Nlrc5 (NLR family CARD domain containing 5) - Rat Genome Database

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Gene: Nlrc5 (NLR family CARD domain containing 5) Chinchilla lanigera
Analyze
Symbol: Nlrc5
Name: NLR family CARD domain containing 5
RGD ID: 9066676
Description: ENCODES a protein that exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN innate immune response (ortholog); negative regulation of type I interferon-mediated signaling pathway (ortholog); positive regulation of MHC class I biosynthetic process (ortholog); ASSOCIATED WITH Alcoholic Fatty Liver (ortholog); Bardet-Biedl syndrome (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NLR family, CARD domain containing 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,670,207 - 14,751,782 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,670,273 - 14,752,739 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nlrc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,670,207 - 14,751,782 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,670,273 - 14,752,739 (+)NCBIChiLan1.0ChiLan1.0
NLRC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,989,557 - 57,083,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,989,485 - 57,083,531 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,023,469 - 57,117,432 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,580,911 - 55,674,937 (+)NCBINCBI36Build 36hg18NCBI36
Celera1641,523,685 - 41,617,251 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,920,360 - 42,987,302 (+)NCBIHuRef
CHM1_11658,458,904 - 58,524,899 (+)NCBICHM1_1
T2T-CHM13v2.01662,785,869 - 62,879,790 (+)NCBIT2T-CHM13v2.0
Nlrc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,160,963 - 95,253,900 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,160,984 - 95,253,900 (+)EnsemblGRCm39 Ensembl
GRCm38894,434,335 - 94,527,272 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,434,356 - 94,527,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,996,663 - 97,051,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,048,967 - 97,051,164 (+)NCBIMGSCv36mm8
Celera898,805,231 - 98,860,906 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.55NCBI
Nlrc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,483,601 - 10,587,223 (-)NCBIGRCr8
mRatBN7.21910,477,638 - 10,581,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,477,628 - 10,562,121 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01910,904,381 - 11,006,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,905,542 - 10,976,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,896,530 - 10,916,728 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01910,932,869 - 10,967,808 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,918,833 - 10,966,224 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,882,205 - 10,970,980 (-)NCBI
Celera1910,365,727 - 10,449,817 (-)NCBICelera
Cytogenetic Map19p13NCBI
NLRC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,461,740 - 66,555,560 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,382,441 - 72,476,395 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,267,541 - 37,361,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,401,941 - 56,495,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,433,204 - 56,494,027 (+)Ensemblpanpan1.1panPan2
NLRC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,279,535 - 59,359,327 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,280,390 - 59,338,931 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,907,747 - 55,987,516 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,817,866 - 59,897,661 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,819,140 - 59,874,151 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,649,129 - 56,728,854 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,656,447 - 57,736,010 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,550,596 - 58,630,406 (-)NCBIUU_Cfam_GSD_1.0
Nlrc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,370,576 - 50,451,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,168,391 - 9,217,251 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,137,929 - 9,218,682 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,937,677 - 19,036,820 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,933,179 - 19,036,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NLRC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,942,875 - 43,035,043 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,974,300 - 43,035,351 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,284,988 - 33,376,978 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlrc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,954,016 - 29,030,322 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,954,009 - 29,030,337 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000007849   ⟹   ENSCLAP00000007730
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543314,670,207 - 14,751,782 (+)Ensembl
RefSeq Acc Id: XM_013516135   ⟹   XP_013371589
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,273 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516136   ⟹   XP_013371590
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,389 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516137   ⟹   XP_013371591
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,682,131 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516138   ⟹   XP_013371592
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,308 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516139   ⟹   XP_013371593
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,350 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516140   ⟹   XP_013371594
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,345 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516141   ⟹   XP_013371595
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,273 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516142   ⟹   XP_013371596
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,273 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516143   ⟹   XP_013371597
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,273 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516144   ⟹   XP_013371598
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,273 - 14,752,739 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001234727
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,273 - 14,751,759 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001234728
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543314,670,273 - 14,747,068 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013371589   ⟸   XM_013516135
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013371596   ⟸   XM_013516142
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013371597   ⟸   XM_013516143
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013371598   ⟸   XM_013516144
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013371595   ⟸   XM_013516141
- Peptide Label: isoform X2
- UniProtKB: A0A8C2V552 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013371592   ⟸   XM_013516138
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013371594   ⟸   XM_013516140
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013371593   ⟸   XM_013516139
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013371590   ⟸   XM_013516136
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013371591   ⟸   XM_013516137
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000007730   ⟸   ENSCLAT00000007849
Protein Domains
NACHT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005423 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007849 ENTREZGENE
  ENSCLAT00000007849.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_Cys-con_subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLRC5_atypical_Card UniProtKB/TrEMBL
  NLRP_HD2 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Nlrc5 ENTREZGENE
PANTHER NACHT, LRR AND CARD DOMAINS-CONTAINING UniProtKB/TrEMBL
  RIBONUCLEASE_ANGIOGENIN INHIBITOR 1 UniProtKB/TrEMBL
Pfam Atypical_Card UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
PRINTS DISEASERSIST UniProtKB/TrEMBL
PROSITE NACHT UniProtKB/TrEMBL
SMART LRR_CC UniProtKB/TrEMBL
  LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2V552 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Nlrc5  NLR family CARD domain containing 5    NLR family, CARD domain containing 5  Symbol and/or name change 5135510 APPROVED