Fdx1 (ferredoxin 1) - Rat Genome Database

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Gene: Fdx1 (ferredoxin 1) Chinchilla lanigera
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Symbol: Fdx1
Name: ferredoxin 1
RGD ID: 8852822
Description: ENCODES a protein that exhibits 2 iron, 2 sulfur cluster binding (ortholog); cholesterol monooxygenase (side-chain-cleaving) activity (ortholog); electron transfer activity (ortholog); INVOLVED IN adrenal gland development (ortholog); cellular response to cAMP (ortholog); cellular response to epinephrine stimulus (ortholog); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; estradiol biosynthetic pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); chromosome 11 partial duplication syndrome (ortholog); intellectual disability (ortholog); FOUND IN mitochondrial crista (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adrenodoxin, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541212,286,408 - 12,316,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541212,280,900 - 12,312,930 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fdx1Chinchillapancreatitis  ISORGD:620369068941mRNA:increased expression:pancreatic acinar cell (rat) RGDPMID:12709512|REF_RGD_ID:4145666
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fdx1Chinchillaataxia telangiectasia  ISORGD:13471308554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571|PMID:25614872|PMID:28492532
Fdx1Chinchillachromosome 11 partial duplication syndrome  ISORGD:13471308554872ClinVar Annotator: match by term: Distal trisomy 11qClinVarPMID:25741868
Fdx1Chinchillaintellectual disability  ISORGD:13471308554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 


Biological Process
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fdx1Chinchillaadrenal gland development  ISORGD:620369068941 RGDPMID:8097866|REF_RGD_ID:4145970
Fdx1Chinchillacellular response to cAMP acts_upstream_of_or_withinISORGD:623289068941 PMID:7495857MGIPMID:7495857
Fdx1Chinchillacellular response to epinephrine stimulus  ISORGD:620369068941 RGDPMID:11064152|REF_RGD_ID:4145763
Fdx1Chinchillacellular response to forskolin acts_upstream_of_or_withinISORGD:623289068941 PMID:7495857MGIPMID:7495857
Fdx1Chinchillacellular response to forskolin  ISORGD:620369068941 RGDPMID:11064152|REF_RGD_ID:4145763
Fdx1Chinchillacellular response to leptin stimulus  ISORGD:620369068941 RGDPMID:10098510|REF_RGD_ID:4145764
Fdx1Chinchillacholesterol metabolic process involved_inISORGD:13471309068941 PMID:21636783UniProtPMID:21636783
Fdx1Chinchillahormone biosynthetic process involved_inISORGD:13471309068941 PMID:21636783UniProtPMID:21636783
Fdx1Chinchillapositive regulation of oxidoreductase activity  ISORGD:620369068941p-nitrophenol hydroxylase, dimethylnitrosamine demethylaseRGDPMID:11325963|REF_RGD_ID:4145669
Fdx1Chinchillaregulation of catalytic activity  ISORGD:620369068941 RGDPMID:8789462|REF_RGD_ID:2326068
Fdx1Chinchillaregulation of NADP metabolic process  ISORGD:620369068941 RGDPMID:10525147|REF_RGD_ID:727285
Fdx1Chinchillaresponse to gonadotropin  ISORGD:620369068941 RGDPMID:16139340|REF_RGD_ID:4145663
Fdx1Chinchillaresponse to leptin  ISORGD:620369068941 RGDPMID:11604238|REF_RGD_ID:4145667
1 to 13 of 13 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fdx1Chinchillamitochondrial crista  ISORGD:620369068941 RGDPMID:16139340|REF_RGD_ID:4145663
Fdx1Chinchillamitochondrial matrix located_inISORGD:620369068941PMID:2170421UniProtPMID:2170421|REF_RGD_ID:13506267
Fdx1Chinchillamitochondrion located_inISORGD:13471309068941 HPAGO_REF:0000052
Fdx1Chinchillamitochondrion located_inISORGD:13471309068941 PMID:34800366FlyBasePMID:34800366

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fdx1Chinchilla2 iron, 2 sulfur cluster binding enablesISORGD:13471309068941 PMID:21636783UniProtPMID:21636783
Fdx1Chinchillacholesterol monooxygenase (side-chain-cleaving) activity contributes_toISORGD:620369068941 RGDPMID:8789462|REF_RGD_ID:2326068
Fdx1Chinchillaelectron transfer activity enablesISORGD:13471309068941 PMID:21636783UniProtPMID:21636783
Fdx1Chinchillaferredoxin-[NAD(P)H] reductase activity contributes_toISORGD:620369068941NADPH-cytochrome c reductionRGDPMID:8789462|REF_RGD_ID:2326068

