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Gene: Mon1a (MON1 homolog A, secretory trafficking associated) Rattus norvegicus

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Symbol:

Mon1a

Name:

MON1 homolog A, secretory trafficking associated

RGD ID:

1308823

Description:

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in protein secretion. Predicted to act upstream of or within establishment of localization in cell; intracellular iron ion homeostasis; and protein transport. Predicted to be part of Mon1-Ccz1 complex. Orthologous to human MON1A (MON1 homolog A, secretory trafficking associated); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC315999; MON1 homolog A; MON1 homolog A (yeast); MON1 secretory trafficking family member A; RGD1308823; similar to RIKEN cDNA 2810468K17; vacuolar fusion protein MON1 homolog A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,452,868 - 117,471,780 (+)	NCBI		GRCr8
mRatBN7.2	8	108,574,272 - 108,593,163 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,574,388 - 108,593,156 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,200,995 - 114,219,691 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,400,178 - 112,418,878 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,242,954 - 110,261,654 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,657,345 - 116,682,172 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,657,371 - 116,682,178 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,011,445 - 116,036,522 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,150,262 - 113,171,196 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,169,736 - 113,190,645 (+)	NCBI
Celera	8	107,880,144 - 107,897,365 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mon1a	Rat	Aicardi-Goutieres Syndrome 1		ISO	RGD:1601843	8554872	ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 1	ClinVar	PMID:16845398\|PMID:28492532
Mon1a	Rat	congenital diarrhea		ISO	RGD:1601843	8554872	ClinVar Annotator: match by term: Congenital diarrhea	ClinVar	PMID:25741868
Mon1a	Rat	developmental and epileptic encephalopathy		ISO	RGD:1601843	8554872	ClinVar Annotator: match by term: Developmental and epileptic encephalopathy	ClinVar	PMID:24358150\|PMID:28492532
Mon1a	Rat	early infantile epileptic encephalopathy		ISO	RGD:1601843	8554872	ClinVar Annotator: match by term: Early infantile epileptic encephalopathy	ClinVar	PMID:24358150\|PMID:28492532
Mon1a	Rat	primary ciliary dyskinesia		ISO	RGD:1601843	8554872	ClinVar Annotator: match by term: Primary ciliary dyskinesia	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mon1a	Rat	iron metabolism disease		ISO	RGD:1601843	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17632513

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mon1a	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1550257	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MON1A mRNA	CTD	PMID:22206623
Mon1a	Rat	17beta-estradiol	increases expression	ISO	RGD:1601843	6480464	Estradiol results in increased expression of MON1A mRNA	CTD	PMID:31614463
Mon1a	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1550257	6480464	Tetrachlorodibenzodioxin affects the expression of MON1A mRNA	CTD	PMID:21570461\|PMID:28213091
Mon1a	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of MON1A mRNA	CTD	PMID:33387578
Mon1a	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1550257	6480464	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MON1A gene]	CTD	PMID:28213091
Mon1a	Rat	2,4-dinitrotoluene	affects expression	EXP		6480464	2,4-dinitrotoluene affects the expression of MON1A mRNA	CTD	PMID:21346803
Mon1a	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...	CTD	PMID:36041667
Mon1a	Rat	Aflatoxin B2 alpha	decreases methylation	ISO	RGD:1601843	6480464	aflatoxin B2 results in decreased methylation of MON1A intron	CTD	PMID:30157460
Mon1a	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1601843	6480464	Tretinoin results in decreased expression of MON1A mRNA	CTD	PMID:33167477
Mon1a	Rat	aristolochic acid A	increases expression	ISO	RGD:1601843	6480464	aristolochic acid I results in increased expression of MON1A mRNA	CTD	PMID:33212167
Mon1a	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1550257	6480464	Benzo(a)pyrene results in decreased expression of MON1A mRNA	CTD	PMID:20127859
Mon1a	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1601843	6480464	Benzo(a)pyrene results in decreased expression of MON1A mRNA	CTD	PMID:32234424
Mon1a	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1550257	6480464	Benzo(a)pyrene results in decreased methylation of MON1A 3' UTR; Benzo(a)pyrene results in decreased methylation of more ...	CTD	PMID:27901495
Mon1a	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1601843	6480464	Benzo(a)pyrene affects the methylation of MON1A promoter	CTD	PMID:27901495
Mon1a	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1550257	6480464	Benzo(a)pyrene results in increased expression of MON1A mRNA	CTD	PMID:22228805
Mon1a	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of MON1A mRNA	CTD	PMID:25181051
Mon1a	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...	CTD	PMID:36041667
Mon1a	Rat	bisphenol F	decreases expression	ISO	RGD:1550257	6480464	bisphenol F results in decreased expression of MON1A mRNA	CTD	PMID:38685157
Mon1a	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...	CTD	PMID:36041667
Mon1a	Rat	cadmium atom	decreases expression	EXP		6480464	Cadmium results in decreased expression of MON1A mRNA	CTD	PMID:39025289
Mon1a	Rat	cadmium dichloride	increases methylation	EXP		6480464	Cadmium Chloride results in increased methylation of MON1A promoter	CTD	PMID:22457795
Mon1a	Rat	caffeine	affects phosphorylation	ISO	RGD:1601843	6480464	Caffeine affects the phosphorylation of MON1A protein	CTD	PMID:35688186
Mon1a	Rat	chlorpyrifos	increases expression	ISO	RGD:1550257	6480464	Chlorpyrifos results in increased expression of MON1A mRNA	CTD	PMID:37019170
Mon1a	Rat	cyclosporin A	increases expression	ISO	RGD:1601843	6480464	Cyclosporine results in increased expression of MON1A mRNA	CTD	PMID:25562108
Mon1a	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1601843	6480464	di-n-butylphosphoric acid affects the expression of MON1A mRNA	CTD	PMID:37042841
Mon1a	Rat	dibutyl phthalate	increases expression	EXP		6480464	Dibutyl Phthalate results in increased expression of MON1A mRNA	CTD	PMID:21266533
Mon1a	Rat	dioxygen	decreases expression	ISO	RGD:1601843	6480464	Oxygen deficiency results in decreased expression of MON1A mRNA	CTD	PMID:26516004
Mon1a	Rat	doxorubicin	decreases expression	ISO	RGD:1601843	6480464	Doxorubicin results in decreased expression of MON1A mRNA	CTD	PMID:29803840
Mon1a	Rat	fipronil	decreases expression	EXP		6480464	fipronil results in decreased expression of MON1A mRNA	CTD	PMID:23962444
Mon1a	Rat	folic acid	multiple interactions	ISO	RGD:1550257	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MON1A mRNA	CTD	PMID:22206623
Mon1a	Rat	FR900359	increases phosphorylation	ISO	RGD:1601843	6480464	FR900359 results in increased phosphorylation of MON1A protein	CTD	PMID:37730182
Mon1a	Rat	ketamine	decreases expression	EXP		6480464	Ketamine results in decreased expression of MON1A mRNA	CTD	PMID:20080153
Mon1a	Rat	paracetamol	decreases expression	ISO	RGD:1601843	6480464	Acetaminophen results in decreased expression of MON1A mRNA	CTD	PMID:22230336\|PMID:29067470
Mon1a	Rat	sodium arsenite	decreases expression	ISO	RGD:1601843	6480464	sodium arsenite results in decreased expression of MON1A mRNA	CTD	PMID:38568856
Mon1a	Rat	sodium arsenite	increases expression	ISO	RGD:1601843	6480464	sodium arsenite results in increased expression of MON1A mRNA	CTD	PMID:34032870
Mon1a	Rat	testosterone	decreases expression	ISO	RGD:1601843	6480464	Testosterone results in decreased expression of MON1A mRNA	CTD	PMID:33359661
Mon1a	Rat	tetrachloroethene	decreases expression	ISO	RGD:1550257	6480464	Tetrachloroethylene results in decreased expression of MON1A mRNA	CTD	PMID:28973375
Mon1a	Rat	titanium dioxide	decreases methylation	ISO	RGD:1550257	6480464	titanium dioxide results in decreased methylation of MON1A gene	CTD	PMID:35295148
Mon1a	Rat	titanium dioxide	increases methylation	ISO	RGD:1550257	6480464	titanium dioxide results in increased methylation of MON1A gene	CTD	PMID:35295148
Mon1a	Rat	triptonide	increases expression	ISO	RGD:1550257	6480464	triptonide results in increased expression of MON1A mRNA	CTD	PMID:33045310
Mon1a	Rat	urethane	increases expression	ISO	RGD:1601843	6480464	Urethane results in increased expression of MON1A mRNA	CTD	PMID:28818685
Mon1a	Rat	valproic acid	increases expression	ISO	RGD:1550257	6480464	Valproic Acid results in increased expression of MON1A mRNA	CTD	PMID:21427059

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mon1a	Rat	establishment of localization in cell	acts_upstream_of_or_within	ISO	RGD:1550257	1624291	PMID:17632513	RGD	PMID:17632513
Mon1a	Rat	intracellular iron ion homeostasis	acts_upstream_of_or_within	ISO	RGD:1550257	1624291	PMID:17632513	RGD	PMID:17632513
Mon1a	Rat	protein secretion	involved_in	IBA	MGI:1920075\|PANTHER:PTN008545073	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Mon1a	Rat	protein secretion	acts_upstream_of_or_within	ISO	RGD:1550257	1624291	PMID:17632513	RGD	PMID:17632513
Mon1a	Rat	protein targeting to vacuole	involved_in	IEA	UniRule:UR001350786	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Mon1a	Rat	protein targeting to vacuole	involved_in	IEA	InterPro:IPR004353	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Mon1a	Rat	protein transport	acts_upstream_of_or_within	ISO	RGD:1550257	1624291	PMID:17632513	RGD	PMID:17632513
Mon1a	Rat	vesicle-mediated transport	involved_in	IEA	InterPro:IPR043970\|InterPro:IPR043971\|InterPro:IPR043972	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mon1a	Rat	Mon1-Ccz1 complex	part_of	ISO	RGD:1601843	1624291	PMID:29038162	RGD	PMID:29038162
Mon1a	Rat	Mon1-Ccz1 complex	part_of	IEA	UniProtKB:Q86VX9\|ensembl:ENSP00000296473	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mon1a	Rat	Mon1-Ccz1 complex	part_of	IBA	FB:FBgn0031640\|PANTHER:PTN000315023\|SGD:S000003092\|UniProtKB:Q7L1V2\|UniProtKB:Q86VX9	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mon1a	Rat	guanyl-nucleotide exchange factor activity	enables	ISO	RGD:1601843	1624291	PMID:23084991	RGD	PMID:23084991
Mon1a	Rat	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB:Q86VX9\|ensembl:ENSP00000296473	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mon1a	Rat	protein binding	enables	ISO	RGD:1601843	1624291	UniProtKB:P86791 PMID:23084991	RGD	PMID:23084991

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:12477932	PMID:17632513	PMID:23084991	PMID:29038162

Mon1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,452,868 - 117,471,780 (+)	NCBI		GRCr8
mRatBN7.2	8	108,574,272 - 108,593,163 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,574,388 - 108,593,156 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	114,200,995 - 114,219,691 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,400,178 - 112,418,878 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,242,954 - 110,261,654 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,657,345 - 116,682,172 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,657,371 - 116,682,178 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	116,011,445 - 116,036,522 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	113,150,262 - 113,171,196 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	113,169,736 - 113,190,645 (+)	NCBI
Celera	8	107,880,144 - 107,897,365 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

MON1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	49,908,873 - 49,929,811 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	49,907,160 - 49,930,173 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	49,946,306 - 49,967,244 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	49,921,310 - 49,942,261 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	49,912,397 - 49,933,686 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	50,004,584 - 50,025,375 (-)	NCBI		HuRef
CHM1_1	3	49,898,388 - 49,919,531 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	49,938,770 - 49,959,744 (-)	NCBI		T2T-CHM13v2.0

Mon1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,765,282 - 107,780,338 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,765,350 - 107,780,338 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	107,888,083 - 107,903,139 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,888,151 - 107,903,139 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,790,460 - 107,805,470 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,746,283 - 107,761,226 (+)	NCBI		MGSCv36	mm8
Celera	9	107,496,336 - 107,511,353 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	59.07	NCBI

Mon1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	1,790,929 - 1,812,125 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	1,793,233 - 1,811,675 (-)	NCBI	ChiLan1.0	ChiLan1.0

MON1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	49,895,233 - 49,916,587 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	49,900,006 - 49,921,362 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	49,840,824 - 49,862,101 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	51,077,398 - 51,099,498 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,077,398 - 51,099,498 (-)	Ensembl	panpan1.1		panPan2

MON1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,368,757 - 39,383,175 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	39,378,694 - 39,383,175 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	39,289,596 - 39,304,013 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,724,113 - 39,740,247 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,726,120 - 39,740,246 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	39,092,662 - 39,107,083 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	39,497,123 - 39,511,553 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,776,441 - 39,790,866 (+)	NCBI		UU_Cfam_GSD_1.0

Mon1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	64,753,299 - 64,766,678 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	1,513,753 - 1,527,506 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	1,513,796 - 1,527,121 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MON1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	32,426,736 - 32,437,862 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	32,426,733 - 32,437,735 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	35,607,468 - 35,618,469 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MON1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,315,251 - 11,334,295 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,315,396 - 11,333,991 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	155,661,356 - 155,682,339 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mon1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	3,821,485 - 3,841,452 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	3,818,653 - 3,833,697 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Mon1a
165 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	72
Count of miRNA genes:	66
Interacting mature miRNAs:	72
Transcripts:	ENSRNOT00000024966
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	102370617	108923645	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001126284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010053983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024966 ⟹ ENSRNOP00000024966

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	108,574,388 - 108,593,156 (+)	Ensembl
Rnor_6.0 Ensembl	8	116,657,371 - 116,682,178 (+)	Ensembl

RefSeq Acc Id:

NM_001126284 ⟹ NP_001119756

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,452,946 - 117,471,779 (+)	NCBI
mRatBN7.2	8	108,574,323 - 108,593,162 (+)	NCBI
Rnor_6.0	8	116,657,399 - 116,682,171 (+)	NCBI
Rnor_5.0	8	116,011,445 - 116,036,522 (+)	NCBI
RGSC_v3.4	8	113,150,262 - 113,171,196 (+)	RGD
Celera	8	107,880,144 - 107,897,365 (+)	RGD

Sequence:

