Tesl (testis derived transcript-like) - Rat Genome Database

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Gene: Tesl (testis derived transcript-like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tesl
Name: testis derived transcript-like
RGD ID: 1305365
Description: Predicted to enable zinc ion binding activity. Predicted to be located in cytoplasm and focal adhesion. Human ortholog(s) of this gene implicated in childhood acute lymphocytic leukemia; gastrointestinal system cancer (multiple); high grade glioma; lung non-small cell carcinoma; and uterine cancer (multiple). Orthologous to human TES (testin LIM domain protein); INTERACTS WITH bisphenol A; rotenone; trichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316142; Tes; testis derived transcript
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X119,485,153 - 119,498,721 (-)NCBIGRCr8
mRatBN7.2X114,680,227 - 114,693,795 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX114,680,227 - 114,693,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX116,711,725 - 116,725,292 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X120,202,992 - 120,216,559 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X117,756,593 - 117,770,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X121,053,287 - 121,066,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX121,053,297 - 121,066,855 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X121,200,296 - 121,213,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X9,556,982 - 9,570,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X9,562,538 - 9,576,004 (+)NCBI
CeleraX113,867,642 - 113,881,010 (-)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TeslRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of TESL mRNACTDPMID:25181051
TeslRatrotenone increases expressionEXP 6480464Rotenone results in increased expression of TESL mRNACTDPMID:28374803
TeslRattrichloroethene decreases methylationEXP 6480464Trichloroethylene results in decreased methylation of TESL geneCTDPMID:27618143


Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TeslRatanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
TeslRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
TeslRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
TeslRatfocal adhesion located_inIEAUniProtKB-SubCell:SL-01181600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TeslRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
TeslRatzinc ion binding enablesIEAInterPro:IPR0104421600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932  



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Variants in Tesl
64 total Variants

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:49
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000044165
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat

1 to 10 of 11 rows



alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
1 1 6 4 2 2 1 2 6 2 5 20


RefSeq Transcripts NM_001113750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC158595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044165   ⟹   ENSRNOP00000050413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX114,680,227 - 114,693,808 (-)Ensembl
Rnor_6.0 EnsemblX121,053,297 - 121,066,855 (-)Ensembl
RefSeq Acc Id: NM_001113750   ⟹   NP_001107222
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X119,485,153 - 119,498,721 (-)NCBI
mRatBN7.2X114,680,227 - 114,693,795 (-)NCBI
Rnor_6.0X121,053,287 - 121,066,855 (-)NCBI
Rnor_5.0X121,200,296 - 121,213,864 (-)NCBI
RGSC_v3.4X9,556,982 - 9,570,550 (+)RGD
CeleraX113,867,642 - 113,881,010 (-)RGD
Sequence:
Protein RefSeqs NP_001107222 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58596 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050413
  ENSRNOP00000050413.2
RefSeq Acc Id: NP_001107222   ⟸   NM_001113750
- UniProtKB: B0BMX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050413   ⟸   ENSRNOT00000044165
LIM zinc-binding   PET

Name Modeler Protein Id AA Range Protein Structure
AF-B0BMX0-F1-model_v2 AlphaFold B0BMX0 1-406 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-1338 BioCyc
Ensembl Genes ENSRNOG00000033628 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044165 ENTREZGENE
  ENSRNOT00000044165.3 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111579 IMAGE-MGC_LOAD
InterPro LIM1_Testin UniProtKB/TrEMBL
  LIM2_Testin UniProtKB/TrEMBL
  PET_domain UniProtKB/TrEMBL
  PET_testin UniProtKB/TrEMBL
  Pk/Esn/Tes UniProtKB/TrEMBL
  Znf_LIM UniProtKB/TrEMBL
KEGG Report rno:316142 UniProtKB/TrEMBL
MGC_CLONE MGC:187428 IMAGE-MGC_LOAD
NCBI Gene 316142 ENTREZGENE
PANTHER LIM DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR24211:SF1 UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
  PET UniProtKB/TrEMBL
PhenoGen Tesl PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
  PET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033628 RatGTEx
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt B0BMX0 ENTREZGENE, UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-05 Tesl  testis derived transcript-like  Tes_predicted  testis derived transcript (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Tes_predicted  testis derived transcript (predicted)      Symbol and Name status set to approved 70820 APPROVED