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Gene: Gins2 (GINS complex subunit 2) Chinchilla lanigera

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Symbol:

Gins2

Name:

GINS complex subunit 2

RGD ID:

8876902

Description:

INVOLVED IN DNA unwinding involved in DNA replication (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); persistent fetal circulation syndrome (ortholog); Salivary Gland Neoplasms (ortholog); FOUND IN CMG complex (ortholog); GINS complex (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA replication complex GINS protein PSF2; GINS complex subunit 2 (Psf2 homolog)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GINS2 (GINS complex subunit 2)	NCBI	Ortholog
Mus musculus (house mouse):	Gins2 (GINS complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gins2 (GINS complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GINS2 (GINS complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GINS2 (GINS complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gins2 (GINS complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GINS2 (GINS complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GINS2 (GINS complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gins2 (GINS complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	809,079 - 816,807 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	809,079 - 816,807 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

persistent fetal circulation syndrome (ISO)

Salivary Gland Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA unwinding involved in DNA replication (ISO)

Cellular Component

CMG complex (ISO)

GINS complex (ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gins2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	809,079 - 816,807 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	809,079 - 816,807 (-)	NCBI	ChiLan1.0	ChiLan1.0

GINS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	85,676,198 - 85,688,954 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	85,676,198 - 85,690,073 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	85,709,804 - 85,722,560 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	84,268,781 - 84,280,081 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	70,014,391 - 70,025,701 (-)	NCBI		Celera
Cytogenetic Map	16	q24.1	NCBI
HuRef	16	71,453,444 - 71,464,751 (-)	NCBI		HuRef
CHM1_1	16	87,122,632 - 87,133,940 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	91,741,711 - 91,754,467 (-)	NCBI		T2T-CHM13v2.0

Gins2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	121,308,005 - 121,315,814 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	121,305,372 - 121,316,043 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	120,581,266 - 120,589,075 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	120,578,633 - 120,589,304 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	123,105,166 - 123,112,975 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	123,105,166 - 123,112,975 (-)	NCBI		MGSCv36	mm8
Celera	8	124,796,891 - 124,804,700 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	69.86	NCBI

Gins2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	65,535,492 - 65,548,270 (-)	NCBI		GRCr8
mRatBN7.2	19	48,626,770 - 48,639,523 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	48,626,770 - 48,639,339 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	55,421,090 - 55,433,627 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	56,101,777 - 56,114,341 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	58,315,053 - 58,327,545 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	54,151,048 - 54,163,701 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,151,048 - 54,163,608 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	64,873,928 - 64,886,729 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	50,915,108 - 50,927,668 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	50,923,424 - 50,943,902 (-)	NCBI
Celera	19	47,880,377 - 47,892,745 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

GINS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	95,426,567 - 95,439,433 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	101,343,842 - 101,356,693 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	66,344,706 - 66,356,079 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	85,681,716 - 85,691,625 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	85,681,716 - 85,691,626 (-)	Ensembl	panpan1.1		panPan2

GINS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	66,982,033 - 66,997,115 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	66,982,137 - 67,000,338 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	66,997,756 - 67,012,257 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	67,210,094 - 67,224,295 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	67,210,118 - 67,224,961 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	67,231,886 - 67,245,913 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	67,065,416 - 67,096,781 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	67,480,810 - 67,511,339 (+)	NCBI		UU_Cfam_GSD_1.0

Gins2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	27,017,226 - 27,022,812 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936641	2,757,150 - 2,776,681 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936641	2,757,150 - 2,775,904 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GINS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	3,218,702 - 3,243,899 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	3,218,655 - 3,252,740 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	3,528,016 - 3,552,398 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GINS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	71,088,766 - 71,099,845 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	71,089,564 - 71,099,688 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	4,641,567 - 4,651,970 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gins2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	2,109,667 - 2,116,925 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	2,109,655 - 2,116,957 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005410979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01071360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01071361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01052450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000001274 ⟹ ENSCLAP00000001233

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955541	809,079 - 816,807 (-)	Ensembl

RefSeq Acc Id:

XM_005410979 ⟹ XP_005411036

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955541	809,079 - 816,807 (-)	NCBI

Sequence:

show sequence

GGGGCGGGCCCCGAGCCGCGGCGGGAAAAGCGGCGGCCGTGGCGCGTCTTCCGAGCGGCCCCGG
GCTGTGAGGGGCTCCCCGTCGGCGTGCGGCGTCGCCATGGACGCGGCCGAGGTGGAGTTCCTGG
CCGAGAAGGAGCTGGTTACCATCATCCCGAACTTCAGTCTCGATAAGATCTACCTTATCGGGGG
GGACCTGGGCCCGTTCGACCCCGGCCTCCCCGTGGACGTGCCGCTGTGGCTGGCCGTCAGCCTG
AAGCAGAGGCAGAAGTGTCGCCTGCTGCCGCCGCCCTGGATGGACGTCGAGAAGTTGGAGAAGA
TGAGGGATCACGAACGAAAGGAGGAAACTTTCACTCCAGCGCCCAGCCCCTACTACATGGAACT
CACCAAGCTCCTGCTAACTCACGCGTCAGACAACATCCCCAAAGCAGATGCGATCCGGACCCTG
ATCAAAGATCTGTGGGACACGCGCATGGCCAAGCTGCGGGTGTCCGCCGACAGCTTTGTGCGGC
AGCAGGAGGCACACGCCAAGCTGGATAACTTGACCTTGATGGAGATCAACACCAGCGGGGCCTT
CCTCACAGAGGCGCTCCGCCACATGTACAAGCTGCGCACCAACCTCCAGCCTTCCGAGAGCGCC
GCGTCGCAGGACTTCTAGAGGAGAGCCGGTGCTTGTGGAGCCACAGGGCCTCCCCCTGCTGCCA
GGAGGCTTGCTGGGCGCTGTGAGTGCGTGCTGCGGACGTGACAGAGGGACTCACGGTTCTAGAG
TTCAGGTCAGGACACATTTTTGAACACGTGAAAAAGGTATGATGATTCCAGGAGTGAATTTAAC
AAACAGGTGAGAGAGCAACGAGCTTGTGATTGATCAGTCTGCGAACAGGGCTCCCCTGGACTCA
GTCACCATCCCGTTCTGGGAGCCAGCTCTTCTCCTGTGGGGTAAGGAAGAAGCTTTAGGCAAGC
GAGTTGTTCCTCCTAGCAGACGTGGGCCTCCGCTGTGAGAATGCCATGCTCAGCTGTGTGCCTG
GCGACCGGTGGATGCACAGGGACGGTGATGTGGCCGGGGGCATTTGCATTTCTCGATCTTGGTT
TCTTGGCTAAAGTTAGAACCTCTTGTAGACACGGCTCACACAGAACAGTGGCCGATGAAGGCTG
GTAATGCTGACCGTGTTCGCCGTCCAGGTCTCAATCCACAATAAAGATGTGCTCAGCTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005411036	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000001233
	ENSCLAP00000001233.1

RefSeq Acc Id:	XP_005411036 ⟸ XM_005410979
- UniProtKB:	A0A8C2YIJ0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFDPGLPVDVPLWLAVSLKQRQKCRLLPPP WMDVEKLEKMRDHERKEETFTPAPSPYYMELTKLLLTHASDNIPKADAIRTLIKDLWDTRMAKL RVSADSFVRQQEAHAKLDNLTLMEINTSGAFLTEALRHMYKLRTNLQPSESAASQDF hide sequence

Ensembl Acc Id:

ENSCLAP00000001233 ⟸ ENSCLAT00000001274

Protein Domains

GINS subunit

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000000938	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000001274	ENTREZGENE
	ENSCLAT00000001274.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.1020	UniProtKB/TrEMBL
	3.40.5.50	UniProtKB/TrEMBL
InterPro	GINS_A	UniProtKB/TrEMBL
	GINS_bundle-like_dom_sf	UniProtKB/TrEMBL
	GINS_Psf2	UniProtKB/TrEMBL
NCBI Gene	Gins2	ENTREZGENE
PANTHER	DNA REPLICATION COMPLEX GINS PROTEIN PSF2	UniProtKB/TrEMBL
	PTHR12772	UniProtKB/TrEMBL
Pfam	Sld5	UniProtKB/TrEMBL
PIRSF	GINS_Psf2_subgr	UniProtKB/TrEMBL
Superfamily-SCOP	PriA/YqbF domain	UniProtKB/TrEMBL
	SSF158573	UniProtKB/TrEMBL
UniProt	A0A8C2YIJ0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Gins2	GINS complex subunit 2		GINS complex subunit 2 (Psf2 homolog)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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