show sequence

CGGGGCCTCCGCCACCAGAGGCCGGTGAAAGCTGTCTTCCTGCGCCGGTGGCCGGTAAAGGGTCGGCAGGAGAGATCAGTTCCTCCGCTGTGGTCATGTCTGTATTCTCCAGGGGCGGTAGCCCCACG
AAGTTGTACCCTAAGGCCAGGCACGGCTGGACACTCACATCTCCCCAGGGGACTGGCAGAGGGCAGTGACTGGCACCCTTGGTAGGTCCTGTGTTCCCCCAAGAAACAGGACAGCCCAGAAGATGGCT
GCTGACATGCCGAGGAAGAGAAGCGGCGAATGCCCCGAGGGCACACTGGCTCCTTCCACCGGCCAAAGTGTGGAAAGAGCTGAGAGCCCCACACCAGGGCTGACCCAGGGAATGGAGCCAGACAGCCC
CAAAGAGTATGTTGGGAGTCCCCCACCACTGCCTACAGACATACGCCAGATTAGCCAGGACTTCAGCGAACTAAGCACCCAGCTGACAGGTGTGGCCCGAGACCTGCAGGAGGAAATGCTGCCAGGAA
GCTCTGAAGACTGGCTGGAACCCCAGGGGGCGGCTGGACGACCAGCCACAGAGCCCTCCCAAGAGAGCTCAACTGAAGGGGAAGAGGAGGATGCCACAGAGGCATGGCGTCTCCACCAGAAGCACGTA
TTTGTACTGAGTGAGGCAGGGAAGCCTGTGTATTCTCGCTATGGGTCTGAGGAAGCGCTTTCCAGCACTATGGGTGTCATGGTTGCCTTGGTGTCCTTCCTGGAGGCAGACAAGAATGCCATCCGCTC
CATCCATGCAGATGGCTACAAGGTAGTATTCGTGCGCCGGAGCCCTCTGGTGCTGGTGGCGGTGGCCCGCACGCGGCAGTCGGCCCAGGAGCTGGCGCAGGAGCTACTGTACATCTACTACCAGATTC
TGAGCCTCCTTACCGGCGCGCAGCTGAGCCACATCTTCCAGCAGAAGCAGAACTACGACCTGCGGCGCCTGCTCTCGGGCTCGGAGCGGATCACCGATAACCTGCTGCAGCTAATGGCTCGAGACCCC
AGTTTCCTGATGGGTGCGGCGAGGTGCCTGCCTTTGGCAGCGGCCGTGCGGGACACGGTGAGTGCCAGCCTGCAGCAGGCGCGTGTTCGCAGCCTGGTCTTTTCCATCCTGCTGGCCCGCAACCAGCT
AGTGGCGCTCGTGCGCCGCAAGGACCAATTCCTGCATCCCATCGACCTGCACCTGCTTTTCAACCTCATTAGCTCCTCCTCATCCTTCCGTGAGGGCGAGGCTTGGACTCCCGTGTGCCTGCCAAAGT
TCAATGCGGCCGGCTTCTTCCACGCACACATCTCTTACCTAGAACCCGACACCGACCTCTGCCTGCTGCTGGTCTCCACTGACCGTGAGGACTTCTTCGCAGTCTCTGACTGTCGTCGCCGCTTCCTG
GAACGCATTCGAAAGCGGGGAGCCCATTTGGCCCTGCGGGAGGCGCTGCGCACACCTTACTACAGCGTGGCCCAAGTAGGCATCCCTGACCTTCGCCACTTCCTCTATAAATCAAAGAGCTCAGGACT
CTTCACCAGTCCGGAGATTGAGGCCCCATACACCAGTGAAGAGGAGCAGGAGCGGCTGTTGGGCCTCTACCAGTACCTGCACAGCCGTGCCCACAATGCCTCCCGCCCACTCAAGACCATCTACTACA
CAGGCCCCAATGAGAACCTCCTAGCCTGGGTGACAGGTGCCTTTGAGCTCTACTTGTGCTACAGCCCACTGGGAACCAAGGCATCAGCCGTCAGTGCCATCCATAAGCTGATGCGCTGGATCCGTAAA
GAGGAAGACCGGCTCTTCATCCTCACGCCCCTCACCTACTGACGGAAGTGGGAAGGCACACTGGGCATGGGAAGCCATGGGAGCCTCCAGGTGAGGCCGGCTTCCTCTGCCCAGCCAGCAGGCAGGGA
CCGTGGGCTGGTGCGTGCATTAAAGTGCATTGGAAAGAC

hide sequence

RefSeq Acc Id:

XM_039081597 ⟹ XP_038937525

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,452,868 - 117,471,780 (+)	NCBI
mRatBN7.2	8	108,574,274 - 108,593,163 (+)	NCBI

RefSeq Acc Id:

XR_010053983

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,452,896 - 117,471,409 (+)	NCBI


Protein RefSeqs	NP_001119756	(Get FASTA)	NCBI Sequence Viewer
	XP_038937525	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61958	(Get FASTA)	NCBI Sequence Viewer
	EDL77213	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024966
	ENSRNOP00000024966.4

RefSeq Acc Id:

NP_001119756 ⟸ NM_001126284

- UniProtKB:

B1WC06 (UniProtKB/TrEMBL), A6I314 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAADMPRKRSGECPEGTLAPSTGQSVERAESPTPGLTQGMEPDSPKEYVGSPPPLPTDIRQISQDFSELSTQLTGVARDLQEEMLPGSSEDWLEPQGAAGRPATEPSQESSTEGEEEDATEAWRLHQK
HVFVLSEAGKPVYSRYGSEEALSSTMGVMVALVSFLEADKNAIRSIHADGYKVVFVRRSPLVLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITDNLLQLMAR
DPSFLMGAARCLPLAAAVRDTVSASLQQARVRSLVFSILLARNQLVALVRRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNAAGFFHAHISYLEPDTDLCLLLVSTDREDFFAVSDCRRR
FLERIRKRGAHLALREALRTPYYSVAQVGIPDLRHFLYKSKSSGLFTSPEIEAPYTSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLAWVTGAFELYLCYSPLGTKASAVSAIHKLMRWI
RKEEDRLFILTPLTY

hide sequence

Ensembl Acc Id:

ENSRNOP00000024966 ⟸ ENSRNOT00000024966

RefSeq Acc Id:	XP_038937525 ⟸ XM_039081597
- Peptide Label:	isoform X1
- UniProtKB:	B1WC06 (UniProtKB/TrEMBL), A6I314 (UniProtKB/TrEMBL)

Protein Domains

FUZ/MON1/HPS1 first Longin FUZ/MON1/HPS1 second Longin FUZ/MON1/HPS1 third Longin

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1WC06-F1-model_v2	AlphaFold	B1WC06	1-555	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13696282

Promoter ID:

EPDNEW_R6807

Type:

initiation region

Name:

Mon1a_1

Description:

MON1 homolog A, secretory trafficking associated

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	116,657,400 - 116,657,460	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-29170	BioCyc
Ensembl Genes	ENSRNOG00000018502	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024966	ENTREZGENE
	ENSRNOT00000024966.8	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9027405	IMAGE-MGC_LOAD
InterPro	FUZ/MON1/HPS1_longin_1	UniProtKB/TrEMBL
	FUZ/MON1/HPS1_longin_2	UniProtKB/TrEMBL
	FUZ/MON1/HPS1_longin_3	UniProtKB/TrEMBL
	Vacuolar_fusion_protein_MON1	UniProtKB/TrEMBL
KEGG Report	rno:315999	UniProtKB/TrEMBL
MGC_CLONE	MGC:187760	IMAGE-MGC_LOAD
NCBI Gene	315999	ENTREZGENE
PANTHER	DUF254_SAND	UniProtKB/TrEMBL
	VACUOLAR FUSION PROTEIN MON1 HOMOLOG A	UniProtKB/TrEMBL
Pfam	Fuz_longin_1	UniProtKB/TrEMBL
	Fuz_longin_2	UniProtKB/TrEMBL
	Fuz_longin_3	UniProtKB/TrEMBL
PhenoGen	Mon1a	PhenoGen
PRINTS	YEAST73DUF	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018502	RatGTEx
UniProt	A6I314	ENTREZGENE, UniProtKB/TrEMBL
	B1WC06	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Mon1a	MON1 homolog A, secretory trafficking associated	Mon1a	MON1 secretory trafficking family member A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-11-19	Mon1a	MON1 secretory trafficking family member A	Mon1a	MON1 homolog A (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Mon1a	MON1 homolog A (yeast)	Mon1a_predicted	MON1 homolog A (yeast) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Mon1a_predicted	MON1 homolog A (yeast) (predicted)	RGD1308823_predicted	similar to RIKEN cDNA 2810468K17 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1308823_predicted	similar to RIKEN cDNA 2810468K17 (predicted)	LOC315999_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC315999_predicted	similar to RIKEN cDNA 2810468K17 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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