Sh2d3c (SH2 domain containing 3C) - Rat Genome Database

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Gene: Sh2d3c (SH2 domain containing 3C) Rattus norvegicus
Analyze
Symbol: Sh2d3c
Name: SH2 domain containing 3C
RGD ID: 1307287
Description: Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in cytosol. Orthologous to human SH2D3C (SH2 domain containing 3C); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362111; NSP3; SH2 domain-containing protein 3C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,408,305 - 36,444,191 (+)NCBIGRCr8
mRatBN7.2316,010,622 - 16,046,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,078,919 - 19,114,707 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,663,924 - 27,699,712 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,915,240 - 25,951,556 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,756,427 - 11,793,547 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,095,296 - 17,130,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,687,031 - 11,731,868 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,617,288 - 11,627,810 (+)NCBI
Celera310,751,515 - 10,786,059 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sh2d3cRatcongenital disorder of glycosylation Iu  ISOSH2D3C (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23109149 and PMID:28492532
Sh2d3cRatdevelopmental and epileptic encephalopathy  ISOSH2D3C (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:18469812 more ...
Sh2d3cRatdevelopmental and epileptic encephalopathy 31A  ISOSH2D3C (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathy more ...ClinVarPMID:18469812 more ...
Sh2d3cRatdystonia  ISOSH2D3C (Homo sapiens)8554872ClinVar Annotator: match by term: Dystonic disorderClinVarPMID:28492532
Sh2d3cRatearly infantile epileptic encephalopathy  ISOSH2D3C (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:18469812 more ...
Sh2d3cRatprimary coenzyme Q10 deficiency 7  ISOSH2D3C (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndromeClinVarPMID:22368301 more ...

1 to 20 of 70 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sh2d3cRat(1->4)-beta-D-glucan multiple interactionsISOSh2d3c (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SH2D3C mRNACTDPMID:36331819
Sh2d3cRat17alpha-ethynylestradiol affects expressionISOSh2d3c (Mus musculus)6480464Ethinyl Estradiol affects the expression of SH2D3C mRNACTDPMID:17555576
Sh2d3cRat17beta-estradiol multiple interactionsISOSH2D3C (Homo sapiens)6480464[Estradiol binds to ESR2 protein] which results in increased expression of SH2D3C mRNA and Estradiol promotes the reaction [ESR2 protein affects the expression of SH2D3C mRNA]CTDPMID:20404318
Sh2d3cRat17beta-estradiol increases expressionISOSH2D3C (Homo sapiens)6480464Estradiol results in increased expression of SH2D3C mRNACTDPMID:31614463
Sh2d3cRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SH2D3C mRNACTDPMID:32741896
Sh2d3cRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SH2D3C mRNACTDPMID:32741896
Sh2d3cRat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOSh2d3c (Mus musculus)64804642 more ...CTDPMID:31388691
Sh2d3cRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SH2D3C mRNACTDPMID:22298810 and PMID:34747641
Sh2d3cRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOSh2d3c (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of SH2D3C mRNACTDPMID:21354282
Sh2d3cRat4,4'-diaminodiphenylmethane decreases expressionISOSh2d3c (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of SH2D3C mRNACTDPMID:18648102
Sh2d3cRat4,4'-sulfonyldiphenol decreases methylationISOSh2d3c (Mus musculus)6480464bisphenol S results in decreased methylation of SH2D3C exonCTDPMID:33297965
Sh2d3cRat4,4'-sulfonyldiphenol affects methylationISOSh2d3c (Mus musculus)6480464bisphenol S affects the methylation of SH2D3C geneCTDPMID:31683443
Sh2d3cRat4-hydroxyphenyl retinamide increases expressionISOSh2d3c (Mus musculus)6480464Fenretinide results in increased expression of SH2D3C mRNACTDPMID:28973697
Sh2d3cRat5-aza-2'-deoxycytidine affects expressionISOSH2D3C (Homo sapiens)6480464Decitabine affects the expression of SH2D3C mRNACTDPMID:23300844
Sh2d3cRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of SH2D3C mRNACTDPMID:24780913
Sh2d3cRatacetamide increases expressionEXP 6480464acetamide results in increased expression of SH2D3C mRNACTDPMID:31881176
Sh2d3cRatacrylamide decreases expressionISOSH2D3C (Homo sapiens)6480464Acrylamide results in decreased expression of SH2D3C mRNACTDPMID:32763439
Sh2d3cRatall-trans-retinoic acid increases expressionISOSH2D3C (Homo sapiens)6480464Tretinoin results in increased expression of SH2D3C mRNACTDPMID:33167477
Sh2d3cRatarsane affects expressionISOSH2D3C (Homo sapiens)6480464Arsenic affects the expression of SH2D3C mRNACTDPMID:18414638
Sh2d3cRatarsenic atom affects expressionISOSH2D3C (Homo sapiens)6480464Arsenic affects the expression of SH2D3C mRNACTDPMID:18414638

1 to 20 of 70 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sh2d3cRatsmall GTPase-mediated signal transduction involved_inIEAInterPro:IPR001895 and InterPro:IPR0369641600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sh2d3cRatcytosol located_inISOSH2D3C (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Sh2d3cRatcytosol located_inIEAUniProtKB:Q8N5H7 and ensembl:ENSP000003178171600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function

  


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:29966723  



Sh2d3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,408,305 - 36,444,191 (+)NCBIGRCr8
mRatBN7.2316,010,622 - 16,046,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,078,919 - 19,114,707 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,663,924 - 27,699,712 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,915,240 - 25,951,556 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,756,427 - 11,793,547 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,095,296 - 17,130,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,687,031 - 11,731,868 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,617,288 - 11,627,810 (+)NCBI
Celera310,751,515 - 10,786,059 (+)NCBICelera
Cytogenetic Map3p11NCBI
SH2D3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,738,317 - 127,778,666 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,738,317 - 127,778,710 (-)EnsemblGRCh38hg38GRCh38
GRCh379130,500,596 - 130,540,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,540,419 - 129,580,733 (-)NCBINCBI36Build 36hg18NCBI36
Celera9101,151,465 - 101,191,912 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,117,130 - 100,157,604 (-)NCBIHuRef
CHM1_19130,652,151 - 130,692,598 (-)NCBICHM1_1
T2T-CHM13v2.09139,945,763 - 139,986,120 (-)NCBIT2T-CHM13v2.0
Sh2d3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,611,072 - 32,645,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,611,067 - 32,645,524 (+)EnsemblGRCm39 Ensembl
GRCm38232,721,037 - 32,755,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,721,055 - 32,755,512 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,576,592 - 32,610,514 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,543,081 - 32,577,003 (+)NCBIMGSCv36mm8
Celera232,427,779 - 32,461,735 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Sh2d3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419891,133 - 921,062 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419891,133 - 921,062 (+)NCBIChiLan1.0ChiLan1.0
SH2D3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,569,377 - 11,616,556 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,571,776 - 11,618,903 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,858,018 - 98,899,661 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,530,733 - 127,571,016 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,530,733 - 127,571,016 (-)Ensemblpanpan1.1panPan2
SH2D3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,626,379 - 55,656,667 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,626,360 - 55,656,507 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,819,942 - 54,850,176 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,547,903 - 56,578,173 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,547,816 - 56,578,171 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,308,165 - 55,338,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,622,873 - 55,653,134 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,714,308 - 55,744,373 (+)NCBIUU_Cfam_GSD_1.0
Sh2d3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,642,351 - 195,671,839 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,410,877 - 15,440,347 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,410,878 - 15,440,326 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2D3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,238,973 - 268,270,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,238,967 - 268,270,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,129,597 - 302,137,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH2D3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,352,947 - 10,395,023 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,354,061 - 10,396,230 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,826,055 - 5,867,966 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh2d3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,771,456 - 7,800,464 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,771,646 - 7,800,487 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Sh2d3c
205 total Variants

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:129
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000031511, ENSRNOT00000065915
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat

1 to 10 of 25 rows
RH127491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,046,208 - 16,046,413 (+)MAPPERmRatBN7.2
Rnor_6.0311,793,272 - 11,793,476NCBIRnor6.0
Rnor_5.0317,130,242 - 17,130,446UniSTSRnor5.0
RGSC_v3.4311,731,593 - 11,731,797UniSTSRGSC3.4
Celera310,785,784 - 10,785,988UniSTS
RH 3.4 Map371.1UniSTS
Cytogenetic Map3p11UniSTS
RH138706  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,036,423 - 16,036,650 (+)MAPPERmRatBN7.2
Rnor_6.0311,783,487 - 11,783,713NCBIRnor6.0
Rnor_5.0317,120,457 - 17,120,683UniSTSRnor5.0
RGSC_v3.4311,721,808 - 11,722,034UniSTSRGSC3.4
Celera310,775,999 - 10,776,225UniSTS
RH 3.4 Map360.6UniSTS
Cytogenetic Map3p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000078366   ⟹   ENSRNOP00000072798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,017,500 - 16,046,484 (+)Ensembl
Rnor_6.0 Ensembl311,763,706 - 11,793,547 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087762   ⟹   ENSRNOP00000070659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)Ensembl
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098941   ⟹   ENSRNOP00000079271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,034,838 - 16,041,141 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106524   ⟹   ENSRNOP00000084559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,034,838 - 16,046,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110408   ⟹   ENSRNOP00000078942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,017,500 - 16,046,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113142   ⟹   ENSRNOP00000088575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,014,594 - 16,046,484 (+)Ensembl
RefSeq Acc Id: NM_001108579   ⟹   NP_001102049
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,408,326 - 36,444,191 (+)NCBI
mRatBN7.2316,010,625 - 16,046,484 (+)NCBI
Rnor_6.0311,756,427 - 11,793,547 (+)NCBI
Rnor_5.0317,095,296 - 17,130,517 (+)NCBI
RGSC_v3.4311,687,031 - 11,731,868 (+)RGD
Celera310,751,515 - 10,786,059 (+)RGD
Sequence:
RefSeq Acc Id: XM_008761759   ⟹   XP_008759981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,415,038 - 36,444,191 (+)NCBI
mRatBN7.2316,017,336 - 16,046,491 (+)NCBI
Rnor_6.0311,762,339 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761760   ⟹   XP_008759982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,425,248 - 36,444,191 (+)NCBI
mRatBN7.2316,030,174 - 16,046,491 (+)NCBI
Rnor_6.0311,777,946 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591882   ⟹   XP_017447371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,425,248 - 36,444,191 (+)NCBI
mRatBN7.2316,030,174 - 16,046,491 (+)NCBI
Rnor_6.0311,777,946 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105377   ⟹   XP_038961305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,408,305 - 36,444,191 (+)NCBI
mRatBN7.2316,010,622 - 16,046,491 (+)NCBI
RefSeq Acc Id: XM_039105378   ⟹   XP_038961306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,430,103 - 36,444,191 (+)NCBI
mRatBN7.2316,032,393 - 16,046,491 (+)NCBI
RefSeq Acc Id: XM_063284070   ⟹   XP_063140140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,415,285 - 36,444,191 (+)NCBI
1 to 5 of 13 rows
1 to 5 of 13 rows
RefSeq Acc Id: NP_001102049   ⟸   NM_001108579
- UniProtKB: A0A0G2JYH7 (UniProtKB/TrEMBL),   A6JU82 (UniProtKB/TrEMBL),   A0A8I6A5D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759981   ⟸   XM_008761759
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZME7 (UniProtKB/TrEMBL),   A0A2Z5DT54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759982   ⟸   XM_008761760
- Peptide Label: isoform X3
- UniProtKB: A0A2Z5DT54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447371   ⟸   XM_017591882
- Peptide Label: isoform X4
- UniProtKB: A0A2Z5DT54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070659   ⟸   ENSRNOT00000087762
Ras-GEF   SH2

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYH7-F1-model_v2 AlphaFold A0A0G2JYH7 1-853 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692001
Promoter ID:EPDNEW_R2517
Type:single initiation site
Name:Sh2d3c_1
Description:SH2 domain containing 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,763,690 - 11,763,750EPDNEW


1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-50125 BioCyc
Ensembl Genes ENSRNOG00000054560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078366.2 UniProtKB/TrEMBL
  ENSRNOT00000087762.2 UniProtKB/TrEMBL
  ENSRNOT00000098941.1 UniProtKB/TrEMBL
  ENSRNOT00000106524.1 UniProtKB/TrEMBL
  ENSRNOT00000110408 ENTREZGENE
  ENSRNOT00000110408.1 UniProtKB/TrEMBL
  ENSRNOT00000113142 ENTREZGENE
  ENSRNOT00000113142.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2-Ras-GEF_adapter UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH2_SHEP1/BCAR3/NSP1 UniProtKB/TrEMBL
KEGG Report rno:362111 UniProtKB/TrEMBL
NCBI Gene 362111 ENTREZGENE
PANTHER BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN UniProtKB/TrEMBL
  SH2 DOMAIN-CONTAINING PROTEIN 3C UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Sh2d3c PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE RASGEF_CAT UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054560 RatGTEx
SMART RasGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2JYH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z5DT54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMD8_RAT UniProtKB/TrEMBL
  A0A8I5ZME7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAN0 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sh2d3c  SH2 domain containing 3C   Sh2d3c_predicted  SH2 domain containing 3C (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sh2d3c_predicted  SH2 domain containing 3C (predicted)      Symbol and Name status set to approved 70820 APPROVED