Aplp2 (amyloid beta precursor like protein 2) - Rat Genome Database

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Gene: Aplp2 (amyloid beta precursor like protein 2) Chinchilla lanigera
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Symbol: Aplp2
Name: amyloid beta precursor like protein 2
RGD ID: 8913623
Description: ENCODES a protein that exhibits identical protein binding (ortholog); serine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN cholesterol metabolic process (ortholog); extracellular matrix organization (ortholog); forebrain development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); Dwarfism (ortholog); FOUND IN nucleus (ortholog); spine apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: amyloid beta (A4) precursor-like protein 2; amyloid-like protein 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541231,043,320 - 31,075,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541231,043,320 - 31,075,617 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (ISO)
spine apparatus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Aplp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541231,043,320 - 31,075,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541231,043,320 - 31,075,617 (+)NCBIChiLan1.0ChiLan1.0
APLP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811130,069,894 - 130,144,805 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11130,068,147 - 130,144,811 (+)EnsemblGRCh38hg38GRCh38
GRCh3711129,939,789 - 130,014,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611129,445,011 - 129,519,910 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411129,445,010 - 129,519,910NCBI
Celera11127,107,986 - 127,182,408 (+)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11125,891,358 - 125,966,057 (+)NCBIHuRef
CHM1_111129,825,308 - 129,900,554 (+)NCBICHM1_1
T2T-CHM13v2.011130,106,007 - 130,180,474 (+)NCBIT2T-CHM13v2.0
Aplp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39931,060,853 - 31,123,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl931,060,853 - 31,123,111 (-)EnsemblGRCm39 Ensembl
GRCm38931,149,557 - 31,211,848 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl931,149,557 - 31,211,815 (-)EnsemblGRCm38mm10GRCm38
MGSCv37930,957,142 - 31,019,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36930,899,122 - 30,961,380 (-)NCBIMGSCv36mm8
Celera928,408,874 - 28,471,021 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map916.66NCBI
Aplp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,857,407 - 37,920,487 (-)NCBIGRCr8
mRatBN7.2829,599,230 - 29,662,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,599,230 - 29,661,855 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx833,668,572 - 33,730,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0831,962,969 - 32,025,119 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0829,830,857 - 29,892,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0832,298,526 - 32,328,821 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,298,532 - 32,328,839 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0832,323,516 - 32,353,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera831,060,571 - 31,122,969 (-)NCBICelera
Cytogenetic Map8q13NCBI
APLP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29130,749,892 - 130,822,357 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111131,860,588 - 131,933,070 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011124,881,191 - 124,944,472 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111128,812,227 - 128,847,482 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11128,775,329 - 128,847,482 (+)Ensemblpanpan1.1panPan2
APLP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.154,704,155 - 4,786,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl54,705,491 - 4,786,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha54,764,879 - 4,846,709 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.054,663,992 - 4,746,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl54,663,992 - 4,746,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.154,725,302 - 4,807,340 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.054,706,890 - 4,788,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.054,734,652 - 4,816,738 (-)NCBIUU_Cfam_GSD_1.0
Aplp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947112,172,610 - 112,244,835 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365722,205,478 - 2,277,842 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365722,205,527 - 2,277,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APLP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl956,798,810 - 56,872,642 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1956,798,781 - 56,871,849 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2962,965,051 - 63,035,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APLP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,150,296 - 121,224,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,150,291 - 121,224,534 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660434,883,243 - 4,956,688 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aplp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248124,490,798 - 4,571,623 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248124,490,798 - 4,571,500 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000021730   ⟹   ENSCLAP00000021527
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541231,043,320 - 31,075,617 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000021731   ⟹   ENSCLAP00000021528
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541231,043,320 - 31,075,617 (+)Ensembl
RefSeq Acc Id: XM_005378559   ⟹   XP_005378616
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541231,043,320 - 31,075,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005378560   ⟹   XP_005378617
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541231,043,320 - 31,075,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005378561   ⟹   XP_005378618
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541231,043,320 - 31,075,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005378562   ⟹   XP_005378619
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541231,043,328 - 31,075,617 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005378617   ⟸   XM_005378560
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W372 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005378616   ⟸   XM_005378559
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W372 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005378618   ⟸   XM_005378561
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VYX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005378619   ⟸   XM_005378562
- Peptide Label: isoform X4
- UniProtKB: A0A8C2VYX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021528   ⟸   ENSCLAT00000021731
RefSeq Acc Id: ENSCLAP00000021527   ⟸   ENSCLAT00000021730
Protein Domains
BPTI/Kunitz inhibitor   E1   E2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014734 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021730 ENTREZGENE
  ENSCLAT00000021730.1 UniProtKB/TrEMBL
  ENSCLAT00000021731 ENTREZGENE
  ENSCLAT00000021731.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.770 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.1490.140 UniProtKB/TrEMBL
  3.90.570.10 UniProtKB/TrEMBL
  4.10.410.10 UniProtKB/TrEMBL
  6.10.250.1670 UniProtKB/TrEMBL
InterPro Amyloid_Cu-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco UniProtKB/TrEMBL
  Amyloid_glyco_Cu-bd UniProtKB/TrEMBL
  Amyloid_glyco_E2_domain UniProtKB/TrEMBL
  Amyloid_glyco_extra UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco_intracell_CS UniProtKB/TrEMBL
  APP_amyloid_C UniProtKB/TrEMBL
  APP_CUBD_CS UniProtKB/TrEMBL
  E2_sf UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
NCBI Gene Aplp2 ENTREZGENE
PANTHER AMYLOID-LIKE PROTEIN 2 UniProtKB/TrEMBL
  PTHR23103 UniProtKB/TrEMBL
Pfam APP_amyloid UniProtKB/TrEMBL
  APP_Cu_bd UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_N UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
PRINTS AMYLOIDA4 UniProtKB/TrEMBL
  BASICPTASE UniProtKB/TrEMBL
PROSITE APP_CUBD UniProtKB/TrEMBL
  APP_E1 UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_INTRA UniProtKB/TrEMBL
  BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
SMART A4_EXTRA UniProtKB/TrEMBL
  SM00131 UniProtKB/TrEMBL
Superfamily-SCOP SSF109843 UniProtKB/TrEMBL
  SSF56491 UniProtKB/TrEMBL
  SSF57362 UniProtKB/TrEMBL
  SSF89811 UniProtKB/TrEMBL
UniProt A0A8C2VYX5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W372 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Aplp2  amyloid beta precursor like protein 2    amyloid beta (A4) precursor-like protein 2  Symbol and/or name change 5135510 APPROVED