Cdc45 (cell division cycle 45) - Rat Genome Database

Name: Cdc45
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Cdc45 (cell division cycle 45) Chinchilla lanigera

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Symbol:

Cdc45

Name:

cell division cycle 45

RGD ID:

8824899

Description:

INVOLVED IN DNA unwinding involved in DNA replication (ortholog); ASSOCIATED WITH androgen insensitivity syndrome (ortholog); Androgen Insensitivity Syndrome due to Coactivator Deficiency (ortholog); autism spectrum disorder (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); CMG complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cell division control protein 45 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CDC45 (cell division cycle 45)	NCBI	Ortholog
Mus musculus (house mouse):	Cdc45 (cell division cycle 45)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cdc45 (cell division cycle 45)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CDC45 (cell division cycle 45)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CDC45 (cell division cycle 45)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdc45 (cell division cycle 45)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CDC45 (cell division cycle 45)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CDC45 (cell division cycle 45)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cdc45 (cell division cycle 45)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	18,514,731 - 18,547,805 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	18,513,398 - 18,548,317 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

androgen insensitivity syndrome (ISO)

Androgen Insensitivity Syndrome due to Coactivator Deficiency (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

chromosome 22q11.2 microduplication syndrome (ISO)

COVID-19 (ISO)

DiGeorge syndrome (ISO)

epilepsy (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

immunodeficiency 51 (ISO)

intellectual disability (ISO)

megacolon (ISO)

Meier-Gorlin syndrome (ISO)

Meier-Gorlin syndrome 7 (ISO)

microcephaly (ISO)

Neurodevelopmental Disorders (ISO)

Polyarteritis Nodosa, Childhood-Onset (ISO)

primary immunodeficiency disease (ISO)

schizophrenia (ISO)

velocardiofacial syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA unwinding involved in DNA replication (ISO)

Cellular Component

centrosome (ISO)

ciliary basal body (ISO)

CMG complex (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cdc45
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	18,514,731 - 18,547,805 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	18,513,398 - 18,548,317 (-)	NCBI	ChiLan1.0	ChiLan1.0

CDC45
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	19,479,466 - 19,520,612 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	19,479,457 - 19,520,612 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	19,466,989 - 19,508,135 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	17,847,416 - 17,888,135 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	17,841,969 - 17,882,688	NCBI
Celera	22	3,319,674 - 3,360,395 (+)	NCBI		Celera
Cytogenetic Map	22	q11.21	NCBI
HuRef	22	3,088,162 - 3,128,966 (+)	NCBI		HuRef
CHM1_1	22	19,466,920 - 19,507,702 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	19,856,299 - 19,897,453 (+)	NCBI		T2T-CHM13v2.0

Cdc45
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	18,599,202 - 18,632,371 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	18,599,197 - 18,630,737 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	18,780,447 - 18,811,972 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	18,780,447 - 18,811,987 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	18,780,540 - 18,812,065 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	18,694,015 - 18,725,535 (-)	NCBI		MGSCv36	mm8
Celera	16	19,354,501 - 19,386,029 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	11.63	NCBI

Cdc45
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	95,689,702 - 95,714,980 (+)	NCBI		GRCr8
mRatBN7.2	11	82,185,427 - 82,210,630 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	82,185,473 - 82,210,619 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	90,917,527 - 90,942,110 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	83,578,747 - 83,603,331 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	82,632,015 - 82,656,850 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	86,328,785 - 86,354,099 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	86,329,012 - 86,358,453 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	89,431,161 - 89,456,065 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	11	80,966,334 - 80,990,943 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

CDC45
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	29,104,120 - 29,145,481 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	31,651,826 - 31,693,203 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	2,239,040 - 2,279,807 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	17,913,729 - 17,955,195 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	17,913,729 - 17,955,195 (+)	Ensembl	panpan1.1		panPan2

