Osgep (O-sialoglycoprotein endopeptidase) - Rat Genome Database

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Gene: Osgep (O-sialoglycoprotein endopeptidase) Rattus norvegicus
Analyze
Symbol: Osgep
Name: O-sialoglycoprotein endopeptidase
RGD ID: 1308578
Description: Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in nuclear speck and plasma membrane. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 3. Orthologous to human OSGEP (O-sialoglycoprotein endopeptidase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290028; N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotease; pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1; probable O-sialoglycoprotein endopeptidase; probable tRNA N6-adenosine threonylcarbamoyltransferase; probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgep; Prsmg1/Gcpl1; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep; tRNA N6-adenosine threonylcarbamoyltransferase; tRNA threonylcarbamoyladenosine biosynthesis protein Osgep
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21524,137,149 - 24,144,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,137,153 - 24,144,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,908,335 - 26,915,754 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01527,867,039 - 27,874,458 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01526,116,878 - 26,124,297 (-)NCBIRnor_WKY
Rnor_6.01527,842,447 - 27,849,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,842,422 - 27,849,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,674,872 - 31,682,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,896,592 - 26,904,011 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,912,465 - 26,919,623 (-)NCBI
Celera1524,457,277 - 24,464,696 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
EKC/KEOPS complex  (IBA,IEA,ISO,ISS)
nuclear speck  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8086453   PMID:10631378   PMID:12477932   PMID:27903914   PMID:28805828  


Genomics

Comparative Map Data
Osgep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21524,137,149 - 24,144,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,137,153 - 24,144,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,908,335 - 26,915,754 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01527,867,039 - 27,874,458 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01526,116,878 - 26,124,297 (-)NCBIRnor_WKY
Rnor_6.01527,842,447 - 27,849,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,842,422 - 27,849,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,674,872 - 31,682,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,896,592 - 26,904,011 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,912,465 - 26,919,623 (-)NCBI
Celera1524,457,277 - 24,464,696 (-)NCBICelera
Cytogenetic Map15p14NCBI
OSGEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,446,401 - 20,454,812 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1420,446,401 - 20,455,089 (-)EnsemblGRCh38hg38GRCh38
GRCh371420,914,560 - 20,922,971 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,985,056 - 19,993,038 (-)NCBINCBI36Build 36hg18NCBI36
Build 341419,985,055 - 19,993,038NCBI
Celera14776,357 - 784,417 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,036,962 - 1,044,886 (-)NCBIHuRef
CHM1_11420,916,587 - 20,924,647 (-)NCBICHM1_1
T2T-CHM13v2.01414,643,301 - 14,651,715 (-)NCBIT2T-CHM13v2.0
Osgep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,152,831 - 51,162,350 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,143,935 - 51,162,350 (-)EnsemblGRCm39 Ensembl
GRCm381450,915,374 - 50,924,893 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,906,478 - 50,924,893 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,535,049 - 51,544,568 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,837,325 - 49,846,844 (-)NCBIMGSCv36mm8
Celera1447,206,136 - 47,224,482 (-)NCBICelera
Cytogenetic Map14C1NCBI
Osgep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,265,401 - 1,273,299 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,266,191 - 1,273,093 (-)NCBIChiLan1.0ChiLan1.0
OSGEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11419,373,836 - 19,381,888 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,373,836 - 19,381,888 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0141,321,599 - 1,329,604 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OSGEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,780,474 - 17,786,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,780,476 - 17,811,173 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,263,462 - 18,269,439 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,037,539 - 18,043,534 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,037,541 - 18,043,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,720,433 - 17,726,396 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,775,053 - 17,781,030 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,904,232 - 17,910,209 (-)NCBIUU_Cfam_GSD_1.0
Osgep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,678,727 - 77,685,347 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936877659,881 - 666,169 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSGEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,454,666 - 78,462,258 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,454,667 - 78,462,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,482,276 - 83,490,100 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OSGEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12920,960,710 - 20,969,321 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2920,960,378 - 20,968,903 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,451,480 - 25,460,413 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Osgep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,714,993 - 4,721,884 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,715,133 - 4,721,884 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000012790
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 34 18 19 18 1 1 72 26 41 11 1
Low 7 23 23 23 7 10 2 9 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012790   ⟹   ENSRNOP00000012789
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,137,153 - 24,144,568 (-)Ensembl
Rnor_6.0 Ensembl1527,842,422 - 27,849,974 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097357   ⟹   ENSRNOP00000092779
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,137,153 - 24,144,537 (-)Ensembl
RefSeq Acc Id: NM_001100510   ⟹   NP_001093980
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21524,137,149 - 24,144,568 (-)NCBI
Rnor_6.01527,842,447 - 27,849,866 (-)NCBI
Rnor_5.01531,674,872 - 31,682,291 (-)NCBI
RGSC_v3.41526,896,592 - 26,904,011 (-)RGD
Celera1524,457,277 - 24,464,696 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093105   ⟹   XP_038949033
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21524,137,149 - 24,144,529 (-)NCBI
RefSeq Acc Id: XM_039093106   ⟹   XP_038949034
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21524,137,149 - 24,144,553 (-)NCBI
RefSeq Acc Id: XR_005493700
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21524,137,149 - 24,144,559 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001093980   ⟸   NM_001100510
- UniProtKB: B0BMW7 (UniProtKB/Swiss-Prot),   Q9WVS2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012789   ⟸   ENSRNOT00000012790
RefSeq Acc Id: XP_038949034   ⟸   XM_039093106
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949033   ⟸   XM_039093105
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000092779   ⟸   ENSRNOT00000097357
Protein Domains
TsaD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVS2-F1-model_v2 AlphaFold Q9WVS2 1-335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699624
Promoter ID:EPDNEW_R10146
Type:initiation region
Name:Osgep_1
Description:O-sialoglycoprotein endopeptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01527,849,891 - 27,849,951EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308578 AgrOrtholog
BioCyc Gene G2FUF-14052 BioCyc
Ensembl Genes ENSRNOG00000009333 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012789 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000092779.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012790 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000097357.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126956 IMAGE-MGC_LOAD
  IMAGE:8362956 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gcp-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kae1/OSGEP UniProtKB/Swiss-Prot
  KAE1/TsaD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kae1_archaea_euk UniProtKB/TrEMBL
  Peptidase_M22_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290028 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187386 IMAGE-MGC_LOAD
  MGC:95102 IMAGE-MGC_LOAD
NCBI Gene 290028 ENTREZGENE
PANTHER PTHR11735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11735:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Osgep PhenoGen
PRINTS OSIALOPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLYCOPROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs gcp_kae1 UniProtKB/Swiss-Prot
UniProt A0A8I6AEB6_RAT UniProtKB/TrEMBL
  B0BMW7 ENTREZGENE
  OSGEP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B0BMW7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Osgep  O-sialoglycoprotein endopeptidase  Osgep_predicted  O-sialoglycoprotein endopeptidase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Osgep_predicted  O-sialoglycoprotein endopeptidase (predicted)      Symbol and Name status set to approved 70820 APPROVED