Tmod3 (tropomodulin 3) - Rat Genome Database

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Gene: Tmod3 (tropomodulin 3) Rattus norvegicus
Analyze
Symbol: Tmod3
Name: tropomodulin 3
RGD ID: 1311030
Description: Predicted to enable tropomyosin binding activity. Predicted to be involved in pointed-end actin filament capping. Predicted to act upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Predicted to be located in striated muscle thin filament. Orthologous to human TMOD3 (tropomodulin 3); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC300838; tropomodulin-3
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,131,295 - 85,191,477 (-)NCBIGRCr8
mRatBN7.2876,248,978 - 76,310,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,248,979 - 76,310,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,758,229 - 81,818,417 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0880,023,230 - 80,083,483 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,857,563 - 77,917,754 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,432,165 - 82,492,243 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,432,169 - 82,492,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0882,035,308 - 82,095,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4880,317,882 - 80,377,994 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1880,336,938 - 80,397,048 (-)NCBI
Celera876,040,427 - 76,100,486 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmod3RatBloom syndrome  ISOTMOD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
Tmod3Ratcolorectal cancer  ISOTMOD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
Tmod3Ratparaplegia  ISOTMOD3 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:21620353 more ...

1 to 20 of 65 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmod3Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TMOD3 mRNA]CTDPMID:31150632
Tmod3Rat1,2-dimethylhydrazine decreases expressionISOTmod3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of TMOD3 mRNACTDPMID:22206623
Tmod3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTmod3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of TMOD3 mRNACTDPMID:19465110
Tmod3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TMOD3 mRNACTDPMID:34747641
Tmod3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTmod3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TMOD3 mRNACTDPMID:21570461
Tmod3Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of TMOD3 mRNACTDPMID:21346803
Tmod3Rat2,6-dimethoxyphenol multiple interactionsISOTMOD3 (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 more ...CTDPMID:38598786
Tmod3Rat4,4'-sulfonyldiphenol increases expressionISOTMOD3 (Homo sapiens)6480464bisphenol S results in increased expression of TMOD3 proteinCTDPMID:34186270
Tmod3Rataristolochic acid A decreases expressionISOTMOD3 (Homo sapiens)6480464aristolochic acid I results in decreased expression of TMOD3 mRNACTDPMID:33212167
Tmod3Ratbenzo[a]pyrene increases expressionISOTmod3 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of TMOD3 mRNACTDPMID:22228805
Tmod3Ratbenzo[a]pyrene affects methylationISOTMOD3 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of TMOD3 5' UTR and Benzo(a)pyrene affects the methylation of TMOD3 promoterCTDPMID:27901495
Tmod3Ratbenzo[a]pyrene decreases expressionISOTMOD3 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of TMOD3 proteinCTDPMID:32717239
Tmod3Ratbenzo[a]pyrene diol epoxide I decreases expressionISOTMOD3 (Homo sapiens)64804647 more ...CTDPMID:20018196
Tmod3RatBenzo[ghi]perylene increases expressionISOTmod3 (Mus musculus)64804641 and 12-benzoperylene results in increased expression of TMOD3 mRNACTDPMID:26377693
Tmod3Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of TMOD3 mRNACTDPMID:25181051
Tmod3Ratbisphenol A decreases expressionISOTMOD3 (Homo sapiens)6480464bisphenol A results in decreased expression of TMOD3 proteinCTDPMID:37567409
Tmod3Ratbisphenol A increases expressionISOTMOD3 (Homo sapiens)6480464bisphenol A results in increased expression of TMOD3 proteinCTDPMID:34186270
Tmod3Ratbisphenol A decreases methylationISOTMOD3 (Homo sapiens)6480464bisphenol A results in decreased methylation of TMOD3 geneCTDPMID:31601247
Tmod3Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of TMOD3 mRNACTDPMID:34947998
Tmod3Ratbisphenol AF increases expressionISOTMOD3 (Homo sapiens)6480464bisphenol AF results in increased expression of TMOD3 proteinCTDPMID:34186270

1 to 20 of 65 rows

Biological Process
1 to 9 of 9 rows

  
1 to 9 of 9 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmod3Ratcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Tmod3Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Tmod3Ratstriated muscle thin filament located_inIEAUniProtKB:Q9JHJ0 and ensembl:ENSMUSP000000720871600115GO_REF:0000107EnsemblGO_REF:0000107
Tmod3Ratstriated muscle thin filament located_inISOTmod3 (Mus musculus)1624291 PMID:20368620RGDPMID:20368620

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tmod3Ratprotein binding enablesISOTMOD3 (Homo sapiens)1624291UniProtKB:Q9JJ28 and PMID:37126682RGDPMID:37126682
Tmod3Rattropomyosin binding enablesIEAInterPro:IPR0049341600115GO_REF:0000002InterProGO_REF:0000002
Tmod3Rattropomyosin binding enablesIEAUniProtKB:Q9JHJ0 and ensembl:ENSMUSP000000720871600115GO_REF:0000107EnsemblGO_REF:0000107
Tmod3Rattropomyosin binding enablesISOTmod3 (Mus musculus)1624291 PMID:20368620RGDPMID:20368620


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:20368620   PMID:24159174   PMID:24625528   PMID:25002582   PMID:25468996   PMID:35352799  



Tmod3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,131,295 - 85,191,477 (-)NCBIGRCr8
mRatBN7.2876,248,978 - 76,310,855 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,248,979 - 76,310,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,758,229 - 81,818,417 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0880,023,230 - 80,083,483 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,857,563 - 77,917,754 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,432,165 - 82,492,243 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,432,169 - 82,492,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0882,035,308 - 82,095,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4880,317,882 - 80,377,994 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1880,336,938 - 80,397,048 (-)NCBI
Celera876,040,427 - 76,100,486 (-)NCBICelera
Cytogenetic Map8q24NCBI
TMOD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381551,829,653 - 51,915,725 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1551,829,628 - 51,947,295 (+)EnsemblGRCh38hg38GRCh38
GRCh371552,121,850 - 52,207,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map15q21.2NCBI
HuRef1528,952,327 - 29,034,886 (+)NCBIHuRef
CHM1_11552,239,893 - 52,322,383 (+)NCBICHM1_1
T2T-CHM13v2.01549,637,162 - 49,723,313 (+)NCBIT2T-CHM13v2.0
Tmod3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39975,405,066 - 75,466,939 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl975,404,989 - 75,466,939 (-)EnsemblGRCm39 Ensembl
GRCm38975,497,784 - 75,559,657 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl975,497,707 - 75,559,657 (-)EnsemblGRCm38mm10GRCm38
MGSCv37975,345,591 - 75,407,464 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36975,283,693 - 75,345,566 (-)NCBIMGSCv36mm8
Celera972,658,788 - 72,720,531 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map942.3NCBI
TMOD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,862,244 - 119,948,880 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,864,878 - 119,948,795 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21132,955,318 - 133,000,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3

.

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Variants in Tmod3
643 total Variants

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:66
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000013852
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 56 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat

1 to 10 of 56 rows
RH129438  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,251,005 - 76,251,215 (+)MAPPERmRatBN7.2
Rnor_6.0882,432,364 - 82,432,573NCBIRnor6.0
Rnor_5.0882,035,507 - 82,035,716UniSTSRnor5.0
RGSC_v3.4880,318,081 - 80,318,290UniSTSRGSC3.4
Celera876,040,626 - 76,040,835UniSTS
Cytogenetic Map8q24UniSTS
RH129766  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,250,844 - 76,251,024 (+)MAPPERmRatBN7.2
Rnor_6.0882,432,203 - 82,432,382NCBIRnor6.0
Rnor_5.0882,035,346 - 82,035,525UniSTSRnor5.0
RGSC_v3.4880,317,920 - 80,318,099UniSTSRGSC3.4
Celera876,040,465 - 76,040,644UniSTS
Cytogenetic Map8q24UniSTS
BF404332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,283,623 - 76,283,816 (+)MAPPERmRatBN7.2
Rnor_6.0882,465,010 - 82,465,202NCBIRnor6.0
Rnor_5.0882,068,165 - 82,068,357UniSTSRnor5.0
RGSC_v3.4880,350,738 - 80,350,930UniSTSRGSC3.4
Celera876,073,247 - 76,073,439UniSTS
RH 3.4 Map8896.49UniSTS
Cytogenetic Map8q24UniSTS
RH138160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,274,058 - 76,274,193 (+)MAPPERmRatBN7.2
Rnor_6.0882,455,445 - 82,455,579NCBIRnor6.0
Rnor_5.0882,058,600 - 82,058,734UniSTSRnor5.0
RGSC_v3.4880,341,172 - 80,341,306UniSTSRGSC3.4
Celera876,063,680 - 76,063,814UniSTS
Cytogenetic Map8q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000013852   ⟹   ENSRNOP00000013852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl876,256,102 - 76,310,977 (-)Ensembl
Rnor_6.0 Ensembl882,432,169 - 82,492,243 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103318   ⟹   ENSRNOP00000091060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl876,248,979 - 76,310,962 (-)Ensembl
RefSeq Acc Id: NM_001011997   ⟹   NP_001011997
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,131,295 - 85,191,341 (-)NCBI
mRatBN7.2876,250,807 - 76,310,855 (-)NCBI
Rnor_6.0882,432,165 - 82,492,243 (-)NCBI
Rnor_5.0882,035,308 - 82,095,422 (-)NCBI
RGSC_v3.4880,317,882 - 80,377,994 (-)RGD
Celera876,040,427 - 76,100,486 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081147   ⟹   XP_038937075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,131,295 - 85,147,208 (-)NCBI
mRatBN7.2876,248,978 - 76,267,539 (-)NCBI
RefSeq Acc Id: XM_063265181   ⟹   XP_063121251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,131,295 - 85,191,477 (-)NCBI
Protein RefSeqs NP_001011997 (Get FASTA)   NCBI Sequence Viewer  
  XP_038937075 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121251 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79290 (Get FASTA)   NCBI Sequence Viewer  
  EDL77792 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013852.5
  ENSRNOP00000091060.1
  ENSRNOP00000111996
RefSeq Acc Id: NP_001011997   ⟸   NM_001011997
- UniProtKB: Q6AXW2 (UniProtKB/TrEMBL),   A6I1D5 (UniProtKB/TrEMBL),   F7F0R0 (UniProtKB/TrEMBL),   A0A8I6GJC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013852   ⟸   ENSRNOT00000013852
RefSeq Acc Id: XP_038937075   ⟸   XM_039081147
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000091060   ⟸   ENSRNOT00000103318
RefSeq Acc Id: XP_063121251   ⟸   XM_063265181
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJC0 (UniProtKB/TrEMBL),   A6I1D5 (UniProtKB/TrEMBL),   Q6AXW2 (UniProtKB/TrEMBL),   F7F0R0 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXW2-F1-model_v2 AlphaFold Q6AXW2 1-352 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696130
Promoter ID:EPDNEW_R6655
Type:initiation region
Name:Tmod3_1
Description:tropomodulin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0882,492,323 - 82,492,383EPDNEW


1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29813 BioCyc
Ensembl Genes ENSRNOG00000032436 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013852.5 UniProtKB/TrEMBL
  ENSRNOT00000103318.1 UniProtKB/TrEMBL
  ENSRNOT00000155874 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134366 IMAGE-MGC_LOAD
InterPro L_dom-like UniProtKB/TrEMBL
  Tropomodulin UniProtKB/TrEMBL
KEGG Report rno:300838 UniProtKB/TrEMBL
MGC_CLONE MGC:94421 IMAGE-MGC_LOAD
NCBI Gene 300838 ENTREZGENE
PANTHER PTHR10901:SF18 UniProtKB/TrEMBL
  Tropomodulin UniProtKB/TrEMBL
Pfam Tropomodulin UniProtKB/TrEMBL
PhenoGen Tmod3 PhenoGen
RatGTEx ENSRNOG00000032436 RatGTEx
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
UniProt A0A8I6GJC0 ENTREZGENE, UniProtKB/TrEMBL
  A6I1D5 ENTREZGENE, UniProtKB/TrEMBL
  F7F0R0 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXW2 ENTREZGENE
UniProt Secondary Q6AXW2 UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Tmod3  tropomodulin 3  Tmod3_predicted  tropomodulin 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tmod3_predicted  tropomodulin 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED