382 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	3,253,071 - 3,329,606 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	8,366,819 - 8,443,359 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

PINX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	27,090,244 - 27,182,377 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	27,021,704 - 27,181,968 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	27,746,795 - 27,839,000 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	27,245,097 - 27,337,408 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	27,244,824 - 27,336,999 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	27,199,192 - 27,291,630 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	27,093,374 - 27,185,602 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	27,247,284 - 27,339,666 (+)	NCBI		UU_Cfam_GSD_1.0

Pinx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	5,879,927 - 5,944,300 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	2,640,068 - 2,706,238 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	2,641,851 - 2,706,201 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PINX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	13,967,070 - 14,041,788 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	13,965,733 - 14,041,841 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	15,432,132 - 15,483,040 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PINX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	8,259,537 - 8,336,586 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	8,259,692 - 8,336,603 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	34,091,837 - 34,171,496 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pinx1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	24,589,743 - 24,666,598 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	24,589,990 - 24,666,355 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Pinx1
366 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	57
Count of miRNA genes:	51
Interacting mature miRNAs:	57
Transcripts:	ENSRNOT00000016027
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	27885774	86257085	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat

RH128783

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	38,156,801 - 38,157,021 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	47,270,002 - 47,270,221	NCBI	Rnor6.0
Rnor_5.0	15	51,029,396 - 51,029,615	UniSTS	Rnor5.0
RGSC_v3.4	15	43,184,268 - 43,184,487	UniSTS	RGSC3.4
Celera	15	37,838,485 - 37,838,704	UniSTS
Cytogenetic Map	15	p12	UniSTS

RH132666

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	38,144,331 - 38,144,527 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	47,258,112 - 47,258,307	NCBI	Rnor6.0
Rnor_5.0	15	51,017,506 - 51,017,701	UniSTS	Rnor5.0
RGSC_v3.4	15	43,171,798 - 43,171,993	UniSTS	RGSC3.4
Celera	15	37,826,007 - 37,826,202	UniSTS
Cytogenetic Map	15	p12	UniSTS

BQ195852

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	38,116,239 - 38,116,454 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	47,229,722 - 47,229,936	NCBI	Rnor6.0
Rnor_5.0	15	50,989,116 - 50,989,330	UniSTS	Rnor5.0
RGSC_v3.4	15	43,143,541 - 43,143,755	UniSTS	RGSC3.4
Celera	15	37,798,008 - 37,798,222	UniSTS
RH 3.4 Map	15	282.4	UniSTS
Cytogenetic Map	15	p12	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001083337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010057820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010057821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010057822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC158553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF446165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016027 ⟹ ENSRNOP00000016027

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	38,097,886 - 38,157,130 (+)	Ensembl
Rnor_6.0 Ensembl	15	47,211,583 - 47,270,317 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102140 ⟹ ENSRNOP00000085367

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	38,098,756 - 38,157,140 (+)	Ensembl

RefSeq Acc Id:

NM_001083337 ⟹ NP_001076806

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	42,273,805 - 42,333,047 (+)	NCBI
mRatBN7.2	15	38,097,896 - 38,157,143 (+)	NCBI
Rnor_6.0	15	47,211,682 - 47,270,108 (+)	NCBI
Rnor_5.0	15	50,970,703 - 51,029,737 (+)	NCBI
RGSC_v3.4	15	43,124,973 - 43,184,374 (+)	RGD
Celera	15	37,779,927 - 37,838,591 (+)	RGD

Sequence:

