Gpr119 (G protein-coupled receptor 119)

Gene: Gpr119 (G protein-coupled receptor 119) Rattus norvegicus

Analyze

Symbol:

Gpr119

Name:

G protein-coupled receptor 119

RGD ID:

727808

Description:

Predicted to enable G protein-coupled receptor activity and phosphatidylcholine binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within insulin secretion. Predicted to be part of receptor complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GPR119 (G protein-coupled receptor 119); INTERACTS WITH bisphenol A; cadmium dichloride; Tesaglitazar.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

G-protein coupled receptor 119; glucose-dependent insulinotropic receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPR119 (G protein-coupled receptor 119)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gpr119 (G-protein coupled receptor 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpr119 (G protein-coupled receptor 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPR119 (G protein-coupled receptor 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR119 (G protein-coupled receptor 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpr119 (G protein-coupled receptor 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR119 (G protein-coupled receptor 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPR119 (G protein-coupled receptor 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpr119 (G protein-coupled receptor 119)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GPR119 (G protein-coupled receptor 119)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gpr119 (G-protein coupled receptor 119)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr119	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	132,730,027 - 132,736,080 (-)	NCBI		GRCr8
mRatBN7.2	X	127,852,145 - 127,858,198 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	127,852,145 - 127,858,198 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	129,977,934 - 129,983,962 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	133,548,684 - 133,554,737 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	131,075,102 - 131,081,130 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	135,515,545 - 135,521,598 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	135,515,545 - 135,521,598 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	135,585,869 - 135,591,922 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	135,080,163 - 135,086,216 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	135,153,595 - 135,159,649 (-)	NCBI
Celera	X	126,800,234 - 126,806,174 (-)	NCBI		Celera
Cytogenetic Map	X	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

aflatoxin B1 (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

potassium dichromate (ISO)

Tesaglitazar (EXP)

titanium dioxide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA)

insulin secretion (ISO)

regulation of metabolic process (IBA)

Cellular Component

cytoplasm (IBA)

plasma membrane (IBA)

receptor complex (ISO)

Molecular Function

G protein-coupled receptor activity (IBA)

phosphatidylcholine binding (IBA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.	Fredriksson R, etal., FEBS Lett 2003 Nov 20;554(3):381-8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15607732	PMID:23069642	PMID:23382219	PMID:24451185	PMID:25578601	PMID:27391814	PMID:27581068

Genomics

Comparative Map Data

Gpr119
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	132,730,027 - 132,736,080 (-)	NCBI		GRCr8
mRatBN7.2	X	127,852,145 - 127,858,198 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	127,852,145 - 127,858,198 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	129,977,934 - 129,983,962 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	133,548,684 - 133,554,737 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	131,075,102 - 131,081,130 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	135,515,545 - 135,521,598 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	135,515,545 - 135,521,598 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	135,585,869 - 135,591,922 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	135,080,163 - 135,086,216 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	135,153,595 - 135,159,649 (-)	NCBI
Celera	X	126,800,234 - 126,806,174 (-)	NCBI		Celera
Cytogenetic Map	X	q36	NCBI

GPR119
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	130,379,449 - 130,385,674 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	130,379,449 - 130,385,674 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	129,513,423 - 129,519,648 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	129,346,095 - 129,347,102 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	129,243,948 - 129,244,956	NCBI
Celera	X	129,904,784 - 129,905,976 (-)	NCBI		Celera
Cytogenetic Map	X	q26.1	NCBI
HuRef	X	118,912,749 - 118,913,941 (-)	NCBI		HuRef
CHM1_1	X	129,429,952 - 129,431,144 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	128,698,231 - 128,704,458 (-)	NCBI		T2T-CHM13v2.0

Gpr119
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	47,756,856 - 47,763,355 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	47,756,856 - 47,763,355 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	48,667,979 - 48,674,478 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	48,667,979 - 48,674,478 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	46,021,156 - 46,027,655 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	44,917,878 - 44,918,885 (-)	NCBI		MGSCv36	mm8
Celera	X	36,171,845 - 36,178,348 (-)	NCBI		Celera
Cytogenetic Map	X	A5	NCBI
cM Map	X	25.69	NCBI

Gpr119
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955473	4,686,225 - 4,687,232 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955473	4,686,225 - 4,687,232 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR119
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	129,800,132 - 129,806,361 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	129,803,746 - 129,809,975 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	119,511,372 - 119,512,611 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	129,803,294 - 129,804,512 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	129,803,383 - 129,804,390 (-)	Ensembl	panpan1.1		panPan2

GPR119
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	101,518,313 - 101,520,677 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	101,518,977 - 101,519,984 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	87,692,390 - 87,698,073 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	103,374,107 - 103,379,790 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	103,378,287 - 103,379,294 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	100,788,832 - 100,794,515 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	102,634,515 - 102,640,198 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	102,413,036 - 102,418,383 (-)	NCBI		UU_Cfam_GSD_1.0

Gpr119
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	99,723,913 - 99,725,096 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	1,262,484 - 1,263,491 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	1,262,399 - 1,263,596 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR119
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	106,872,225 - 106,873,299 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	106,872,225 - 106,873,299 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	122,640,688 - 122,641,762 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR119
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	105,641,691 - 105,646,692 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	105,644,002 - 105,645,009 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	43,063,792 - 43,065,043 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr119
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624797	9,664,216 - 9,665,220 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624797	9,664,097 - 9,666,243 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gpr119
55 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	20
Count of miRNA genes:	19
Interacting mature miRNAs:	20
Transcripts:	ENSRNOT00000033619
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	93956491	138956491	Rat
1598856	Memor1	Memory QTL 1	1.9		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	X	103312877	148312877	Rat
1598809	Memor15	Memory QTL 15	4.4		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	103312877	148312877	Rat
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	100567703	150256146	Rat
634346	Insul4	Insulin level QTL 4	0		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	X	126975089	152453651	Rat
738029	Stresp2	Stress response QTL 2	3.4	0.0004	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	112934952	138400867	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low					1				8			3
Below cutoff	3	7	25	9	16	9	5	5	3	10	7	6	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_181770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY288429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033619 ⟹ ENSRNOP00000036164

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	127,852,145 - 127,858,198 (-)	Ensembl
Rnor_6.0 Ensembl	X	135,515,545 - 135,521,598 (-)	Ensembl

RefSeq Acc Id:

NM_181770 ⟹ NP_861435

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	132,730,027 - 132,736,080 (-)	NCBI
mRatBN7.2	X	127,852,145 - 127,858,198 (-)	NCBI
Rnor_6.0	X	135,515,545 - 135,521,598 (-)	NCBI
Rnor_5.0	X	135,585,869 - 135,591,922 (-)	NCBI
RGSC_v3.4	X	135,080,163 - 135,086,216 (-)	RGD
Celera	X	126,800,234 - 126,806,174 (-)	RGD

Sequence:

show sequence

ATGGAGTCATCTTTCTCATTTGGAGTGATCCTTGCTGTCCTGACCATCCTTATCATTGCTGTTA
ATGCGCTGGTGGTTGTGGCTATGCTGCTATCAATCTACAAGAATGATGGTGTTGGCCTTTGCTT
CACCTTAAATCTGGCCGTGGCTGATACCTTGATTGGCGTGGCTATTTCTGGGCTAGTTACAGAC
CAGCTCTCCAGCTCTGCTCAGCACACACAGAAGACCTTGTGTAGCCTTCGGATGGCATTCGTCA
CTTCTTCTGCAGCCGCCTCTGTCCTCACGGTCATGCTGATTGCCTTTGACAGGTACCTGGCCAT
TAAGCAGCCCCTCCGTTACTTCCAGATCATGAATGGGCTTGTAGCCGGAGGATGCATTGCAGGG
CTGTGGTTGATATCTTACCTTATCGGCTTCCTCCCACTTGGAGTCTCCATATTCCAGCAGACCA
CCTACCATGGGCCCTGCACCTTCTTTGCTGTGTTTCACCCAAGGTTTGTGCTGACCCTCTCCTG
TGCTGGCTTCTTCCCAGCTGTGCTCCTCTTTGTCTTCTTCTACTGTGACATGCTCAAGATTGCC
TCTGTGCACAGCCAGCACATCCGGAAGATGGAACATGCAGGAGCCATGGTTGGAGCTTGCCGGC
CCCCACGGCCTGTCAATGACTTCAAGGCTGTCCGGACTGTATCTGTCCTTATTGGGAGCTTCAC
CCTGTCCTGGTCTCCGTTTCTCATCACTAGCATTGTGCAGGTGGCCTGCCACAAATGCTGCCTC
TACCAAGTGCTGGAAAAATACCTCTGGCTCCTTGGAGTTGGCAACTCCCTGCTCAACCCACTCA
TCTATGCCTATTGGCAGAGGGAGGTTCGGCAGCAGCTCTGCCACATGGCCCTGGGGCTACTTGC
TGATGGCAGTACACAACCCCAAATTGAGACACTGAAAGGGAAGGAAGAGAGAAAGAAGGTAGGA
AGAAAGACGCTGTACACATGTGATGCACAGACGCTGTACACATGTGATGCACAGACGCTGTACA
CATGTGATGCACAGACGCTGTACACATGTGATGCATGTGATACACAGACACTGTACACATGTGA
TGCACAGACGCTGTACACATGTGATGCACAGACGCTGTACACATGTGATGCACAGACGCTGTAC
ACATGTGATGCACAGACGCTGTACACATGTGATGCACAGACACTGTACACATGTGATACACAGA
CGCTGTACACATGTGATGCACAGACGCTGTACACATGTGATGCACAGACGCTGTACACATGTGA
TGCACAGACGCTGTACACATGTGATGCACAGACGCTGTACACATCAAGTTTGGTAACTGGCCAA
ACTGAGCAGACACCACTGAAACGAGCAAACATGAGTGATCCTCTGAGGACATGCAGGGGATAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_861435	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP72138	(Get FASTA)	NCBI Sequence Viewer
	EDM10924	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000036164.3
	ENSRNOP00055021052
GenBank Protein	Q7TQN8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_861435 ⟸ NM_181770

- UniProtKB:

Q7TQN8 (UniProtKB/Swiss-Prot), A6JMR2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTD
QLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAG
LWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIA
SVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCL
YQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVG
RKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLY
TCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQ
TEQTPLKRANMSDPLRTCRG

hide sequence

Ensembl Acc Id:

ENSRNOP00000036164 ⟸ ENSRNOT00000033619

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TQN8-F1-model_v2	AlphaFold	Q7TQN8	1-468	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727808	AgrOrtholog
BioCyc Gene	G2FUF-1126	BioCyc
Ensembl Genes	ENSRNOG00000024517	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055015100	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000033619.4	UniProtKB/Swiss-Prot
	ENSRNOT00055025813	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPR119	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:302813	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	302813	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLUCOSE-DEPENDENT INSULINOTROPIC RECEPTOR	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gpr119	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000024517	RatGTEx
	ENSRNOG00055015100	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6JMR2	ENTREZGENE, UniProtKB/TrEMBL
	GP119_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-12-14	Gpr119	G protein-coupled receptor 119			Symbol and Name status set to approved	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_homology	does not appear to be closely related to any other sequences in the GPCR superfamily	1302390

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar