Ddx46 (DEAD-box helicase 46) - Rat Genome Database

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Gene: Ddx46 (DEAD-box helicase 46) Rattus norvegicus
Analyze
Symbol: Ddx46
Name: DEAD-box helicase 46
RGD ID: 708480
Description: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in fibrillar center and nuclear speck. Predicted to be part of U2-type spliceosomal complex. Predicted to be active in nucleus. Orthologous to human DDX46 (DEAD-box helicase 46); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; DEAD box protein 46; helicase of 117.4 kDa; LOC245957; probable ATP-dependent RNA helicase DDX46; RNA helicase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,947,237 - 8,993,705 (-)NCBIGRCr8
mRatBN7.2178,942,070 - 8,988,440 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,944,454 - 8,988,439 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,957,611 - 9,003,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,487,079 - 10,533,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,954,003 - 9,000,024 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,475,275 - 9,519,545 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,475,538 - 9,519,595 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,582,729 - 11,626,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,985,633 - 15,029,607 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11714,985,632 - 15,029,607 (-)NCBI
Celera179,026,373 - 9,070,389 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ddx46Ratautistic disorder  ISORGD:7342668554872ClinVar Annotator: match by term: AutismClinVarPMID:25741868
Ddx46Ratfamilial adenomatous polyposis 1  ISORGD:7342668554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004|PMID:18487285|PMID:19279422|PMID:19409520|PMID:20685668|PMID:21643010|PMID:28492532
Ddx46RatHereditary Neoplastic Syndromes  ISORGD:7342668554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004|PMID:18487285|PMID:19279422|PMID:19409520|PMID:20685668|PMID:21643010|PMID:28492532
Ddx46RatNeurodevelopmental Disorders  ISORGD:7342668554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868

1 to 20 of 92 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ddx46Rat1,2-dimethylhydrazine increases expressionISORGD:73426764804641,2-Dimethylhydrazine results in increased expression of DDX46 mRNACTDPMID:22206623
Ddx46Rat17alpha-ethynylestradiol multiple interactionsISORGD:7342676480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDX46 mRNACTDPMID:17942748
Ddx46Rat17beta-estradiol increases expressionISORGD:7342676480464Estradiol results in increased expression of DDX46 mRNACTDPMID:39298647
Ddx46Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:7342676480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDX46 mRNACTDPMID:17942748
Ddx46Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of DDX46 mRNACTDPMID:34747641
Ddx46Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:7342676480464Tetrachlorodibenzodioxin affects the expression of DDX46 mRNACTDPMID:21570461|PMID:26377647
Ddx46Rat2,4,6-tribromophenol decreases expressionISORGD:73426664804642,4,6-tribromophenol results in decreased expression of DDX46 mRNACTDPMID:31675489
Ddx46Rat2,4-dinitrotoluene affects expressionEXP 64804642,4-dinitrotoluene affects the expression of DDX46 mRNACTDPMID:21346803
Ddx46Rat2,6-dinitrotoluene affects expressionEXP 64804642,6-dinitrotoluene affects the expression of DDX46 mRNACTDPMID:21346803
Ddx46Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641,2-dithiol-3-thione results in decreased expression of DDX46 mRNACTDPMID:19162173
Ddx46Rat4,4'-sulfonyldiphenol increases expressionISORGD:7342676480464bisphenol S results in increased expression of DDX46 mRNACTDPMID:39298647
Ddx46Rat5-aza-2'-deoxycytidine affects expressionISORGD:7342666480464Decitabine affects the expression of DDX46 mRNACTDPMID:23300844
Ddx46Ratacrolein multiple interactionsISORGD:7342666480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...CTDPMID:32699268
Ddx46Rataflatoxin B1 increases expressionISORGD:7342676480464Aflatoxin B1 results in increased expression of DDX46 mRNACTDPMID:19770486
Ddx46Rataflatoxin B1 increases methylationISORGD:7342666480464Aflatoxin B1 results in increased methylation of DDX46 intronCTDPMID:30157460
Ddx46Ratallethrin multiple interactionsEXP 6480464[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in more ...CTDPMID:34896426
Ddx46Ratalpha-pinene multiple interactionsISORGD:7342666480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...CTDPMID:32699268
Ddx46Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of DDX46 mRNACTDPMID:16483693
Ddx46Rataristolochic acid A decreases expressionISORGD:7342666480464aristolochic acid I results in decreased expression of DDX46 mRNACTDPMID:33212167
Ddx46RatAroclor 1254 decreases expressionISORGD:7342676480464Chlorodiphenyl (54% Chlorine) results in decreased expression of DDX46 mRNACTDPMID:23650126