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fdx1Chinchillaaldosterone biosynthetic pathway   ISORGD:13471309068941 RGDPMID:18821018|REF_RGD_ID:2325883
Fdx1Chinchillacortisol biosynthetic pathway   ISORGD:13471309068941 RGDPMID:18821018|REF_RGD_ID:2325883
Fdx1Chinchillaestradiol biosynthetic pathway   ISORGD:13471309068941 RGDPMID:18821018|REF_RGD_ID:2325883
Fdx1Chinchillamitochondrial iron-sulfur cluster protein biogenesis pathway   ISORGD:13471309068941 RGDPMID:25245479|REF_RGD_ID:11554190
Fdx1Chinchillasteroid hormone biosynthetic pathway   ISORGD:13471309068941 RGDPMID:18821018|REF_RGD_ID:2325883
Fdx1Chinchillatestosterone biosynthetic pathway   ISORGD:13471309068941 RGDPMID:18821018|REF_RGD_ID:2325883

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074   PMID:30032202  



Fdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541212,286,408 - 12,316,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541212,280,900 - 12,312,930 (+)NCBIChiLan1.0ChiLan1.0
FDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811110,429,331 - 110,464,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11110,429,948 - 110,464,884 (+)EnsemblGRCh38hg38GRCh38
GRCh3711110,300,672 - 110,335,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611109,805,804 - 109,840,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411109,805,803 - 109,840,814NCBI
Celera11107,454,082 - 107,489,091 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11106,225,358 - 106,260,247 (+)NCBIHuRef
CHM1_111110,183,752 - 110,218,730 (+)NCBICHM1_1
T2T-CHM13v2.011110,439,522 - 110,475,104 (+)NCBIT2T-CHM13v2.0
Fdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,854,323 - 51,874,902 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,854,606 - 51,874,856 (-)EnsemblGRCm39 Ensembl
GRCm38951,943,023 - 51,963,602 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,943,306 - 51,963,556 (-)EnsemblGRCm38mm10GRCm38
MGSCv37951,751,412 - 51,771,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36951,695,672 - 51,715,898 (-)NCBIMGSCv36mm8
Celera949,216,519 - 49,236,839 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map928.62NCBI
Fdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8861,164,839 - 61,183,645 (-)NCBIGRCr8
mRatBN7.2852,268,536 - 52,287,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl852,268,536 - 52,287,414 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx857,817,827 - 57,836,608 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0856,096,794 - 56,115,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,961,051 - 53,979,836 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0856,373,729 - 56,393,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl856,373,723 - 56,393,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,958,315 - 54,977,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4855,291,396 - 55,310,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1855,323,249 - 55,329,561 (-)NCBI
Celera851,793,129 - 51,811,786 (-)NCBICelera
Cytogenetic Map8q24NCBI
FDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29111,170,868 - 111,207,767 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111112,262,007 - 112,298,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011105,311,613 - 105,345,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111109,158,419 - 109,190,869 (+)NCBIpanpan1.1PanPan1.1panPan2
FDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1522,452,011 - 22,485,581 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl522,451,209 - 22,485,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha522,371,400 - 22,404,749 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0522,477,844 - 22,511,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl522,479,333 - 22,511,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1522,536,376 - 22,569,968 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0522,436,016 - 22,540,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0522,485,417 - 22,518,946 (-)NCBIUU_Cfam_GSD_1.0
Fdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494792,799,925 - 92,827,430 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366123,874,748 - 3,905,825 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366123,878,179 - 3,905,678 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl938,375,984 - 38,404,832 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1938,376,147 - 38,399,026 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11101,777,499 - 101,813,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1101,777,678 - 101,816,379 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604324,135,097 - 24,172,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247845,406,459 - 5,460,581 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000019736   ⟹   ENSCLAP00000019543
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541212,286,408 - 12,316,707 (+)Ensembl
RefSeq Acc Id: XM_013511103   ⟹   XP_013366557
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541212,280,900 - 12,312,930 (+)NCBI
Sequence:
Protein RefSeqs XP_013366557 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019543
  ENSCLAP00000019543.1
RefSeq Acc Id: XP_013366557   ⟸   XM_013511103
- Sequence:
Ensembl Acc Id: ENSCLAP00000019543   ⟸   ENSCLAT00000019736
2Fe-2S ferredoxin-type



1 to 18 of 18 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000013409 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019736 ENTREZGENE
  ENSCLAT00000019736.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.30 UniProtKB/TrEMBL
InterPro 2Fe-2S_ferredoxin-like_sf UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-type UniProtKB/TrEMBL
  Adrenodoxin UniProtKB/TrEMBL
  Adrenodoxin_Fe-S_BS UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/TrEMBL
NCBI Gene LOC102014654 ENTREZGENE
PANTHER ADRENODOXIN, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR23426 UniProtKB/TrEMBL
Pfam Fer2 UniProtKB/TrEMBL
PRINTS ADRENODOXIN UniProtKB/TrEMBL
PROSITE 2FE2S_FER_2 UniProtKB/TrEMBL
  ADX UniProtKB/TrEMBL
Superfamily-SCOP SSF54292 UniProtKB/TrEMBL
UniProt A0A8C2VRR6_CHILA UniProtKB/TrEMBL
1 to 18 of 18 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Fdx1  ferredoxin 1  LOC102014654  uncharacterized LOC102014654  Symbol and/or name change 5135510 APPROVED