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Gene: Slc22a12 (solute carrier family 22 member 12) Ictidomys tridecemlineatus

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Symbol:

Slc22a12

Name:

solute carrier family 22 member 12

RGD ID:

12661228

Description:

ENCODES a protein that exhibits PDZ domain binding (inferred); transmembrane transporter activity (inferred); urate transmembrane transporter activity (inferred); INVOLVED IN cellular response to insulin stimulus (ortholog); renal urate salt excretion (ortholog); urate transport (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); clear cell renal cell carcinoma (ortholog); Congenital Abnormalities (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mIctTri1.hap1 - mIctTri1.hap1 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	4	8,070,975 - 8,077,003 (-)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404947	8,250,573 - 8,258,303 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	4,693,352 - 4,698,721 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	4,693,493 - 4,698,556 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

clear cell renal cell carcinoma (ISO)

Congenital Abnormalities (ISO)

diabetes mellitus (ISO)

Familial Renal Hypouricemia due to Tubular Hypersecretion (ISO)

genetic disease (ISO)

malignant hyperthermia (ISO)

Renal Hypouricemia (ISO)

Renal Hypouricemia 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (ISO)

renal urate salt excretion (ISO)

response to xenobiotic stimulus (IEA)

transmembrane transport (IEA)

urate metabolic process (IEA)

urate transport (IEA,ISO)

Cellular Component

apical plasma membrane (IEA,ISO)

brush border membrane (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

PDZ domain binding (IEA)

transmembrane transporter activity (IEA)

urate transmembrane transporter activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Slc22a12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	4	8,070,975 - 8,077,003 (-)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404947	8,250,573 - 8,258,303 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	4,693,352 - 4,698,721 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	4,693,493 - 4,698,556 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC22A12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	64,591,220 - 64,602,344 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	64,590,641 - 64,602,353 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	11	64,358,692 - 64,369,816 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	64,114,858 - 64,126,396 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	64,114,857 - 64,126,396	NCBI
Celera	11	61,684,540 - 61,696,078 (+)	NCBI		Celera
Cytogenetic Map	11	q13.1	NCBI
HuRef	11	60,685,738 - 60,696,371 (+)	NCBI		HuRef
CHM1_1	11	64,241,496 - 64,253,033 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	64,583,895 - 64,595,327 (+)	NCBI		T2T-CHM13v2.0

Slc22a12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	6,585,884 - 6,593,100 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	6,585,875 - 6,593,062 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	6,535,854 - 6,543,070 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	6,535,845 - 6,543,032 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	19	6,535,854 - 6,543,070 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	6,535,854 - 6,543,006 (-)	NCBI		MGSCv36	mm8
Celera	19	6,408,578 - 6,415,794 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	5.05	NCBI

Slc22a12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	213,274,266 - 213,282,793 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	213,274,275 - 213,281,380 (-)	Ensembl				GRCr8
mRatBN7.2	1	203,845,039 - 203,852,496 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	203,845,048 - 203,853,555 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	212,194,211 - 212,201,339 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	219,290,324 - 219,297,440 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	211,981,381 - 211,988,497 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	1	212,634,387 - 212,641,501 (-)	NCBI
Lyon_Normotensive	1	217,543,147 - 217,550,263 (-)	NCBI
Lyon_Hypertensive	1	214,298,621 - 214,305,735 (-)	NCBI
F344_StmMcwi	1	212,529,920 - 212,537,032 (-)	NCBI
Rnor_6.0	1	221,910,787 - 221,919,277 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	221,910,767 - 221,919,301 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	1	228,902,080 - 228,910,569 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	209,320,804 - 209,327,918 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	201,379,795 - 201,386,875 (-)	NCBI		Celera
RGSC_v3.1	1	209,479,477 - 209,480,301 (-)	NCBI
Cytogenetic Map	1	q43	NCBI

Slc22a12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	20,556,098 - 20,596,012 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955422	20,555,458 - 20,561,818 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC22A12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	65,815,712 - 65,826,489 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	66,861,088 - 66,871,842 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	59,944,311 - 59,956,102 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	63,289,393 - 63,300,742 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	63,290,329 - 63,299,047 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

SLC22A12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	52,541,820 - 52,550,037 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	52,542,497 - 52,549,655 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	51,149,805 - 51,156,963 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	53,587,392 - 53,595,590 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	53,587,387 - 53,595,227 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	52,678,526 - 52,685,694 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	52,264,797 - 52,271,967 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	53,048,889 - 53,056,060 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

SLC22A12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	7,558,535 - 7,565,751 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	2	7,557,822 - 7,565,801 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	6,688,333 - 6,696,292 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC22A12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	1	9,627,989 - 9,639,594 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666038	107,023,694 - 107,035,578 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	1	9,633,589 - 9,644,519 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	9,632,645 - 9,643,664 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Slc22a12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624767	21,771,137 - 21,780,305 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624767	21,772,744 - 21,779,230 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl

Slc22a12
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	1,139,141 - 1,146,225 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_078045748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_078045749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JBPVTT010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000023338 ⟹ ENSSTOP00000015284

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936599	4,693,352 - 4,698,721 (-)	Ensembl

RefSeq Acc Id:

XM_005333483 ⟹ XP_005333540

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
mIctTri1.hap1	4	8,070,975 - 8,077,002 (-)	NCBI
HiC_Itri_2	NW_024404947	8,250,573 - 8,258,303 (-)	NCBI
SpeTri2.0	NW_004936599	4,693,493 - 4,698,556 (-)	NCBI

Sequence:

show sequence

ATGGCATTTCCGGAACTCCTGGACCAAGTAGGTGGCATGGGCAGGTTCCAGATCCTCCAGCTGA
TGGCCCTGGTGGTCCCCATCGTCCTGCTCACCATGCAGAACATGGCCGAGAACTTCTCGGCCGC
TGTGCCCAGCCACCGCTGCTGGGTGCCCCTCCTGGACAACGCCACCAGCCAGGCCGGCGTCGCA
GGGGCCCTGAGTCCCGAGGCCCTCCTGGCTGTCTCCATCCCACGGGGCCCCGACCAGCAGCCAC
ACCAGTGTCTCCGCTTCCGCCAGCCGCAGTGGCAGCTCCTGGACTCCAACGTCACGGCCACCAA
CTGGAGCGAGGCCACCACAGAGCCGTGTGTGGACGGCTGGGTCTATGACCGCGGCACCTTCACC
TCCACCACCGTGACCAAGTGGGACCTGGTGTGTGACTCCCAGTTTCTGAAGCCCATGGCCCAGT
CCATCTACCTGGCGGGGGTCCTGGTGGGAGCTGCGGTGTGTGGCCACGCCTCGGACAGGTTCGG
GCGCAAGAGGGTGCTGACGTGGAACTACCTGCAGACAGCCGTGTCGGGGACGGTGGCTGCCTTC
GCCCCCACCTTCCCCCTGTACTGCCTGTTCCGCTTCCTGGTGGCCTTCGCCGTGGCGGGCATCA
TGATGAACTCGGGCAGTCTCCTGATGGAGTGGACATCGGCGCGGGCCCGCCCCTTGGTGATGAC
CTTGAACTCCGTGGGCTTCAGCTTTGGCCAGATGCTGATGGCCGCGGTGGCCTATGGTGTGCGT
GACTGGTGGCTGCTGCAGCTGGCCATCTCCGTGCCCTTCATCCTCAGCTTTGTGTACTCATGGT
GGCTGCCCGAATCCGCGAGATGGCTCCTCATCACGGGCAAGCTGGACTGGGGCCTGCGGGAGCT
GCAGAAGGTGGCCGCCATCAACGGCAAGAGGGCAGCAGGGGACACACTGACCATGGAGGTGGTG
CTCTCAGCCTTGCAGGAGGAGGTGAGCAGGGGCCAGGACCCCGTCAGCCTGGGCGCCCTGTTCT
GCACACCCGGGCTGCGCCTGCGGACCTGGGTCTCCCTGATGATCTGGTTCGCCTTTGCCTTCAC
CTTCTACGGCCTGGCCCTGAACCTGCAGGCCCTGGGCAGCAACATCTTCCTGCTCCAGCTGCTC
ATCGGGGCCGTGGACCTCCCGGCCAAGATGGGCACACTGCTGCTGCTGAGCCGCCTGGGCCGCC
GCCCGCTGCAGGCCGGCTCCCTGGTGCTGTCGGGGCTCTGCGTCCTGGCCAACACCCTGGTGCC
CCACGAGATGGGGGCCCTGCGCTCAGCCCTGGCCGTGCTGGGGCTGGGGGCGCTGGGGGCCAGC
TTCACCTGCGTGAGCATCTTCCTCAGTGAACTCTTCCCCACGGTGCTCAGGATGACAGCGGTGG
GCCTGGGCCAGATGGCCGCCCGTGGGGGAGCCATCCTGGGACCCCTGGTCCTGCTGCTGGGCGT
CTATGGCCCCTCACTGCCCCTGCTGGTTCACGGGACCGTGCCATTGTTGAGTGGCCTGGCTGCA
CTCCTGCTGCCCGAAACCCAGAACTTGCCGCTGCCCGACACCATCCACGATATACAGAACCAGG
CAGTAAAGAAAGCAAGACACGGCCCTCCGAGGTGTGTGGTCCTCAAGGCCACCCAGCTCTAG

