Lrguk (leucine rich repeats and guanylate kinase domain containing) - Rat Genome Database

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Gene: Lrguk (leucine rich repeats and guanylate kinase domain containing) Chinchilla lanigera
Analyze
Symbol: Lrguk
Name: leucine rich repeats and guanylate kinase domain containing
RGD ID: 8998574
Description: INVOLVED IN axoneme assembly (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); FOUND IN acrosomal vesicle (ortholog); manchette (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeats and guanylate kinase domain containing
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541033,753,999 - 33,870,523 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541033,753,411 - 33,870,512 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Lrguk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541033,753,999 - 33,870,523 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541033,753,411 - 33,870,512 (-)NCBIChiLan1.0ChiLan1.0
LRGUK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387134,127,340 - 134,276,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7134,127,299 - 134,264,595 (+)EnsemblGRCh38hg38GRCh38
GRCh377133,812,093 - 133,949,347 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,462,645 - 133,599,473 (+)NCBINCBI36Build 36hg18NCBI36
Celera7128,549,620 - 128,686,380 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7128,113,745 - 128,250,751 (+)NCBIHuRef
CHM1_17133,746,675 - 133,883,286 (+)NCBICHM1_1
T2T-CHM13v2.07135,424,298 - 135,584,803 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27133,156,684 - 133,293,312 (+)NCBI
Lrguk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,006,183 - 34,110,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,006,379 - 34,110,969 (+)EnsemblGRCm39 Ensembl
GRCm38634,029,245 - 34,134,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,029,448 - 34,134,034 (+)EnsemblGRCm38mm10GRCm38
MGSCv37633,979,448 - 34,084,034 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36633,959,606 - 34,064,192 (+)NCBIMGSCv36mm8
Celera634,025,402 - 34,131,289 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map614.75NCBI
Lrguk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8463,614,431 - 63,737,463 (+)NCBIGRCr8
mRatBN7.2462,647,222 - 62,770,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl462,647,264 - 62,770,319 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,598,875 - 67,705,095 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,514,587 - 63,620,819 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0461,917,002 - 62,023,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,419,987 - 61,544,748 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,420,009 - 61,544,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,143,324 - 61,265,284 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,348,199 - 61,458,380 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1461,624,343 - 61,733,924 (+)NCBI
Celera457,700,495 - 57,807,232 (+)NCBICelera
Cytogenetic Map4q22NCBI
LRGUK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26170,942,941 - 171,097,100 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1722,955,438 - 23,107,079 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07126,087,557 - 126,225,253 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17138,595,150 - 138,731,914 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7138,595,150 - 138,731,507 (+)Ensemblpanpan1.1panPan2
LRGUK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1143,191,324 - 3,301,306 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl143,193,813 - 3,301,293 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,846,409 - 2,957,446 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,919,311 - 3,030,563 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,923,556 - 3,030,548 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1143,123,357 - 3,234,896 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0142,867,985 - 2,979,285 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0143,014,095 - 3,125,199 (-)NCBIUU_Cfam_GSD_1.0
Lrguk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511821,359,788 - 21,462,808 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365791,492,389 - 1,595,465 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365791,492,868 - 1,595,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRGUK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1814,957,509 - 15,071,876 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11814,957,257 - 15,074,978 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21815,904,316 - 16,021,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRGUK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121102,753,877 - 102,884,558 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21102,755,344 - 102,884,003 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666042463,822 - 606,248 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrguk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247832,112,121 - 2,263,632 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000010834   ⟹   ENSCLAP00000010702
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541033,753,999 - 33,870,523 (-)Ensembl
RefSeq Acc Id: XM_005377538   ⟹   XP_005377595
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541033,753,411 - 33,870,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013510670   ⟹   XP_013366124
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541033,791,131 - 33,870,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013510671   ⟹   XP_013366125
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541033,791,130 - 33,867,735 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013510673   ⟹   XP_013366127
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541033,790,041 - 33,870,512 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005377595 (Get FASTA)   NCBI Sequence Viewer  
  XP_013366124 (Get FASTA)   NCBI Sequence Viewer  
  XP_013366125 (Get FASTA)   NCBI Sequence Viewer  
  XP_013366127 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000010702
  ENSCLAP00000010702.1
RefSeq Acc Id: XP_005377595   ⟸   XM_005377538
- Peptide Label: isoform X3
- UniProtKB: A0A8C2V5U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013366127   ⟸   XM_013510673
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013366125   ⟸   XM_013510671
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013366124   ⟸   XM_013510670
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSCLAP00000010702   ⟸   ENSCLAT00000010834
Protein Domains
Guanylate kinase-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007385 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000010834 ENTREZGENE
  ENSCLAT00000010834.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro GK/Ca_channel_bsu UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Lrguk ENTREZGENE
PANTHER GUANYLATE KINASE-RELATED UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/TrEMBL
  LRR_9 UniProtKB/TrEMBL
PROSITE GUANYLATE_KINASE_2 UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART GuKc UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2V5U0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Lrguk  leucine rich repeats and guanylate kinase domain containing    leucine-rich repeats and guanylate kinase domain containing  Symbol and/or name change 5135510 APPROVED