CDC45
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	29,707,523 - 29,738,599 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	29,707,564 - 29,739,252 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	29,662,567 - 29,693,731 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	31,108,959 - 31,140,135 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	31,109,000 - 31,139,844 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	29,156,284 - 29,187,449 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	28,782,002 - 28,813,128 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	29,867,112 - 29,899,768 (-)	NCBI		UU_Cfam_GSD_1.0

Cdc45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	139,301,628 - 139,333,944 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	3,420,191 - 3,452,436 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	3,420,110 - 3,452,419 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDC45
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	51,133,408 - 51,158,606 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	51,133,111 - 51,158,604 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	54,750,436 - 54,775,656 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDC45
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	6,232,610 - 6,275,743 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	6,231,591 - 6,275,294 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	658,030 - 701,069 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdc45
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	132,835 - 161,553 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	132,731 - 161,590 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013517954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01038009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01038010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01252151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01252157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000023171 ⟹ ENSCLAP00000022955

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955442	18,514,731 - 18,547,805 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000023172 ⟹ ENSCLAP00000022956

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955442	18,514,731 - 18,547,805 (-)	Ensembl

RefSeq Acc Id:

XM_013517954 ⟹ XP_013373408

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955442	18,513,398 - 18,548,317 (-)	NCBI

Sequence:

show sequence

AATGCATCTACAGCCCTCCGGGCTTTGGTTTCGCCACCTTGGACTCGGGCGGAAGGCAAGTACC
GGTTGTCCTGCTGCCGAGGCTATGTTTGTGTCCGATTTTCGCAAGGAGTTCTACGATCTGGTCC
AGAGCCAGAGAGTCCTTCTCTTCGTGGCTTCGGACGTGGACGCCCTGTGTGCTTGCAAAATCCT
TCAGGCTCTGTTTCAATGTGATCATGTGCAGTACACGCTGGTTCCAGTTTCTGGGTGGCAAGAA
CTTGAAACTGCATATCTTGAACATAAAGAACAGTTCCGTTATTTTATTCTTATAAACTGTGGAG
CTAATGTAGATCTACTGGATATCCTTCAGCCTGATGAAGATGCTATATTCTTTGTGTGTGATAC
CCACAGGCCAGTCAACGTTGTGAATGTGTACAATGACACTCAGATCAAATTACTCATTAAACAA
GATGATGACCTTGAAGTTCCTGCCTATGAAGACCTCTTTAAGGATGAAGAGGAGGATGAAGAGC
ATTCAGGAAATGACAGTGACGGATCAGAGCCTTCTGAGAAGCGCACACGGTTAGAAGAGGAGGT
AGTGGAGCGAACCATGAAGAGGAGGCAGCGGAGAGAGTGGGAGGCCCGGAGACGAGATATCCTC
TTTGACTATGAGCAGTACGAATATCATGGGACATCCTCCGCCATAGTGATGTTTGACCTGGCAT
GGATGCTGTCCAAGGACCTGAACGACATGTTGTGGTGGGCCATCGTTGGACTGACGGACCAGTG
GGTACAAGACAGGATCACCCAAATGAAGTATGTGACTGACGTTGGCATCCTGCAGCGCCATGTG
TCCCGGCACAACCACCGGAATGAAGATGAGGAAAATACCCTTTCTGTGGACTGTACCCGGATCT
CCTTTGAGTACGACCTCTGCCTGGCTCTCTACCACCACTGGTCCCTCTACGACAGTCTGTGCAA
TACCAGCTACACCGCGGCCAGGTTCAAGCTCTGGTCTGTGCATGGGCAGAAGCGGCTTCAGGAG
TTTCTCGCAGACATGGGGCTTCCCCTGAAACAGGTGAAGCAGAAGTTTCAGTCCATGGACATCT
CTTTGAAGGAGAATTTGCGGGAAATGATTGAAGAATCTGCAAATAAATTTGGGATGAAGGACAT
GCGTATACAGACTTTCAGCATCCATTTTGGTTTCAAGCATAAGTTCCTGGCCAGCGACGTGGTC
TTTGCCACCATGTCTCTAATGGAAAGCCCTGAGAAGGATGGCTCCGGGACGGATCACTTCATAC
AGGCTCTGGACAGTCTCTCCAGGAATAACCTGGACAAGCTATACATGGGCCTGGAACTCGCCAA
AAAGAAACTACAAGCCACCCAGCAGACCATTGCCAGCTGCCTCTGCACCAACCTTGTTATCTCC
CAGGGGCCTTTCCTCTACTGCTCCCTCATGGAGGGCACTCCAGATGTTGTGCTGTTCTCCAAGC
CAGTATCCTTGAGCCTGCTCAGCAGACATCTGCTCAAGTCCTTTGTGTGTTCGACAAAGAACCG
ACGCTGCAAGCTGCTGCCTCTGGTGATGGCTGCCCCCCTGAGTGTGGAGCAGGGCACAGTGACC
ATGGTGGGCATTCCCCCAGAGACCGACAGCTCAGACAGAAAGAACTTTTTTGGACGAGCGTTTG
AGAAGGCGGCAGAAAGCACTAACTCCCGGACACTGCACAACCACTTTGACCTCTCAGTAATTGA
GCTGAAAACTGAGGATCGGAGCAAGTTCCTTGATGCTCTCGTCTCCCTGCTGTCCTGAGGAATT
TGATTTCTTCAGAAATGATTTCCTTCTCCTTATTTATATTACCTGGCTTTTATTTAGATTGTAA
ATTATGGACAATTTCAAATGCAGCAACGGTGGTTTTAATAGAATAAAATGCTTCTTTTATGTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_013373408	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022955
	ENSCLAP00000022955.1
	ENSCLAP00000022956.1

