Clic2 (chloride intracellular channel 2)

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Gene: Clic2 (chloride intracellular channel 2) Chinchilla lanigera

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Symbol:

Clic2

Name:

chloride intracellular channel 2

RGD ID:

8851300

Description:

ENCODES a protein that exhibits glutathione peroxidase activity (ortholog); glutathione transferase activity (ortholog); INVOLVED IN negative regulation of ryanodine-sensitive calcium-release channel activity (ortholog); regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; famotidine pharmacodynamics pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); autosomal hemophilia A (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

chloride intracellular channel protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955594	374,208 - 393,389 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955594	374,332 - 393,802 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Barth syndrome (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

Experimental Liver Cirrhosis (ISO)

factor VIII deficiency (ISO)

favism (ISO)

immunodeficiency 33 (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

Splenomegaly (ISO)

Waisman syndrome (ISO)

X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of ryanodine-sensitive calcium-release channel activity (ISO)

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

nucleoplasm (ISO)

plasma membrane (ISO)

Molecular Function

glutathione peroxidase activity (ISO)

glutathione transferase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cimetidine pharmacodynamics pathway (ISO)

esomeprazole pharmacodynamics pathway (ISO)

famotidine pharmacodynamics pathway (ISO)

lansoprazole pharmacodynamics pathway (ISO)

nizatidine pharmacodynamics pathway (ISO)

omeprazole pharmacodynamics pathway (ISO)

pantoprazole pharmacodynamics pathway (ISO)

pirenzepine pharmacodynamics pathway (ISO)

rabeprazole pharmacodynamics pathway (ISO)

ranitidine pharmacodynamics pathway (ISO)

roxatidine acetate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data

Clic2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955594	374,208 - 393,389 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955594	374,332 - 393,802 (+)	NCBI	ChiLan1.0	ChiLan1.0

CLIC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	155,276,211 - 155,334,614 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	155,276,211 - 155,334,657 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	154,505,500 - 154,563,923 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	154,158,694 - 154,217,180 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	154,070,159 - 154,127,661	NCBI
Celera	X	154,664,011 - 154,722,432 (-)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	143,049,088 - 143,107,752 (-)	NCBI		HuRef
CHM1_1	X	154,416,162 - 154,475,622 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	153,513,523 - 153,571,950 (-)	NCBI		T2T-CHM13v2.0

Clic2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	154,630 - 169,655 (+)	NCBI		GRCr8
mRatBN7.2	20	149,337 - 164,375 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	148,907 - 164,355 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	163,856 - 179,662 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	167,322 - 183,128 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	157,735 - 172,759 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	295,338 - 310,363 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	295,250 - 310,380 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	289,420 - 304,445 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	66,518 - 81,543 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	66,517 - 81,536 (+)	NCBI
Celera	20	1,021,508 - 1,036,650 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

CLIC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	155,241,784 - 155,350,478 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	155,245,392 - 155,354,086 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	144,742,839 - 144,851,524 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	154,581,649 - 154,641,515 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	154,581,649 - 154,641,515 (-)	Ensembl	panpan1.1		panPan2

CLIC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	123,268,867 - 123,291,467 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	123,268,867 - 123,291,467 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	108,256,144 - 108,278,751 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	126,397,663 - 126,420,289 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	126,397,666 - 126,420,733 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	122,138,186 - 122,160,792 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	124,660,596 - 124,683,207 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	124,381,022 - 124,403,633 (-)	NCBI		UU_Cfam_GSD_1.0

Clic2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	120,156,502 - 120,186,481 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936927	514,899 - 543,693 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936927	514,989 - 543,691 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLIC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	125,546,467 - 125,570,523 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	125,546,451 - 125,560,059 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	142,872,444 - 142,885,806 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLIC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	129,564,187 - 129,606,324 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	129,560,658 - 129,606,438 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	67,544,925 - 67,587,038 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Clic2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624963	21,115 - 47,757 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005414643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01076427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01262822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000000652 ⟹ ENSCLAP00000000619

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955594	374,208 - 393,389 (+)	Ensembl

RefSeq Acc Id:

XM_005414643 ⟹ XP_005414700

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955594	374,332 - 393,802 (+)	NCBI

