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Gene: Osgep (O-sialoglycoprotein endopeptidase) Chinchilla lanigera

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Symbol:

Osgep

Name:

O-sialoglycoprotein endopeptidase

RGD ID:

8802460

Description:

ENCODES a protein that exhibits N(6)-L-threonylcarbamoyladenine synthase activity (ortholog); INVOLVED IN tRNA modification (ortholog); tRNA threonylcarbamoyladenosine modification (ortholog); ASSOCIATED WITH Galloway-Mowat syndrome (ortholog); Galloway-Mowat syndrome 3 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); EKC/KEOPS complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

probable tRNA N6-adenosine threonylcarbamoyltransferase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955550	1,265,401 - 1,273,299 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955550	1,266,191 - 1,273,093 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Osgep	Chinchilla	Galloway-Mowat syndrome		ISO	OSGEP (Homo sapiens)	8554872	ClinVar Annotator: match by term: Galloway-Mowat syndrome	ClinVar	PMID:17897280 more ...
Osgep	Chinchilla	Galloway-Mowat syndrome 3		ISO	OSGEP (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:11519896 more ...
Osgep	Chinchilla	genetic disease		ISO	OSGEP (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:16199547 more ...
Osgep	Chinchilla	nephrotic syndrome		ISO	OSGEP (Homo sapiens)	8554872	ClinVar Annotator: match by term: Nephrotic syndrome	ClinVar	PMID:11519896 more ...
Osgep	Chinchilla	purine nucleoside phosphorylase deficiency		ISO	OSGEP (Homo sapiens)	8554872	ClinVar Annotator: match by term: Purine-nucleoside phosphorylase deficiency	ClinVar	PMID:24767876 and PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Osgep	Chinchilla	Galloway-Mowat syndrome 3		ISO	OSGEP (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Osgep	Chinchilla	tRNA modification	involved_in	ISO	OSGEP (Homo sapiens)	9068941	PMID:28805828	UniProt	PMID:28805828
Osgep	Chinchilla	tRNA threonylcarbamoyladenosine modification	involved_in	ISO	OSGEP (Homo sapiens)	9068941	PMID:28805828	UniProt	PMID:28805828
Osgep	Chinchilla	tRNA threonylcarbamoyladenosine modification	involved_in	ISO	OSGEP (Homo sapiens)	9068941	PMID:31481669	UniProt	PMID:31481669

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Osgep	Chinchilla	cytoplasm	located_in	ISO	OSGEP (Homo sapiens)	9068941	PMID:28805828	UniProt	PMID:28805828
Osgep	Chinchilla	cytosol	located_in	ISO	OSGEP (Homo sapiens)	9068941		HPA	GO_REF:0000052
Osgep	Chinchilla	EKC/KEOPS complex	part_of	ISO	OSGEP (Homo sapiens)	9068941	PMID:27903914 more ...	UniProt	PMID:27903914 more ...
Osgep	Chinchilla	nucleoplasm	located_in	ISO	OSGEP (Homo sapiens)	9068941		HPA	GO_REF:0000052
Osgep	Chinchilla	nucleus	located_in	ISO	OSGEP (Homo sapiens)	9068941	PMID:27903914 and PMID:28805828	UniProt	PMID:27903914 and PMID:28805828

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Osgep	Chinchilla	N(6)-L-threonylcarbamoyladenine synthase activity	enables	ISO	OSGEP (Homo sapiens)	9068941	PMID:28805828	UniProt	PMID:28805828
Osgep	Chinchilla	protein binding	enables	ISO	UniProtKB:Q14657 and UniProtKB:Q96S44	9068941	PMID:28514442 and PMID:33961781	IntAct	PMID:28514442 and PMID:33961781
Osgep	Chinchilla	protein binding	enables	ISO	UniProtKB:Q96S44	9068941	PMID:23414517 more ...	IntAct	PMID:23414517 more ...
Osgep	Chinchilla	protein binding	enables	ISO	UniProtKB:O95817 and UniProtKB:Q14657	9068941	PMID:32296183	IntAct	PMID:32296183
Osgep	Chinchilla	protein binding	enables	ISO	UniProtKB:Q14657 more ...	9068941	PMID:27903914	UniProt	PMID:27903914