RefSeq Acc Id:

XP_013373408 ⟸ XM_013517954

- Sequence:

show sequence

MHLQPSGLWFRHLGLGRKASTGCPAAEAMFVSDFRKEFYDLVQSQRVLLFVASDVDALCACKIL
QALFQCDHVQYTLVPVSGWQELETAYLEHKEQFRYFILINCGANVDLLDILQPDEDAIFFVCDT
HRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDLFKDEEEDEEHSGNDSDGSEPSEKRTRLEEEV
VERTMKRRQRREWEARRRDILFDYEQYEYHGTSSAIVMFDLAWMLSKDLNDMLWWAIVGLTDQW
VQDRITQMKYVTDVGILQRHVSRHNHRNEDEENTLSVDCTRISFEYDLCLALYHHWSLYDSLCN
TSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQSMDISLKENLREMIEESANKFGMKDM
RIQTFSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRNNLDKLYMGLELAK
KKLQATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVVLFSKPVSLSLLSRHLLKSFVCSTKNR
RCKLLPLVMAAPLSVEQGTVTMVGIPPETDSSDRKNFFGRAFEKAAESTNSRTLHNHFDLSVIE
LKTEDRSKFLDALVSLLS

hide sequence

Ensembl Acc Id:

ENSCLAP00000022955 ⟸ ENSCLAT00000023171

Ensembl Acc Id:

ENSCLAP00000022956 ⟸ ENSCLAT00000023172

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015752	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023171	ENTREZGENE
	ENSCLAT00000023171.1	UniProtKB/TrEMBL
	ENSCLAT00000023172.1	UniProtKB/TrEMBL
InterPro	CDC45	UniProtKB/TrEMBL
NCBI Gene	Cdc45	ENTREZGENE
PANTHER	CELL DIVISION CONTROL PROTEIN 45 HOMOLOG	UniProtKB/TrEMBL
	PTHR10507	UniProtKB/TrEMBL
Pfam	CDC45	UniProtKB/TrEMBL
UniProt	A0A8C2W487_CHILA	UniProtKB/TrEMBL
	A0A8C2W6K7_CHILA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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