Slc22a12 (solute carrier family 22 member 12) - Rat Genome Database

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Gene: Slc22a12 (solute carrier family 22 member 12) Chinchilla lanigera
Analyze
Symbol: Slc22a12
Name: solute carrier family 22 member 12
RGD ID: 8938081
Description: ENCODES a protein that exhibits PDZ domain binding (ortholog); urate transmembrane transporter activity (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); renal urate salt excretion (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); clear cell renal cell carcinoma (ortholog); Congenital Abnormalities (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: solute carrier family 22 (organic anion/urate transporter), member 12
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,556,098 - 20,596,012 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495542220,555,458 - 20,561,818 (-)NCBIChiLan1.0ChiLan1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Slc22a12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,556,098 - 20,596,012 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495542220,555,458 - 20,561,818 (-)NCBIChiLan1.0ChiLan1.0
SLC22A12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,591,220 - 64,602,344 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,590,641 - 64,602,353 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371164,358,692 - 64,369,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,114,858 - 64,126,396 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341164,114,857 - 64,126,396NCBI
Celera1161,684,540 - 61,696,078 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,685,738 - 60,696,371 (+)NCBIHuRef
CHM1_11164,241,496 - 64,253,033 (+)NCBICHM1_1
T2T-CHM13v2.01164,583,895 - 64,595,327 (+)NCBIT2T-CHM13v2.0
Slc22a12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,585,884 - 6,593,100 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,585,875 - 6,593,062 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38196,535,854 - 6,543,070 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,535,845 - 6,543,032 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37196,535,854 - 6,543,070 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36196,535,854 - 6,543,006 (-)NCBIMGSCv36mm8
Celera196,408,578 - 6,415,794 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.05NCBI
Slc22a12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,274,266 - 213,282,793 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1213,274,275 - 213,281,380 (-)EnsemblGRCr8
mRatBN7.21203,845,039 - 203,852,496 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,845,048 - 203,853,555 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1212,194,211 - 212,201,339 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,290,324 - 219,297,440 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,981,381 - 211,988,497 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1212,634,387 - 212,641,501 (-)NCBI
Lyon_Normotensive1217,543,147 - 217,550,263 (-)NCBI
Lyon_Hypertensive1214,298,621 - 214,305,735 (-)NCBI
F344_StmMcwi1212,529,920 - 212,537,032 (-)NCBI
Rnor_6.01221,910,787 - 221,919,277 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,910,767 - 221,919,301 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01228,902,080 - 228,910,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41209,320,804 - 209,327,918 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1201,379,795 - 201,386,875 (-)NCBICelera
RGSC_v3.11209,479,477 - 209,480,301 (-)NCBI
Cytogenetic Map1q43NCBI
SLC22A12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,815,712 - 65,826,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,861,088 - 66,871,842 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,944,311 - 59,956,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,289,393 - 63,300,742 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,290,329 - 63,299,047 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
SLC22A12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,541,820 - 52,550,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,542,497 - 52,549,655 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1851,149,805 - 51,156,963 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01853,587,392 - 53,595,590 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,587,387 - 53,595,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,678,526 - 52,685,694 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,264,797 - 52,271,967 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,048,889 - 53,056,060 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc22a12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap148,070,975 - 8,077,003 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_0244049478,250,573 - 8,258,303 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,693,352 - 4,698,721 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,693,493 - 4,698,556 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,558,535 - 7,565,751 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.127,557,822 - 7,565,801 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,688,333 - 6,696,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap119,627,989 - 9,639,594 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666038107,023,694 - 107,035,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.119,633,589 - 9,644,519 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,632,645 - 9,643,664 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Slc22a12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476721,771,137 - 21,780,305 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462476721,772,744 - 21,779,230 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Slc22a12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v121,139,141 - 1,146,225 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000022928   ⟹   ENSCLAP00000022719
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542220,556,098 - 20,596,012 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000022929   ⟹   ENSCLAP00000022720
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542220,556,098 - 20,562,058 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000022930   ⟹   ENSCLAP00000022721
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542220,579,585 - 20,596,012 (-)Ensembl
RefSeq Acc Id: XM_005384586   ⟹   XP_005384643
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542220,555,458 - 20,561,818 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005384588   ⟹   XP_005384645
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542220,555,458 - 20,561,818 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005384590   ⟹   XP_005384647
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542220,555,458 - 20,560,435 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005384643 (Get FASTA)   NCBI Sequence Viewer  
  XP_005384645 (Get FASTA)   NCBI Sequence Viewer  
  XP_005384647 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000022719.1
  ENSCLAP00000022720
  ENSCLAP00000022720.1
RefSeq Acc Id: XP_005384645   ⟸   XM_005384588
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VYY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005384643   ⟸   XM_005384586
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VYZ0 (UniProtKB/TrEMBL),   A0A8C2VYY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005384647   ⟸   XM_005384590
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSCLAP00000022721   ⟸   ENSCLAT00000022930
Ensembl Acc Id: ENSCLAP00000022720   ⟸   ENSCLAT00000022929
Ensembl Acc Id: ENSCLAP00000022719   ⟸   ENSCLAT00000022928
Protein Domains
Major facilitator superfamily (MFS) profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000022928.1 UniProtKB/TrEMBL
  ENSCLAT00000022929 ENTREZGENE
  ENSCLAT00000022929.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
NCBI Gene Slc22a12 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A8C2VYY0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VYZ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Slc22a12  solute carrier family 22 member 12    solute carrier family 22 (organic anion/urate transporter), member 12  Symbol and/or name change 5135510 APPROVED