Ndufs8 (NADH:ubiquinone oxidoreductase core subunit S8)

Gene: Ndufs8 (NADH:ubiquinone oxidoreductase core subunit S8) Mus musculus

Analyze

Symbol:

Ndufs8

Name:

NADH:ubiquinone oxidoreductase core subunit S8

RGD ID:

1319780

MGI Page

MGI

Description:

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; and response to oxidative stress. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. Is expressed in several structures, including early conceptus and oocyte. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BC021616; CI-23kD; complex I-23kD; MGC101957; MGC37950; NADH dehydrogenase (ubiquinone) Fe-S protein 8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; NADH-ubiquinone oxidoreductase 23 kDa subunit; TYKY

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	3,958,863 - 3,962,774 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	3,958,863 - 3,962,774 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	3,908,863 - 3,912,774 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	3,908,863 - 3,912,774 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	3,908,870 - 3,912,717 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	3,908,871 - 3,912,760 (-)	NCBI		MGSCv36	mm8
Celera	19	3,789,245 - 3,793,092 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	3.63	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Leigh disease (ISO)

mitochondrial complex I deficiency (ISO)

nuclear type mitochondrial complex I deficiency 1 (ISO)

nuclear type mitochondrial complex I deficiency 2 (ISO)

osteoarthritis (ISO)

osteopetrosis (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

Subacute Necrotizing Encephalopathy of Leigh, Infantile (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (EXP)

1,2-dichloroethane (EXP)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

amitrole (ISO)

arsenous acid (EXP)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

chloropicrin (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

CU-O LINKAGE (EXP)

cyclosporin A (ISO)

diarsenic trioxide (EXP)

dibutyl phthalate (EXP)

doxorubicin (EXP,ISO)

flutamide (EXP,ISO)

folic acid (EXP)

formaldehyde (ISO)

isoniazide (EXP)

isoprenaline (ISO)

isotretinoin (ISO)

ivermectin (ISO)

lipopolysaccharide (ISO)

metformin (EXP)

methamphetamine (ISO)

methimazole (ISO)

methotrexate (ISO)

N,N-diethyl-m-toluamide (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (ISO)

niclosamide (ISO)

ochratoxin A (ISO)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

permethrin (ISO)

phlorizin (EXP)

Pyridostigmine bromide (ISO)

resveratrol (EXP)

rimonabant (EXP)

rotenone (ISO)

sodium fluoride (EXP)

streptozocin (EXP)

sulfadimethoxine (ISO)

T-2 toxin (ISO)

temozolomide (ISO)

thapsigargin (EXP)

thioacetamide (ISO)

toluene (ISO)

trichloroethene (EXP)

Triptolide (EXP)

tungsten (EXP)

valproic acid (ISO)

vinclozolin (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aerobic respiration (NAS)

mitochondrial electron transport, NADH to ubiquinone (IBA,ISO)

mitochondrial respiratory chain complex I assembly (IBA,ISO)

proton motive force-driven mitochondrial ATP synthesis (NAS)

response to oxidative stress (ISO)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (ISO)

mitochondrial respiratory chain complex I (IBA,IDA,ISO)

mitochondrion (HDA,ISO)

respirasome (IEA)

Molecular Function

4 iron, 4 sulfur cluster binding (IEA)

iron-sulfur cluster binding (IEA)

metal ion binding (IEA)

NADH dehydrogenase (ubiquinone) activity (ISO)

NADH dehydrogenase activity (IBA,ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on NAD(P)H (IEA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

Alzheimer's disease pathway (IEA)

Huntington's disease pathway (IEA)

oxidative phosphorylation pathway (IEA)

Parkinson's disease pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal egg cylinder morphology (IEA)

absent head fold (IEA)

absent primitive node (IEA)

decreased embryo size (IEA)

embryonic growth arrest (IEA)

embryonic lethality prior to organogenesis (IEA)

embryonic lethality, complete penetrance (IEA)

failure of primitive streak formation (IEA)

failure to gastrulate (IEA)

preweaning lethality, complete penetrance (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	MGDs mouse GO annotations	MGD data from the GO Consortium
2.	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:9750190	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:12904583	PMID:14610273	PMID:15747579
PMID:16141072	PMID:16141073	PMID:16602821	PMID:17967808	PMID:18614015	PMID:18614564	PMID:18799693	PMID:21556144	PMID:21873635	PMID:26697723	PMID:30030361	PMID:30550785
PMID:31536960	PMID:32376682	PMID:36293380

Genomics

Comparative Map Data

Ndufs8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	3,958,863 - 3,962,774 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	3,958,863 - 3,962,774 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	3,908,863 - 3,912,774 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	3,908,863 - 3,912,774 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	3,908,870 - 3,912,717 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	3,908,871 - 3,912,760 (-)	NCBI		MGSCv36	mm8
Celera	19	3,789,245 - 3,793,092 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	3.63	NCBI

NDUFS8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	68,030,681 - 68,036,644 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	68,030,617 - 68,036,644 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	67,798,148 - 67,804,111 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	67,554,685 - 67,560,690 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	67,554,684 - 67,560,690	NCBI
Celera	11	65,131,755 - 65,137,785 (+)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	64,133,431 - 64,139,457 (+)	NCBI		HuRef
CHM1_1	11	67,681,851 - 67,687,870 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	68,034,333 - 68,040,285 (+)	NCBI		T2T-CHM13v2.0

Ndufs8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	210,569,823 - 210,573,707 (-)	NCBI		GRCr8
mRatBN7.2	1	201,140,585 - 201,144,573 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	201,140,585 - 201,144,511 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	209,513,776 - 209,517,650 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	216,602,574 - 216,606,449 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	209,276,776 - 209,280,651 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	219,141,289 - 219,144,610 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	219,141,292 - 219,144,610 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	226,013,894 - 226,017,284 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	206,433,596 - 206,437,478 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	206,587,046 - 206,589,998 (-)	NCBI
Celera	1	198,693,138 - 198,697,932 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

Ndufs8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	17,781,204 - 17,784,404 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	17,781,374 - 17,785,395 (-)	NCBI	ChiLan1.0	ChiLan1.0

NDUFS8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	68,981,112 - 68,987,279 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	70,024,356 - 70,030,542 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	63,112,536 - 63,118,600 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	66,421,076 - 66,427,101 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	66,421,378 - 66,427,101 (+)	Ensembl	panpan1.1		panPan2

NDUFS8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	49,796,558 - 49,800,805 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	49,796,560 - 49,799,979 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	48,405,896 - 48,410,143 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	50,717,789 - 50,722,042 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	50,716,518 - 50,721,799 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	49,931,355 - 49,935,599 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	49,506,173 - 49,510,431 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	50,299,726 - 50,303,986 (-)	NCBI		UU_Cfam_GSD_1.0

Ndufs8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	5,639,144 - 5,643,676 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	2,081,079 - 2,084,730 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	2,081,493 - 2,085,635 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NDUFS8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	4,862,589 - 4,867,393 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	4,863,295 - 4,867,392 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	3,491,223 - 3,495,317 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NDUFS8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	6,499,371 - 6,505,685 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	6,499,249 - 6,505,699 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	103,777,597 - 103,783,589 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ndufs8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	18,822,526 - 18,827,057 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	18,822,763 - 18,826,907 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ndufs8
119 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	181
Count of miRNA genes:	168
Interacting mature miRNAs:	179
Transcripts:	ENSMUST00000075092
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300776	Lfp3_m	long free running period 3 (mouse)			Not determined		19	1	20328703	Mouse
4142161	Drinksac2_m	drink saccharin 2 (mouse)			Not determined			1	20695286	Mouse
4142302	Nstr1_m	nerve sheath tumor resistance QTL 1 (mouse)			Not determined		19	1	22371338	Mouse
1301271	Datd_m	dopamine transporter density (mouse)			Not determined		19	1	32340234	Mouse
4142406	Pbctlp1_m	peripheral blood cytotoxic T lymphocyte percentage 1 (mouse)			Not determined			1	32875174	Mouse
1300904	Chab5_m	cholesterol absorption 5 (mouse)			Not determined		19	1653764	35653927	Mouse
26884385	Skwq14_m	skull length QTL 14, 16 week (mouse)					19	3250000	35877400	Mouse
1301800	Faq10_m	fluctuating asymmetry QTL 10 (mouse)			Not determined		19	3323216	37323348	Mouse
1300923	Bits4_m	bitterness sensitivity 4 (mouse)			Not determined		19	3323216	37323348	Mouse
1302126	Skull26_m	skull morphology 26 (mouse)			Not determined		19	3323216	37323348	Mouse
1300591	Pas3_m	pulmonary adenoma susceptibility 3 (mouse)			Not determined		19	3323216	37323348	Mouse
1357819	Tgct2_m	testicular germ cell tumor 2 (mouse)			Not determined		19	3328551	20539663	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001271444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_144870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK135069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK149674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK153182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK153900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK164901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK167907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY096002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC021616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP775598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000075092 ⟹ ENSMUSP00000074600

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	19	3,958,867 - 3,962,734 (-)	Ensembl
GRCm38.p6 Ensembl	19	3,908,867 - 3,912,734 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000235301 ⟹ ENSMUSP00000158267

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	19	3,960,928 - 3,962,768 (-)	Ensembl
GRCm38.p6 Ensembl	19	3,910,928 - 3,912,768 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000235847 ⟹ ENSMUSP00000158029

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	19	3,958,870 - 3,962,734 (-)	Ensembl
GRCm38.p6 Ensembl	19	3,908,870 - 3,912,734 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000236801 ⟹ ENSMUSP00000158541

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	19	3,958,863 - 3,962,488 (-)	Ensembl
GRCm38.p6 Ensembl	19	3,908,863 - 3,912,488 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000237341 ⟹ ENSMUSP00000158327

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	19	3,958,867 - 3,962,774 (-)	Ensembl
GRCm38.p6 Ensembl	19	3,908,867 - 3,912,774 (-)	Ensembl

RefSeq Acc Id:

NM_001271443 ⟹ NP_001258372

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	19	3,958,863 - 3,962,774 (-)	NCBI
GRCm38	19	3,908,863 - 3,912,774 (-)	NCBI
Celera	19	3,789,238 - 3,793,149 (-)	NCBI

Sequence:

show sequence

GAGCTTAGGCTCCGCCTTCCGGTTGAACCGCATCTGGGCCAGGGAAGGAGCCGCAGCACTTCAA
GATGTATCGCCTGAGCTCATCAATGCTGCCACGGGCCTTGGCCCAGGCCATGCGCACAGGACAT
CTTAATGGACAAAGCCTTCATAGCAGCGCAGTGGCGGCAACGTACAAGTATGTGAATAAGAAGG
AACAGGAGTCTGAGGTGGACATGAAGTCCGCAACTGACAATGCAGCTCGGATTCTGATGTGGAC
AGAACTCATCCGAGGACTGGGCATGACCCTAAGTTACCTCTTTCGAGAGCCTGCCACCATCAAC
TACCCCTTTGAGAAGGGCCCACTGAGTCCGCGCTTCCGTGGGGAGCATGCACTGCGCCGCTACC
CATCTGGAGAGGAGCGTTGCATTGCCTGCAAACTCTGTGAGGCCATCTGTCCTGCACAGGCCAT
CACCATTGAGGCTGAGCCAAGAGCCGATGGCAGCCGCCGAACGACACGCTATGACATCGACATG
ACCAAGTGTATCTACTGTGGTTTCTGCCAGGAAGCCTGCCCTGTTGATGCCATTGTGGAGGGCC
CCAACTTCGAGTTCTCCACCGAGACACACGAGGAGTTGCTGTACAACAAGGAGAAGCTACTCAA
CAATGGAGACAAGTGGGAGGCCGAGATCGCTGCCAACATCCAGGCTGACTACCTGTACCGGTGA
CCAGACCACTGGTGACCTTGGCCACCTGGCTCAGCCTTGTGGCCCCTTTAGCCCATAAAGAAAC
TATGATCCCACAGCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001271444 ⟹ NP_001258373

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	19	3,958,863 - 3,962,774 (-)	NCBI
GRCm38	19	3,908,863 - 3,912,774 (-)	NCBI
Celera	19	3,789,238 - 3,793,149 (-)	NCBI

Sequence:

show sequence

GAGCTTAGGCTCCGCCTTCCGGTTGAACCGCATCTGGGCCAGGGAAGGAGCCGCAGCACTTCAA
GGTGGGTGGCCAGGGCAAGGCGGCGAAGACAGGGTCTGGGTGACGCAACGACAGGGTTGAACGG
GGTGTCACCGCTGACCTTATGAAGTCTGGGATCTAGCGCTTCGGCTCGGGACCCGCGGCTTGTG
CGTCCTTCCCGAGCTGCGGACCGGAAAGCCTGCACCCTCAGGCGCATGCGCTGCCTCGCCGGCT
GCCTTCTGCGTTCATAGGGTCAGAGGTCAAGGGGAAGGTCTGAGAGAAAATGTATCGCCTGAGC
TCATCAATGCTGCCACGGGCCTTGGCCCAGGCCATGCGCACAGGACATCTTAATGGACAAAGCC
TTCATAGCAGCGCAGTGGCGGCAACGTACAAGTATGTGAATAAGAAGGAACAGGAGTCTGAGGT
GGACATGAAGTCCGCAACTGACAATGCAGCTCGGATTCTGATGTGGACAGAACTCATCCGAGGA
CTGGGCATGACCCTAAGTTACCTCTTTCGAGAGCCTGCCACCATCAACTACCCCTTTGAGAAGG
GCCCACTGAGTCCGCGCTTCCGTGGGGAGCATGCACTGCGCCGCTACCCATCTGGAGAGGAGCG
TTGCATTGCCTGCAAACTCTGTGAGGCCATCTGTCCTGCACAGGCCATCACCATTGAGGCTGAG
CCAAGAGCCGATGGCAGCCGCCGAACGACACGCTATGACATCGACATGACCAAGTGTATCTACT
GTGGTTTCTGCCAGGAAGCCTGCCCTGTTGATGCCATTGTGGAGGGCCCCAACTTCGAGTTCTC
CACCGAGACACACGAGGAGTTGCTGTACAACAAGGAGAAGCTACTCAACAATGGAGACAAGTGG
GAGGCCGAGATCGCTGCCAACATCCAGGCTGACTACCTGTACCGGTGACCAGACCACTGGTGAC
CTTGGCCACCTGGCTCAGCCTTGTGGCCCCTTTAGCCCATAAAGAAACTATGATCCCACAGCTA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_144870 ⟹ NP_659119

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	19	3,958,863 - 3,962,774 (-)	NCBI
GRCm38	19	3,908,863 - 3,912,774 (-)	NCBI
MGSCv37	19	3,908,870 - 3,912,717 (-)	RGD
Celera	19	3,789,238 - 3,793,149 (-)	NCBI
cM Map	19		ENTREZGENE