hide sequence

RefSeq Acc Id:

XM_078045748 ⟹ XP_077901874

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
mIctTri1.hap1	4	8,070,975 - 8,077,003 (-)	NCBI

RefSeq Acc Id:

XM_078045749 ⟹ XP_077901875

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
mIctTri1.hap1	4	8,070,975 - 8,077,003 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005333540	(Get FASTA)	NCBI Sequence Viewer
	XP_077901874	(Get FASTA)	NCBI Sequence Viewer
	XP_077901875	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000015284.1
	ENSSTOP00015027151
GenBank Protein	KAG3284762	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005333540 ⟸ XM_005333483
- Peptide Label:	isoform X2
- UniProtKB:	I3MT39 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFPELLDQVGGMGRFQILQLMALVVPIVLLTMQNMAENFSAAVPSHRCWVPLLDNATSQAGVA GALSPEALLAVSIPRGPDQQPHQCLRFRQPQWQLLDSNVTATNWSEATTEPCVDGWVYDRGTFT STTVTKWDLVCDSQFLKPMAQSIYLAGVLVGAAVCGHASDRFGRKRVLTWNYLQTAVSGTVAAF APTFPLYCLFRFLVAFAVAGIMMNSGSLLMEWTSARARPLVMTLNSVGFSFGQMLMAAVAYGVR DWWLLQLAISVPFILSFVYSWWLPESARWLLITGKLDWGLRELQKVAAINGKRAAGDTLTMEVV LSALQEEVSRGQDPVSLGALFCTPGLRLRTWVSLMIWFAFAFTFYGLALNLQALGSNIFLLQLL IGAVDLPAKMGTLLLLSRLGRRPLQAGSLVLSGLCVLANTLVPHEMGALRSALAVLGLGALGAS FTCVSIFLSELFPTVLRMTAVGLGQMAARGGAILGPLVLLLGVYGPSLPLLVHGTVPLLSGLAA LLLPETQNLPLPDTIHDIQNQAVKKARHGPPRCVVLKATQL hide sequence

Ensembl Acc Id:

ENSSTOP00000015284 ⟸ ENSSTOT00000023338

RefSeq Acc Id:	XP_077901875 ⟸ XM_078045749
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_077901874 ⟸ XM_078045748
- Peptide Label:	isoform X1

Protein Domains

Major facilitator superfamily (MFS) profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027520	Ensembl, UniProtKB/TrEMBL
	ENSSTOG00015021964	ENTREZGENE
Ensembl Transcript	ENSSTOT00000023338.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/TrEMBL
InterPro	MFS_dom	UniProtKB/TrEMBL
	MFS_sugar_transport-like	UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/TrEMBL
KEGG Report	iti:101956484	UniProtKB/TrEMBL
NCBI Gene	Slc22a12	ENTREZGENE
PANTHER	SOLUTE CARRIER FAMILY 22 MEMBER	UniProtKB/TrEMBL
Pfam	Sugar_tr	UniProtKB/TrEMBL
PROSITE	MFS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103473	UniProtKB/TrEMBL
UniProt	I3MT39	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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