Zp1 (zona pellucida glycoprotein 1)

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Gene: Zp1 (zona pellucida glycoprotein 1) Ictidomys tridecemlineatus

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Symbol:

Zp1

Name:

zona pellucida glycoprotein 1

RGD ID:

12438134

Description:

ENCODES a protein that exhibits acrosin binding (inferred); structural constituent of egg coat (inferred); INVOLVED IN binding of sperm to zona pellucida (inferred); prevention of polyspermy (inferred); single fertilization (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); leukocyte adhesion deficiency 3 (ortholog); FOUND IN collagen-containing extracellular matrix (inferred); egg coat (inferred); extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

zona pellucida sperm-binding protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	11,937,032 - 11,945,684 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936581	2,050,883 - 2,057,719 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936581	2,050,908 - 2,057,689 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

leukocyte adhesion deficiency 3 (ISO)

Oocyte Maturation Defect 1 (ISO)

Oocyte Maturation Defect 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

binding of sperm to zona pellucida (IEA)

prevention of polyspermy (IEA)

single fertilization (IEA)

Cellular Component

collagen-containing extracellular matrix (IEA)

egg coat (IEA)

extracellular region (IEA)

plasma membrane (IEA)

Molecular Function

acrosin binding (IEA)

protein binding (ISO)

structural constituent of egg coat (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Zp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	11,937,032 - 11,945,684 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936581	2,050,883 - 2,057,719 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936581	2,050,908 - 2,057,689 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	60,867,542 - 60,875,687 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	60,867,542 - 60,875,693 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	60,635,015 - 60,643,160 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	60,391,591 - 60,399,740 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	57,995,899 - 58,004,048 (+)	NCBI		Celera
Cytogenetic Map	11	q12.2	NCBI
HuRef	11	56,981,172 - 56,989,320 (+)	NCBI		HuRef
CHM1_1	11	60,501,326 - 60,509,477 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	60,818,698 - 60,826,844 (+)	NCBI		T2T-CHM13v2.0

Zp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	10,891,660 - 10,897,965 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	10,891,651 - 10,897,996 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	10,914,296 - 10,920,601 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	10,914,287 - 10,920,632 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	10,988,786 - 10,995,091 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	10,981,331 - 10,987,677 (-)	NCBI		MGSCv36	mm8
Celera	19	11,607,287 - 11,613,538 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	7.36	NCBI

Zp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	216,984,343 - 216,993,882 (-)	NCBI		GRCr8
mRatBN7.2	1	207,560,881 - 207,567,261 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	207,560,881 - 207,567,261 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	215,935,714 - 215,942,094 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	222,996,450 - 223,002,844 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	215,690,111 - 215,696,491 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	226,966,366 - 226,972,746 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	226,966,366 - 226,972,746 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	234,031,784 - 234,038,434 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	213,410,162 - 213,416,542 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	213,568,591 - 213,574,972 (-)	NCBI
Celera	1	205,053,056 - 205,059,447 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

ZP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	62,036,708 - 62,045,474 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	63,080,497 - 63,093,549 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	56,129,347 - 56,142,385 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	59,571,453 - 59,579,640 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	59,571,453 - 59,579,640 (+)	Ensembl	panpan1.1		panPan2

ZP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	55,405,991 - 55,416,033 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	53,980,786 - 53,988,616 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	56,455,989 - 56,463,822 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	55,513,546 - 55,521,347 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	55,135,035 - 55,142,863 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	56,016,200 - 56,024,032 (-)	NCBI		UU_Cfam_GSD_1.0

ZP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	12,969,406 - 12,979,231 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	12,969,439 - 12,978,545 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	110,336,749 - 110,346,364 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005331637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000021814 ⟹ ENSSTOP00000022988

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936581	2,050,883 - 2,057,719 (-)	Ensembl

RefSeq Acc Id:

XM_005331637 ⟹ XP_005331694

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	11,937,032 - 11,944,620 (-)	NCBI
SpeTri2.0	NW_004936581	2,050,908 - 2,057,689 (-)	NCBI

Sequence:

show sequence

CTGATGGCTGCAGCCACCCTGGGGCTGGGTCAGGGGCCGTTCCCCAAGCTCAGCCTCCCAGGCC
TGTGGCACAGCTATGACTGTGGGATCCGGGGCATGCAGCTGCGTGTCGTTCCAAGGCCAGGCCA
GACAATCCGCTTCAAGGTGCTGGACGAATTTGGGAACCGGTTTGAGGTGAATAACTGCTCCGTC
TGCTACCACTGGGTCACCTCCACGCCCCAGGAGCTGGCCGTCTTCTCGGCCGACTACAGAGGCT
GCCACGTGCTGGAGAAGGACGGGCGGTTCCACCTGAGGGTCTTCATGGAAGCTGTGCTGCCAGA
TGGTCACGTGGATATCACCCAGGAGGCCACTCTGATCTGCCCTAAACCTGACCGCACCTGGACT
CCGGATTCCAGCCTGGTGGCGCCCACCACACCCTCACCTTCCACCCCTCATCTGCTTCCCCTCC
GCCCCATCTCCAGCCACCCCTCGCCTGGCTCTGGCTATGCCTTGCCCACCTCATCGTACCTAGA
ACACGGTTTCGTCCATCTGACTGCTGCTCCGCTGTCTTTTGGACCAGGGCCTACCGGCCCCACC
CTGGCGCGGCCTCAGCGGGGCACCACGGACCACTGGGAAGTGGACGAGCCTGACTACATTGGTG
CCCACCTGCCGCAGGAGCAGTGCCAGGTGGTCTCTGGGCACATCCCCTGCGTGGTGAGAAACAG
CTCCAGGGAAGCCTGTCATCAGGCTGGCTGCTGCTATGACGACACCAGGGAAGTGCCCTGTTAC
TATGGCAACTCAGCCACCGTCCAGTGTTTCAGAAGTGGCTACTTCATCCTGGTCATTTCTCAAG
AAACGGCCTTGGCACGCAGGATCACGCTGGCCAACATCCACCTGGCTTATGCCCCTGCCAGCTG
CCCCCCAACCCAGGAGACGAGTGCTTTCGTGGTCTTCCGAGTTCCGCTCACACACTGCGGCACC
ACGGTCCAGGCAGTTGGCGATCAGCTCATCTACGAGAACCAGCTGGTGTCTGACCTTGACATCC
AGAAGGGACCCCAGGGTTCCATCACTCGGGACAGCACTTTCCGGCTTCACGTCCGCTGTCTCTT
CAACGCTGGTGACTTCCTACCCATCCAGGCATCCATCGCCCCGCCCCCGTCGCCTGCCCCCGTG
ACTCAGTCGGGCCCCCTGCGGCTGGAGCTGCGAATTGCCAAGGACGAGACCTTCAGCTCCTACT
ACGGGGAGGGTGACTACCCCCTGGTGAGGCTGCTCCGAGAACCAGTCCACGTGGAGGTCCGTCT
TGTGCAGAGGACTGACCCTGGTCTGGTCCTGGTGCTGCACCAGTGCTGGGCCACTCCTAGTGCC
AACCCCTTCCAGCAGCCCCAGTGGCCCATCCTGTCAGACGGGTGTCCTTTCGAGGGTGACAGCT
ACAGAACCCAAATGGTATCCTTGGACCAGGCAGAGCTGCCCTTCCGGTCTCACTACCAGCGCTT
CACGGTCGCCACCTTTGCTCTCCTGGACTTTAGCTCCCAGAGAGCCCTCAGGGGCCCGGTCTAC
TTCTTCTGCAGCGCCTCTGCCTGCTACCCCTCGAGGCTGCAGCCATGCACCCCCACGTGTGCCT
TGGGGACTGCAAGACAGCGACGATCCTCGGGTTTCCACAACAGCACCACCAGGCCCGTGGACAT
CGTGAGCTCCCCAGGACCCATTGGCTTCCGGGACTCTTATGGATGGAGGACCACAGGCTCCAGC
AGGCACTCCAACCCAAGGCCACTCCTCTGGGTCCTCCTCTGCTGCTGGCTGCTGCCCTGGTTTT
GCAGGCTGCTGGGTCTGTGGGCCTGA

hide sequence

RefSeq Acc Id:

XM_040284257 ⟹ XP_040140191

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	11,937,032 - 11,944,619 (-)	NCBI

RefSeq Acc Id:

XM_040284258 ⟹ XP_040140192

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	11,937,032 - 11,945,684 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005331694	(Get FASTA)	NCBI Sequence Viewer
	XP_040140191	(Get FASTA)	NCBI Sequence Viewer
	XP_040140192	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022988.2
GenBank Protein	KAG3284935	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005331694 ⟸ XM_005331637
- Peptide Label:	isoform X2
- UniProtKB:	I3NF41 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAATLGLGQGPFPKLSLPGLWHSYDCGIRGMQLRVVPRPGQTIRFKVLDEFGNRFEVNNCSVC YHWVTSTPQELAVFSADYRGCHVLEKDGRFHLRVFMEAVLPDGHVDITQEATLICPKPDRTWTP DSSLVAPTTPSPSTPHLLPLRPISSHPSPGSGYALPTSSYLEHGFVHLTAAPLSFGPGPTGPTL ARPQRGTTDHWEVDEPDYIGAHLPQEQCQVVSGHIPCVVRNSSREACHQAGCCYDDTREVPCYY GNSATVQCFRSGYFILVISQETALARRITLANIHLAYAPASCPPTQETSAFVVFRVPLTHCGTT VQAVGDQLIYENQLVSDLDIQKGPQGSITRDSTFRLHVRCLFNAGDFLPIQASIAPPPSPAPVT QSGPLRLELRIAKDETFSSYYGEGDYPLVRLLREPVHVEVRLVQRTDPGLVLVLHQCWATPSAN PFQQPQWPILSDGCPFEGDSYRTQMVSLDQAELPFRSHYQRFTVATFALLDFSSQRALRGPVYF FCSASACYPSRLQPCTPTCALGTARQRRSSGFHNSTTRPVDIVSSPGPIGFRDSYGWRTTGSSR HSNPRPLLWVLLCCWLLPWFCRLLGLWA hide sequence

RefSeq Acc Id:	XP_040140192 ⟸ XM_040284258
- Peptide Label:	isoform X1
- UniProtKB:	I3NF41 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040140191 ⟸ XM_040284257
- Peptide Label:	isoform X1
- UniProtKB:	I3NF41 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000022988 ⟸ ENSSTOT00000021814

Protein Domains

P-type ZP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000027607	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000021814.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.4100	UniProtKB/TrEMBL
	Zona pellucida, ZP-N domain	UniProtKB/TrEMBL
InterPro	P_trefoil_CS	UniProtKB/TrEMBL
	P_trefoil_dom	UniProtKB/TrEMBL
	P_trefoil_dom_sf	UniProtKB/TrEMBL
	Zona_Pellucida_Domain_gp	UniProtKB/TrEMBL
	ZP-C	UniProtKB/TrEMBL
	ZP_chr	UniProtKB/TrEMBL
	ZP_dom	UniProtKB/TrEMBL
	ZP_dom_CS	UniProtKB/TrEMBL
NCBI Gene	Zp1	ENTREZGENE
PANTHER	ZONA PELLUCIDA SPERM-BINDING PROTEIN	UniProtKB/TrEMBL
	ZONA PELLUCIDA SPERM-BINDING PROTEIN 1	UniProtKB/TrEMBL
Pfam	Trefoil	UniProtKB/TrEMBL
	Zona_pellucida	UniProtKB/TrEMBL
	ZP1_ZP4_Ig-like	UniProtKB/TrEMBL
PRINTS	ZPELLUCIDA	UniProtKB/TrEMBL
PROSITE	P_TREFOIL_1	UniProtKB/TrEMBL
	P_TREFOIL_2	UniProtKB/TrEMBL
	ZP_1	UniProtKB/TrEMBL
	ZP_2	UniProtKB/TrEMBL
SMART	SM00018	UniProtKB/TrEMBL
	SM00241	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57492	UniProtKB/TrEMBL
UniProt	I3NF41	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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