Klhl7 (kelch-like family member 7) - Rat Genome Database

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Gene: Klhl7 (kelch-like family member 7) Rattus norvegicus
Analyze
Symbol: Klhl7
Name: kelch-like family member 7
RGD ID: 1305564
Description: Predicted to enable protein homodimerization activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in several cellular components, including cytosol; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 3 and retinitis pigmentosa 42. Orthologous to human KLHL7 (kelch like family member 7); INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kelch-like 7; kelch-like 7 (Drosophila); kelch-like protein 7; LOC362303
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,898,766 - 11,947,796 (-)NCBIGRCr8
mRatBN7.2411,006,366 - 11,055,399 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl411,006,375 - 11,055,541 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx416,152,746 - 16,201,662 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,972,670 - 12,028,668 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,324,733 - 10,373,649 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,532,881 - 7,582,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,532,889 - 7,582,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,544,411 - 7,593,562 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,373,343 - 6,422,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,373,344 - 6,422,371 (-)NCBI
Celera46,620,792 - 6,669,688 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl7RatBohring Syndrome  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Bohring-Opitz syndromeClinVarPMID:25741868
Klhl7Ratcold-induced sweating syndrome 1  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Cold-induced sweating syndrome 1ClinVarPMID:21828050 more ...
Klhl7Ratcold-induced sweating syndrome 3  ISOKLHL7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Klhl7Ratdistal arthrogryposis  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Distal arthrogryposisClinVarPMID:18414213 more ...
Klhl7Ratfundus dystrophy  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:19520207 more ...
Klhl7Ratgenetic disease  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:21828050 more ...
Klhl7Ratpleomorphic xanthoastrocytoma  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Klhl7Ratprimary ciliary dyskinesia  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
Klhl7Ratretinitis pigmentosa  ISOKLHL7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19520207 more ...
Klhl7Ratretinitis pigmentosa  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVarPMID:19520207 more ...
Klhl7Ratretinitis pigmentosa  ISOKLHL7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19520207 more ...
Klhl7Ratretinitis pigmentosa 42  ISOKLHL7 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosa 42ClinVarPMID:17576681 more ...
1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl7Ratcold-induced sweating syndrome  ISOKLHL7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Klhl7Ratretinitis pigmentosa 42  ISOKLHL7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl7Ratcold-induced sweating syndrome 3  ISOKLHL7 (Homo sapiens)7240710 OMIM 
Klhl7Ratretinitis pigmentosa 42  ISOKLHL7 (Homo sapiens)7240710 OMIM 

1 to 20 of 68 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl7Rat1,2-dimethylhydrazine decreases expressionISOKlhl7 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of KLHL7 mRNACTDPMID:22206623
Klhl7Rat2,3',4,4',5-Pentachlorobiphenyl decreases expressionISOKlhl7 (Mus musculus)64804642 more ...CTDPMID:31388691
Klhl7Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of KLHL7 mRNACTDPMID:21346803
Klhl7Rat2-methylcholine affects expressionISOKLHL7 (Homo sapiens)6480464beta-methylcholine affects the expression of KLHL7 mRNACTDPMID:21179406
Klhl7Rat5-aza-2'-deoxycytidine affects expressionISOKLHL7 (Homo sapiens)6480464Decitabine affects the expression of KLHL7 mRNACTDPMID:23300844
Klhl7Rat5-fluorouracil affects response to substanceISOKLHL7 (Homo sapiens)6480464KLHL7 protein affects the susceptibility to FluorouracilCTDPMID:16217747
Klhl7Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of KLHL7 mRNACTDPMID:24780913
Klhl7Ratall-trans-retinoic acid decreases expressionISOKLHL7 (Homo sapiens)6480464Tretinoin results in decreased expression of KLHL7 mRNACTDPMID:21934132
Klhl7Ratantirheumatic drug increases expressionISOKLHL7 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of KLHL7 mRNACTDPMID:24449571
Klhl7RatAroclor 1254 decreases expressionISOKlhl7 (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of KLHL7 mRNACTDPMID:23650126
Klhl7Ratbenzo[a]pyrene decreases expressionEXP 6480464Benzo(a)pyrene results in decreased expression of KLHL7 mRNACTDPMID:21839799
Klhl7Ratbenzo[a]pyrene increases expressionISOKlhl7 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of KLHL7 mRNACTDPMID:22228805
Klhl7Ratbeta-lapachone decreases expressionISOKLHL7 (Homo sapiens)6480464beta-lapachone results in decreased expression of KLHL7 mRNACTDPMID:38218311
Klhl7Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of KLHL7 geneCTDPMID:28505145
Klhl7RatC60 fullerene decreases expressionEXP 6480464fullerene C60 results in decreased expression of KLHL7 mRNACTDPMID:19167457
Klhl7Ratcadmium atom multiple interactionsISOKlhl7 (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of KLHL7 mRNACTDPMID:37325564
Klhl7Ratcadmium dichloride decreases expressionEXP 6480464Cadmium Chloride results in decreased expression of KLHL7 mRNACTDPMID:33453195
Klhl7Ratcadmium dichloride multiple interactionsISOKlhl7 (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of KLHL7 mRNACTDPMID:37325564
Klhl7Ratcadmium sulfate multiple interactionsISOKLHL7 (Homo sapiens)6480464[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL7 mRNACTDPMID:18654764
Klhl7Ratchlormequat chloride decreases expressionEXP 6480464Chlormequat results in decreased expression of KLHL7 proteinCTDPMID:34958886

1 to 20 of 68 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl7Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIBAFB:FBgn0037978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Klhl7Ratprotein ubiquitination involved_inISSUniProtKB:Q8IXQ51600115GO_REF:0000024UniProtGO_REF:0000024
Klhl7Ratprotein ubiquitination involved_inIEAUniProtKB:Q8IXQ5 and ensembl:ENSP000003432731600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl7Ratprotein ubiquitination involved_inIEAInterPro:IPR0305991600115GO_REF:0000002InterProGO_REF:0000002
Klhl7Ratprotein ubiquitination involved_inISOKLHL7 (Homo sapiens)1624291 PMID:21828050RGDPMID:21828050
Klhl7Ratprotein ubiquitination involved_inIEAUniPathway:UPA001431600115GO_REF:0000041UniProtGO_REF:0000041

Cellular Component
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klhl7RatCul3-RING ubiquitin ligase complex part_ofISSUniProtKB:Q8IXQ51600115GO_REF:0000024UniProtGO_REF:0000024
Klhl7RatCul3-RING ubiquitin ligase complex part_ofIEAInterPro:IPR0305991600115GO_REF:0000002InterProGO_REF:0000002
Klhl7RatCul3-RING ubiquitin ligase complex part_ofIEAUniProtKB:Q8IXQ5 and ensembl:ENSP000003432731600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl7RatCul3-RING ubiquitin ligase complex part_ofIBAFB:FBgn0037978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Klhl7RatCul3-RING ubiquitin ligase complex part_ofISOKLHL7 (Homo sapiens)1624291 PMID:21828050RGDPMID:21828050
Klhl7Ratcytoplasm is_active_inIBAMGI:1858732 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Klhl7Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Klhl7Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Klhl7Ratcytosol located_inISOKLHL7 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Klhl7Ratcytosol located_inIEAUniProtKB:Q8IXQ5 and ensembl:ENSP000003432731600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl7Ratnucleolus located_inIEAUniProtKB:Q8IXQ5 and ensembl:ENSP000003432731600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl7Ratnucleolus located_inISOKLHL7 (Homo sapiens)1624291 RGDGO_REF:0000054
Klhl7Ratnucleoplasm located_inIEAUniProtKB:Q8IXQ5 and ensembl:ENSP000003432731600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl7Ratnucleoplasm located_inISOKLHL7 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Klhl7Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Klhl7Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Klhl7Ratperinuclear region of cytoplasm located_inISSUniProtKB:Q8IXQ51600115GO_REF:0000024UniProtGO_REF:0000024
Klhl7Ratperinuclear region of cytoplasm located_inIEAUniProtKB:Q8IXQ5 and ensembl:ENSP000003432731600115GO_REF:0000107EnsemblGO_REF:0000107
Klhl7Ratperinuclear region of cytoplasm located_inISOKLHL7 (Homo sapiens)1624291 PMID:27392078RGDPMID:27392078
Klhl7Ratplasma membrane located_inISOKLHL7 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
1 to 20 of 21 rows

Molecular Function

  