show sequence

ATGTCGATGCTAGCGGAGCGTCGGCGGAAGCAGAAATGGGCTGTGGATCCCAGAAATACTGCGTGGAGTAATGATGATTCCAAGTTTGGCCAGAAGATGCTTGAGAAGATGGGGTGGTCTAAAGGAAA
GGGTTTGGGGGCTCAGGAGCAAGGAGCCACAGAACATATTAAAGTTAAAGTTAAAAATAACCACCTGGGACTTGGAGCTACAAACAATAATGAAGACAACTGGATTGCTCACCAGGATGACTTCAACC
AGCTTTTGGCAGCACTCAACACTTGCCATGGTCAGGAAACAGCAGACTCCTCAGACAACAAGGAAAAGAAATCTTTTAGCCTTGAAGAAAAATCCAAAATCTCCAAAAACCGGGTTCATTATATGAAA
TTCACCAAAGGGAAGGACCTGTCCTCTCGGAGCGAAACCGACCTGGATTGTATTTTTGGAAAAAGGAGGAACAAGAAGCTTGCTCAGGACGGCTGCAGCAACTCCACTGCGGATGAGGCGGACACCTC
CCTGACCACGACCACAACCACAACCAGTGCCTTCACCATCCAGGAATATTTTGCCAAGAGGATGGCCCAGTTAAAGAGCAAGTCACAGGCCGCAGCTCCAGGGTCTGACCTTTCAGAGACCCCCATTG
AATGGAAAAAGGGAAAGAAAAAAACCAAAGAGGCAGCAGGCACAGATATAGAGAACTCTCCCCAACACAAGGCCAAGCGGCATAAAAAGAAGAAGCGAGTGGAAGCAGAGAGGGGGCCTGCGGCCAAG
AAGAGAGACCAAGTCGAGCTGCAGCCTGGAGGCCCCAGTGGGGACGAGTGTTCCGACGCCTCTGTGGAGGCTGCAGAGGATCGTGTGCAGACACCAGACACCCAGGATGATGTCCCAAAGCCCAGGAA
GAGGAGAGCAAAGAAGACGCTGCAGAGGCCAGGAGGAGTGGCAGTAGACACTGCACCGGACAGCGCACCAGTGAAGAAGAAGAAGAAAGTTTCCAGATAG

hide sequence

RefSeq Acc Id:

XM_006252181 ⟹ XP_006252243

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	42,277,104 - 42,333,047 (+)	NCBI
mRatBN7.2	15	38,100,334 - 38,157,143 (+)	NCBI
Rnor_6.0	15	47,213,876 - 47,270,343 (+)	NCBI
Rnor_5.0	15	50,970,703 - 51,029,737 (+)	NCBI

Sequence:

