Mtln (mitoregulin) - Rat Genome Database

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Gene: Mtln (mitoregulin) Mus musculus
Analyze
Symbol: Mtln
Name: mitoregulin
RGD ID: 2292400
MGI Page MGI
Description: Involved in several processes, including positive regulation of fatty acid beta-oxidation; positive regulation of sequestering of calcium ion; and striated muscle cell differentiation. Located in mitochondrial inner membrane. Is expressed in Meckel's cartilage; axial skeleton; esophagus; heart; and retina nuclear layer. Orthologous to human MTLN (mitoregulin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1500011K16Rik; lncRNA-encoded micropeptide; micropeptide in mitochondria; micropeptide regulator of beta-oxidation; Mo; Moxi; Mpm; RIKEN cDNA 1500011K16 gene; small integral membrane protein 37
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,633,302 - 127,634,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,633,308 - 127,634,408 (-)EnsemblGRCm39 Ensembl
GRCm382127,791,382 - 127,792,488 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,791,388 - 127,792,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,617,113 - 127,618,224 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,482,829 - 127,483,929 (-)NCBIMGSCv36mm8
Celera2129,024,511 - 129,025,623 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MtlnMouseautism spectrum disorder  ISOMTLN (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:24807792 and PMID:25255310
MtlnMousecone dystrophy  ISOMTLN (Homo sapiens)8554872ClinVar Annotator: match by term: Cone dystrophyClinVarPMID:28041643
MtlnMousenephronophthisis 1  ISOMTLN (Homo sapiens)8554872ClinVar Annotator: match by term: Nephronophthisis 1ClinVarPMID:10839884 more ...

1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MtlnMouse1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MTLN mRNACTDPMID:22206623
MtlnMouse4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of MTLN mRNACTDPMID:39298647
MtlnMousebenzo[a]pyrene multiple interactionsISOMTLN (Homo sapiens)6480464[AHR gene mutant form affects the susceptibility to Benzo(a)pyrene] which results in decreased expression of MTLN mRNACTDPMID:38036013
MtlnMousebisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of MTLN mRNACTDPMID:30245210 and PMID:35598803
MtlnMousebisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of MTLN mRNACTDPMID:32156529 and PMID:38074096
MtlnMousebisphenol A multiple interactionsISOMTLN (Homo sapiens)6480464[bisphenol A co-treated with Fulvestrant] results in increased methylation of MTLN geneCTDPMID:31601247
MtlnMousebisphenol F decreases expressionEXP 6480464bisphenol F results in decreased expression of MTLN mRNACTDPMID:38685157
MtlnMouseDibutyl phosphate affects expressionISOMTLN (Homo sapiens)6480464di-n-butylphosphoric acid affects the expression of MTLN mRNACTDPMID:37042841
MtlnMousedoxorubicin increases expressionISOMTLN (Homo sapiens)6480464Doxorubicin results in increased expression of MTLN mRNACTDPMID:29803840
MtlnMouseepoxiconazole increases expressionEXP 6480464epoxiconazole results in increased expression of MTLN mRNACTDPMID:35436446
MtlnMousefenthion increases expressionEXP 6480464Fenthion results in increased expression of MTLN mRNACTDPMID:34813904
MtlnMousefipronil multiple interactionsISOMTLN (Homo sapiens)6480464[fipronil co-treated with DEET] results in increased expression of MTLN mRNACTDPMID:28991164
MtlnMousefolic acid multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MTLN mRNACTDPMID:22206623
MtlnMousefulvestrant multiple interactionsISOMTLN (Homo sapiens)6480464[bisphenol A co-treated with Fulvestrant] results in increased methylation of MTLN geneCTDPMID:31601247
MtlnMouseN,N-diethyl-m-toluamide multiple interactionsISOMTLN (Homo sapiens)6480464[fipronil co-treated with DEET] results in increased expression of MTLN mRNACTDPMID:28991164
MtlnMouseperfluorohexanesulfonic acid increases expressionEXP 6480464perfluorohexanesulfonic acid results in increased expression of MTLN mRNACTDPMID:37995155
MtlnMousesodium arsenite decreases expressionISOMTLN (Homo sapiens)6480464sodium arsenite results in decreased expression of MTLN mRNACTDPMID:38568856
MtlnMousesodium arsenite increases expressionISOMTLN (Homo sapiens)6480464sodium arsenite results in increased expression of MTLN mRNACTDPMID:34032870
MtlnMousethiram decreases expressionISOMTLN (Homo sapiens)6480464Thiram results in decreased expression of MTLN mRNACTDPMID:38568856
MtlnMousetris(2-butoxyethyl) phosphate affects expressionISOMTLN (Homo sapiens)6480464tris(2-butoxyethyl) phosphate affects the expression of MTLN mRNACTDPMID:29024780

1 to 20 of 21 rows

Biological Process
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MtlnMousecellular respiration involved_inIMP 2290270 PMID:31296841UniProtPMID:31296841
MtlnMousefatty acid beta-oxidation involved_inISOUniProtKB:Q8NCU82290270 GO_CentralGO_REF:0000119
MtlnMousefatty acid beta-oxidation involved_inISSUniProtKB:Q8NCU82290270 UniProtGO_REF:0000024
MtlnMouselipid metabolic process involved_inIMP 2290270 PMID:30796188UniProtPMID:30796188
MtlnMousepositive regulation of fatty acid beta-oxidation involved_inIMP 2290270 PMID:29949755UniProtPMID:29949755
MtlnMousepositive regulation of mitochondrial membrane potential involved_inISOUniProtKB:Q8NCU82290270 GO_CentralGO_REF:0000119
MtlnMousepositive regulation of mitochondrial membrane potential involved_inISSUniProtKB:Q8NCU82290270 UniProtGO_REF:0000024
MtlnMousepositive regulation of mitochondrial membrane potential involved_inIBAPANTHER:PTN002201359 and UniProtKB:Q8NCU82290270 GO_CentralGO_REF:0000033
MtlnMousepositive regulation of protein-containing complex assembly involved_inIMP 2290270 PMID:29949756UniProtPMID:29949756
MtlnMousepositive regulation of sequestering of calcium ion involved_inISOUniProtKB:Q8NCU82290270 GO_CentralGO_REF:0000119
MtlnMousepositive regulation of sequestering of calcium ion involved_inIDA 2290270 PMID:29949756UniProtPMID:29949756
MtlnMousepositive regulation of sequestering of calcium ion involved_inIBAPANTHER:PTN002201359 more ...2290270 GO_CentralGO_REF:0000033
MtlnMousestriated muscle cell differentiation involved_inIMP 2290270 PMID:31296841UniProtPMID:31296841
MtlnMousetriglyceride homeostasis involved_inISSUniProtKB:Q8NCU82290270 UniProtGO_REF:0000024
MtlnMousetriglyceride homeostasis involved_inISOUniProtKB:Q8NCU82290270 GO_CentralGO_REF:0000119
1 to 15 of 15 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MtlnMousemitochondrial inner membrane located_inIDA 2290270 PMID:29949755 more ...UniProtPMID:29949755 more ...
MtlnMousemitochondrial inner membrane is_active_inIBAPANTHER:PTN002201359 and MGI:19151352290270 GO_CentralGO_REF:0000033
MtlnMousemitochondrion located_inIDA 2290270 PMID:30796188 and PMID:32393776UniProtPMID:30796188 and PMID:32393776
MtlnMousemitochondrion located_inISOUniProtKB:Q8NCU82290270 GO_CentralGO_REF:0000119

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MtlnMouseprotein binding enablesIPIUniProtKB:Q9DCN22290270 PMID:30796188UniProtPMID:30796188
MtlnMouseprotein binding enablesIPIUniProtKB:Q8BMS1 and UniProtKB:Q99JY02290270 PMID:29949755UniProtPMID:29949755


#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15226823   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635  
PMID:24059539   PMID:27899360   PMID:29949755   PMID:29949756   PMID:30796188   PMID:31296841   PMID:32243843   PMID:32393776   PMID:32554809   PMID:36174793   PMID:37108753   PMID:37240452  
PMID:37664623   PMID:39163918  