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

PMID:22301074	PMID:30032202

Osgep
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955550	1,265,401 - 1,273,299 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955550	1,266,191 - 1,273,093 (-)	NCBI	ChiLan1.0	ChiLan1.0

OSGEP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	20,446,401 - 20,454,812 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	20,446,401 - 20,455,089 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	20,914,560 - 20,922,971 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	19,985,056 - 19,993,038 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	19,985,055 - 19,993,038	NCBI
Celera	14	776,357 - 784,417 (-)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	1,036,962 - 1,044,886 (-)	NCBI		HuRef
CHM1_1	14	20,916,587 - 20,924,647 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	14,643,301 - 14,651,715 (-)	NCBI		T2T-CHM13v2.0

Osgep
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	51,152,831 - 51,162,350 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	51,143,935 - 51,162,350 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	50,915,374 - 50,924,893 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	50,906,478 - 50,924,893 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	51,535,049 - 51,544,568 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	49,837,325 - 49,846,844 (-)	NCBI		MGSCv36	mm8
Celera	14	47,206,136 - 47,224,482 (-)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	26.3	NCBI

Osgep
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	26,610,694 - 26,618,113 (-)	NCBI		GRCr8
mRatBN7.2	15	24,137,149 - 24,144,568 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	24,137,153 - 24,144,568 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	26,908,335 - 26,915,754 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	27,867,039 - 27,874,458 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	26,116,878 - 26,124,297 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	27,842,447 - 27,849,866 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	27,842,422 - 27,849,974 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	31,674,872 - 31,682,291 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	26,896,592 - 26,904,011 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	26,912,465 - 26,919,623 (-)	NCBI
Celera	15	24,457,277 - 24,464,696 (-)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

OSGEP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	21,956,556 - 21,964,635 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	21,173,043 - 21,181,122 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	1,321,599 - 1,329,604 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	19,373,836 - 19,381,888 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	19,373,836 - 19,381,888 (-)	Ensembl	panpan1.1		panPan2

OSGEP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	17,780,474 - 17,786,452 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	17,780,476 - 17,811,173 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	18,263,462 - 18,269,439 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	18,037,539 - 18,043,534 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	18,037,541 - 18,043,514 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	17,720,433 - 17,726,396 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	17,775,053 - 17,781,030 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	17,904,232 - 17,910,209 (-)	NCBI		UU_Cfam_GSD_1.0

Osgep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	77,678,727 - 77,685,347 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936877	659,874 - 666,026 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936877	659,881 - 666,169 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OSGEP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	78,454,666 - 78,462,258 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	78,454,667 - 78,462,260 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	83,482,276 - 83,490,100 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OSGEP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	20,960,710 - 20,969,321 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	20,960,378 - 20,968,903 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	25,451,480 - 25,460,413 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Osgep
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624825	4,714,993 - 4,721,884 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624825	4,715,133 - 4,721,884 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005412061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01072559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01128287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000001266 ⟹ ENSCLAP00000001225

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955550	1,265,401 - 1,273,299 (-)	Ensembl

RefSeq Acc Id:

XM_005412061 ⟹ XP_005412118

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955550	1,266,191 - 1,273,093 (-)	NCBI

Sequence:

show sequence

GGCCCCCGCACTCCATTTTTTGGCTGTTTGTGGAAGCGCCGGTGTGATGAGTTATTCTACCACCGCGACCAAACAACGTAATACTGTGCAAAAGGGAAGAAAACATTGAGAAGGCTGGGCTGGACTAC
AGGGCACAGGCAGGGGCACCAACAGGGCCGCAGGCGCAGAGGTGGTTCGCGCCGCGGCAGGCGGAAGGGCAGGTCCTGGAAGGGGCCTTGCGGGCAGCGGCGCCGCGGGCGCGCGCTCCCCCTGCCGG
GGCCCCGCGGAGTTGTTCGTGTCCGCGCCCCGCGTGTGTGCGGGCTGAGCGGGCTCCGCGCTCCGGAACCGCCCCCGGCACGGACAGTCGCGGGCTTAGCGCCGCGGGTGTGCGGAGGCCGCCGGCGC
TTTCTCCCGGCCTGCACCATGCCGGCGGTGCTGGGTTTCGAGGGCAGCGCCAACAAGATCGGCGTGGGGGTGGTTCGCGACGGCGAGGTGCTAGCGAACCCGCGGCGAACCTACGTTACGCCCCCGGG
CACAGGATTCCTCCCAGGTGCTACTGCCAGGCACCACCGAGCTGTTATCCTAGACTTGCTTCAGGAAGCACTAACAGAAGCTAGATTGACCTCCCAAGACATCGATTGCATTGCTTACACCAAAGGTC
CTGGCATGGGTGCCCCATTGGCTTCAGTAGCAGTTGTGGCCCGTACGGTGGCCCAGATGTGGAATAAACCATTGATAGGTGTGAACCATTGTATAGGCCACATTGAAATGGGCCGCCTCATCACTGGA
GCCAGCAGCCCAACTGTGTTGTATGTGAGCGGAGGAAATACTCAGGTCATTGCCTACTCTGAACATCGGTACCGAATCTTCGGGGAAACCATCGATATTGCTGTGGGTAATTGTCTGGATCGCTTTGC
TCGAGTGCTGAAGATTTCCAATGACCCAAGTCCAGGTTACAACATCGAACAGATGGCAAAACGAGGCAAGAAGCTAGTTGAGCTGCCTTATACTGTAAAGGGGATGGATGTCTCATTCTCAGGGATTC
TGTCTTTCATTGAGGATGCAGCCCTGCGGATGTTAGCAACAGGCGAGTGTACCCCTGAGGATCTGTGTTTCTCACTGCAGGAAACTGTGTTTGCAATGCTGGTGGAGATCACAGAGCGAGCCATGGCA
CACTGTGGCTCCCAGGAGGCCCTCATTGTGGGAGGTGTTGGGTGTAATGTGAGGCTGCAGGAGATGATGCAGACAATGTGCCGGGAACGCGGGGCCCAGCTTTTTGCTACAGATGAGAGATTCTGCAT
TGACAATGGAGCCATGATAGCCCAAGCTGGCTGGGAGATGTTTCAGGCTGGACACAGGACCCCTCTCAGTGATTCTGGGATTACACAAAGGTATCGAACAGATGAAGTAGAAGTGACATGGAGGGACT
AACAAGATTAACGAGATCAGAGTAGGTAGTTCTCTAAGTGGAGCTCCGAGGACTGGGCATAATCTCTCTCCTGGTGTGGAAATCTTGGCAGTGCTGTAGACTCCACGAAAGGCTTGTGGTCTTCTGTA
GAACCTCAAGATGACTCTGCAATAAAATATTTTTGGTTTTGTA

hide sequence


Protein RefSeqs	XP_005412118	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000001225
	ENSCLAP00000001225.1

RefSeq Acc Id:

XP_005412118 ⟸ XM_005412061

- UniProtKB:

A0A8C2UIW4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPAVLGFEGSANKIGVGVVRDGEVLANPRRTYVTPPGTGFLPGATARHHRAVILDLLQEALTEARLTSQDIDCIAYTKGPGMGAPLASVAVVARTVAQMWNKPLIGVNHCIGHIEMGRLITGASSPTV
LYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDAALRMLATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSQE
ALIVGGVGCNVRLQEMMQTMCRERGAQLFATDERFCIDNGAMIAQAGWEMFQAGHRTPLSDSGITQRYRTDEVEVTWRD

hide sequence

Ensembl Acc Id:

ENSCLAP00000001225 ⟸ ENSCLAT00000001266

Protein Domains

Gcp-like

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000000932	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000001266	ENTREZGENE
	ENSCLAT00000001266.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.420.40	UniProtKB/TrEMBL
InterPro	ATPase_NBD	UniProtKB/TrEMBL
	Gcp-like_dom	UniProtKB/TrEMBL
	KAE1/TsaD	UniProtKB/TrEMBL
	Kae1_archaea_euk	UniProtKB/TrEMBL
	Peptidase_M22_CS	UniProtKB/TrEMBL
NCBI Gene	Osgep	ENTREZGENE
PANTHER	PTHR11735	UniProtKB/TrEMBL
	PTHR11735:SF14	UniProtKB/TrEMBL
Pfam	TsaD	UniProtKB/TrEMBL
PRINTS	OSIALOPTASE	UniProtKB/TrEMBL
PROSITE	GLYCOPROTEASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53067	UniProtKB/TrEMBL
UniProt	A0A8C2UIW4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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