Scpep1 (serine carboxypeptidase 1)

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Gene: Scpep1 (serine carboxypeptidase 1) Chinchilla lanigera

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Symbol:

Scpep1

Name:

serine carboxypeptidase 1

RGD ID:

8986950

Description:

ENCODES a protein that exhibits serine-type carboxypeptidase activity (ortholog); INVOLVED IN blood vessel diameter maintenance (ortholog); negative regulation of blood pressure (ortholog); retinoic acid metabolic process (ortholog); ASSOCIATED WITH COVID-19 (ortholog); hereditary breast ovarian cancer syndrome (ortholog); Joubert syndrome 1 (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

retinoid-inducible serine carboxypeptidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	5,846,552 - 5,876,851 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	5,847,371 - 5,876,286 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Joubert syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood vessel diameter maintenance (ISO)

negative regulation of blood pressure (ISO)

retinoic acid metabolic process (ISO)

Molecular Function

serine-type carboxypeptidase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Scpep1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	5,846,552 - 5,876,851 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	5,847,371 - 5,876,286 (-)	NCBI	ChiLan1.0	ChiLan1.0

SCPEP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	56,978,131 - 57,006,768 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	56,978,129 - 57,006,768 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	55,055,492 - 55,084,129 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	52,410,467 - 52,439,128 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	52,410,487 - 52,439,123	NCBI
Celera	17	51,517,044 - 51,545,707 (+)	NCBI		Celera
Cytogenetic Map	17	q22	NCBI
HuRef	17	50,416,496 - 50,445,158 (+)	NCBI		HuRef
CHM1_1	17	55,120,690 - 55,149,356 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	57,855,772 - 57,884,410 (+)	NCBI		T2T-CHM13v2.0

Scpep1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	88,814,846 - 88,846,268 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	88,814,846 - 88,846,291 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	88,924,020 - 88,955,442 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	88,924,020 - 88,955,465 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	88,785,334 - 88,816,756 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	88,740,110 - 88,771,522 (-)	NCBI		MGSCv36	mm8
Celera	11	98,535,098 - 98,568,204 (-)	NCBI		Celera
Cytogenetic Map	11	C	NCBI
cM Map	11	54.34	NCBI

Scpep1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	74,200,491 - 74,230,107 (-)	NCBI		GRCr8
mRatBN7.2	10	73,703,275 - 73,732,892 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	73,703,278 - 73,732,850 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	78,318,490 - 78,347,988 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	77,823,415 - 77,852,910 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	73,286,585 - 73,316,078 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	76,230,371 - 76,263,866 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	76,230,373 - 76,263,866 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	73,846,394 - 73,880,406 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	77,347,473 - 77,377,945 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	77,361,844 - 77,392,315 (-)	NCBI
Celera	10	72,609,315 - 72,638,737 (-)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

SCPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	73,151,012 - 73,179,770 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	77,961,953 - 77,990,686 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	51,055,293 - 51,084,032 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	55,915,746 - 55,944,374 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	55,915,746 - 55,944,377 (+)	Ensembl	panpan1.1		panPan2

SCPEP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	31,770,494 - 31,803,741 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	31,774,602 - 31,803,741 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	31,010,418 - 31,043,464 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	32,578,347 - 32,611,364 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	32,578,396 - 32,611,601 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	31,363,955 - 31,397,132 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	31,647,649 - 31,680,837 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	31,731,073 - 31,764,270 (+)	NCBI		UU_Cfam_GSD_1.0

Scpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	31,143,599 - 31,171,166 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	5,904,396 - 5,939,915 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	5,903,884 - 5,939,953 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCPEP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	33,265,562 - 33,298,142 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	33,265,509 - 33,296,805 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	33,995,016 - 34,027,373 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCPEP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	36,398,059 - 36,427,429 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	36,398,615 - 36,427,404 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	7,216,719 - 7,246,075 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Scpep1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	12,016,302 - 12,042,353 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	12,016,363 - 12,041,615 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005394064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01043182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01043183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01043184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01000239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000022319 ⟹ ENSCLAP00000022114

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955451	5,846,552 - 5,876,851 (-)	Ensembl

RefSeq Acc Id:

XM_005394064 ⟹ XP_005394121

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955451	5,847,371 - 5,876,286 (-)	NCBI

Sequence:

show sequence

GTGACAGGCCCGGTTCCAGCCTGTGGCGGCGGCCGCAGCGCGGTATTCGTCATGGAGCCGGCGC
CGCGGAGCTGTCCGTGGCCGCGGTGGCTGCTGCTGTTCCCGCTGCTCCTGGGCCTCAGCGCGGG
AGCTGTCATTGACCGGCCGGCAGTAGAGGGCAAGGAAGTATGGGACTACGTGACTGTCCGGAAA
GACGCCCACATGTTCTGGTGGCTCTATTATACCACCAACCCCTGCAAGAACTTCTCACAGCTGC
CCCTGGTCATGTGGCTTCAGGGTGGTCCAGGCGGTTCCAGCACTGGATTTGGAAACTTTGAGGA
AATTGGACCCCTTGACAGTGATCTGAAACCACGAGGGACCACCTGGCTCCAGGCTGCCAGCCTT
CTCTTCGTGGATAACCCCGTGGGCACCGGCTTCAGTTACGTGAACGCGAGTGACGCGTATGCCA
AGGACCTTGCTACGGTGGCTTCGGACATGCTGGTCCTCCTGAAGGCCTTCTTTGATTGCCACAA
AGAATTCCAGACAGTTCCATTCTACATTTTCTCTGAGTCCTATGGAGGAAAAATGGCGGCTGGC
ATCGGTCTGGAGCTTTATAAGGCTGTTCAGCAAGGAACCATCAAGTGCAACTTTTCTGGGGTTG
CTTTGGGCGATTCTTGGATCTCTCCTGTTGATTCGGTGCTCTCCTGGGGACCTTACCTGTACAG
CATGTCTCTCCTTGACGACACAGGTCTGGCAGAGGTGTCCACCATTGCAGAAAAGGTCTTGGCC
GCTGTAAATAACAAACTCTACAAGGAGGCCACCCAGCTCTGGGGTGAGGCAGAAATGGTCATTG
AAAAGAATGCTGATGGGGTGAACTTCTATAACATCTTAACCAAAAGCACTCCCAACTCGGCCAT
GGAATCCAGCCTAGAGTTCATGCCGAACCACTTAGCCCGTCTTTCTCAGCGCCACGTGAGACGC
CTGCACCGAGACGCCCTAAGTCAGCTCATGAACGGCCCCATCAGAAAGAAGCTCGGAATTATTC
CCAAGGATTTCTCCTGGGGAGCCCAGTCTTCTTACGTCTTCATGAACATGGAAGAGGACTTCAT
GAAGCCAGCCATCAGCATTGTGGACGAGCTGCTGGAAGCTGGGGTCAACGTGACCGTGTACAAT
GGACAACTGGATCTCATTGTGGACACCATGGGGCAGGAGGCCTGGCTGCGGAGGCTGAAGTGGC
CAGAGCTGCCCAAATTCAATCAGCTGAGGTGGAAGGCACTGTACAGCAACCCCAAGTCATCGGA
GACGTCTGCTTTTGTGAAGTCCTACAAGAACCTGTCTTTCTTCTGGATTCTAGGCGCGGGCCAC
ATGGTTCCCTCTGACCGAGGAGAGATGGCTCTGAAGATGATGAGGCTGGTGACTCAGCAGGAGT
AGGCCGCCCTGGACTTTGATGAGCAGGGTTGGCCCTGGGGACACAGGAGCGAACCACGGACCTA
GAGCTGTGGGGACCACCTGCAGCCCCCAAATCCAGCACGGTCTGTGACTGCGAAGGCTCTCCAG
CTCCCACAGAGGGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005394121	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022114
	ENSCLAP00000022114.1

RefSeq Acc Id:

XP_005394121 ⟸ XM_005394064

- UniProtKB:

A0A8C2W230 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPAPRSCPWPRWLLLFPLLLGLSAGAVIDRPAVEGKEVWDYVTVRKDAHMFWWLYYTTNPCKN
FSQLPLVMWLQGGPGGSSTGFGNFEEIGPLDSDLKPRGTTWLQAASLLFVDNPVGTGFSYVNAS
DAYAKDLATVASDMLVLLKAFFDCHKEFQTVPFYIFSESYGGKMAAGIGLELYKAVQQGTIKCN
FSGVALGDSWISPVDSVLSWGPYLYSMSLLDDTGLAEVSTIAEKVLAAVNNKLYKEATQLWGEA
EMVIEKNADGVNFYNILTKSTPNSAMESSLEFMPNHLARLSQRHVRRLHRDALSQLMNGPIRKK
LGIIPKDFSWGAQSSYVFMNMEEDFMKPAISIVDELLEAGVNVTVYNGQLDLIVDTMGQEAWLR
RLKWPELPKFNQLRWKALYSNPKSSETSAFVKSYKNLSFFWILGAGHMVPSDRGEMALKMMRLV
TQQE

hide sequence

Ensembl Acc Id:

ENSCLAP00000022114 ⟸ ENSCLAT00000022319

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015159	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022319	ENTREZGENE
	ENSCLAT00000022319.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	Peptidase_S10	UniProtKB/TrEMBL
	Ser_caboxypep_ser_AS	UniProtKB/TrEMBL
NCBI Gene	Scpep1	ENTREZGENE
PANTHER	PTHR11802	UniProtKB/TrEMBL
	RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE	UniProtKB/TrEMBL
Pfam	Peptidase_S10	UniProtKB/TrEMBL
PRINTS	CRBOXYPTASEC	UniProtKB/TrEMBL
PROSITE	CARBOXYPEPT_SER_SER	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A0A8C2W230	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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