Mon1a (MON1 homolog A, secretory traffciking associated) - Rat Genome Database
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Gene: Mon1a (MON1 homolog A, secretory traffciking associated) Mus musculus
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Symbol: Mon1a
Name: MON1 homolog A, secretory traffciking associated
RGD ID: 1550257
MGI Page MGI
Description: Predicted to have guanyl-nucleotide exchange factor activity. Involved in cellular iron ion homeostasis and protein secretion. Predicted to localize to Mon1-Ccz1 complex. Orthologous to human MON1A (MON1 homolog A, secretory trafficking associated); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810468K17Rik; MON1 homolog A; vacuolar fusion protein MON1 homolog A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,765,282 - 107,780,338 (+)NCBIGRCm39mm39
GRCm389107,888,083 - 107,903,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,888,151 - 107,903,139 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,790,460 - 107,805,470 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,746,283 - 107,761,226 (+)NCBImm8
Celera9107,496,336 - 107,511,353 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17632513   PMID:20305638   PMID:21873635  
PMID:22665492   PMID:24121729   PMID:32325033  


Genomics

Comparative Map Data
Mon1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,765,282 - 107,780,338 (+)NCBIGRCm39mm39
GRCm389107,888,083 - 107,903,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,888,151 - 107,903,139 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,790,460 - 107,805,470 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,746,283 - 107,761,226 (+)NCBImm8
Celera9107,496,336 - 107,511,353 (+)NCBICelera
Cytogenetic Map9F1NCBI
MON1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,907,160 - 49,930,173 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,908,869 - 49,930,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,946,302 - 49,967,445 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,921,310 - 49,942,261 (-)NCBINCBI36hg18NCBI36
Celera349,912,397 - 49,933,686 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,004,584 - 50,025,375 (-)NCBIHuRef
CHM1_1349,898,388 - 49,919,531 (-)NCBICHM1_1
Mon1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08116,657,345 - 116,682,172 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,657,371 - 116,682,178 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,011,445 - 116,036,522 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,150,262 - 113,171,196 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,169,736 - 113,190,645 (+)NCBI
Celera8107,880,144 - 107,897,365 (+)NCBICelera
Cytogenetic Map8q32NCBI
Mon1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,790,929 - 1,812,125 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,793,233 - 1,811,675 (-)NCBIChiLan1.0ChiLan1.0
MON1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,077,398 - 51,099,498 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,077,398 - 51,099,498 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,840,824 - 49,862,101 (-)NCBIMhudiblu_PPA_v0panPan3
MON1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,378,694 - 39,383,175 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,368,757 - 39,383,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mon1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,513,796 - 1,527,121 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MON1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,422,873 - 32,439,533 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,426,733 - 32,437,735 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,607,468 - 35,618,469 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MON1A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,315,251 - 11,334,295 (-)NCBI
ChlSab1.1 Ensembl2211,315,396 - 11,333,991 (-)Ensembl
Mon1a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,818,653 - 3,833,697 (-)NCBI

Position Markers
D9Dcr103  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,891,731 - 107,891,832UniSTSGRCm38
MGSCv379107,794,062 - 107,794,163UniSTSGRCm37
Celera9107,499,962 - 107,500,059UniSTS
Cytogenetic Map9F1UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:240
Interacting mature miRNAs:257
Transcripts:ENSMUST00000035202
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035202   ⟹   ENSMUSP00000035202
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,888,182 - 107,903,139 (+)Ensembl
RefSeq Acc Id: ENSMUST00000191906   ⟹   ENSMUSP00000141516
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,888,151 - 107,903,134 (+)Ensembl
RefSeq Acc Id: NM_028369   ⟹   NP_082645
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,765,328 - 107,780,338 (+)NCBI
GRCm389107,888,129 - 107,903,139 (+)NCBI
MGSCv379107,790,460 - 107,805,470 (+)RGD
Celera9107,496,336 - 107,511,353 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313611   ⟹   XP_017169100
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,765,316 - 107,780,338 (+)NCBI
GRCm389107,888,117 - 107,903,139 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001779021
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,765,282 - 107,780,338 (+)NCBI
GRCm389107,888,083 - 107,903,139 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082645   ⟸   NM_028369
- UniProtKB: Q6PDG8 (UniProtKB/Swiss-Prot),   A0A0R4J0D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169100   ⟸   XM_017313611
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000141516   ⟸   ENSMUST00000191906
RefSeq Acc Id: ENSMUSP00000035202   ⟸   ENSMUST00000035202
Protein Domains
Fuz_longin_1   Fuz_longin_2   Fuz_longin_3

Promoters
RGD ID:6844810
Promoter ID:MM_KWN:58746
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_028369,   NM_028369_MON1A,   UC009RNH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369107,790,171 - 107,790,671 (+)MPROMDB
RGD ID:6848913
Promoter ID:MM_TRO:10289
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:MTR008365.9.2303.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369107,803,436 - 107,803,936 (+)MPROMDB
RGD ID:8670836
Promoter ID:EPDNEW_M13447
Type:initiation region
Name:Mon1a_1
Description:Mus musculus MON1 homolog A, secretory traffciking associated, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389107,888,182 - 107,888,242EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920075 AgrOrtholog
Ensembl Genes ENSMUSG00000032583 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035202 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000141516 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035202 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000191906 UniProtKB/TrEMBL
InterPro FUZ/MON1/HPS1_longin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FUZ/MON1/HPS1_longin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FUZ/MON1/HPS1_longin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mon1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72825 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1920075 ENTREZGENE
NCBI Gene 72825 ENTREZGENE
PANTHER PTHR13027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fuz_longin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fuz_longin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fuz_longin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mon1a PhenoGen
PRINTS YEAST73DUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.38037 ENTREZGENE
UniProt A0A0R4J0D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0R4J2D4_MOUSE UniProtKB/TrEMBL
  MON1A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q80UP6 UniProtKB/Swiss-Prot
  Q9CYS2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Mon1a  MON1 homolog A, secretory traffciking associated    MON1 homolog A (yeast)  Symbol and/or name change 5135510 APPROVED