#
Reference Title
Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:15489334   PMID:21828050   PMID:27392078  



Klhl7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,898,766 - 11,947,796 (-)NCBIGRCr8
mRatBN7.2411,006,366 - 11,055,399 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl411,006,375 - 11,055,541 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx416,152,746 - 16,201,662 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,972,670 - 12,028,668 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,324,733 - 10,373,649 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,532,881 - 7,582,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,532,889 - 7,582,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,544,411 - 7,593,562 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,373,343 - 6,422,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,373,344 - 6,422,371 (-)NCBI
Celera46,620,792 - 6,669,688 (-)NCBICelera
Cytogenetic Map4q11NCBI
KLHL7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38723,105,785 - 23,177,914 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl723,105,758 - 23,177,914 (+)EnsemblGRCh38hg38GRCh38
GRCh37723,145,404 - 23,217,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36723,111,927 - 23,181,565 (+)NCBINCBI36Build 36hg18NCBI36
Build 34722,918,641 - 22,988,161NCBI
Celera723,131,633 - 23,201,326 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef723,028,775 - 23,097,583 (+)NCBIHuRef
CHM1_1723,146,175 - 23,215,829 (+)NCBICHM1_1
T2T-CHM13v2.0723,242,311 - 23,314,438 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2723,197,216 - 23,266,913 (+)NCBI
Klhl7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,305,563 - 24,368,363 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,305,603 - 24,365,790 (+)EnsemblGRCm39 Ensembl
GRCm38524,100,565 - 24,163,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,100,605 - 24,160,792 (+)EnsemblGRCm38mm10GRCm38
MGSCv37523,606,408 - 23,667,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,610,675 - 23,670,850 (+)NCBIMGSCv36mm8
Celera521,052,978 - 21,115,929 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.67NCBI
Klhl7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541025,406,386 - 25,478,111 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541025,406,775 - 25,477,552 (+)NCBIChiLan1.0ChiLan1.0
KLHL7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2627,968,574 - 28,038,275 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1776,293,299 - 76,364,262 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0723,788,760 - 23,858,965 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1723,399,130 - 23,467,919 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl723,399,135 - 23,467,919 (+)Ensemblpanpan1.1panPan2
KLHL7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11436,793,691 - 36,859,483 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1436,802,984 - 36,887,588 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1436,334,667 - 36,401,129 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01436,717,668 - 36,784,962 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1436,717,363 - 36,848,532 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11436,839,253 - 36,905,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01436,536,704 - 36,603,149 (+)NCBIUNSW_CanFamBas_1.0
Klhl7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511881,067,860 - 81,125,924 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936478279,067 - 337,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936478279,580 - 337,655 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl991,924,495 - 91,971,695 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1991,901,876 - 91,971,706 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29101,467,797 - 101,486,805 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12135,148,265 - 35,218,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2135,148,043 - 35,218,160 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604269,385,698 - 69,455,826 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247397,470,306 - 7,535,166 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247397,470,304 - 7,534,886 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Klhl7
184 total Variants

Predicted Target Of
Summary Value
Count of predictions:467
Count of miRNA genes:238
Interacting mature miRNAs:287
Transcripts:ENSRNOT00000013932
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat

1 to 10 of 29 rows
RH129062  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8411,898,871 - 11,899,090 (+)Marker Load Pipeline
mRatBN7.2411,006,471 - 11,006,690 (+)MAPPERmRatBN7.2
Rnor_6.047,532,987 - 7,533,205NCBIRnor6.0
Rnor_5.047,544,517 - 7,544,735UniSTSRnor5.0
RGSC_v3.446,373,449 - 6,373,667UniSTSRGSC3.4
Celera46,620,898 - 6,621,116UniSTS
Cytogenetic Map4q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000013932   ⟹   ENSRNOP00000013932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl411,006,387 - 11,055,541 (-)Ensembl
Rnor_6.0 Ensembl47,532,889 - 7,582,207 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108635   ⟹   ENSRNOP00000096925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl411,006,375 - 11,055,521 (-)Ensembl
RefSeq Acc Id: NM_001012187   ⟹   NP_001012187
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,898,766 - 11,947,796 (-)NCBI
mRatBN7.2411,006,366 - 11,055,399 (-)NCBI
Rnor_6.047,532,881 - 7,582,032 (-)NCBI
Rnor_5.047,544,411 - 7,593,562 (-)NCBI
RGSC_v3.446,373,343 - 6,422,371 (-)RGD
Celera46,620,792 - 6,669,688 (-)RGD
Sequence:
Protein RefSeqs NP_001012187 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83903 (Get FASTA)   NCBI Sequence Viewer  
  EDL99383 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013932
  ENSRNOP00000013932.4
GenBank Protein Q5XHZ6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012187   ⟸   NM_001012187
- UniProtKB: Q5XHZ6 (UniProtKB/Swiss-Prot),   A6K574 (UniProtKB/TrEMBL),   A0A8I6AU73 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013932   ⟸   ENSRNOT00000013932
Ensembl Acc Id: ENSRNOP00000096925   ⟸   ENSRNOT00000108635
BACK   BTB

Name Modeler Protein Id AA Range Protein Structure
AF-Q5XHZ6-F1-model_v2 AlphaFold Q5XHZ6 1-586 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692796
Promoter ID:EPDNEW_R3320
Type:initiation region
Name:Klhl7_1
Description:kelch-like family member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.047,582,125 - 7,582,185EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-46027 BioCyc
Ensembl Genes ENSRNOG00000010453 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013932 ENTREZGENE
  ENSRNOT00000013932.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot
  2.120.10.80 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133606 IMAGE-MGC_LOAD
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  KLHL7 UniProtKB/Swiss-Prot
  KLHL7_BACK UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:362303 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95261 IMAGE-MGC_LOAD
NCBI Gene 362303 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/Swiss-Prot
  RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372 UniProtKB/Swiss-Prot
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
PhenoGen Klhl7 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010453 RatGTEx
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot
  SSF54695 UniProtKB/Swiss-Prot
UniProt A0A8I6AU73 ENTREZGENE, UniProtKB/TrEMBL
  A6K574 ENTREZGENE, UniProtKB/TrEMBL
  KLHL7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-06 Klhl7  kelch-like family member 7  Klhl7  kelch-like 7 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Klhl7  kelch-like 7 (Drosophila)  Klhl7_predicted  kelch-like 7 (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Klhl7_predicted  kelch-like 7 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED