Gpr68 (G protein-coupled receptor 68) - Rat Genome Database

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Gene: Gpr68 (G protein-coupled receptor 68) Chinchilla lanigera
Analyze
Symbol: Gpr68
Name: G protein-coupled receptor 68
RGD ID: 8958151
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to acidic pH (ortholog); cellular response to pH (ortholog); ASSOCIATED WITH achondrogenesis type IA (ortholog); amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 2A6 (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ovarian cancer G-protein coupled receptor 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543813,555,379 - 13,559,465 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543813,553,770 - 13,575,093 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpr68ChinchillaCOVID-19  ISOGPR68 (Homo sapiens)9068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpr68Chinchillaachondrogenesis type IA  ISOGPR68 (Homo sapiens)8554872ClinVar Annotator: match by term: Achondrogenesis and type IAClinVarPMID:28492532
Gpr68Chinchillaamelogenesis imperfecta  ISOGPR68 (Homo sapiens)8554872ClinVar Annotator: match by term: Amelogenesis imperfectaClinVarPMID:27693231
Gpr68Chinchillaamelogenesis imperfecta type 2A6  ISOGPR68 (Homo sapiens)8554872ClinVar Annotator: match by term: Amelogenesis imperfecta more ...ClinVarPMID:25741868 and PMID:27693231
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpr68ChinchillaExperimental Liver Cirrhosis  ISOGPR68 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpr68Chinchillaamelogenesis imperfecta type 2A6  ISOGPR68 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpr68Chinchillaadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOGPR68 (Homo sapiens)9068941 PMID:39753132UniProtPMID:39753132
Gpr68Chinchillacellular response to acidic pH involved_inISOGPR68 (Homo sapiens)9068941 PMID:33478938 and PMID:39753132UniProtPMID:33478938 and PMID:39753132
Gpr68Chinchillacellular response to pH acts_upstream_of_or_withinISOMGI:54450019068941 PMID:22733973MGIPMID:22733973
Gpr68Chinchillainsulin secretion acts_upstream_ofISOMGI:54450019068941 PMID:22733973MGIPMID:22733973
Gpr68Chinchillamonocyte differentiation acts_upstream_ofISOMGI:38494579068941 PMID:19479052MGIPMID:19479052
Gpr68Chinchillanegative regulation of monocyte differentiation acts_upstream_of_or_withinISOMGI:38494579068941 PMID:19479052MGIPMID:19479052
Gpr68Chinchillaosteoclast development acts_upstream_ofISOMGI:38494579068941 PMID:19479052MGIPMID:19479052
Gpr68Chinchillaphospholipase C-activating G protein-coupled receptor signaling pathway involved_inISOGPR68 (Homo sapiens)9068941 PMID:39753132UniProtPMID:39753132
Gpr68Chinchillapositive regulation of insulin secretion acts_upstream_of_or_withinISOMGI:54450019068941 PMID:22733973MGIPMID:22733973
Gpr68Chinchillapositive regulation of insulin secretion involved in cellular response to glucose stimulus acts_upstream_of_or_withinISOMGI:54450019068941 PMID:22733973MGIPMID:22733973
Gpr68Chinchillapositive regulation of osteoclast development acts_upstream_of_or_withinISOMGI:38494579068941 PMID:19479052MGIPMID:19479052
1 to 11 of 11 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpr68Chinchillaplasma membrane is_active_inISOGPR68 (Homo sapiens)9068941 PMID:39753132UniProtPMID:39753132

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gpr68ChinchillaG protein-coupled receptor activity enablesISOGPR68 (Homo sapiens)9068941 PMID:33478938 and PMID:39753132UniProtPMID:33478938 and PMID:39753132


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074   PMID:30032202  



Gpr68
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543813,555,379 - 13,559,465 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543813,553,770 - 13,575,093 (-)NCBIChiLan1.0ChiLan1.0
GPR68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381491,232,532 - 91,270,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1491,232,532 - 91,253,925 (-)EnsemblGRCh38hg38GRCh38
GRCh371491,698,876 - 91,720,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361490,768,629 - 90,789,977 (-)NCBINCBI36Build 36hg18NCBI36
Build 341490,769,964 - 90,790,022NCBI
Celera1471,747,337 - 71,768,677 (-)NCBICelera
Cytogenetic Map14q32.11NCBI
HuRef1471,875,167 - 71,896,408 (-)NCBIHuRef
CHM1_11491,636,649 - 91,657,972 (-)NCBICHM1_1
T2T-CHM13v2.01485,458,030 - 85,496,278 (-)NCBIT2T-CHM13v2.0
Gpr68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912100,842,941 - 100,874,457 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12100,842,941 - 100,874,457 (-)EnsemblGRCm39 Ensembl
GRCm3812100,876,679 - 100,908,198 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,876,682 - 100,908,198 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712102,114,892 - 102,146,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612101,277,735 - 101,288,931 (-)NCBIMGSCv36mm8
Celera12102,103,729 - 102,135,412 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.1NCBI
Gpr68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86125,865,205 - 125,895,674 (-)NCBIGRCr8
mRatBN7.26120,135,620 - 120,166,089 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6120,135,436 - 120,166,089 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6120,290,512 - 120,320,967 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06120,587,199 - 120,617,654 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06119,922,046 - 119,952,502 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06124,874,151 - 124,903,949 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6124,874,151 - 124,876,710 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06134,095,815 - 134,123,783 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46125,134,284 - 125,174,033 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16125,139,362 - 125,140,542 (-)NCBI
Celera6117,663,888 - 117,694,277 (-)NCBICelera
Cytogenetic Map6q32NCBI
GPR68
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21592,382,587 - 92,414,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11491,599,095 - 91,631,206 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01471,859,025 - 71,891,126 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11491,206,261 - 91,227,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1491,207,679 - 91,208,806 (-)Ensemblpanpan1.1panPan2
GPR68
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1862,090,050 - 62,108,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl862,092,135 - 62,093,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha861,668,237 - 61,696,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0862,362,350 - 62,390,680 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl862,362,354 - 62,374,835 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1862,042,914 - 62,071,212 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0862,092,632 - 62,120,928 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0862,421,632 - 62,450,098 (-)NCBIUU_Cfam_GSD_1.0
Gpr68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864013,789,934 - 13,811,716 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648818,259,866 - 18,260,993 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648818,257,765 - 18,278,530 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR68
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7112,885,163 - 112,904,246 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17112,885,160 - 112,904,214 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27119,457,230 - 119,485,333 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR68
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12468,998,721 - 69,027,237 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2468,998,805 - 68,999,902 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605356,253,057 - 56,281,240 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr68
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473411,360,053 - 11,368,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473411,338,233 - 11,370,239 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000019246   ⟹   ENSCLAP00000019061
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543813,555,379 - 13,559,465 (-)Ensembl
RefSeq Acc Id: XM_005390296   ⟹   XP_005390353
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543813,555,379 - 13,564,356 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005390297   ⟹   XP_005390354
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543813,555,379 - 13,564,356 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005390298   ⟹   XP_005390355
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543813,555,379 - 13,564,356 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005390300   ⟹   XP_005390357
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543813,555,379 - 13,564,356 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005390301   ⟹   XP_005390358
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543813,555,379 - 13,575,093 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005390303   ⟹   XP_005390360
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543813,553,770 - 13,564,357 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517223   ⟹   XP_013372677
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543813,555,379 - 13,564,356 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517224   ⟹   XP_013372678
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543813,555,379 - 13,559,465 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005390360   ⟸   XM_005390303
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005390358   ⟸   XM_005390301
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YS14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005390357   ⟸   XM_005390300
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YS14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005390354   ⟸   XM_005390297
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YS14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005390353   ⟸   XM_005390296
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YS14 (UniProtKB/TrEMBL)
- Sequence:


1 to 17 of 17 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000013052 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019246 ENTREZGENE
  ENSCLAT00000019246.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  OGR1_rcpt UniProtKB/TrEMBL
NCBI Gene Gpr68 ENTREZGENE
PANTHER LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR UniProtKB/TrEMBL
  OVARIAN CANCER G-PROTEIN COUPLED RECEPTOR 1 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OGR1RECEPTOR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C2YS14 ENTREZGENE, UniProtKB/TrEMBL
1 to 17 of 17 rows