Mtln (mitoregulin) - Rat Genome Database

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Gene: Mtln (mitoregulin) Rattus norvegicus
Analyze
Symbol: Mtln
Name: mitoregulin
RGD ID: 10401149
Description: Predicted to be involved in several processes, including positive regulation of fatty acid beta-oxidation; positive regulation of mitochondrial membrane potential; and triglyceride homeostasis. Predicted to be located in mitochondrial inner membrane. Orthologous to human MTLN (mitoregulin); INTERACTS WITH 1,2-dimethylhydrazine (ortholog); bisphenol A (ortholog); Dibutyl phosphate (ortholog).
Type: ncrna (Ensembl: protein-coding)
RefSeq Status: VALIDATED
Previously known as: ENSRNOG00000070641; LOC106631776; small integral membrane protein 37; Smim37; uncharacterized LOC106631776
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,472,081 - 135,472,939 (-)NCBIGRCr8
mRatBN7.23115,018,810 - 115,019,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,019,473 - 115,019,643 (-)NCBImRatBN7.2 Ensembl
mRatBN7.2 Ensembl3115,019,473 - 115,019,643 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,908,652 - 118,909,508 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,504,196 - 127,505,052 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,164,533 - 125,165,389 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,372,665 - 120,373,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera3113,853,266 - 113,854,124 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12060780   PMID:24059539   PMID:29949756  


Genomics

Comparative Map Data
Mtln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,472,081 - 135,472,939 (-)NCBIGRCr8
mRatBN7.23115,018,810 - 115,019,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,019,473 - 115,019,643 (-)NCBImRatBN7.2 Ensembl
mRatBN7.2 Ensembl3115,019,473 - 115,019,643 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,908,652 - 118,909,508 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,504,196 - 127,505,052 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,164,533 - 125,165,389 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,372,665 - 120,373,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera3113,853,266 - 113,854,124 (-)NCBICelera
Cytogenetic Map3q36NCBI
MTLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382110,211,529 - 110,212,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2110,211,529 - 110,245,420 (-)EnsemblGRCh38hg38GRCh38
GRCh372110,969,106 - 110,970,124 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362110,327,155 - 110,329,743 (-)NCBINCBI36Build 36hg18NCBI36
Celera2104,826,911 - 104,838,322 (+)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2104,109,441 - 104,120,850 (-)NCBIHuRef
CHM1_12110,973,360 - 110,984,769 (-)NCBICHM1_1
T2T-CHM13v2.02110,581,192 - 110,582,210 (+)NCBIT2T-CHM13v2.0
Mtln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,633,302 - 127,634,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,633,308 - 127,634,408 (-)EnsemblGRCm39 Ensembl
GRCm382127,791,382 - 127,792,488 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,791,388 - 127,792,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,617,113 - 127,618,224 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,482,829 - 127,483,929 (-)NCBIMGSCv36mm8
Celera2129,024,511 - 129,025,623 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.1NCBI
MTLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,565,140 - 17,566,400 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A17,567,905 - 17,569,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A91,481,706 - 91,514,106 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A111,712,688 - 111,745,069 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A111,713,514 - 111,713,933 (-)Ensemblpanpan1.1panPan2
MTLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1734,910,137 - 34,911,111 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,912,380 - 35,913,354 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,913,159 - 35,913,329 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11735,040,424 - 35,041,417 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01735,108,672 - 35,109,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01735,318,708 - 35,319,683 (-)NCBIUU_Cfam_GSD_1.0
Mtln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407898340 - 1,449 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004943304685 - 1,449 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11413,595,687 - 13,596,974 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660806,093,527 - 6,094,789 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Mtln
4 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000104806   ⟹   ENSRNOP00000088023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3115,019,473 - 115,019,643 (-)Ensembl
RefSeq Acc Id: NR_132743
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,472,081 - 135,472,939 (-)NCBI
mRatBN7.23115,018,810 - 115,019,668 (-)NCBI
Rnor_6.03120,372,665 - 120,373,523 (-)NCBI
Celera3113,853,266 - 113,854,124 (-)NCBI
Sequence:
Protein Sequences
Ensembl Protein ENSRNOP00000088023.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000088023   ⟸   ENSRNOT00000104806

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:10401149 AgrOrtholog
BioCyc Gene G2FUF-47958 BioCyc
Ensembl Genes ENSRNOG00000070641 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000104806.1 UniProtKB/TrEMBL
InterPro Mtln UniProtKB/TrEMBL
NCBI Gene LOC106631776 ENTREZGENE
PANTHER MITOREGULIN UniProtKB/TrEMBL
  PTHR37154 UniProtKB/TrEMBL
PhenoGen Mtln PhenoGen
RatGTEx ENSRNOG00000070641 RatGTEx
RNAcentral URS00008E39A9 RNACentral
UniProt A0A8I6A6Z7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Mtln  mitoregulin  Mtln  mitoregulin  Data merged from RGD:150343732 737654 PROVISIONAL
2022-01-06 Mtln  mitoregulin  ENSRNOG00000070641    Symbol and/or name change 19259462 PROVISIONAL
2021-08-31 ENSRNOG00000070641        Symbol and Name status set to provisional 45752 PROVISIONAL
2018-07-20 Mtln  mitoregulin  Smim37  small integral membrane protein 37  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-11-17 Smim37  small integral membrane protein 37  LOC106631776  uncharacterized LOC106631776  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-09-29 LOC106631776  uncharacterized LOC106631776      Symbol and Name status set to provisional 70820 PROVISIONAL