Sequence:

show sequence

GAGCTTAGGCTCCGCCTTCCGGTTGAACCGCATCTGGGCCAGGGAAGGAGCCGCAGCACTTCAA
GGTGGGTGGCCAGGGCAAGGCGGCGAAGACAGGGTCTGGGTGACGCAACGACAGGGTTGAACGG
GGTGTCACCGCTGACCTTATGAAGTCTGGGATCTAGCGCTTCGGCTCGGGACCCGCGGCTTGTG
CGTCCTTCCCGAGCTGCGGACCGGAAAGCCTGCACCCTCAGGCGCATGCGCTGCCTCGCCGGCT
GCCTTCTGCGTTCATAGGGTCAGAGGTCAAGGGGAAGGTCTGAGAGAAAGTGATGTATCGCCTG
AGCTCATCAATGCTGCCACGGGCCTTGGCCCAGGCCATGCGCACAGGACATCTTAATGGACAAA
GCCTTCATAGCAGCGCAGTGGCGGCAACGTACAAGTATGTGAATAAGAAGGAACAGGAGTCTGA
GGTGGACATGAAGTCCGCAACTGACAATGCAGCTCGGATTCTGATGTGGACAGAACTCATCCGA
GGACTGGGCATGACCCTAAGTTACCTCTTTCGAGAGCCTGCCACCATCAACTACCCCTTTGAGA
AGGGCCCACTGAGTCCGCGCTTCCGTGGGGAGCATGCACTGCGCCGCTACCCATCTGGAGAGGA
GCGTTGCATTGCCTGCAAACTCTGTGAGGCCATCTGTCCTGCACAGGCCATCACCATTGAGGCT
GAGCCAAGAGCCGATGGCAGCCGCCGAACGACACGCTATGACATCGACATGACCAAGTGTATCT
ACTGTGGTTTCTGCCAGGAAGCCTGCCCTGTTGATGCCATTGTGGAGGGCCCCAACTTCGAGTT
CTCCACCGAGACACACGAGGAGTTGCTGTACAACAAGGAGAAGCTACTCAACAATGGAGACAAG
TGGGAGGCCGAGATCGCTGCCAACATCCAGGCTGACTACCTGTACCGGTGACCAGACCACTGGT
GACCTTGGCCACCTGGCTCAGCCTTGTGGCCCCTTTAGCCCATAAAGAAACTATGATCCCACAG
CTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001258372	(Get FASTA)	NCBI Sequence Viewer
	NP_001258373	(Get FASTA)	NCBI Sequence Viewer
	NP_659119	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH21616	(Get FASTA)	NCBI Sequence Viewer
	AAH86766	(Get FASTA)	NCBI Sequence Viewer
	AAM34451	(Get FASTA)	NCBI Sequence Viewer
	BAE22408	(Get FASTA)	NCBI Sequence Viewer
	BAE29018	(Get FASTA)	NCBI Sequence Viewer
	BAE31784	(Get FASTA)	NCBI Sequence Viewer
	BAE32243	(Get FASTA)	NCBI Sequence Viewer
	BAE37960	(Get FASTA)	NCBI Sequence Viewer
	BAE39914	(Get FASTA)	NCBI Sequence Viewer
	EDL32969	(Get FASTA)	NCBI Sequence Viewer
	EDL32970	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000074600
	ENSMUSP00000074600.7
	ENSMUSP00000158029
	ENSMUSP00000158029.2
	ENSMUSP00000158267.2
	ENSMUSP00000158327
	ENSMUSP00000158327.2
	ENSMUSP00000158541.2
GenBank Protein	Q8K3J1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_659119 ⟸ NM_144870

- UniProtKB:

Q8K3J1 (UniProtKB/Swiss-Prot), Q3UY05 (UniProtKB/TrEMBL), Q5M9P5 (UniProtKB/TrEMBL), Q8VC72 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYRLSSSMLPRALAQAMRTGHLNGQSLHSSAVAATYKYVNKKEQESEVDMKSATDNAARILMWT
ELIRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAI
TIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLN
NGDKWEAEIAANIQADYLYR

hide sequence

RefSeq Acc Id:

NP_001258372 ⟸ NM_001271443

- UniProtKB:

