Zp1 (zona pellucida glycoprotein 1) - Rat Genome Database

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Gene: Zp1 (zona pellucida glycoprotein 1) Mus musculus
Analyze
Symbol: Zp1
Name: zona pellucida glycoprotein 1
RGD ID: 734032
MGI Page MGI
Description: Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to act upstream of or within single fertilization. Located in collagen-containing extracellular matrix. Is expressed in early conceptus; ovary; and secondary oocyte. Orthologous to human ZP1 (zona pellucida glycoprotein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: truncated zona pellicida glycoprotein 1; zona pellucida sperm-binding protein 1; zp-1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,891,660 - 10,897,965 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,891,651 - 10,897,996 (-)EnsemblGRCm39 Ensembl
GRCm381910,914,296 - 10,920,601 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,914,287 - 10,920,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371910,988,786 - 10,995,091 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,981,331 - 10,987,677 (-)NCBIMGSCv36mm8
Celera1911,607,287 - 11,613,538 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, etal., Hum Mol Genet 2004 Oct 1;13(19):2263-78. Epub 2004 Aug 18.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7592984   PMID:7635043   PMID:7822321   PMID:7841460   PMID:8995758   PMID:9107690   PMID:9237231   PMID:9763662   PMID:9826670   PMID:9988213   PMID:10433913   PMID:10542331  
PMID:10729725   PMID:10790544   PMID:10876093   PMID:11023867   PMID:11291774   PMID:11440986   PMID:11906903   PMID:12477932   PMID:12493692   PMID:12799386   PMID:15326356   PMID:15970507  
PMID:16416028   PMID:16690745   PMID:16964442   PMID:16966370   PMID:18354036   PMID:19014927   PMID:21677750   PMID:21873635   PMID:22685254   PMID:22734000   PMID:24357321   PMID:24934154  
PMID:30122633   PMID:30973865   PMID:31162612   PMID:31657143   PMID:34174788  


Genomics

Comparative Map Data
Zp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,891,660 - 10,897,965 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,891,651 - 10,897,996 (-)EnsemblGRCm39 Ensembl
GRCm381910,914,296 - 10,920,601 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,914,287 - 10,920,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371910,988,786 - 10,995,091 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,981,331 - 10,987,677 (-)NCBIMGSCv36mm8
Celera1911,607,287 - 11,613,538 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.36NCBI
ZP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,867,542 - 60,875,687 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,867,542 - 60,875,693 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,635,015 - 60,643,160 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,391,591 - 60,399,740 (+)NCBINCBI36Build 36hg18NCBI36
Celera1157,995,899 - 58,004,048 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,981,172 - 56,989,320 (+)NCBIHuRef
CHM1_11160,501,326 - 60,509,477 (+)NCBICHM1_1
T2T-CHM13v2.01160,818,698 - 60,826,844 (+)NCBIT2T-CHM13v2.0
Zp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,984,343 - 216,993,882 (-)NCBIGRCr8
mRatBN7.21207,560,881 - 207,567,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,560,881 - 207,567,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,935,714 - 215,942,094 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,996,450 - 223,002,844 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,690,111 - 215,696,491 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,966,366 - 226,972,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,966,366 - 226,972,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01234,031,784 - 234,038,434 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,410,162 - 213,416,542 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,568,591 - 213,574,972 (-)NCBI
Celera1205,053,056 - 205,059,447 (-)NCBICelera
Cytogenetic Map1q43NCBI
ZP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,036,708 - 62,045,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,080,497 - 63,093,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,129,347 - 56,142,385 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,571,453 - 59,579,640 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,571,453 - 59,579,640 (+)Ensemblpanpan1.1panPan2
ZP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11855,405,991 - 55,416,033 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1853,980,786 - 53,988,616 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01856,455,989 - 56,463,822 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11855,513,546 - 55,521,347 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01855,135,035 - 55,142,863 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01856,016,200 - 56,024,032 (-)NCBIUU_Cfam_GSD_1.0
Zp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,937,032 - 11,945,684 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,050,883 - 2,057,719 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,050,908 - 2,057,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,969,406 - 12,979,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,969,439 - 12,978,545 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,336,749 - 110,346,364 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zp1
169 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:260
Count of miRNA genes:229
Interacting mature miRNAs:243
Transcripts:ENSMUST00000025641, ENSMUST00000168708
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse

Markers in Region
Zp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381910,919,464 - 10,920,529UniSTSGRCm38
MGSCv371910,993,954 - 10,995,019UniSTSGRCm37
Celera1911,612,455 - 11,613,466UniSTS
Cytogenetic Map19AUniSTS
cM Map192.0UniSTS
cM Map192.0UniSTS
Zp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381910,918,744 - 10,919,056UniSTSGRCm38
MGSCv371910,993,234 - 10,993,546UniSTSGRCm37
Celera1911,611,735 - 11,612,047UniSTS
Cytogenetic Map19AUniSTS
cM Map192.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025641   ⟹   ENSMUSP00000025641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1910,891,653 - 10,897,996 (-)Ensembl
GRCm38.p6 Ensembl1910,914,289 - 10,920,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168708   ⟹   ENSMUSP00000128543
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1910,891,651 - 10,893,662 (-)Ensembl
GRCm38.p6 Ensembl1910,914,287 - 10,916,298 (-)Ensembl
RefSeq Acc Id: NM_009580   ⟹   NP_033606
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391910,891,660 - 10,897,965 (-)NCBI
GRCm381910,914,296 - 10,920,601 (-)ENTREZGENE
MGSCv371910,988,786 - 10,995,091 (-)RGD
Celera1911,607,287 - 11,613,538 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033606   ⟸   NM_009580
- Peptide Label: precursor
- UniProtKB: Q62016 (UniProtKB/Swiss-Prot),   Q62005 (UniProtKB/Swiss-Prot),   Q059L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000128543   ⟸   ENSMUST00000168708
RefSeq Acc Id: ENSMUSP00000025641   ⟸   ENSMUST00000025641
Protein Domains
P-type   ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62005-F1-model_v2 AlphaFold Q62005 1-623 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103073 AgrOrtholog
Ensembl Genes ENSMUSG00000024734 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025641 ENTREZGENE
  ENSMUST00000025641.2 UniProtKB/Swiss-Prot
  ENSMUST00000168708.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P_trefoil_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_chr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22786 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103073 ENTREZGENE
NCBI Gene 22786 ENTREZGENE
PANTHER ZONA PELLUCIDA SPERM-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZONA PELLUCIDA SPERM-BINDING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trefoil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zona_pellucida UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zp1 PhenoGen
PRINTS ZPELLUCIDA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_TREFOIL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_TREFOIL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00018 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57492 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A346M702_MOUSE UniProtKB/TrEMBL
  F7CW32_MOUSE UniProtKB/TrEMBL
  Q059L1 ENTREZGENE, UniProtKB/TrEMBL
  Q62005 ENTREZGENE
  Q62016 ENTREZGENE
  ZP1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q62016 UniProtKB/Swiss-Prot