Afm (afamin) - Rat Genome Database

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Gene: Afm (afamin) Mus musculus
Analyze
Symbol: Afm
Name: afamin
RGD ID: 735381
MGI Page MGI
Description: Predicted to enable vitamin E binding activity. Predicted to be involved in protein stabilization; protein transport within extracellular region; and vitamin transport. Predicted to be located in extracellular space. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; liver; and metanephros. Orthologous to human AFM (afamin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; Alf; alpha albumin; alpha-Alb; alpha-albumin; MGC118711
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,666,808 - 90,701,403 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,666,791 - 90,701,402 (+)EnsemblGRCm39 Ensembl
GRCm38590,518,949 - 90,553,544 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,518,932 - 90,553,543 (+)EnsemblGRCm38mm10GRCm38
MGSCv37590,947,975 - 90,982,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,594,163 - 91,641,425 (+)NCBIMGSCv36mm8
Celera588,680,306 - 88,704,975 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AfmMouseacute kidney failure  ISOAFM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28885000
AfmMouseDrug-Related Side Effects and Adverse Reactions  ISOAFM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28885000
AfmMouseExperimental Liver Cirrhosis  ISOAFM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136

1 to 20 of 89 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AfmMouse(+)-schisandrin B multiple interactionsISOAfm (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AFM mRNA]CTDPMID:31150632
AfmMouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AFM mRNACTDPMID:36331819
AfmMouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of AFM mRNACTDPMID:22206623
AfmMouse1-naphthyl isothiocyanate decreases expressionISOAfm (Rattus norvegicus)64804641-Naphthylisothiocyanate results in decreased expression of AFM mRNACTDPMID:25380136 and PMID:30723492
AfmMouse17beta-estradiol decreases expressionISOAFM (Homo sapiens)6480464Estradiol results in decreased expression of AFM mRNACTDPMID:20106945
AfmMouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of AFM mRNACTDPMID:39298647
AfmMouse17beta-estradiol increases expressionISOAfm (Rattus norvegicus)6480464Estradiol results in increased expression of AFM mRNACTDPMID:32145629
AfmMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of AFM mRNACTDPMID:19770486
AfmMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOAFM (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of AFM mRNACTDPMID:20106945 and PMID:26159488
AfmMouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAFM (Homo sapiens)6480464[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AFM mRNACTDPMID:26159488
AfmMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOAfm (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of AFM mRNACTDPMID:20959002 more ...
AfmMouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
AfmMouse2,4-dinitrotoluene affects expressionISOAfm (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of AFM mRNACTDPMID:21346803
AfmMouse2,6-dinitrotoluene affects expressionISOAfm (Rattus norvegicus)64804642 and 6-dinitrotoluene affects the expression of AFM mRNACTDPMID:21346803
AfmMouse3,3',4,4',5-pentachlorobiphenyl decreases expressionISOAfm (Rattus norvegicus)64804643 more ...CTDPMID:20959002
AfmMouse4,4'-diaminodiphenylmethane decreases expressionISOAfm (Rattus norvegicus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of AFM mRNACTDPMID:25380136
AfmMouse4,4'-diaminodiphenylmethane increases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in increased expression of AFM mRNACTDPMID:18648102
AfmMouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of AFM mRNACTDPMID:39298647
AfmMouse5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expressionISOAfm (Rattus norvegicus)6480464Omeprazole affects the expression of AFM mRNACTDPMID:19483382
AfmMouse6-propyl-2-thiouracil affects expressionISOAfm (Rattus norvegicus)6480464Propylthiouracil affects the expression of AFM mRNACTDPMID:19483382

1 to 20 of 89 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AfmMouseprotein stabilization involved_inISOUniProtKB:P436522290270 GO_CentralGO_REF:0000119
AfmMouseprotein stabilization involved_inISSUniProtKB:P436522290270 UniProtGO_REF:0000024
AfmMouseprotein transport within extracellular region involved_inISOUniProtKB:P436522290270 GO_CentralGO_REF:0000119
AfmMouseprotein transport within extracellular region involved_inISSUniProtKB:P436522290270 UniProtGO_REF:0000024
AfmMousevitamin transport involved_inISSUniProtKB:P436522290270 UniProtGO_REF:0000024
AfmMousevitamin transport involved_inIBAPANTHER:PTN000147369 and UniProtKB:P436522290270 GO_CentralGO_REF:0000033
AfmMousevitamin transport involved_inISOUniProtKB:P436522290270 GO_CentralGO_REF:0000119

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AfmMousecytoplasm is_active_inIBAPANTHER:PTN000147344 more ...2290270 GO_CentralGO_REF:0000033
AfmMouseextracellular space  ISOAfm (Rattus norvegicus)9068941 RGDPMID:7509788 and REF_RGD_ID:724795
AfmMouseextracellular space located_inISSUniProtKB:P436522290270 UniProtGO_REF:0000024
AfmMouseextracellular space located_inISOUniProtKB:P436522290270 GO_CentralGO_REF:0000119
AfmMouseextracellular space located_inISOAfm (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AfmMouseprotein binding enablesISOUniProtKB:P274679068941 PMID:26902720UniProtPMID:26902720
AfmMouseprotein binding enablesISOUniProtKB:P27467 and UniProtKB:P567039068941 PMID:26902720IntActPMID:26902720
AfmMousevitamin E binding enablesISSUniProtKB:P436522290270 UniProtGO_REF:0000024
AfmMousevitamin E binding enablesIBAPANTHER:PTN000147369 and UniProtKB:P436522290270 GO_CentralGO_REF:0000033
AfmMousevitamin E binding enablesISOUniProtKB:P436522290270 GO_CentralGO_REF:0000119

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AfmMouseabnormal coping response  IEA 5509061 MGI 
AfmMouseincreased hemoglobin content  IEA 5509061 MGI 
AfmMouseoligodactyly  IEA 5509061 MGI 

#
Reference Title
Reference Citation
1. Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Gabant P, etal., Proc Natl Acad Sci U S A 2002 Oct 1;99(20):12865-70. Epub 2002 Sep 24.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16944957   PMID:17330941   PMID:19733224  
PMID:20979532   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22749887  



Afm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,666,808 - 90,701,403 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,666,791 - 90,701,402 (+)EnsemblGRCm39 Ensembl
GRCm38590,518,949 - 90,553,544 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,518,932 - 90,553,543 (+)EnsemblGRCm38mm10GRCm38
MGSCv37590,947,975 - 90,982,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,594,163 - 91,641,425 (+)NCBIMGSCv36mm8
Celera588,680,306 - 88,704,975 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
AFM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,481,745 - 73,504,001 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,481,745 - 73,504,001 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,347,462 - 74,369,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,566,326 - 74,588,582 (+)NCBINCBI36Build 36hg18NCBI36
Build 34474,712,496 - 74,734,753NCBI
Celera471,707,194 - 71,729,436 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,158,855 - 70,181,099 (+)NCBIHuRef
CHM1_1474,383,462 - 74,405,708 (+)NCBICHM1_1
T2T-CHM13v2.0476,825,372 - 76,847,610 (+)NCBIT2T-CHM13v2.0
Afm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,815,194 - 17,848,042 (-)NCBIGRCr8
mRatBN7.21417,531,022 - 17,563,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,531,024 - 17,563,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,525,337 - 17,550,140 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,844,268 - 18,869,067 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,536,413 - 17,568,193 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01419,078,678 - 19,132,212 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1419,078,680 - 19,132,208 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01419,035,336 - 19,039,510 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01418,988,809 - 19,008,149 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41419,049,664 - 19,082,977 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11419,049,663 - 19,082,977 (-)NCBI
Celera1416,899,392 - 16,930,240 (-)NCBICelera
Cytogenetic Map14p22NCBI
AFM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,559,516 - 56,583,201 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,748,574 - 56,771,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,691,556 - 50,714,140 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,523,712 - 56,545,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,519,389 - 56,545,974 (-)Ensemblpanpan1.1panPan2
AFM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,212,230 - 62,235,136 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,053,814 - 62,294,709 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1361,881,887 - 61,904,769 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,021,767 - 63,044,655 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,021,855 - 63,044,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,633,366 - 62,656,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,126,432 - 62,149,372 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,262,556 - 63,285,453 (+)NCBIUU_Cfam_GSD_1.0
AFM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,706,896 - 69,728,255 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,706,823 - 69,728,269 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2873,806,942 - 73,828,360 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1721,950,222 - 21,972,612 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl721,950,705 - 21,972,739 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084824,453 - 846,386 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Afm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473533,945,107 - 34,015,900 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Afm
1428 total Variants

Predicted Target Of
Summary Value
Count of predictions:403
Count of miRNA genes:334
Interacting mature miRNAs:360
Transcripts:ENSMUST00000113179, ENSMUST00000128740
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 57 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse

1 to 10 of 57 rows
Afm  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38590,548,828 - 90,550,274UniSTSGRCm38
MGSCv37590,977,854 - 90,979,300UniSTSGRCm37
Celera588,700,256 - 88,701,702UniSTS
Cytogenetic Map5E1UniSTS
cM Map5 UniSTS







Ensembl Acc Id: ENSMUST00000113179   ⟹   ENSMUSP00000108804
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,666,791 - 90,701,402 (+)Ensembl
GRCm38.p6 Ensembl590,518,932 - 90,553,543 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128740   ⟹   ENSMUSP00000117180
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl590,666,808 - 90,696,916 (+)Ensembl
GRCm38.p6 Ensembl590,518,949 - 90,549,057 (+)Ensembl
RefSeq Acc Id: NM_145146   ⟹   NP_660128
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39590,666,808 - 90,701,403 (+)NCBI
GRCm38590,518,949 - 90,553,544 (+)ENTREZGENE
MGSCv37590,947,975 - 90,982,570 (+)RGD
Celera588,680,306 - 88,704,975 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_660128   ⟸   NM_145146
- Peptide Label: precursor
- UniProtKB: Q497E6 (UniProtKB/Swiss-Prot),   Q3UNV0 (UniProtKB/Swiss-Prot),   Q8R0J9 (UniProtKB/Swiss-Prot),   O89020 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000108804   ⟸   ENSMUST00000113179
Ensembl Acc Id: ENSMUSP00000117180   ⟸   ENSMUST00000128740
Albumin

Name Modeler Protein Id AA Range Protein Structure
AF-O89020-F1-model_v2 AlphaFold O89020 1-608 view protein structure

RGD ID:6887114
Promoter ID:EPDNEW_M7008
Type:single initiation site
Name:Afm_1
Description:Mus musculus afamin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38590,518,949 - 90,519,009EPDNEW
RGD ID:6837007
Promoter ID:MM_KWN:42839
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000083498,   OTTMUST00000083555
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36590,947,706 - 90,948,206 (+)MPROMDB


1 to 31 of 31 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000029369 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000113179 ENTREZGENE
  ENSMUST00000113179.9 UniProtKB/Swiss-Prot
  ENSMUST00000128740.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.246.10 UniProtKB/Swiss-Prot
InterPro ALB/AFP/VDB UniProtKB/Swiss-Prot
  Serum_albumin-like UniProtKB/Swiss-Prot
  Serum_albumin/AFP/Afamin UniProtKB/Swiss-Prot
  Serum_albumin_CS UniProtKB/Swiss-Prot
  Serum_albumin_N UniProtKB/Swiss-Prot
KEGG Report mmu:280662 UniProtKB/Swiss-Prot
MGD MGI:2429409 ENTREZGENE
NCBI Gene 280662 ENTREZGENE
PANTHER AFAMIN UniProtKB/Swiss-Prot
  PTHR11385 UniProtKB/Swiss-Prot
Pfam Serum_albumin UniProtKB/Swiss-Prot
PhenoGen Afm PhenoGen
PIRSF Serum_albumin_subgroup UniProtKB/Swiss-Prot
PRINTS AFETOPROTEIN UniProtKB/Swiss-Prot
  SERUMALBUMIN UniProtKB/Swiss-Prot
PROSITE ALBUMIN_1 UniProtKB/Swiss-Prot
  ALBUMIN_2 UniProtKB/Swiss-Prot
SMART ALBUMIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48552 UniProtKB/Swiss-Prot
UniProt AFAM_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UNV0 ENTREZGENE
  Q497E6 ENTREZGENE
  Q8R0J9 ENTREZGENE
UniProt Secondary Q3UNV0 UniProtKB/Swiss-Prot
  Q497E6 UniProtKB/Swiss-Prot
  Q8R0J9 UniProtKB/Swiss-Prot
1 to 31 of 31 rows