Q8K3J1 (UniProtKB/Swiss-Prot), Q3UY05 (UniProtKB/TrEMBL), Q5M9P5 (UniProtKB/TrEMBL), Q8VC72 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYRLSSSMLPRALAQAMRTGHLNGQSLHSSAVAATYKYVNKKEQESEVDMKSATDNAARILMWT
ELIRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAI
TIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLN
NGDKWEAEIAANIQADYLYR

hide sequence

RefSeq Acc Id:

NP_001258373 ⟸ NM_001271444

- UniProtKB:

Q8K3J1 (UniProtKB/Swiss-Prot), Q3UY05 (UniProtKB/TrEMBL), Q5M9P5 (UniProtKB/TrEMBL), Q8VC72 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYRLSSSMLPRALAQAMRTGHLNGQSLHSSAVAATYKYVNKKEQESEVDMKSATDNAARILMWT
ELIRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAI
TIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLN
NGDKWEAEIAANIQADYLYR

hide sequence

RefSeq Acc Id:

ENSMUSP00000158327 ⟸ ENSMUST00000237341

RefSeq Acc Id:

ENSMUSP00000158541 ⟸ ENSMUST00000236801

RefSeq Acc Id:

ENSMUSP00000074600 ⟸ ENSMUST00000075092

RefSeq Acc Id:

ENSMUSP00000158029 ⟸ ENSMUST00000235847

RefSeq Acc Id:

ENSMUSP00000158267 ⟸ ENSMUST00000235301

Protein Domains

4Fe-4S ferredoxin-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8K3J1-F1-model_v2	AlphaFold	Q8K3J1	1-212	view protein structure

Promoters

RGD ID:

6847572

Promoter ID:

MM_ACW:25752

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_2Hour

Transcripts:

NDUFS8.FSEP07-UNSPLICED

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	19	3,908,856 - 3,909,356 (-)	MPROMDB

RGD ID:

6830242

Promoter ID:

MM_KWN:25949

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

ENSMUST00000075092, NM_144870, UC008FXO.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	19	3,912,526 - 3,913,667 (-)	MPROMDB

RGD ID:

13678354

Promoter ID:

EPDNEW_M23326

Type:

initiation region

Name:

Ndufs8_1

Description:

Mus musculus NADH dehydrogenase Fe-S protein 8 , transcript variant3, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	19	3,912,750 - 3,912,810	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2385079	AgrOrtholog
Ensembl Genes	ENSMUSG00000059734	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000075092	ENTREZGENE
	ENSMUST00000075092.8	UniProtKB/Swiss-Prot
	ENSMUST00000235301.2	UniProtKB/TrEMBL
	ENSMUST00000235847	ENTREZGENE
	ENSMUST00000235847.2	UniProtKB/Swiss-Prot
	ENSMUST00000236801.2	UniProtKB/Swiss-Prot
	ENSMUST00000237341	ENTREZGENE
	ENSMUST00000237341.2	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.70.3270	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	4Fe4S_Fe-S-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4Fe4S_Fe_S_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADH_quinone_OxRdtase_chainI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:225887	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:2385079	ENTREZGENE
NCBI Gene	225887	ENTREZGENE
PANTHER	NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10849	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Fer4_7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ndufs8	PhenoGen
PROSITE	4FE4S_FER_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4FE4S_FER_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	4Fe-4S ferredoxins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A494BAW8_MOUSE	UniProtKB/TrEMBL
	NDUS8_MOUSE	UniProtKB/Swiss-Prot
	Q3UY05	ENTREZGENE, UniProtKB/TrEMBL
	Q5M9P5	ENTREZGENE, UniProtKB/TrEMBL
	Q8K3J1	ENTREZGENE
	Q8VC72	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-22	Ndufs8	NADH:ubiquinone oxidoreductase core subunit S8		NADH dehydrogenase (ubiquinone) Fe-S protein 8	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype