Ptpa (protein phosphatase 2 phosphatase activator) - Rat Genome Database

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Gene: Ptpa (protein phosphatase 2 phosphatase activator) Rattus norvegicus
Analyze
Symbol: Ptpa
Name: protein phosphatase 2 phosphatase activator
RGD ID: 1308354
Description: Predicted to enable several functions, including ATP binding activity; protein homodimerization activity; and protein phosphatase 2A binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in mitotic spindle organization and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of ATPase complex; calcium channel complex; and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362102; Ppp2r4; protein phosphatase 2 regulatory subunit 4; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A regulatory subunit 4; protein phosphatase 2A, regulatory subunit B (PR 53); protein phosphatase 2a, regulatory subunit b' (pr 53); serine/threonine-protein phosphatase 2A activator
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,087,637 - 34,118,100 (+)NCBIGRCr8
mRatBN7.2313,689,742 - 13,720,287 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,689,741 - 13,722,549 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx316,761,350 - 16,791,813 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,346,312 - 25,376,773 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,592,281 - 23,622,965 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,982,122 - 9,012,585 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,982,122 - 9,012,585 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0314,334,896 - 14,365,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,461,718 - 9,492,181 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.139,472,909 - 9,491,620 (+)NCBI
Celera38,456,362 - 8,486,834 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtpaRatdevelopmental and epileptic encephalopathy  ISOPTPA (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
PtpaRatdystonia  ISOPTPA (Homo sapiens)8554872ClinVar Annotator: match by term: Dystonic disorderClinVarPMID:28492532
PtpaRatearly infantile epileptic encephalopathy  ISOPTPA (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
PtpaRatParkinson's disease 25  ISOPTPA (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinson disease 25 more ...ClinVarPMID:36073231
PtpaRatprimary coenzyme Q10 deficiency 7  ISOPTPA (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndromeClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtpaRatDisease Progression  ISOPTPA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21364753
PtpaRatStomach Neoplasms  ISOPTPA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21364753
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtpaRatParkinson's disease 25  ISOPTPA (Homo sapiens)7240710 OMIM 

1 to 20 of 77 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtpaRat1,2-dimethylhydrazine increases expressionISOPtpa (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PTPA mRNACTDPMID:22206623
PtpaRat1,2-dimethylhydrazine multiple interactionsISOPtpa (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PTPA mRNACTDPMID:22206623
PtpaRat17alpha-ethynylestradiol affects expressionISOPtpa (Mus musculus)6480464Ethinyl Estradiol affects the expression of PTPA mRNACTDPMID:17555576
PtpaRat17beta-estradiol multiple interactionsISOPTPA (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PTPA mRNACTDPMID:20823114
PtpaRat17beta-estradiol increases expressionISOPtpa (Mus musculus)6480464Estradiol results in increased expression of PTPA mRNACTDPMID:39298647
PtpaRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of PTPA mRNACTDPMID:32145629
PtpaRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPtpa (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PTPA mRNACTDPMID:21570461 and PMID:24680724
PtpaRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PTPA mRNACTDPMID:34747641
PtpaRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of PTPA mRNACTDPMID:21346803
PtpaRat3,4-methylenedioxymethamphetamine increases expressionISOPtpa (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PTPA mRNACTDPMID:20188158
PtpaRat4,4'-diaminodiphenylmethane increases expressionISOPtpa (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of PTPA mRNACTDPMID:18648102
PtpaRat4,4'-sulfonyldiphenol increases expressionISOPtpa (Mus musculus)6480464bisphenol S results in increased expression of PTPA mRNACTDPMID:39298647
PtpaRat4,4'-sulfonyldiphenol increases expressionISOPTPA (Homo sapiens)6480464bisphenol S results in increased expression of PTPA proteinCTDPMID:34186270
PtpaRat5-azacytidine increases expressionISOPTPA (Homo sapiens)6480464Azacitidine results in increased expression of PTPA mRNACTDPMID:20823114
PtpaRatacrolein multiple interactionsISOPTPA (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PTPA mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PTPA mRNACTDPMID:32699268
PtpaRataflatoxin B1 increases methylationISOPTPA (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of PTPA intronCTDPMID:30157460
PtpaRatalpha-pinene multiple interactionsISOPTPA (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PTPA mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PTPA mRNACTDPMID:32699268
PtpaRataristolochic acid A increases expressionISOPTPA (Homo sapiens)6480464aristolochic acid I results in increased expression of PTPA proteinCTDPMID:33212167
PtpaRatazoxystrobin multiple interactionsEXP 6480464[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PTPA mRNACTDPMID:33854195
PtpaRatbeta-lapachone increases expressionISOPTPA (Homo sapiens)6480464beta-lapachone results in increased expression of PTPA mRNACTDPMID:38218311

1 to 20 of 77 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtpaRatmitotic spindle organization involved_inIBAPANTHER:PTN000000630 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtpaRatpositive regulation of apoptotic process involved_inISOPTPA (Homo sapiens)1624291 PMID:17333320RGDPMID:17333320

Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtpaRatATPase complex part_ofISOPTPA (Homo sapiens)1624291 PMID:16916641RGDPMID:16916641
PtpaRatcalcium channel complex part_ofISOPTPA (Homo sapiens)1624291 PMID:10830164RGDPMID:10830164
PtpaRatcytoplasm located_inISOPTPA (Homo sapiens)1624291 PMID:17333320RGDPMID:17333320
PtpaRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
PtpaRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
PtpaRatcytoplasm is_active_inIBAPANTHER:PTN000000630 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtpaRatnucleoplasm located_inISOPTPA (Homo sapiens) more ...1624291 RGDGO_REF:0000052
PtpaRatnucleus located_inISOPTPA (Homo sapiens)1624291 PMID:17333320RGDPMID:17333320
PtpaRatnucleus is_active_inIBAFB:FBgn0016698 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtpaRatprotein phosphatase type 2A complex part_ofISOPTPA (Homo sapiens)1624291 PMID:10318862RGDPMID:10318862
PtpaRatprotein phosphatase type 2A complex part_ofIBAPANTHER:PTN000000630 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 11 of 11 rows

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtpaRatATP binding enablesISOPTPA (Homo sapiens)1624291 PMID:16916641RGDPMID:16916641
PtpaRatisomerase activity enablesIEAUniProtKB-KW:KW-04131600115GO_REF:0000043UniProtGO_REF:0000043
PtpaRatpeptidyl-prolyl cis-trans isomerase activity enablesIBAPANTHER:PTN000000630 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtpaRatpeptidyl-prolyl cis-trans isomerase activity enablesIEAUniProtKB-KW:KW-06971600115GO_REF:0000043UniProtGO_REF:0000043
PtpaRatphosphatase activator activity enablesIEAInterPro:IPR004327 and InterPro:IPR0372181600115GO_REF:0000002InterProGO_REF:0000002
PtpaRatphosphatase binding enablesISOPTPA (Homo sapiens)1624291 PMID:16916641RGDPMID:16916641
PtpaRatphosphoprotein phosphatase activity contributes_toISOPTPA (Homo sapiens)1624291 PMID:16916641RGDPMID:16916641
PtpaRatprotein binding enablesISOPTPA (Homo sapiens)1624291UniProtKB:P60510 more ...RGDPMID:25416956 and PMID:33961781
PtpaRatprotein binding enablesISOPTPA (Homo sapiens) and UniProtKB:Q15257-21624291UniProtKB:A2BDD9 more ...RGDPMID:32296183
PtpaRatprotein homodimerization activity enablesISOPTPA (Homo sapiens)1624291 PMID:16916641RGDPMID:16916641
PtpaRatprotein phosphatase 2A binding enablesISOPTPA (Homo sapiens)1624291 PMID:16916641RGDPMID:16916641
PtpaRatprotein phosphatase regulator activity enablesISOPTPA (Homo sapiens)1624291 PMID:16916641RGDPMID:16916641
PtpaRatprotein tyrosine phosphatase activator activity enablesISOPTPA (Homo sapiens)1624291 PMID:16916641RGDPMID:16916641
PtpaRatprotein tyrosine phosphatase activator activity enablesIBAPANTHER:PTN000000630 and UniProtKB:Q152571600115GO_REF:0000033GO_CentralGO_REF:0000033
PtpaRatsignaling receptor binding enablesISOPTPA (Homo sapiens)1624291UniProtKB:Q92736 and PMID:10830164RGDPMID:10830164
1 to 15 of 15 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
PtpaRatp53 signaling pathway   ISOPTPA (Homo sapiens)6484113 PIDPID:200206

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10318862   PMID:10830164   PMID:12477932   PMID:16916641   PMID:17333320   PMID:20568963   PMID:23376485   PMID:23533145  



Ptpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,087,637 - 34,118,100 (+)NCBIGRCr8
mRatBN7.2313,689,742 - 13,720,287 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,689,741 - 13,722,549 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx316,761,350 - 16,791,813 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,346,312 - 25,376,773 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,592,281 - 23,622,965 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,982,122 - 9,012,585 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,982,122 - 9,012,585 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0314,334,896 - 14,365,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,461,718 - 9,492,181 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.139,472,909 - 9,491,620 (+)NCBI
Celera38,456,362 - 8,486,834 (+)NCBICelera
Cytogenetic Map3p12NCBI
PTPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389129,110,950 - 129,148,946 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9129,110,950 - 129,148,946 (+)EnsemblGRCh38hg38GRCh38
GRCh379131,873,229 - 131,911,225 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,913,065 - 130,951,044 (+)NCBINCBI36Build 36hg18NCBI36
Build 349128,953,166 - 128,990,777NCBI
Celera9102,525,511 - 102,563,513 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9101,480,193 - 101,518,132 (+)NCBIHuRef
CHM1_19132,024,045 - 132,062,045 (+)NCBICHM1_1
T2T-CHM13v2.09141,314,397 - 141,352,390 (+)NCBIT2T-CHM13v2.0
Ptpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,306,062 - 30,337,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl230,306,051 - 30,337,818 (+)EnsemblGRCm39 Ensembl
GRCm38230,416,050 - 30,447,807 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,416,039 - 30,447,806 (+)EnsemblGRCm38mm10GRCm38
MGSCv37230,271,570 - 30,303,327 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36230,238,059 - 30,269,813 (+)NCBIMGSCv36mm8
Celera230,120,848 - 30,152,502 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.71NCBI
Ptpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,429,316 - 1,455,562 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555701,429,316 - 1,454,820 (+)NCBIChiLan1.0ChiLan1.0
PTPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21110,202,540 - 10,240,224 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1910,204,886 - 10,242,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09100,236,607 - 100,274,273 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,896,584 - 128,934,651 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,896,584 - 128,934,651 (+)Ensemblpanpan1.1panPan2
PTPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,535,186 - 54,568,632 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,536,180 - 54,566,235 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha953,730,775 - 53,764,220 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0955,430,817 - 55,464,245 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl955,426,235 - 55,461,851 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,217,697 - 54,250,902 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0954,529,536 - 54,562,790 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0954,623,019 - 54,656,500 (-)NCBIUU_Cfam_GSD_1.0
Ptpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,768,400 - 196,795,560 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648716,542,888 - 16,564,646 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648716,536,740 - 16,564,087 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,401,514 - 269,431,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11269,401,776 - 269,431,465 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,417,989 - 303,447,667 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,017,533 - 9,056,856 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,019,024 - 9,056,703 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666096506,991 - 549,730 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247605,974,881 - 6,001,979 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247605,974,881 - 6,001,975 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ptpa
170 total Variants

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:111
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000024914
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat

1 to 10 of 22 rows
D3Mco30  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,708,362 - 13,708,392 (+)MAPPERmRatBN7.2
mRatBN7.2313,708,362 - 13,708,597 (+)MAPPERmRatBN7.2
Rnor_6.039,000,661 - 9,000,895NCBIRnor6.0
Rnor_6.039,000,661 - 9,000,690NCBIRnor6.0
Rnor_5.0314,353,434 - 14,353,463UniSTSRnor5.0
Rnor_5.0314,353,434 - 14,353,668UniSTSRnor5.0
RGSC_v3.439,480,257 - 9,480,491UniSTSRGSC3.4
RGSC_v3.439,480,256 - 9,480,491RGDRGSC3.4
RGSC_v3.439,480,257 - 9,480,286UniSTSRGSC3.4
RGSC_v3.139,480,587 - 9,480,822RGD
Celera38,474,910 - 8,475,144UniSTS
Celera38,474,910 - 8,474,939UniSTS
Cytogenetic Map3p12UniSTS
RH127941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,720,088 - 13,720,271 (+)MAPPERmRatBN7.2
Rnor_6.039,012,387 - 9,012,569NCBIRnor6.0
Rnor_5.0314,365,160 - 14,365,342UniSTSRnor5.0
RGSC_v3.439,491,983 - 9,492,165UniSTSRGSC3.4
Celera38,486,636 - 8,486,818UniSTS
RH 3.4 Map351.81UniSTS
Cytogenetic Map3p12UniSTS
RH125061  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,720,078 - 13,720,273 (+)MAPPERmRatBN7.2
Rnor_6.039,012,377 - 9,012,571NCBIRnor6.0
Rnor_5.0314,365,150 - 14,365,344UniSTSRnor5.0
RGSC_v3.439,491,973 - 9,492,167UniSTSRGSC3.4
Celera38,486,626 - 8,486,820UniSTS
Cytogenetic Map3p12UniSTS
REN36142  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,713,720 - 13,713,971 (+)MAPPERmRatBN7.2
Rnor_6.039,006,019 - 9,006,269NCBIRnor6.0
Rnor_5.0314,358,792 - 14,359,042UniSTSRnor5.0
RGSC_v3.439,485,615 - 9,485,865UniSTSRGSC3.4
Celera38,480,268 - 8,480,518UniSTS
Cytogenetic Map3p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000024914   ⟹   ENSRNOP00000024914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,689,742 - 13,720,271 (+)Ensembl
Rnor_6.0 Ensembl38,982,122 - 9,012,585 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107089   ⟹   ENSRNOP00000097647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,689,741 - 13,722,549 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108066   ⟹   ENSRNOP00000080286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,689,741 - 13,717,299 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108795   ⟹   ENSRNOP00000080651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,689,742 - 13,720,271 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118909   ⟹   ENSRNOP00000097534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,689,742 - 13,720,271 (+)Ensembl
RefSeq Acc Id: NM_001108577   ⟹   NP_001102047
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,087,637 - 34,118,100 (+)NCBI
mRatBN7.2313,689,821 - 13,720,287 (+)NCBI
Rnor_6.038,982,122 - 9,012,585 (+)NCBI
Rnor_5.0314,334,896 - 14,365,358 (+)NCBI
RGSC_v3.439,461,718 - 9,492,181 (+)RGD
Celera38,456,362 - 8,486,834 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105369   ⟹   XP_038961297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,087,709 - 34,113,465 (+)NCBI
mRatBN7.2313,689,742 - 13,715,652 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_001102047 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961297 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66861 (Get FASTA)   NCBI Sequence Viewer  
  EDL93307 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024914.6
  ENSRNOP00000080286.1
  ENSRNOP00000080651.1
  ENSRNOP00000097534.1
  ENSRNOP00000097647.1
  ENSRNOP00000104822
  ENSRNOP00000109918
1 to 11 of 11 rows
RefSeq Acc Id: NP_001102047   ⟸   NM_001108577
- UniProtKB: B2RYQ2 (UniProtKB/TrEMBL),   F7FF51 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024914   ⟸   ENSRNOT00000024914
RefSeq Acc Id: XP_038961297   ⟸   XM_039105369
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000080651   ⟸   ENSRNOT00000108795
Ensembl Acc Id: ENSRNOP00000097534   ⟸   ENSRNOT00000118909

Name Modeler Protein Id AA Range Protein Structure
AF-B2RYQ2-F1-model_v2 AlphaFold B2RYQ2 1-323 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691960
Promoter ID:EPDNEW_R2485
Type:initiation region
Name:Ptpa_1
Description:protein phosphatase 2 phosphatase activator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.038,982,062 - 8,982,122EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-50211 BioCyc
Ensembl Genes ENSRNOG00000018457 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024914.6 UniProtKB/TrEMBL
  ENSRNOT00000107089.1 UniProtKB/TrEMBL
  ENSRNOT00000108066.1 UniProtKB/TrEMBL
  ENSRNOT00000108795.1 UniProtKB/TrEMBL
  ENSRNOT00000118909.1 UniProtKB/TrEMBL
  ENSRNOT00000128095 ENTREZGENE
  ENSRNOT00000135308 ENTREZGENE
Gene3D-CATH 1.20.120.1150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9101723 IMAGE-MGC_LOAD
InterPro Phstyr_phstse_ac UniProtKB/TrEMBL
  PTPA_C_lid UniProtKB/TrEMBL
  PTPA_sf UniProtKB/TrEMBL
KEGG Report rno:362102 UniProtKB/TrEMBL
MGC_CLONE MGC:188770 IMAGE-MGC_LOAD
NCBI Gene 362102 ENTREZGENE
PANTHER PTHR10012 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR UniProtKB/TrEMBL
Pfam PTPA UniProtKB/TrEMBL
PhenoGen Ptpa PhenoGen
PIRSF Phstyr_phstse_ac UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018457 RatGTEx
Superfamily-SCOP SSF140984 UniProtKB/TrEMBL
UniProt A0A8I5ZPZ9_RAT UniProtKB/TrEMBL
  A0A8I5ZTH7_RAT UniProtKB/TrEMBL
  A0A8I6ASU9_RAT UniProtKB/TrEMBL
  A0A8I6AUP5_RAT UniProtKB/TrEMBL
  B2RYQ2 ENTREZGENE, UniProtKB/TrEMBL
  F7FF51 ENTREZGENE, UniProtKB/TrEMBL
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Ptpa  protein phosphatase 2 phosphatase activator  Ppp2r4  protein phosphatase 2 regulatory subunit 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-11 Ppp2r4  protein phosphatase 2 regulatory subunit 4  Ppp2r4  protein phosphatase 2A regulatory subunit 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Ppp2r4  protein phosphatase 2A regulatory subunit 4  Ppp2r4  protein phosphatase 2A activator, regulatory subunit 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Ppp2r4  protein phosphatase 2A activator, regulatory subunit 4  Ppp2r4  protein phosphatase 2A, regulatory subunit B (PR 53)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ppp2r4  protein phosphatase 2A, regulatory subunit B (PR 53)   Ppp2r4_predicted  protein phosphatase 2A, regulatory subunit B (PR 53) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppp2r4_predicted  protein phosphatase 2A, regulatory subunit B' (PR 53) (predicted)      Symbol and Name status set to approved 70820 APPROVED