Ap2s1 (adaptor related protein complex 2 subunit sigma 1) - Rat Genome Database

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Gene: Ap2s1 (adaptor related protein complex 2 subunit sigma 1) Chinchilla lanigera
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Symbol: Ap2s1
Name: adaptor related protein complex 2 subunit sigma 1
RGD ID: 8962386
Description: INVOLVED IN postsynaptic neurotransmitter receptor internalization (ortholog); synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH COVID-19 (ortholog); familial hypocalciuric hypercalcemia 3 (ortholog); genetic disease (ortholog); FOUND IN AP-2 adaptor complex (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adaptor related protein complex 2 sigma 1 subunit; adaptor-related protein complex 2, sigma 1 subunit; AP-2 complex subunit sigma
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574830,910 - 846,161 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574835,272 - 845,710 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ap2s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574830,910 - 846,161 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574835,272 - 845,710 (-)NCBIChiLan1.0ChiLan1.0
AP2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,838,167 - 46,850,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,838,136 - 46,850,846 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,341,424 - 47,354,103 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,033,263 - 52,046,043 (-)NCBINCBI36Build 36hg18NCBI36
Build 341952,033,263 - 52,045,931NCBI
Celera1944,145,679 - 44,158,458 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,766,567 - 43,779,262 (-)NCBIHuRef
CHM1_11947,343,326 - 47,356,098 (-)NCBICHM1_1
T2T-CHM13v2.01949,664,001 - 49,676,674 (-)NCBIT2T-CHM13v2.0
Ap2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,472,369 - 16,483,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,472,335 - 16,483,219 (+)EnsemblGRCm39 Ensembl
GRCm38716,738,444 - 16,749,290 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,738,410 - 16,749,294 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,323,793 - 17,334,639 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,896,984 - 15,907,814 (+)NCBIMGSCv36mm8
Celera713,936,944 - 13,947,790 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Ap2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,545,601 - 86,557,007 (+)NCBIGRCr8
mRatBN7.2177,417,496 - 77,428,903 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,417,477 - 77,428,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,798,123 - 82,809,563 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,362,165 - 91,373,606 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,553,217 - 84,564,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,671,238 - 78,682,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,671,121 - 78,682,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,918,162 - 79,929,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,069,144 - 77,081,190 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,147,255 - 77,159,301NCBI
Celera171,902,755 - 71,914,240 (+)NCBICelera
Cytogenetic Map1q21NCBI
AP2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,985,343 - 52,998,184 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,856,517 - 54,869,298 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,827,907 - 43,840,682 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,357,145 - 52,357,805 (-)NCBIpanpan1.1PanPan1.1panPan2
AP2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,094,098 - 109,105,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,082,221 - 109,105,230 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,573,732 - 108,584,870 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,619,436 - 109,630,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,619,492 - 109,630,604 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,297,177 - 109,308,314 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,930,932 - 108,942,072 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,799,650 - 109,811,014 (+)NCBIUU_Cfam_GSD_1.0
AP2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,695,640 - 52,703,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,695,640 - 52,703,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,066,402 - 48,073,966 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AP2S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,175,106 - 40,194,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607319,888,365 - 19,901,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,787,149 - 6,797,131 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,788,149 - 6,797,026 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000003205   ⟹   ENSCLAP00000003141
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955574830,910 - 846,161 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000003206   ⟹   ENSCLAP00000003142
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955574835,510 - 845,591 (-)Ensembl
RefSeq Acc Id: XM_005413843   ⟹   XP_005413900
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955574835,272 - 845,449 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005413844   ⟹   XP_005413901
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955574835,272 - 845,710 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005413900 (Get FASTA)   NCBI Sequence Viewer  
  XP_005413901 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000003141
  ENSCLAP00000003141.1
  ENSCLAP00000003142.1
RefSeq Acc Id: XP_005413901   ⟸   XM_005413844
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UPB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005413900   ⟸   XM_005413843
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSCLAP00000003141   ⟸   ENSCLAT00000003205
Ensembl Acc Id: ENSCLAP00000003142   ⟸   ENSCLAT00000003206
Protein Domains
AP complex mu/sigma subunit


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002250 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000003205 ENTREZGENE
  ENSCLAT00000003205.1 UniProtKB/TrEMBL
  ENSCLAT00000003206.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.60 UniProtKB/TrEMBL
InterPro AP_complex_ssu UniProtKB/TrEMBL
  AP_mu_sigma_su UniProtKB/TrEMBL
  APS2 UniProtKB/TrEMBL
  Clathrin_sm-chain_CS UniProtKB/TrEMBL
  Longin-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Ap2s1 ENTREZGENE
PANTHER PTHR11753 UniProtKB/TrEMBL
Pfam Clat_adaptor_s UniProtKB/TrEMBL
PIRSF AP_complex_sigma UniProtKB/TrEMBL
PROSITE CLAT_ADAPTOR_S UniProtKB/TrEMBL
Superfamily-SCOP SSF64356 UniProtKB/TrEMBL
UniProt A0A8C2UPB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YJF6_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Ap2s1  adaptor related protein complex 2 subunit sigma 1    adaptor related protein complex 2 sigma 1 subunit  Symbol and/or name change 5135510 APPROVED
2016-08-16 Ap2s1  adaptor related protein complex 2 sigma 1 subunit    adaptor-related protein complex 2, sigma 1 subunit  Symbol and/or name change 5135510 APPROVED