Sequence:

show sequence

CTCTGGAAACACCCCCACCCTTCTAGCCAGTCAATTCATACACACCCCTTGGGCTCCTCCTTGA
TTCAAATGTTAGGTCAAGAGGAAGAAGAAAAACAAATTCAAGAGCTGCTCTTAAGCGTCTAGAA
TTTCTATGTCCCACCTCTCAACAGGAGAGACTGGACCCAGATTTGACTTAATCCACTACATGCT
AAAAACTGTCCTCTTAAAGTACCAGCGTCCCTTGAACCTTTTGATACAATTGGAAGAAGAGTCC
ATGGTACTGTAGCCTCTGCTCAAGGCAGGGATCTGAAAACCAGCAGTAAAAACGGAAAGATGGC
GAGCACGAGGCCCAGCACTCAAGAAGACCCTGAAATTGAGCTTTTCGTGAAGGCTGGAGGTGAT
GGAGAGAGCATCGGGAACTGTCCCTTTTGCCAGCGCCTTTTCATGATCCTCTGGCTTAAAGGAG
TTAAGTTTAATGTGACTACTGTTGACATGACCAGAAAGCCTGAAGAGCTGAAGGACTTGGCCCC
AGGTACCAATCCTCCCTTCTTGCTGTATAACAAGGAACTGAAAACTGACTTCATTAAAATTGAG
GAGTTTCTAGAGCAGACACTAGCTCCTCCAAGGTATCCTCACCTGAGTCCCAGGTACAAGGAGT
CCTTTGATGCAGGCTGTAACCTCTTTGCCAAGTTTTCTGCATACATTAAGAACACACAAAAAGA
AGCAAATAAGAATTTTGAAAAAAATCTCCTCAAAGAATTTAAGCGTTTGGATGACTACTTAAAC
ACCCCACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACTCACAATTTCCCGAAGATTGT
TCTTGGATGGAGATCAGCTAACACTGGCTGACTGCAGCTTGCTGCCCAAGCTGAACATTATTAA
GGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGAAGAATTCTCAGGAGTCTGGCGCTAT
CTGCACAATGCCTATGCCCGTGAAGAATTTATTCATACATGCCCTGAAGACAAAGAAATTGAAA
ACACTTATGCAAGTGTGGCTAAACAGAATTAGGACAGCTCTTTCAGGAGAAAAAGCTCTTTTTG
TTATCAGATTTTATTATCTACCATATTAGAAAGATTTTTGGAAATAAGAATATGAAAAATATTA
TTCCCTCTATCCAACTCATTTATGAAAAGTAACTTTATTTTCTGTATCTAGTTAGCCATAAACT
GTCCACTGTATATTTTATATAACTTCATGTTTTCACTTCATTTTCTTTGTTTCTGTGGCAAATC
ATTGTGATCTTCAAGGACATGGAAAGCATTGAGATGTTTTGCCCTTTGCTTGAGTTCCTAGAGT
GCATAATGTATGAGCTAAGCAGGTTTCTGAAATTACAAATGACATAAGTAGAACCACAATCTCA
AATTGCTCCTTAGAAACAATTCCATCTAAATCATTAAAATAATTTTACATTTGTTACTTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005414700	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000000619
	ENSCLAP00000000619.1

RefSeq Acc Id:

XP_005414700 ⟸ XM_005414643

- UniProtKB:

A0A8C2UGI2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASTRPSTQEDPEIELFVKAGGDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDL
APGTNPPFLLYNKELKTDFIKIEEFLEQTLAPPRYPHLSPRYKESFDAGCNLFAKFSAYIKNTQ
KEANKNFEKNLLKEFKRLDDYLNTPLLDEIDPDSAEELTISRRLFLDGDQLTLADCSLLPKLNI
IKVAAKKYRDFDIPEEFSGVWRYLHNAYAREEFIHTCPEDKEIENTYASVAKQN

hide sequence

Ensembl Acc Id:

ENSCLAP00000000619 ⟸ ENSCLAT00000000652

Protein Domains

GST C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000000498	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000000652	ENTREZGENE
	ENSCLAT00000000652.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1050.10	UniProtKB/TrEMBL
	Glutaredoxin	UniProtKB/TrEMBL
InterPro	CLIC	UniProtKB/TrEMBL
	CLIC_N	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C-like	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	Glutathione_S-Trfase	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
NCBI Gene	Clic2	ENTREZGENE
PANTHER	CHLORIDE INTRACELLULAR CHANNEL PROTEIN	UniProtKB/TrEMBL
	CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED	UniProtKB/TrEMBL
Pfam	CLIC-like_N	UniProtKB/TrEMBL
	GST_C_2	UniProtKB/TrEMBL
PRINTS	INTCLCHANNEL	UniProtKB/TrEMBL
PROSITE	GST_CTER	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47616	UniProtKB/TrEMBL
	SSF52833	UniProtKB/TrEMBL
UniProt	A0A8C2UGI2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB