Mpp3 (MAGUK p55 scaffold protein 3)

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Gene: Mpp3 (MAGUK p55 scaffold protein 3) Chinchilla lanigera

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Symbol:

Mpp3

Name:

MAGUK p55 scaffold protein 3

RGD ID:

8880470

Description:

ENCODES a protein that exhibits PDZ domain binding (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN adherens junction (ortholog); apical plasma membrane (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

MAGUK p55 subfamily member 3; membrane palmitoylated protein 3; membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	17,081,848 - 17,098,513 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	17,085,000 - 17,098,213 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hereditary breast ovarian cancer syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

adherens junction (ISO)

apical plasma membrane (ISO)

plasma membrane (ISO)

Molecular Function

PDZ domain binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Mpp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	17,081,848 - 17,098,513 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	17,085,000 - 17,098,213 (-)	NCBI	ChiLan1.0	ChiLan1.0

MPP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	43,800,811 - 43,833,146 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	43,800,799 - 43,833,170 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	41,878,179 - 41,910,514 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	39,233,693 - 39,266,064 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	39,233,692 - 39,265,136	NCBI
Celera	17	38,586,168 - 38,618,558 (-)	NCBI		Celera
Cytogenetic Map	17	q21.31	NCBI
HuRef	17	37,642,259 - 37,674,618 (-)	NCBI		HuRef
CHM1_1	17	42,113,776 - 42,146,168 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	44,653,356 - 44,685,702 (-)	NCBI		T2T-CHM13v2.0

Mpp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	101,890,488 - 101,925,854 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	101,890,478 - 101,919,287 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	101,999,652 - 102,027,045 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	101,999,652 - 102,028,461 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	101,860,966 - 101,888,269 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	101,815,752 - 101,842,995 (-)	NCBI		MGSCv36	mm8
Celera	11	113,704,881 - 113,732,182 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	65.48	NCBI

Mpp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	87,445,905 - 87,475,461 (-)	NCBI		GRCr8
mRatBN7.2	10	86,945,705 - 86,975,261 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	86,945,714 - 86,974,737 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	91,975,125 - 92,004,013 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	91,450,674 - 91,479,695 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	86,843,985 - 86,873,006 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	89,930,270 - 89,959,462 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	89,930,241 - 89,959,176 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	89,722,759 - 89,751,677 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	91,057,154 - 91,085,728 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	91,087,472 - 91,099,519 (-)	NCBI
Celera	10	85,664,875 - 85,693,097 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

MPP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	21,074,975 - 21,107,714 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	23,039,275 - 23,072,026 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	13,564,292 - 13,597,045 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	13,729,990 - 13,762,907 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	13,730,254 - 13,762,005 (+)	Ensembl	panpan1.1		panPan2

MPP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	19,477,604 - 19,504,530 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	19,477,432 - 19,504,493 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	18,866,460 - 18,893,735 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	20,172,440 - 20,199,738 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	20,171,918 - 20,199,738 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	19,025,075 - 19,052,346 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	19,208,247 - 19,235,532 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	19,353,324 - 19,380,620 (+)	NCBI		UU_Cfam_GSD_1.0

Mpp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	18,812,328 - 18,838,120 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	356,016 - 382,276 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	356,483 - 382,247 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MPP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	19,296,513 - 19,323,692 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	19,296,437 - 19,322,615 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	19,530,840 - 19,556,249 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MPP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	62,567,386 - 62,599,682 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	62,567,484 - 62,600,459 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	33,339,835 - 33,372,065 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mpp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	968,961 - 987,253 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	968,940 - 987,762 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005394510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01043717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01139661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01285648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000023049 ⟹ ENSCLAP00000022838

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955451	17,081,848 - 17,098,513 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000023050 ⟹ ENSCLAP00000022839

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955451	17,094,423 - 17,098,095 (-)	Ensembl

RefSeq Acc Id:

XM_005394510 ⟹ XP_005394567

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955451	17,085,000 - 17,098,213 (-)	NCBI

Sequence:

show sequence

CTTTTCTGAGCAGCCCCTCCAGGCTCGCGCCCCGCCCGCGCCCCACCCCCGAGGCCGCCCAGGG
AGGGGCGGTGCAGACGAGCGGCGGCGGCCGAGGCCCGATCCCTCGCAGCCCGCGGTCCAGAGCC
GAGGTCCCGGCGCGACGAGGAATGTGCGGAGTTCCTGTACCTGTACCTGCTGGACAGCTTGGGA
TGCTGCTGTCCCCTCCGTGAGGTCCTCACCTGCACCTCCCGGGTGGGGTGCTCGGGACCAGGCC
GGCGCAGGCATGCCCATGCTGTCTGAGGACTCTGGCCTGCATGAGACCCTGGCGCTGCTCACGT
CCCAGCTGAGACCTGACTCGAGCCACCGGGAGGAGATGGGCTTCCTGCGGGACGTGTTCAGTGA
GCGGAGCCTCAGCTACCTGATGAAGATACACGAGAAGCTGCGCTGCTACGAGCGGCAGAGCCCG
ACCCCGGTCCTGCACAGCGCCGTGGCCCTGGCCGAGGACGTGGCGGAGGAGCTGCAGGCTGCCT
CTGCGCATGGTGATGAGAGGGAGCTGCTGCAGCTGCTGGCCACGCCCCACCTCAGGGCTGTGCT
CATGGTGCACGACACTGTGGCCCAGAAGAATTTCGACCCCGTGTTGCCGCCTCTGCCCGACAAC
ATCGACGGGGAGTTTGAGGAGGAGTCAGTGAAAATAGTGCGCTTGGTGAAGAATAAGGAGCCCC
TGGGAGCCACCATCCGGCGGGATGAGCACACTGGCGCTGTCGTGGTGGCCAGGATCATGCGAGG
GGGTGCGGCCGACCGCAGCGGCCTGGTCCATGTTGGGGATGAGCTCCGCGAGGTAAACGGAGTC
GCCGTCCTGCACAAGCGGCCAGACGAGATCAGCCAGATTCTGGCCCAGTCCCAGGGCTCCATCA
CCCTCAAGATCATCCCGGCCACCCAGGAGGGGGACCGCTTCAAGGAGAGCAAGGTGTTCATGCG
GGCCCTGTTCCACTACGACCCCCGTGAGGACCGCGCCATCCCCTGCCAGGAGGCGGGGCTGCCG
TTCCAGCGCAGGCAGGTGCTGGAGGTGGTGAGCCAGGACGACCCTACCTGGTGGCAGGCCAAGC
GTGTGGGCGACGCCAACCTCCGGGCCGGCCTCATCCCCTCCAAGCAGTTCCAGGAGAGGCGACT
CAGCTACTGGAGAGCGGTGGGTGCCCTGCCGAGCCCCCCGAGCCTCAGGAAGCCACCCTACGAC
CAGCCTTGTGACCCAGAGACCTGTGACTGTGACGGGCACCTCAAAGGCCACTATGTGGCTGGTC
TGAGGAGGAGCTTCCGGCTCGGCTGCCGTGAGAGGCCAGGCAGCTCGCAGGATGGGAAGGCGCC
TGTGGGCTCGGAGTCCCTGGAGTTGCCCACCTATGAGGAGGTGGCCCGGTACCAGCCCCAGCCC
GGCGAGCGGCCCCGCCTCGCAGTTCTGATTGGGTCTCTGGGTGCCCGGCTGCAGGAGCTGAAGC
AGAAGCTGGTGGCTGAGAACCCGCAGCGCTTTGGCGTCGCCGTGCCACACACCACCCGGCCGCG
GCGGAGCCACGAGAAGGAGGGTGTGGAGTACCACTTCGTCTCCAGGCAGGCATTCGAGACTGAC
GTGCAGCACAGCAGGTTCCTGGAGCACGGCGAGTACCAGGAGCACCTGTACGGGACCAGCCTGG
GGGCCGTGCGCGCCGTCGCGGCCAGGAACAAAGTCTGCGTGGTGGATGTGCAGCCTGAGGCTCT
GAAACAGCTTCGGACCTCAGAGTTCAAGCCCTACGTTGTGTTTGTGAAGCCGGCGGTGCAGGAG
AAGAGGAAGACGCCACCCCCGTTCCCAGCCTGTGAGGACGCAGCAGCCCTGCCTGACGAGGAGC
AGCAGGACGTGGCCGCCTCCGCTGCCTACGTGGAGCAGTGCTACGGGCACCTGGTGGACGCCGT
GCTGGTGCGGGAGGACCTGCCGGGCGCCTGCGCGCAGCTCCGGGCGCTGCTCGAGAGGCTGGGC
ACGGACGCACAGTGGGTGCCCATCAGCTGGGTCAGGTAACTCTGTCCTGGGACATCCTGCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005394567	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022838
	ENSCLAP00000022838.1
	ENSCLAP00000022839.1

RefSeq Acc Id:

XP_005394567 ⟸ XM_005394510

- UniProtKB:

A0A8C2W458 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPMLSEDSGLHETLALLTSQLRPDSSHREEMGFLRDVFSERSLSYLMKIHEKLRCYERQSPTPV
LHSAVALAEDVAEELQAASAHGDERELLQLLATPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDG
EFEEESVKIVRLVKNKEPLGATIRRDEHTGAVVVARIMRGGAADRSGLVHVGDELREVNGVAVL
HKRPDEISQILAQSQGSITLKIIPATQEGDRFKESKVFMRALFHYDPREDRAIPCQEAGLPFQR
RQVLEVVSQDDPTWWQAKRVGDANLRAGLIPSKQFQERRLSYWRAVGALPSPPSLRKPPYDQPC
DPETCDCDGHLKGHYVAGLRRSFRLGCRERPGSSQDGKAPVGSESLELPTYEEVARYQPQPGER
PRLAVLIGSLGARLQELKQKLVAENPQRFGVAVPHTTRPRRSHEKEGVEYHFVSRQAFETDVQH
SRFLEHGEYQEHLYGTSLGAVRAVAARNKVCVVDVQPEALKQLRTSEFKPYVVFVKPAVQEKRK
TPPPFPACEDAAALPDEEQQDVAASAAYVEQCYGHLVDAVLVREDLPGACAQLRALLERLGTDA
QWVPISWVR

hide sequence

Ensembl Acc Id:

ENSCLAP00000022838 ⟸ ENSCLAT00000023049

Ensembl Acc Id:

ENSCLAP00000022839 ⟸ ENSCLAT00000023050

Protein Domains

Guanylate kinase-like L27 PDZ SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015665	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023049	ENTREZGENE
	ENSCLAT00000023049.1	UniProtKB/TrEMBL
	ENSCLAT00000023050.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.42.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	L27 domain	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	GK/Ca_channel_bsu	UniProtKB/TrEMBL
	Guanylate_kin-like_dom	UniProtKB/TrEMBL
	Guanylate_kinase_CS	UniProtKB/TrEMBL
	L27_C	UniProtKB/TrEMBL
	L27_dom	UniProtKB/TrEMBL
	L27_dom_sf	UniProtKB/TrEMBL
	MAGUK	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
NCBI Gene	Mpp3	ENTREZGENE
PANTHER	MAGUK P55 SUBFAMILY MEMBER 3	UniProtKB/TrEMBL
	MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK	UniProtKB/TrEMBL
Pfam	Guanylate_kin	UniProtKB/TrEMBL
	L27	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	SH3_2	UniProtKB/TrEMBL
PROSITE	GUANYLATE_KINASE_1	UniProtKB/TrEMBL
	GUANYLATE_KINASE_2	UniProtKB/TrEMBL
	L27	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	GuKc	UniProtKB/TrEMBL
	L27	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF101288	UniProtKB/TrEMBL
	SSF50044	UniProtKB/TrEMBL
	SSF50156	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8C2VZ87_CHILA	UniProtKB/TrEMBL
	A0A8C2W458	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-09-21	Mpp3	MAGUK p55 scaffold protein 3	Mpp3	membrane palmitoylated protein 3	Symbol and/or name change	5135510	APPROVED
2016-08-03	Mpp3	membrane palmitoylated protein 3		membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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