Klre1 (killer cell lectin-like receptor family E member 1) - Rat Genome Database

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Gene: Klre1 (killer cell lectin-like receptor family E member 1) Mus musculus
Analyze
No known orthologs.
Symbol: Klre1
Name: killer cell lectin-like receptor family E member 1
RGD ID: 736626
MGI Page MGI
Description: Enables identical protein binding activity and transmembrane signaling receptor activity. Acts upstream of or within natural killer cell activation; positive regulation of innate immune response; and positive regulation of type II interferon production. Located in external side of plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: killer cell lectin-like receptor subfamily E member 1; Klre; Klre-1; NKG; NKG2I
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,536,329 - 129,562,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,554,868 - 129,562,790 (+)EnsemblGRCm39 Ensembl
GRCm386129,559,365 - 129,585,828 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,577,905 - 129,585,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv376129,528,304 - 129,535,845 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366129,543,586 - 129,551,520 (+)NCBIMGSCv36mm8
Celera6131,302,961 - 131,310,612 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Westgaard IH, etal., J Exp Med 2003 Jun 2;197(11):1551-61.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12715246   PMID:14707119   PMID:15069013   PMID:16141072   PMID:16141073   PMID:18713988  
PMID:21677750   PMID:21873635  


Genomics

Variants

.
Variants in Klre1
1069 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSMUST00000053708
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141611Btts_mbitterness tasting (mouse)Not determined6125333609134096586Mouse
10412215Cmv3_mcytomegalovirus resistance 3 (mouse)Not determined6128811857137416927Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
4141151Ath38_matherosclerosis 38 (mouse)Not determined128495857136293176Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
10412134Cmv4_mcytomegalovirus resistance 4 (mouse)Not determined6127815180136022150Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
1301084Bpq5_mblood pressure QTL 5 (mouse)Not determined6129330484149588044Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
4141974Skmw14_mskeletal muscle weight 14 (mouse)Not determined6129330484149588044Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301620Insq8_minsulin QTL 8 (mouse)Not determined6129534979149588044Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
1301027Hdlq12_mHDL QTL 12 (mouse)Not determined6128601582149588044Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10766452Sle23_msystematic lupus erythematosus susceptibility 23 (mouse)6128601582149588044Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
10053680Lith25_mlithogenic gene 25 (mouse)Not determined6128601582149588044Mouse
1301686Trmq1_mT cell ratio modifier QTL 1 (mouse)Not determined6129330484149588044Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse

Markers in Region
U70176  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386129,577,426 - 129,577,706UniSTSGRCm38
MGSCv376129,527,444 - 129,527,724UniSTSGRCm37
Celera6131,302,095 - 131,302,375UniSTS
Cytogenetic Map6F3UniSTS
cM Map662.55UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001381986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001381987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001381988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036166121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF306663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY100458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG145575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX518942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000053708   ⟹   ENSMUSP00000055779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6129,554,868 - 129,562,790 (+)Ensembl
GRCm38.p6 Ensembl6129,577,905 - 129,585,827 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203322   ⟹   ENSMUSP00000145085
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6129,555,214 - 129,562,740 (+)Ensembl
GRCm38.p6 Ensembl6129,578,251 - 129,585,777 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203865
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6129,560,382 - 129,562,787 (+)Ensembl
GRCm38.p6 Ensembl6129,583,419 - 129,585,824 (+)Ensembl
RefSeq Acc Id: NM_001381986   ⟹   NP_001368915
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,555,176 - 129,562,790 (+)NCBI
GRCm386129,578,213 - 129,585,827 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001381987   ⟹   NP_001368916
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,555,176 - 129,562,790 (+)NCBI
GRCm386129,578,213 - 129,585,827 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001381988   ⟹   NP_001368917
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,555,176 - 129,562,790 (+)NCBI
GRCm386129,578,213 - 129,585,827 (+)NCBI
Sequence:
RefSeq Acc Id: NM_153590   ⟹   NP_705818
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,555,249 - 129,562,790 (+)NCBI
GRCm386129,578,286 - 129,585,827 (+)NCBI
MGSCv376129,528,304 - 129,535,845 (+)RGD
Celera6131,302,961 - 131,310,612 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506121   ⟹   XP_006506184
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,554,862 - 129,562,790 (+)NCBI
GRCm386129,577,899 - 129,585,827 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006506123   ⟹   XP_006506186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,536,329 - 129,562,790 (+)NCBI
GRCm386129,559,366 - 129,585,827 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006506128   ⟹   XP_006506191
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,554,862 - 129,562,633 (+)NCBI
GRCm386129,577,899 - 129,585,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017321589   ⟹   XP_017177078
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,536,329 - 129,562,790 (+)NCBI
GRCm386129,559,365 - 129,585,827 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036166121   ⟹   XP_036022014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396129,554,862 - 129,560,145 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_705818   ⟸   NM_153590
- Peptide Label: isoform 1
- UniProtKB: Q80WP0 (UniProtKB/Swiss-Prot),   Q8CJC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506186   ⟸   XM_006506123
- Peptide Label: isoform X2
- UniProtKB: Q80WP0 (UniProtKB/Swiss-Prot),   Q8CJC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506184   ⟸   XM_006506121
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006506191   ⟸   XM_006506128
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017177078   ⟸   XM_017321589
- Peptide Label: isoform X2
- UniProtKB: Q80WP0 (UniProtKB/Swiss-Prot),   Q8CJC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001368917   ⟸   NM_001381988
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001368915   ⟸   NM_001381986
- Peptide Label: isoform 1
- UniProtKB: Q8CJC7 (UniProtKB/Swiss-Prot),   Q80WP0 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001368916   ⟸   NM_001381987
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000145085   ⟸   ENSMUST00000203322
RefSeq Acc Id: ENSMUSP00000055779   ⟸   ENSMUST00000053708
RefSeq Acc Id: XP_036022014   ⟸   XM_036166121
- Peptide Label: isoform X4
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJC7-F1-model_v2 AlphaFold Q8CJC7 1-226 view protein structure

Promoters
RGD ID:6891214
Promoter ID:EPDNEW_M9058
Type:multiple initiation site
Name:Klre1_1
Description:Mus musculus killer cell lectin-like receptor family E member1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386129,578,276 - 129,578,336EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2662547 AgrOrtholog
Ensembl Genes ENSMUSG00000050241 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000053708 ENTREZGENE
  ENSMUST00000053708.9 UniProtKB/Swiss-Prot
  ENSMUST00000203322.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  NKR-like_CTLD UniProtKB/Swiss-Prot
KEGG Report mmu:243655 UniProtKB/Swiss-Prot
MGD MGI:2662547 ENTREZGENE
NCBI Gene 243655 ENTREZGENE
PANTHER C-TYPE LECTIN PROTEINS UniProtKB/Swiss-Prot
  KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY E MEMBER 1 UniProtKB/Swiss-Prot
Pfam Lectin_C UniProtKB/Swiss-Prot
PhenoGen Klre1 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt A0A0N4SVG0_MOUSE UniProtKB/TrEMBL
  KLRE1_MOUSE UniProtKB/Swiss-Prot
  Q80WP0 ENTREZGENE
  Q8CJC7 ENTREZGENE
UniProt Secondary Q80WP0 UniProtKB/Swiss-Prot