Scpep1 (serine carboxypeptidase 1)

Gene: Scpep1 (serine carboxypeptidase 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Scpep1

Name:

serine carboxypeptidase 1

RGD ID:

12558934

Description:

ENCODES a protein that exhibits carboxypeptidase activity (inferred); serine-type carboxypeptidase activity (inferred); INVOLVED IN blood vessel diameter maintenance (ortholog); retinoic acid metabolic process (ortholog); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); Joubert syndrome 1 (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

retinoid-inducible serine carboxypeptidase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	31,143,599 - 31,171,166 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	5,904,396 - 5,939,915 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	5,903,884 - 5,939,953 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood vessel diameter maintenance (IEA,ISO)

negative regulation of blood pressure (IEA)

proteolysis (IEA)

retinoic acid metabolic process (ISO)

Molecular Function

carboxypeptidase activity (IEA)

serine-type carboxypeptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Scpep1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	31,143,599 - 31,171,166 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	5,904,396 - 5,939,915 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	5,903,884 - 5,939,953 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCPEP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	56,978,131 - 57,006,768 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	56,978,129 - 57,006,768 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	55,055,492 - 55,084,129 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	52,410,467 - 52,439,128 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	52,410,487 - 52,439,123	NCBI
Celera	17	51,517,044 - 51,545,707 (+)	NCBI		Celera
Cytogenetic Map	17	q22	NCBI
HuRef	17	50,416,496 - 50,445,158 (+)	NCBI		HuRef
CHM1_1	17	55,120,690 - 55,149,356 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	57,855,772 - 57,884,410 (+)	NCBI		T2T-CHM13v2.0

Scpep1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	88,814,846 - 88,846,268 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	88,814,846 - 88,846,291 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	88,924,020 - 88,955,442 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	88,924,020 - 88,955,465 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	88,785,334 - 88,816,756 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	88,740,110 - 88,771,522 (-)	NCBI		MGSCv36	mm8
Celera	11	98,535,098 - 98,568,204 (-)	NCBI		Celera
Cytogenetic Map	11	C	NCBI
cM Map	11	54.34	NCBI

Scpep1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	74,200,491 - 74,230,107 (-)	NCBI		GRCr8
mRatBN7.2	10	73,703,275 - 73,732,892 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	73,703,278 - 73,732,850 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	78,318,490 - 78,347,988 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	77,823,415 - 77,852,910 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	73,286,585 - 73,316,078 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	76,230,371 - 76,263,866 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	76,230,373 - 76,263,866 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	73,846,394 - 73,880,406 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	77,347,473 - 77,377,945 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	77,361,844 - 77,392,315 (-)	NCBI
Celera	10	72,609,315 - 72,638,737 (-)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

Scpep1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	5,846,552 - 5,876,851 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	5,847,371 - 5,876,286 (-)	NCBI	ChiLan1.0	ChiLan1.0

SCPEP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	73,151,012 - 73,179,770 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	77,961,953 - 77,990,686 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	51,055,293 - 51,084,032 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	55,915,746 - 55,944,374 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	55,915,746 - 55,944,377 (+)	Ensembl	panpan1.1		panPan2

SCPEP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	31,770,494 - 31,803,741 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	31,774,602 - 31,803,741 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	31,010,418 - 31,043,464 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	32,578,347 - 32,611,364 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	32,578,396 - 32,611,601 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	31,363,955 - 31,397,132 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	31,647,649 - 31,680,837 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	31,731,073 - 31,764,270 (+)	NCBI		UU_Cfam_GSD_1.0

SCPEP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	33,265,562 - 33,298,142 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	33,265,509 - 33,296,805 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	33,995,016 - 34,027,373 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCPEP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	36,398,059 - 36,427,429 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	36,398,615 - 36,427,404 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	7,216,719 - 7,246,075 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Scpep1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	12,016,302 - 12,042,353 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	12,016,363 - 12,041,615 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013357133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000009346 ⟹ ENSSTOP00000008384

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936490	5,904,396 - 5,939,915 (-)	Ensembl

RefSeq Acc Id:

XM_013357133 ⟹ XP_013212587

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	31,143,599 - 31,171,166 (+)	NCBI
SpeTri2.0	NW_004936490	5,903,884 - 5,939,953 (-)	NCBI

Sequence:

show sequence

GTCCAGCCTGTTGCTGATGCTGCCGCGCTGTATTCATCATGGAGCTGGCGCCGCGGAGCTCTCC
TGTCTCGCGGTGGCTACTGCTGCTGCTGCTATTGGGCCTCAGCACCGTGTCTCTTCCACAGGGT
GGTCCAGGCGGTTCCAGCACTGGATTTGGAAACTTTGAGGAAATCGGGCCCCTCGACAGTCATC
TCAAGCCACGAAAAACCACCTGGCTCCAGGCTGCCAGTCTCCTCTTTGTGGATAATCCTGTGGG
CACTGGCTTCAGTTATGTGAACAAAAGCAATGCGTATGCAAAGGACCTCGCCACGGTGGCTTCT
GACATGATGGTCCTCCTGAAGACCTTCTTCAGTTGCCACAAAGAATTCCAGACGGTTCCATTCT
ACATTTTCTCAGAATCCTATGGAGGAAAAATGGCTGCTGGCATTGGTCTAGAACTTTACAAGGC
CATTCAGCAAGGGACCATCAAGTGCAACTTCTCTGGGGTTGCGTTGGGTGATTCCTGGATCTCC
CCTGTTGATTCGGTGCTCTCCTGGGGACCTTACCTGTACAGCATGTCTCTTCTGGAAGACAAAG
GTCTGGCAGAGGTGTCCAATATCGCGGAGCAAGTCCTGGATGCTGTAAATAAAGGGTTCTACAC
GGAGGCCACCCAGCTGTGGGGGAAAGCAGAAACCATCATTGAAAAGAACGCAGATGGGGTGAAC
TTCTATAACATCTTAACTAAAAGCGATCCCACGTCTGCCATGGAGTCAAGCCTAGAGTTCACCC
AGAGTCATTTAGTCCGTCTTTTTCAACGCCACGTGAGACACCTACAAGGAGATGCCTTAAGTCA
GCTCATGAATGGCCCCATCAGAAAGAAGCTCAAAATTATCCCTGAGGATATCTCCTGGGGAGCC
CAGTCTTCTAGTGTCTTCCTAAATATGGAGGGGGACTTCATGAAGCCGGTCATCAGCATTGTGG
ACGAGTTGCTGGAAGCCGGGGTCAACGTGACTATATATAATGGACAGCTCGACCTCATTGTGGA
CACCATCGGACAGGAGGCCTGGGTGCGGAAGCTGCAGTGGCCAGAACTGCCCAAATTCAATGAG
CTGAAATGGAAGCCCCTGTACAGTGACCCTGAATCCCCCGAAACATCTGCTTTTGTCAAGTCCT
ACAAGAACCTGGCTTTCTACTGGATTCTAAGAGCTGGTCACATGGTTCCTTCTGACCAAGGGGC
CATGGCTCTGAAGATGATGAGGCTGGTGACACAGCAGGAGTAGGAAGTACCGAGCTGAGAGGAG
CTGGCGTGGCCTGGAGGCGCAGGAGCCAACCGAGAACTGGAGGAAGCTGTGCTCCTCCCTGAAT
CTAACTCAGGCTGGGATTGTGAAGGCCCCTACCAGCTGCCACGGCCTCGGGCAGCTTGGGAATC
ATTTCTGCTTCTTAAAAAACGTTTTTTTAATGGATTTGTTTTTATCAAAGTGAAGGATTGTCAT
AGATTGACTTTTTCTGATTGCAAAATCAAAGGATATGATTTGTTTTTTAAAAAAAAGTGGGAAA
TACAGTTAAGCAAAGAACAAAAGAAAGACTCATACCCTCCCTTTCCAGGGGTAAGCACTGCTAC
CAATTCAGTATCTAGCCTCACAGGTATTTTTTGGTTACATATATAGACATTTATATTTTTTACA
AAAATGGAATCATGGCTATATTGTTATTTTACCATCTCCTGTGTTCAGAGATCAATATGTCCCT
AAACACCTTTTAATGTCAATAAATTCTTCTGTGACATTTTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013212587	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008384.3
GenBank Protein	KAG3269322	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013212587 ⟸ XM_013357133

- UniProtKB:

I3MDD8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELAPRSSPVSRWLLLLLLLGLSTVSLPQGGPGGSSTGFGNFEEIGPLDSHLKPRKTTWLQAAS
LLFVDNPVGTGFSYVNKSNAYAKDLATVASDMMVLLKTFFSCHKEFQTVPFYIFSESYGGKMAA
GIGLELYKAIQQGTIKCNFSGVALGDSWISPVDSVLSWGPYLYSMSLLEDKGLAEVSNIAEQVL
DAVNKGFYTEATQLWGKAETIIEKNADGVNFYNILTKSDPTSAMESSLEFTQSHLVRLFQRHVR
HLQGDALSQLMNGPIRKKLKIIPEDISWGAQSSSVFLNMEGDFMKPVISIVDELLEAGVNVTIY
NGQLDLIVDTIGQEAWVRKLQWPELPKFNELKWKPLYSDPESPETSAFVKSYKNLAFYWILRAG
HMVPSDQGAMALKMMRLVTQQE

hide sequence

RefSeq Acc Id:

ENSSTOP00000008384 ⟸ ENSSTOT00000009346

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009343	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009346.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	Peptidase_S10	UniProtKB/TrEMBL
	Ser_caboxypep_ser_AS	UniProtKB/TrEMBL
NCBI Gene	Scpep1	ENTREZGENE
PANTHER	PTHR11802	UniProtKB/TrEMBL
	RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE	UniProtKB/TrEMBL
Pfam	Peptidase_S10	UniProtKB/TrEMBL
PRINTS	CRBOXYPTASEC	UniProtKB/TrEMBL
PROSITE	CARBOXYPEPT_SER_SER	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	I3MDD8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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