Klhl18 (kelch like family member 18) - Rat Genome Database

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Gene: Klhl18 (kelch like family member 18) Chinchilla lanigera
Analyze
Symbol: Klhl18
Name: kelch like family member 18
RGD ID: 9058702
Description: INVOLVED IN positive regulation of mitotic cell cycle phase transition (ortholog); protein ubiquitination (ortholog); ASSOCIATED WITH Luscan-Lumish Syndrome (ortholog); Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like family member 18; kelch-like protein 18
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542024,916,597 - 24,968,706 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542024,917,001 - 24,968,712 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Klhl18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542024,916,597 - 24,968,706 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542024,917,001 - 24,968,712 (-)NCBIChiLan1.0ChiLan1.0
KLHL18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38347,282,944 - 47,346,816 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl347,282,917 - 47,346,816 (+)EnsemblGRCh38hg38GRCh38
GRCh37347,324,434 - 47,388,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36347,299,444 - 47,363,310 (+)NCBINCBI36Build 36hg18NCBI36
Build 34347,299,443 - 47,363,309NCBI
Celera347,262,930 - 47,326,952 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef347,367,362 - 47,431,403 (+)NCBIHuRef
CHM1_1347,274,644 - 47,338,544 (+)NCBICHM1_1
T2T-CHM13v2.0347,299,326 - 47,363,256 (+)NCBIT2T-CHM13v2.0
Klhl18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,254,994 - 110,305,768 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,254,994 - 110,305,762 (-)EnsemblGRCm39 Ensembl
GRCm389110,425,926 - 110,476,737 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,425,926 - 110,476,694 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,328,430 - 110,379,198 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,271,094 - 110,321,510 (-)NCBIMGSCv36mm8
Celera9110,154,967 - 110,206,501 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.92NCBI
Klhl18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,279,081 - 119,337,850 (-)NCBIGRCr8
mRatBN7.28110,400,679 - 110,459,442 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,400,681 - 110,459,323 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,016,229 - 116,074,662 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,215,419 - 114,273,846 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,058,211 - 112,116,640 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,668,809 - 118,737,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,671,312 - 118,696,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,012,502 - 118,079,907 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,804,739 - 114,861,334 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18114,822,260 - 114,880,589 (-)NCBI
Celera8109,685,673 - 109,743,861 (-)NCBICelera
Cytogenetic Map8q32NCBI
KLHL18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2247,239,744 - 47,303,800 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1347,244,512 - 47,308,568 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0347,183,587 - 47,247,574 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1348,282,935 - 48,346,165 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl348,282,935 - 48,346,165 (+)Ensemblpanpan1.1panPan2
KLHL18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12041,532,096 - 41,587,104 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2041,533,012 - 41,587,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2041,447,495 - 41,503,434 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,014,034 - 42,069,824 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,014,037 - 42,069,808 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,255,985 - 41,311,704 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02041,657,332 - 41,713,032 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02041,937,748 - 41,993,468 (-)NCBIUU_Cfam_GSD_1.0
Klhl18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118201,461,811 - 201,514,400 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365961,010,880 - 1,063,518 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365961,010,963 - 1,063,539 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1330,063,188 - 30,141,513 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11330,063,084 - 30,141,513 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21333,355,843 - 33,373,730 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,685,466 - 8,745,089 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,684,945 - 8,745,264 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041158,398,988 - 158,458,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,022,684 - 74,075,393 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473074,023,726 - 74,075,478 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000024262   ⟹   ENSCLAP00000024032
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542024,916,597 - 24,968,706 (-)Ensembl
RefSeq Acc Id: XM_005383411   ⟹   XP_005383468
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542024,917,001 - 24,968,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383412   ⟹   XP_005383469
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542024,917,001 - 24,968,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005383414   ⟹   XP_005383471
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542024,917,001 - 24,956,466 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005383468 (Get FASTA)   NCBI Sequence Viewer  
  XP_005383469 (Get FASTA)   NCBI Sequence Viewer  
  XP_005383471 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024032
  ENSCLAP00000024032.1
Reference Protein Sequences
RefSeq Acc Id: XP_005383469   ⟸   XM_005383412
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YUD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005383468   ⟸   XM_005383411
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005383471   ⟸   XM_005383414
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000024032   ⟸   ENSCLAT00000024262
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016500 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000024262 ENTREZGENE
  ENSCLAT00000024262.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL18_BTB/POZ UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene Klhl18 ENTREZGENE
PANTHER ACTIN-BINDING PROTEIN IPP UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0A8C2YUD8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Klhl18  kelch like family member 18    kelch-like family member 18  Symbol and/or name change 5135510 APPROVED