1 to 20 of 92 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ddx46Ratbiological_process  ND 159840704/2015: no relevant rat dataRGD 
Ddx46RatmRNA processing involved_inIEAUniProtKB-KW:KW-05071600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46RatmRNA splicing, via spliceosome involved_inIBAPANTHER:PTN002775706|PomBase:SPCC10H11.01|SGD:S000000441|UniProtKB:Q7L014|ZFIN:ZDB-GENE-030131-6671600115GO_REF:0000033GO_CentralGO_REF:0000033
Ddx46RatmRNA splicing, via spliceosome involved_inISORGD:7342661624291 PMID:32494006, PMID:34822310, PMID:36797247RGDPMID:32494006|PMID:34822310|PMID:36797247
Ddx46RatmRNA splicing, via spliceosome involved_inISSUniProtKB:Q7L0141600115GO_REF:0000024UniProtGO_REF:0000024
Ddx46RatRNA splicing involved_inIEAUniProtKB-KW:KW-05081600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46RatU2-type prespliceosome assembly involved_inISSUniProtKB:Q7L0141600115GO_REF:0000024UniProtGO_REF:0000024
Ddx46RatU2-type prespliceosome assembly involved_inISORGD:7342661624291 PMID:36797247RGDPMID:36797247

Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ddx46RatCajal body located_inIEAUniProtKB-SubCell:SL-00311600115GO_REF:0000044UniProtGO_REF:0000044
Ddx46Ratfibrillar center located_inIEAUniProtKB:A0A0C4DG89|ensembl:ENSP000004165341600115GO_REF:0000107EnsemblGO_REF:0000107
Ddx46Ratfibrillar center located_inISORGD:7342661624291 RGDGO_REF:0000052
Ddx46Ratnuclear speck located_inIEAUniProtKB-SubCell:SL-01861600115GO_REF:0000044UniProtGO_REF:0000044
Ddx46Ratnuclear speck located_inISORGD:7342661624291 RGDGO_REF:0000052
Ddx46Ratnuclear speck located_inIEAUniProtKB:A0A0C4DG89|ensembl:ENSP000004165341600115GO_REF:0000107EnsemblGO_REF:0000107
Ddx46Ratnucleus is_active_inIBAPANTHER:PTN002775706|PomBase:SPCC10H11.01|UniProtKB:Q7L014|UniProtKB:Q8IJ901600115GO_REF:0000033GO_CentralGO_REF:0000033
Ddx46Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46Ratspliceosomal complex part_ofIEAUniProtKB-KW:KW-07471600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46RatU2-type spliceosomal complex part_ofISSUniProtKB:Q7L0141600115GO_REF:0000024UniProtGO_REF:0000024
Ddx46RatU2-type spliceosomal complex part_ofISORGD:7342661624291 PMID:32494006, PMID:34822310, PMID:36797247RGDPMID:32494006|PMID:34822310|PMID:36797247
1 to 11 of 11 rows

Molecular Function
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ddx46RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46RatATP binding enablesIEAInterPro:IPR0115451600115GO_REF:0000002InterProGO_REF:0000002
Ddx46RatATP hydrolysis activity enablesIEARHEA:130651600115GO_REF:0000116RHEAGO_REF:0000116
Ddx46Rathelicase activity enablesIEAUniProtKB-KW:KW-03471600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46Ratnucleic acid binding enablesIEAInterPro:IPR0115451600115GO_REF:0000002InterProGO_REF:0000002
Ddx46Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46Ratprotein binding enablesISORGD:7342661624291UniProtKB:P78362 PMID:22365833, PMID:23602568, PMID:32707033, PMID:33961781RGDPMID:22365833|PMID:23602568|PMID:32707033|PMID:33961781
Ddx46RatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
Ddx46RatRNA helicase activity enablesIEAEC:3.6.4.131600115GO_REF:0000003UniProtGO_REF:0000003
Ddx46RatRNA helicase activity enablesIEAInterPro:IPR0140141600115GO_REF:0000002InterProGO_REF:0000002
1 to 11 of 11 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ddx46Ratspliceosome pathway   ISORGD:7342669686093 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ddx46Ratspliceosome pathway   IEA 6907045 KEGGrno:03040

