Gpr119 (G protein-coupled receptor 119) - Rat Genome Database

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Gene: Gpr119 (G protein-coupled receptor 119) Rattus norvegicus
Analyze
Symbol: Gpr119
Name: G protein-coupled receptor 119
RGD ID: 727808
Description: Predicted to enable G protein-coupled receptor activity and phosphatidylcholine binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within insulin secretion. Predicted to be part of receptor complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GPR119 (G protein-coupled receptor 119); INTERACTS WITH bisphenol A; cadmium dichloride; Tesaglitazar.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G-protein coupled receptor 119; glucose-dependent insulinotropic receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,730,027 - 132,736,080 (-)NCBIGRCr8
mRatBN7.2X127,852,145 - 127,858,198 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,852,145 - 127,858,198 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,977,934 - 129,983,962 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,548,684 - 133,554,737 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X131,075,102 - 131,081,130 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X135,515,545 - 135,521,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX135,515,545 - 135,521,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,585,869 - 135,591,922 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X135,080,163 - 135,086,216 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X135,153,595 - 135,159,649 (-)NCBI
CeleraX126,800,234 - 126,806,174 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, etal., FEBS Lett 2003 Nov 20;554(3):381-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15607732   PMID:23069642   PMID:23382219   PMID:24451185   PMID:25578601   PMID:27391814   PMID:27581068  


Genomics

Comparative Map Data
Gpr119
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,730,027 - 132,736,080 (-)NCBIGRCr8
mRatBN7.2X127,852,145 - 127,858,198 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,852,145 - 127,858,198 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,977,934 - 129,983,962 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,548,684 - 133,554,737 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X131,075,102 - 131,081,130 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X135,515,545 - 135,521,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX135,515,545 - 135,521,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,585,869 - 135,591,922 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X135,080,163 - 135,086,216 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X135,153,595 - 135,159,649 (-)NCBI
CeleraX126,800,234 - 126,806,174 (-)NCBICelera
Cytogenetic MapXq36NCBI
GPR119
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X130,379,449 - 130,385,674 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX130,379,449 - 130,385,674 (-)EnsemblGRCh38hg38GRCh38
GRCh37X129,513,423 - 129,519,648 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X129,346,095 - 129,347,102 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X129,243,948 - 129,244,956NCBI
CeleraX129,904,784 - 129,905,976 (-)NCBICelera
Cytogenetic MapXq26.1NCBI
HuRefX118,912,749 - 118,913,941 (-)NCBIHuRef
CHM1_1X129,429,952 - 129,431,144 (-)NCBICHM1_1
T2T-CHM13v2.0X128,698,231 - 128,704,458 (-)NCBIT2T-CHM13v2.0
Gpr119
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,756,856 - 47,763,355 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX47,756,856 - 47,763,355 (-)EnsemblGRCm39 Ensembl
GRCm38X48,667,979 - 48,674,478 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX48,667,979 - 48,674,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X46,021,156 - 46,027,655 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X44,917,878 - 44,918,885 (-)NCBIMGSCv36mm8
CeleraX36,171,845 - 36,178,348 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX25.69NCBI
Gpr119
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554734,686,225 - 4,687,232 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554734,686,225 - 4,687,232 (+)NCBIChiLan1.0ChiLan1.0
GPR119
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X129,800,132 - 129,806,361 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X129,803,746 - 129,809,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X119,511,372 - 119,512,611 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X129,803,294 - 129,804,512 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX129,803,383 - 129,804,390 (-)Ensemblpanpan1.1panPan2
GPR119
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X101,518,313 - 101,520,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX101,518,977 - 101,519,984 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX87,692,390 - 87,698,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X103,374,107 - 103,379,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX103,378,287 - 103,379,294 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X100,788,832 - 100,794,515 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X102,634,515 - 102,640,198 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X102,413,036 - 102,418,383 (-)NCBIUU_Cfam_GSD_1.0
Gpr119
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X99,723,913 - 99,725,096 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364791,262,484 - 1,263,491 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364791,262,399 - 1,263,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR119
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX106,872,225 - 106,873,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X106,872,225 - 106,873,299 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X122,640,688 - 122,641,762 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR119
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X105,641,691 - 105,646,692 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX105,644,002 - 105,645,009 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606543,063,792 - 43,065,043 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr119
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247979,664,216 - 9,665,220 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247979,664,097 - 9,666,243 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr119
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000033619
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 8 3
Below cutoff 3 7 25 9 16 9 5 5 3 10 7 6 5

Sequence


RefSeq Acc Id: ENSRNOT00000033619   ⟹   ENSRNOP00000036164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,852,145 - 127,858,198 (-)Ensembl
Rnor_6.0 EnsemblX135,515,545 - 135,521,598 (-)Ensembl
RefSeq Acc Id: NM_181770   ⟹   NP_861435
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,730,027 - 132,736,080 (-)NCBI
mRatBN7.2X127,852,145 - 127,858,198 (-)NCBI
Rnor_6.0X135,515,545 - 135,521,598 (-)NCBI
Rnor_5.0X135,585,869 - 135,591,922 (-)NCBI
RGSC_v3.4X135,080,163 - 135,086,216 (-)RGD
CeleraX126,800,234 - 126,806,174 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_861435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP72138 (Get FASTA)   NCBI Sequence Viewer  
  EDM10924 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036164
  ENSRNOP00000036164.3
  ENSRNOP00055021052
GenBank Protein Q7TQN8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_861435   ⟸   NM_181770
- UniProtKB: Q7TQN8 (UniProtKB/Swiss-Prot),   A6JMR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036164   ⟸   ENSRNOT00000033619
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQN8-F1-model_v2 AlphaFold Q7TQN8 1-468 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727808 AgrOrtholog
BioCyc Gene G2FUF-1126 BioCyc
Ensembl Genes ENSRNOG00000024517 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055015100 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033619 ENTREZGENE
  ENSRNOT00000033619.4 UniProtKB/Swiss-Prot
  ENSRNOT00055025813 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR119 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302813 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 302813 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUCOSE-DEPENDENT INSULINOTROPIC RECEPTOR UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr119 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024517 RatGTEx
  ENSRNOG00055015100 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JMR2 ENTREZGENE, UniProtKB/TrEMBL
  GP119_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Gpr119  G protein-coupled receptor 119      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology does not appear to be closely related to any other sequences in the GPCR superfamily 1302390