show sequence

AATTGAACCCTGGTCCTCTGGAATAACACACAGTACTCTTAACTGCTAAACCATCTCTCCAGCCCACTACATAGCAAATTTCAGGTTAACTTGGGTGCTACGTGAGTCTCCATCTTAACAGTGCCTTA
AATAGTAAATGTTGACATTTGTGAGACTTTGGTTTGTATAAAAGGTTTGGTCTTTACTTGGGGACATCAGGCAGATTTTATTCTCCCAGACTCAGGTTTTCTTTCTCTCTCTCTCTCTCTCTCTCTCT
CTCTCTCTCTCTCTCTCTCTCCCTTTCTTCCTTCCTTTCTTTCTTTCTTTTAACTTTTTATTGATTCTTAGTGAGTTTCACATCACACATCCCAGTTCTTCCTGCTCATCTCCTGTCCCCTCATATAC
CCCCTTTGCCCTTGCGACCTCCCCCCACAATATAAAACACACACAAACAACAAAAGCAAAGCAAAGCAAACATCTCATTGTGGAAGCAGTAGTGTGTCACATTGTATTCCCAGTGTATCTCACTGTCC
ACACATCTTCACTTGCAAATGTTCACTGCAATGAGTCAGGGGTCTGGTTCTAGATCTCTGGTTTCTGTGACACCATCAAAACTTGATCCTTATCGGACTTCTCCTGGTTATCCTGTTGTTGCCCTGTG
TCATGGAGATCCTGCAGCCTTGAATGGTCCCAACTATTCACAGATGATAAAGATTTTGAACCAAATTCAGAGCCCTGGATATGGGTCGGGCAGGTAGCTGAGCTGGTCAGCTTGGCTTTCACTTACCC
ACACCACCAGGGCAGGTGAGCTCCCCAGCACTGCTCCAGCCTATCCAATGCCGCCAGTCATCAGGAGGCAGAGTCCGCTCTCCCGCTCTCTCACCCTCAGGGATGGCTCACCCATGCCTTTGTCATCT
GGGCCAGCTCCACTGTGCTGCCTTGGGTTTTCTTATCAGAAAGGTCGGCGGAAGCAGAAATGGGCTGTGGATCCCAGAAATACTGCGTGGAGTAATGATGATTCCAAGTTTGGCCAGAAGATGCTTGA
GAAGATGGGGTGGTCTAAAGGAAAGGGTTTGGGGGCTCAGGAGCAAGGAGCCACAGAACATATTAAAGTTAAAGTTAAAAATAACCACCTGGGACTTGGAGCTACAAACAATAATGAAGACAACTGGA
TTGCTCACCAGGATGACTTCAACCAGCTTTTGGCAGCACTCAACACTTGCCATGGTCAGGAAACAGCAGATTCCTCAGACAACAAGGAAAAGAAATCTTTTAGCCTTGAAGAAAAATCCAAAATCTCC
AAAAACCGGGTTCATTATATGAAATTCACCAAAGGGAAGGACCTGTCCTCTCGGAGCGAAACCGACCTGGATTGTATTTTTGGAAAAAGGAGGAACAAGAAGCTTGCTCAGGACGGCTGCAGCAACTC
CACTGCGGATGAGGCGGACACCTCCCTGACCACGACCACAACCACAACCAGTGCCTTCACCATCCAGGAATATTTTGCCAAGAGGATGGCCCAGTTAAAGAGCAAGTCACAGGCCGCAGCTCCAGGGT
CTGACCTTTCAGAGACCCCCATTGAATGGAAAAAGGGAAAGAAAAAAACCAAAGAGGCAGCAGGCACAGATATAGAGAACTCTCCCCAACACAAGGCCAAGCGGCATAAAAAGAAGAAGCGAGTGGAA
GCAGAGAGGGGGCCTGCGGCCAAGAAGAGAGACCAAGTCGAGCTGCAGCCTGGAGGCCCCAGTGGGGACGAGTGTTCCGACGCCTCTGTGGAGGCTGCAGAGGATCGTGTGCAGACACCAGACACCCA
GGATGATGTCCCAAAGCCCAGGAAGAGGAGAGCAAAGAAGACGCTGCAGAGGCCAGGAGGAGTGGCAGTAGACACTGCACCGGACAGCGCACCAGTGAAGAAGAAGAAGAAAGTTTCCAGATAGCGTG
TGGCTAGCAGGGTCTCCAGCCACTCAGCACACCACAGGGCAGAACGCTCTGGCCTGCTCAGAGTGCAGCGAGCCCCAGCAGCTCAGCATCTTTCAACTGCCCACAGGTTGCTGGCTCTATGCCCCACA
TCTCCCTCAAGCCACCTTCCTAGGAGAACTGATTTGAATGTTCCAGATCGTGACTTTCAATAAATAAAATAACTTTCAATAAACAAATAGATTCTTTTTTAAA

hide sequence

RefSeq Acc Id:

XM_039093329 ⟹ XP_038949257

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	42,277,104 - 42,292,661 (+)	NCBI
mRatBN7.2	15	38,100,334 - 38,116,756 (+)	NCBI

RefSeq Acc Id:

XM_039093331 ⟹ XP_038949259

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	42,277,104 - 42,333,047 (+)	NCBI
mRatBN7.2	15	38,100,334 - 38,156,547 (+)	NCBI

RefSeq Acc Id:

XM_063274286 ⟹ XP_063130356

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	42,273,814 - 42,292,661 (+)	NCBI

RefSeq Acc Id:

XR_010057820

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	42,277,104 - 42,332,518 (+)	NCBI

RefSeq Acc Id:

XR_010057821

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	42,277,104 - 42,332,518 (+)	NCBI

RefSeq Acc Id:

XR_010057822

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	42,273,814 - 42,332,518 (+)	NCBI


Protein RefSeqs	NP_001076806	(Get FASTA)	NCBI Sequence Viewer
	XP_006252243	(Get FASTA)	NCBI Sequence Viewer
	XP_038949257	(Get FASTA)	NCBI Sequence Viewer
	XP_038949259	(Get FASTA)	NCBI Sequence Viewer
	XP_063130356	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A4L691	(Get FASTA)	NCBI Sequence Viewer
	AAI58554	(Get FASTA)	NCBI Sequence Viewer
	ABO28828	(Get FASTA)	NCBI Sequence Viewer
	EDL85327	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016027.4
	ENSRNOP00000085367.1

RefSeq Acc Id:

NP_001076806 ⟸ NM_001083337

- UniProtKB:

A4L691 (UniProtKB/Swiss-Prot), B0BMT3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSMLAERRRKQKWAVDPRNTAWSNDDSKFGQKMLEKMGWSKGKGLGAQEQGATEHIKVKVKNNHLGLGATNNNEDNWIAHQDDFNQLLAALNTCHGQETADSSDNKEKKSFSLEEKSKISKNRVHYMK
FTKGKDLSSRSETDLDCIFGKRRNKKLAQDGCSNSTADEADTSLTTTTTTTSAFTIQEYFAKRMAQLKSKSQAAAPGSDLSETPIEWKKGKKKTKEAAGTDIENSPQHKAKRHKKKKRVEAERGPAAK
KRDQVELQPGGPSGDECSDASVEAAEDRVQTPDTQDDVPKPRKRRAKKTLQRPGGVAVDTAPDSAPVKKKKKVSR

hide sequence

RefSeq Acc Id:	XP_006252243 ⟸ XM_006252181
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A1H3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPPVIRRQSPLSRSLTLRDGSPMPLSSGPAPLCCLGFSYQKGRRKQKWAVDPRNTAWSNDDSKFGQKMLEKMGWSKGKGLGAQEQGATEHIKVKVKNNHLGLGATNNNEDNWIAHQDDFNQLLAALNT CHGQETADSSDNKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSETDLDCIFGKRRNKKLAQDGCSNSTADEADTSLTTTTTTTSAFTIQEYFAKRMAQLKSKSQAAAPGSDLSETPIEWKKGKKK TKEAAGTDIENSPQHKAKRHKKKKRVEAERGPAAKKRDQVELQPGGPSGDECSDASVEAAEDRVQTPDTQDDVPKPRKRRAKKTLQRPGGVAVDTAPDSAPVKKKKKVSR hide sequence

Ensembl Acc Id:

ENSRNOP00000016027 ⟸ ENSRNOT00000016027

RefSeq Acc Id:	XP_038949259 ⟸ XM_039093331
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038949257 ⟸ XM_039093329
- Peptide Label:	isoform X2

Protein Domains

G-patch

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A4L691-F1-model_v2	AlphaFold	A4L691	1-331	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13699781

Promoter ID:

EPDNEW_R10303

Type:

initiation region

Name:

Pinx1_1

Description:

PIN2/TERF1 interacting, telomerase inhibitor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	47,211,575 - 47,211,635	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-13403	BioCyc
Ensembl Genes	ENSRNOG00000012012	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016027.6	UniProtKB/Swiss-Prot
	ENSRNOT00000102140.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9088212	IMAGE-MGC_LOAD
InterPro	G_patch_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PINX1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:305963	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:187218	IMAGE-MGC_LOAD
NCBI Gene	305963	ENTREZGENE
PANTHER	G PATCH DOMAIN CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PIN2/TERF1-INTERACTING TELOMERASE INHIBITOR 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	G-patch	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pinx1	PhenoGen
PROSITE	G_PATCH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012012	RatGTEx
SMART	G_patch	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A1H3	ENTREZGENE, UniProtKB/TrEMBL
	A4L691	ENTREZGENE
	B0BMT3	ENTREZGENE, UniProtKB/TrEMBL
	PINX1_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-02	Pinx1	PIN2/TERF1 interacting, telomerase inhibitor 1	Pinx1	PIN2-interacting protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Pinx1	PIN2-interacting protein 1	RGD1566025_predicted	similar to Pin2-interacting protein X1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1566025_predicted	similar to Pin2-interacting protein X1 (predicted)	LOC305963	similar to Pin2-interacting protein X1	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC305963	similar to Pin2-interacting protein X1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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