#
Reference Title
Reference Citation
1. Functions of the DExD/H-box proteins in nuclear pre-mRNA splicing. Chang TH, etal., Biochim Biophys Acta. 2013 Aug;1829(8):764-74. doi: 10.1016/j.bbagrm.2013.02.006. Epub 2013 Feb 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. A putative mammalian RNA helicase with an arginine-serine-rich domain colocalizes with a splicing factor. Sukegawa J and Blobel G, J Biol Chem 1995 Jun 30;270(26):15702-6.
PMID:12477932   PMID:15489334   PMID:16791210   PMID:22681889   PMID:31505169  



Ddx46
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,947,237 - 8,993,705 (-)NCBIGRCr8
mRatBN7.2178,942,070 - 8,988,440 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,944,454 - 8,988,439 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx178,957,611 - 9,003,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,487,079 - 10,533,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,954,003 - 9,000,024 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,475,275 - 9,519,545 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,475,538 - 9,519,595 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,582,729 - 11,626,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41714,985,633 - 15,029,607 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11714,985,632 - 15,029,607 (-)NCBI
Celera179,026,373 - 9,070,389 (-)NCBICelera
Cytogenetic Map17p14NCBI
DDX46
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,758,779 - 134,831,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,758,771 - 134,855,133 (+)EnsemblGRCh38hg38GRCh38
GRCh375134,094,469 - 134,166,811 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,122,360 - 134,194,710 (+)NCBINCBI36Build 36hg18NCBI36
Build 345134,122,359 - 134,194,708NCBI
Celera5130,220,831 - 130,294,505 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5129,280,020 - 129,353,042 (+)NCBIHuRef
CHM1_15133,527,063 - 133,599,436 (+)NCBICHM1_1
T2T-CHM13v2.05135,284,406 - 135,358,072 (+)NCBIT2T-CHM13v2.0
Ddx46
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,782,790 - 55,829,080 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,782,841 - 55,829,069 (+)EnsemblGRCm39 Ensembl
GRCm381355,634,975 - 55,681,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,635,027 - 55,681,256 (+)EnsemblGRCm38mm10GRCm38
MGSCv371355,736,388 - 55,782,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,644,673 - 55,688,737 (+)NCBIMGSCv36mm8
Celera1356,689,234 - 56,735,498 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
Ddx46
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,981,229 - 30,031,473 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,981,509 - 30,031,473 (+)NCBIChiLan1.0ChiLan1.0
DDX46
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24130,054,133 - 130,126,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15128,193,694 - 128,266,348 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05130,185,793 - 130,232,208 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15136,302,356 - 136,375,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5136,302,356 - 136,375,992 (+)Ensemblpanpan1.1panPan2
DDX46
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,834,843 - 22,906,976 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,833,926 - 22,905,964 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,583,883 - 21,656,884 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01123,641,148 - 23,714,301 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,640,644 - 23,714,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,340,290 - 22,413,564 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01122,206,581 - 22,279,270 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,848,522 - 22,921,627 (+)NCBIUU_Cfam_GSD_1.0
DDX46
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,972,507 - 137,030,430 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,972,504 - 137,030,186 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,588,602 - 142,644,674 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDX46
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12337,547,227 - 37,613,632 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603440,299,339 - 40,374,103 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddx46
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,230,678 - 12,294,258 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,229,562 - 12,294,301 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Ddx46
266 total Variants

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:95
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000029885
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat

1 to 10 of 22 rows
RH134219  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,944,582 - 8,944,773 (+)MAPPERmRatBN7.2
Rnor_6.0179,475,661 - 9,475,851NCBIRnor6.0
Rnor_5.01711,583,113 - 11,583,303UniSTSRnor5.0
RGSC_v3.41714,985,754 - 14,985,944UniSTSRGSC3.4
Celera179,026,494 - 9,026,684UniSTS
Cytogenetic Map17p14UniSTS
BE109072  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera98,835,297 - 8,835,480UniSTS
Cytogenetic Map17p14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000029885   ⟹   ENSRNOP00000030772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,944,462 - 8,988,439 (-)Ensembl
Rnor_6.0 Ensembl179,475,538 - 9,519,595 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114045   ⟹   ENSRNOP00000088007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,944,454 - 8,985,084 (-)Ensembl
RefSeq Acc Id: NM_001395621   ⟹   NP_001382550
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,947,237 - 8,993,603 (-)NCBI
mRatBN7.2178,942,070 - 8,988,440 (-)NCBI
RefSeq Acc Id: NM_139098   ⟹   NP_620798
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,947,237 - 8,993,603 (-)NCBI
mRatBN7.2178,942,070 - 8,988,440 (-)NCBI
Rnor_6.0179,475,540 - 9,519,514 (-)NCBI
Rnor_5.01711,582,729 - 11,626,991 (-)NCBI
RGSC_v3.41714,985,633 - 15,029,607 (-)RGD
Celera179,026,373 - 9,070,389 (-)RGD
Sequence:
RefSeq Acc Id: XM_063276054   ⟹   XP_063132124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,949,620 - 8,993,705 (-)NCBI
RefSeq Acc Id: XM_063276055   ⟹   XP_063132125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,949,620 - 8,993,705 (-)NCBI
RefSeq Acc Id: XR_010058808
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,966,335 - 8,993,705 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_001382550 (Get FASTA)   NCBI Sequence Viewer  
  NP_620798 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132124 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132125 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52210 (Get FASTA)   NCBI Sequence Viewer  
  AAI07591 (Get FASTA)   NCBI Sequence Viewer  
  EDL93959 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088007
GenBank Protein Q62780 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_620798   ⟸   NM_139098
- Peptide Label: isoform 1
- UniProtKB: Q62780 (UniProtKB/Swiss-Prot),   A0A8I6A8E8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030772   ⟸   ENSRNOT00000029885
Ensembl Acc Id: ENSRNOP00000088007   ⟸   ENSRNOT00000114045
RefSeq Acc Id: NP_001382550   ⟸   NM_001395621
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A8E8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132125   ⟸   XM_063276055
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A8E8 (UniProtKB/TrEMBL)
DEAD-box RNA helicase Q   Helicase ATP-binding   Helicase C-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q62780-F1-model_v2 AlphaFold Q62780 1-1032 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700296
Promoter ID:EPDNEW_R10819
Type:multiple initiation site
Name:Ddx46_1
Description:DEAD-box helicase 46
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,519,528 - 9,519,588EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-10220 BioCyc
Ensembl Genes ENSRNOG00000021637 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000114045 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7461248 IMAGE-MGC_LOAD
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot
  Helicase_ATP-bd UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  RNA-helicase_DEAD-box_CS UniProtKB/Swiss-Prot
  RNA_helicase_DEAD_Q_motif UniProtKB/Swiss-Prot
KEGG Report rno:245957 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124939 IMAGE-MGC_LOAD
NCBI Gene 245957 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE DBP3 UniProtKB/Swiss-Prot
Pfam DEAD UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
PhenoGen Ddx46 PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/Swiss-Prot
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot
  HELICASE_CTER UniProtKB/Swiss-Prot
  Q_MOTIF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021637 RatGTEx
SMART DEXDc UniProtKB/Swiss-Prot
  HELICc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6A8E8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QHF2_RAT UniProtKB/TrEMBL
  A6KAQ1_RAT UniProtKB/TrEMBL
  DDX46_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Ddx46  DEAD-box helicase 46  Ddx46  DEAD (Asp-Glu-Ala-Asp) box polypeptide 46  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ddx46  DEAD (Asp-Glu-Ala-Asp) box polypeptide 46    RNA helicase  Name updated 1299863 APPROVED
2004-09-10 Ddx46  RNA helicase  LOC245957    Symbol and Name updated 1299863 APPROVED