Mtln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,633,302 - 127,634,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,633,308 - 127,634,408 (-)EnsemblGRCm39 Ensembl
GRCm382127,791,382 - 127,792,488 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,791,388 - 127,792,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,617,113 - 127,618,224 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,482,829 - 127,483,929 (-)NCBIMGSCv36mm8
Celera2129,024,511 - 129,025,623 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.1NCBI
MTLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382110,211,529 - 110,212,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2110,211,529 - 110,245,420 (-)EnsemblGRCh38hg38GRCh38
GRCh372110,969,106 - 110,970,124 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362110,327,155 - 110,329,743 (-)NCBINCBI36Build 36hg18NCBI36
Celera2104,826,911 - 104,838,322 (+)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2104,109,441 - 104,120,850 (-)NCBIHuRef
CHM1_12110,973,360 - 110,984,769 (-)NCBICHM1_1
T2T-CHM13v2.02110,581,192 - 110,582,210 (+)NCBIT2T-CHM13v2.0
Mtln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,472,081 - 135,472,939 (-)NCBIGRCr8
mRatBN7.23115,018,810 - 115,019,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,019,473 - 115,019,643 (-)NCBImRatBN7.2 Ensembl
mRatBN7.2 Ensembl3115,019,473 - 115,019,643 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,908,652 - 118,909,508 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,504,196 - 127,505,052 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,164,533 - 125,165,389 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,372,665 - 120,373,523 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera3113,853,266 - 113,854,124 (-)NCBICelera
Cytogenetic Map3q36NCBI
MTLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,565,140 - 17,566,400 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A17,567,905 - 17,569,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A91,481,706 - 91,514,106 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A111,712,688 - 111,745,069 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A111,713,514 - 111,713,933 (-)Ensemblpanpan1.1panPan2
MTLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1734,910,137 - 34,911,111 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,912,380 - 35,913,354 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,913,159 - 35,913,329 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11735,040,424 - 35,041,417 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01735,108,672 - 35,109,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01735,318,708 - 35,319,683 (-)NCBIUU_Cfam_GSD_1.0
Mtln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407898340 - 1,449 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004943304685 - 1,449 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11413,595,687 - 13,596,974 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660806,093,527 - 6,094,789 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Mtln
39 total Variants

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:92
Interacting mature miRNAs:99
Transcripts:ENSMUST00000135091
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 52 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126041920135441920Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse

1 to 10 of 52 rows
UniSTS:492322  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382127,792,244 - 127,792,489UniSTSGRCm38
MGSCv372127,617,980 - 127,618,225UniSTSGRCm37
Celera2129,025,379 - 129,025,624UniSTS
Cytogenetic Map2F1UniSTS
RH126827  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814124,498,042 - 124,498,246UniSTSGRCm38
GRCm382127,800,331 - 127,800,535UniSTSGRCm38
MGSCv3714124,897,264 - 124,897,468UniSTSGRCm37
MGSCv372127,626,067 - 127,626,271UniSTSGRCm37
Celera2129,026,550 - 129,026,754UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map2F1UniSTS
cM Map273.0UniSTS
cM Map1459.0UniSTS
Whitehead/MRC_RH21588.23UniSTS







Ensembl Acc Id: ENSMUST00000135091   ⟹   ENSMUSP00000141107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,633,308 - 127,634,408 (-)Ensembl
GRCm38.p6 Ensembl2127,791,388 - 127,792,488 (-)Ensembl
RefSeq Acc Id: NM_001384135   ⟹   NP_001371064
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,633,302 - 127,634,408 (-)NCBI
GRCm382127,791,382 - 127,792,488 (-)NCBI
Sequence:
Protein RefSeqs NP_001371064 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC25674 (Get FASTA)   NCBI Sequence Viewer  
  BAE38178 (Get FASTA)   NCBI Sequence Viewer  
  EDL28208 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000141107
  ENSMUSP00000141107.2
GenBank Protein Q8BT35 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001371064   ⟸   NM_001384135
- UniProtKB: Q8BT35 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000141107   ⟸   ENSMUST00000135091

Name Modeler Protein Id AA Range Protein Structure
AF-Q8BT35-F1-model_v2 AlphaFold Q8BT35 1-56 view protein structure

RGD ID:6831711
Promoter ID:MM_KWN:31623
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:LINCRNA_611,   NR_015476_1500011K16RIK
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362127,617,956 - 127,618,456 (-)MPROMDB
RGD ID:6878670
Promoter ID:EPDNEW_M2786
Type:multiple initiation site
Name:1500011K16Rik_1
Description:Mus musculus RIKEN cDNA 1500011K16 gene , long non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382127,792,488 - 127,792,548EPDNEW


1 to 11 of 11 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000051319 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000135091 ENTREZGENE
  ENSMUST00000135091.2 UniProtKB/Swiss-Prot
InterPro Mtln UniProtKB/Swiss-Prot
MGD MGI:1915135 ENTREZGENE
NCBI Gene 67885 ENTREZGENE
PANTHER MITOREGULIN UniProtKB/Swiss-Prot
  PTHR37154 UniProtKB/Swiss-Prot
Pfam MTLN UniProtKB/Swiss-Prot
PhenoGen Mtln PhenoGen
UniProt MTLN_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
1 to 11 of 11 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-14 Mtln  mitoregulin  1500011K16Rik  RIKEN cDNA 1500011K16 gene  Symbol and/or name change 5135510 APPROVED