Rapgefl1 (Rap guanine nucleotide exchange factor like 1) - Rat Genome Database

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Gene: Rapgefl1 (Rap guanine nucleotide exchange factor like 1) Chinchilla lanigera
Analyze
Symbol: Rapgefl1
Name: Rap guanine nucleotide exchange factor like 1
RGD ID: 8819795
Description: ASSOCIATED WITH familial cold autoinflammatory syndrome 2 (ortholog); hypertrophic cardiomyopathy 25 (ortholog); prostate cancer (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Rap guanine nucleotide exchange factor (GEF)-like 1; rap guanine nucleotide exchange factor-like 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,809,630 - 14,816,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,802,094 - 14,818,096 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rapgefl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,809,630 - 14,816,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,802,094 - 14,818,096 (+)NCBIChiLan1.0ChiLan1.0
RAPGEFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,177,010 - 40,195,650 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,177,010 - 40,195,656 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,333,263 - 38,351,902 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,591,394 - 35,605,426 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,588,138 - 35,605,426NCBI
Celera1734,994,758 - 35,012,421 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1734,127,434 - 34,145,100 (+)NCBIHuRef
CHM1_11738,569,927 - 38,587,592 (+)NCBICHM1_1
T2T-CHM13v2.01741,040,889 - 41,059,520 (+)NCBIT2T-CHM13v2.0
Rapgefl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,727,611 - 98,744,519 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,727,611 - 98,744,523 (+)EnsemblGRCm39 Ensembl
GRCm381198,836,785 - 98,853,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,836,785 - 98,853,697 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,698,099 - 98,714,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,653,244 - 98,669,095 (+)NCBIMGSCv36mm8
Celera11108,491,920 - 108,508,404 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.7NCBI
Rapgefl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,289,980 - 84,306,614 (+)NCBIGRCr8
mRatBN7.21083,793,711 - 83,810,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,793,694 - 83,810,371 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01086,749,220 - 86,765,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,763,117 - 86,765,675 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,545,478 - 86,561,332 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,607,651 - 87,620,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1082,541,374 - 82,554,813 (+)NCBICelera
Cytogenetic Map10q31NCBI
RAPGEFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,759,538 - 24,777,374 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,654,350 - 26,672,187 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,093,714 - 17,111,187 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,315,114 - 17,335,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,315,114 - 17,335,258 (-)Ensemblpanpan1.1panPan2
RAPGEFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,385,970 - 22,399,584 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,387,786 - 22,394,887 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,846,496 - 21,871,864 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,166,995 - 23,192,372 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,167,166 - 23,192,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,940,814 - 21,966,167 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,199,543 - 22,224,894 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,324,485 - 22,349,849 (-)NCBIUU_Cfam_GSD_1.0
Rapgefl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,779,660 - 21,793,695 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,281,433 - 15,296,636 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,281,462 - 15,295,479 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,181,849 - 22,195,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,180,928 - 22,195,841 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,546,729 - 22,561,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,978,561 - 65,995,738 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607736,883,727 - 36,901,319 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgefl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,036,543 - 3,045,595 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,036,245 - 3,045,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000020122   ⟹   ENSCLAP00000019929
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545114,809,630 - 14,816,762 (+)Ensembl
RefSeq Acc Id: XM_013519122   ⟹   XP_013374576
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545114,802,094 - 14,818,096 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013374576 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019929.1
RefSeq Acc Id: XP_013374576   ⟸   XM_013519122
- Sequence:
Ensembl Acc Id: ENSCLAP00000019929   ⟸   ENSCLAT00000020122
Protein Domains
Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013660 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000020122.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro Ras-like_GEF UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Rapgefl1 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1 UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
PROSITE RASGEF_CAT UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C2VUP4_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Rapgefl1  Rap guanine nucleotide exchange factor like 1    Rap guanine nucleotide exchange factor (GEF)-like 1  Symbol and/or name change 5135510 APPROVED