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Gene: Ndufs8 (NADH:ubiquinone oxidoreductase core subunit S8) Chinchilla lanigera

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Symbol:

Ndufs8

Name:

NADH:ubiquinone oxidoreductase core subunit S8

RGD ID:

8721742

Description:

ENCODES a protein that exhibits NADH dehydrogenase (ubiquinone) activity (ortholog); NADH dehydrogenase activity (ortholog); INVOLVED IN mitochondrial electron transport, NADH to ubiquinone (ortholog); mitochondrial respiratory chain complex I assembly (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog); respiratory chain complex I (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	17,781,204 - 17,784,404 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	17,781,374 - 17,785,395 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Leigh disease (ISO)

mitochondrial complex I deficiency (ISO)

nuclear type mitochondrial complex I deficiency 1 (ISO)

nuclear type mitochondrial complex I deficiency 2 (ISO)

osteoarthritis (ISO)

osteopetrosis (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

Subacute Necrotizing Encephalopathy of Leigh, Infantile (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial electron transport, NADH to ubiquinone (ISO)

mitochondrial respiratory chain complex I assembly (ISO)

Cellular Component

mitochondrial inner membrane (ISO)

mitochondrion (ISO)

respiratory chain complex I (ISO)

Molecular Function

NADH dehydrogenase (ubiquinone) activity (ISO)

NADH dehydrogenase activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ndufs8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	17,781,204 - 17,784,404 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	17,781,374 - 17,785,395 (-)	NCBI	ChiLan1.0	ChiLan1.0

NDUFS8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	68,030,681 - 68,036,644 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	68,030,617 - 68,036,644 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	67,798,148 - 67,804,111 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	67,554,685 - 67,560,690 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	67,554,684 - 67,560,690	NCBI
Celera	11	65,131,755 - 65,137,785 (+)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	64,133,431 - 64,139,457 (+)	NCBI		HuRef
CHM1_1	11	67,681,851 - 67,687,870 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	68,034,333 - 68,040,285 (+)	NCBI		T2T-CHM13v2.0

Ndufs8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	3,958,863 - 3,962,774 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	3,958,863 - 3,962,774 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	3,908,863 - 3,912,774 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	3,908,863 - 3,912,774 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	3,908,870 - 3,912,717 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	3,908,871 - 3,912,760 (-)	NCBI		MGSCv36	mm8
Celera	19	3,789,245 - 3,793,092 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	3.63	NCBI

Ndufs8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	210,569,823 - 210,573,707 (-)	NCBI		GRCr8
mRatBN7.2	1	201,140,585 - 201,144,573 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	201,140,585 - 201,144,511 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	209,513,776 - 209,517,650 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	216,602,574 - 216,606,449 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	209,276,776 - 209,280,651 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	219,141,289 - 219,144,610 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	219,141,292 - 219,144,610 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	226,013,894 - 226,017,284 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	206,433,596 - 206,437,478 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	206,587,046 - 206,589,998 (-)	NCBI
Celera	1	198,693,138 - 198,697,932 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

NDUFS8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	68,981,112 - 68,987,279 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	70,024,356 - 70,030,542 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	63,112,536 - 63,118,600 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	66,421,076 - 66,427,101 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	66,421,378 - 66,427,101 (+)	Ensembl	panpan1.1		panPan2

NDUFS8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	49,796,558 - 49,800,805 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	49,796,560 - 49,799,979 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	48,405,896 - 48,410,143 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	50,717,789 - 50,722,042 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	50,716,518 - 50,721,799 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	49,931,355 - 49,935,599 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	49,506,173 - 49,510,431 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	50,299,726 - 50,303,986 (-)	NCBI		UU_Cfam_GSD_1.0

Ndufs8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	5,639,144 - 5,643,676 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	2,081,079 - 2,084,730 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	2,081,493 - 2,085,635 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NDUFS8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	4,862,589 - 4,867,393 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	4,863,295 - 4,867,392 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	3,491,223 - 3,495,317 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NDUFS8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	6,499,371 - 6,505,685 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	6,499,249 - 6,505,699 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	103,777,597 - 103,783,589 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ndufs8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	18,822,526 - 18,827,057 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	18,822,763 - 18,826,907 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005384289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013514041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01022932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01002250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000025239 ⟹ ENSCLAP00000024995

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955422	17,781,204 - 17,784,404 (-)	Ensembl

RefSeq Acc Id:

XM_005384289 ⟹ XP_005384346

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955422	17,781,374 - 17,785,395 (-)	NCBI

Sequence:

show sequence

CCCCGGAAATGGCGAAGCCAGCCGACCCAATAGTAGTGTCGCAGAGTTAGGCTCCGCCTCTCGG
CTGTCCAGCACGCTCGGCTAGAGAGGGAGCTACCGCTCCTCAAGATGCAATGCCTGACCACGCC
CACACTGCTGCGGGCCCTGGCCCAGGCTGTGCGCACAGGACATGCTAGTGGCCGGAGCTTCCAC
AGCAGTGCCATGGTAGCGACCTATAAGTACGTGAATATGCAGGAACCAGAGATGGACATGAGGT
CAGTGACTGACCGCGCAGCTCGGACCCTGTTTTGGACTGAGCTCTTCCGAGGCCTGGGCATGAC
GCTGAGCTACCTGTTCCGGGAGCCAGCTACCATCAACTACCCGTTTGAGAAGGGCCCGCTAAGC
CCACGCTTCCGAGGGGAGCATGCTCTGCGCCGTTACCCGTCTGGGGAGGAGCGCTGCATCGCCT
GCAAGCTTTGCGAGGCTGTCTGTCCTGCCCAGGCCATCACCATTGAGGCCGAGCCCAGGGCTGA
TGGCAGCCGCCGGACCACCCGCTATGACATTGACATGACCAAGTGCATCTACTGTGGCTTCTGC
CAGGAGGCCTGCCCTGTGGATGCCATCGTGGAGGGCCCCAACTTTGAGTTCTCCACTGAGACGC
ACGAGGAGCTGCTGTACAACAAGGAGAAGCTGCTGAACAACGGGGACAAGTGGGAGGCTGAGAT
TGCCGCCAACATCCAGGCTGACTACCTCTACCGGTGATGTGCCCACCTCTGCTCGGTGCCCGCA
GCCCCTGCTGCCCAATAAAAGCTCTGACCCTCA

hide sequence

RefSeq Acc Id:

XM_013514041 ⟹ XP_013369495

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955422	17,781,374 - 17,785,257 (-)	NCBI

Sequence:

show sequence

GACCTGTGCAGCGCGGAGTCAAGGATGCAATGCCTGACCACGCCCACACTGCTGCGGGCCCTGG
CCCAGGCTGTGCGCACAGGACATGCTAGTGGCCGGAGCTTCCACAGCAGTGCCATGGTAGCGAC
CTATAAGTACGTGAATATGCAGGAACCAGAGATGGACATGAGGTCAGTGACTGACCGCGCAGCT
CGGACCCTGTTTTGGACTGAGCTCTTCCGAGGCCTGGGCATGACGCTGAGCTACCTGTTCCGGG
AGCCAGCTACCATCAACTACCCGTTTGAGAAGGGCCCGCTAAGCCCACGCTTCCGAGGGGAGCA
TGCTCTGCGCCGTTACCCGTCTGGGGAGGAGCGCTGCATCGCCTGCAAGCTTTGCGAGGCTGTC
TGTCCTGCCCAGGCCATCACCATTGAGGCCGAGCCCAGGGCTGATGGCAGCCGCCGGACCACCC
GCTATGACATTGACATGACCAAGTGCATCTACTGTGGCTTCTGCCAGGAGGCCTGCCCTGTGGA
TGCCATCGTGGAGGGCCCCAACTTTGAGTTCTCCACTGAGACGCACGAGGAGCTGCTGTACAAC
AAGGAGAAGCTGCTGAACAACGGGGACAAGTGGGAGGCTGAGATTGCCGCCAACATCCAGGCTG
ACTACCTCTACCGGTGATGTGCCCACCTCTGCTCGGTGCCCGCAGCCCCTGCTGCCCAATAAAA
GCTCTGACCCTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005384346	(Get FASTA)	NCBI Sequence Viewer
	XP_013369495	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000024995
	ENSCLAP00000024995.1

RefSeq Acc Id:

XP_005384346 ⟸ XM_005384289

- UniProtKB:

A0A8C2W6I4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQCLTTPTLLRALAQAVRTGHASGRSFHSSAMVATYKYVNMQEPEMDMRSVTDRAARTLFWTEL
FRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITI
EAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNG
DKWEAEIAANIQADYLYR

hide sequence

RefSeq Acc Id:

XP_013369495 ⟸ XM_013514041

- UniProtKB:

A0A8C2W6I4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQCLTTPTLLRALAQAVRTGHASGRSFHSSAMVATYKYVNMQEPEMDMRSVTDRAARTLFWTEL
FRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITI
EAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNG
DKWEAEIAANIQADYLYR

hide sequence

Ensembl Acc Id:

ENSCLAP00000024995 ⟸ ENSCLAT00000025239

Protein Domains

4Fe-4S ferredoxin-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000017156	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000025239	ENTREZGENE
	ENSCLAT00000025239.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.3270	UniProtKB/TrEMBL
InterPro	4Fe4S_Fe-S-bd	UniProtKB/TrEMBL
	4Fe4S_Fe_S_CS	UniProtKB/TrEMBL
	NADH_quinone_OxRdtase_chainI	UniProtKB/TrEMBL
NCBI Gene	Ndufs8	ENTREZGENE
PANTHER	NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR10849	UniProtKB/TrEMBL
Pfam	Fer4_7	UniProtKB/TrEMBL
PROSITE	4FE4S_FER_1	UniProtKB/TrEMBL
	4FE4S_FER_2	UniProtKB/TrEMBL
Superfamily-SCOP	4Fe-4S ferredoxins	UniProtKB/TrEMBL
UniProt	A0A8C2W6I4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Ndufs8	NADH:ubiquinone oxidoreductase core subunit S8		NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - CTD

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