Asah2 (N-acylsphingosine amidohydrolase 2) - Rat Genome Database

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Gene: Asah2 (N-acylsphingosine amidohydrolase 2) Mus musculus
Analyze
Symbol: Asah2
Name: N-acylsphingosine amidohydrolase 2
RGD ID: 69455
MGI Page MGI
Description: Exhibits N-acylsphingosine amidohydrolase activity. Involved in lipid digestion and sphingolipid metabolic process. Localizes to several cellular components, including caveola; extracellular space; and mitochondrion. Predicted to colocalize with membrane raft. Orthologous to several human genes including ASAH2B (N-acylsphingosine amidohydrolase 2B); PARTICIPATES IN sphingolipid metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: acylsphingosine deacylase 2; AI585898; N-CDase; NCDase; neutral ceramidase; neutral/alkaline ceramidase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391931,962,046 - 32,080,540 (-)NCBIGRCm39mm39
GRCm39 Ensembl1931,959,997 - 32,085,611 (-)Ensembl
GRCm381931,984,646 - 32,103,140 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1931,982,597 - 32,108,211 (-)EnsemblGRCm38mm10GRCm38
MGSCv371932,059,136 - 32,177,630 (-)NCBIGRCm37mm9NCBIm37
MGSCv361932,050,643 - 32,169,137 (-)NCBImm8
Celera1932,772,701 - 32,889,548 (-)NCBICelera
Cytogenetic Map19C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10652340   PMID:10753931   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11591392   PMID:12435403   PMID:12477932   PMID:12921776  
PMID:14557071   PMID:14651853   PMID:14681479   PMID:15489334   PMID:16126722   PMID:16141072   PMID:16141073   PMID:16380386   PMID:16418170   PMID:18614015   PMID:18955860   PMID:19345744  
PMID:20803549   PMID:21267068   PMID:21613224   PMID:21873635   PMID:22940715   PMID:23096701   PMID:24659784   PMID:26747710   PMID:26900161  


Genomics

Comparative Map Data
Asah2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391931,962,046 - 32,080,540 (-)NCBIGRCm39mm39
GRCm39 Ensembl1931,959,997 - 32,085,611 (-)Ensembl
GRCm381931,984,646 - 32,103,140 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1931,982,597 - 32,108,211 (-)EnsemblGRCm38mm10GRCm38
MGSCv371932,059,136 - 32,177,630 (-)NCBIGRCm37mm9NCBIm37
MGSCv361932,050,643 - 32,169,137 (-)NCBImm8
Celera1932,772,701 - 32,889,548 (-)NCBICelera
Cytogenetic Map19C1NCBI
ASAH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1050,182,778 - 50,279,720 (-)EnsemblGRCh38hg38GRCh38
GRCh381050,184,861 - 50,251,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371051,944,621 - 52,011,276 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361051,617,078 - 51,678,319 (-)NCBINCBI36hg18NCBI36
Celera1075,112,386 - 75,164,225 (-)NCBI
Cytogenetic Map10q11.23NCBI
HuRef1045,946,293 - 46,007,775 (-)NCBIHuRef
CHM1_11052,228,873 - 52,290,233 (-)NCBICHM1_1
Asah2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21229,865,662 - 229,973,253 (-)NCBI
Rnor_6.0 Ensembl1250,557,044 - 250,630,677 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01250,557,042 - 250,665,083 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01257,790,747 - 257,898,648 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,000,768 - 236,072,477 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11236,164,792 - 236,236,500 (-)NCBI
Celera1226,986,485 - 227,059,852 (-)NCBICelera
Cytogenetic Map1q52NCBI
Asah2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554255,840,355 - 5,931,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554255,840,355 - 5,931,891 (+)NCBIChiLan1.0ChiLan1.0
LOC100985247
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11048,970,524 - 49,025,245 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1048,969,434 - 49,025,336 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01046,842,830 - 46,908,811 (-)NCBIMhudiblu_PPA_v0panPan3
ASAH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12637,136,601 - 37,228,215 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2637,136,897 - 37,218,783 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2637,022,117 - 37,103,999 (-)NCBI
ROS_Cfam_1.02638,669,614 - 38,751,828 (-)NCBI
UMICH_Zoey_3.12636,577,467 - 36,659,447 (-)NCBI
UNSW_CanFamBas_1.02636,157,741 - 36,239,965 (-)NCBI
UU_Cfam_GSD_1.02637,398,030 - 37,480,024 (-)NCBI
Asah2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721376,700,488 - 76,788,640 (-)NCBI
SpeTri2.0NW_0049367352,004,373 - 2,092,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASAH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1499,025,005 - 99,129,100 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11499,018,111 - 99,141,374 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214107,865,243 - 107,969,067 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASAH2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1980,409,649 - 80,501,527 (-)NCBI
ChlSab1.1 Ensembl980,409,478 - 80,476,731 (-)Ensembl
Vero_WHO_p1.0NW_02366604841,060,629 - 41,133,632 (-)NCBI
Asah2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479112,906,908 - 13,059,033 (-)NCBI

Position Markers
AI585898  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,984,422 - 31,984,529UniSTSGRCm38
MGSCv371932,058,912 - 32,059,019UniSTSGRCm37
Celera1932,772,477 - 32,772,584UniSTS
Cytogenetic Map19C3UniSTS
Whitehead/MRC_RH19316.53UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132362870Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132897810Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19167640035676563Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19320000035900000Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19334585237345984Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19334585237345984Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19334585237345984Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19334585237345984Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19533596239336106Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19932831543328421Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19981005343810202Mouse
14928311Manh85_mmandible shape 85 (mouse)191193738945937389Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191494561648945738Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191593520749935319Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191593520749935319Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191831776252317981Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191831776252317981Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192025691554257062Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192025691554257062Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192139025755390480Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192200672732935319Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192233596253923073Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192500000059000000Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192515863842400477Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192543847859438566Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192739715561397266Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192779458535317981Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2815190961431566Mouse
4141562Pas3b_mpulmonary adenoma susceptibility 3b (mouse)Not determined2977296261431566Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193015278561431566Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193015279261431566Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193015279261431566Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193090944161431566Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:627
Count of miRNA genes:414
Interacting mature miRNAs:487
Transcripts:ENSMUST00000096119
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_018830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB037111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB037181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000096119   ⟹   ENSMUSP00000093830
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1931,984,654 - 32,061,469 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235213   ⟹   ENSMUSP00000158290
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1931,986,524 - 32,103,124 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235273   ⟹   ENSMUSP00000157557
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1932,014,406 - 32,108,211 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235395
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1932,061,295 - 32,068,744 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236030   ⟹   ENSMUSP00000158185
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1931,986,692 - 32,108,149 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236122
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1932,041,472 - 32,108,166 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236208   ⟹   ENSMUSP00000157392
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1932,024,833 - 32,108,168 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236504   ⟹   ENSMUSP00000157744
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1931,984,634 - 32,103,140 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237104   ⟹   ENSMUSP00000157424
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1931,982,597 - 32,108,156 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237697
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1932,012,463 - 32,016,804 (-)Ensembl
RefSeq Acc Id: NM_018830   ⟹   NP_061300
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391931,962,046 - 32,080,540 (-)NCBI
GRCm381931,984,646 - 32,103,140 (-)NCBI
MGSCv371932,059,136 - 32,177,630 (-)RGD
Celera1932,772,701 - 32,889,548 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061300   ⟸   NM_018830
- UniProtKB: Q9JHE3 (UniProtKB/Swiss-Prot),   B9EHG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000157424   ⟸   ENSMUST00000237104
RefSeq Acc Id: ENSMUSP00000157744   ⟸   ENSMUST00000236504
RefSeq Acc Id: ENSMUSP00000158185   ⟸   ENSMUST00000236030
RefSeq Acc Id: ENSMUSP00000157392   ⟸   ENSMUST00000236208
RefSeq Acc Id: ENSMUSP00000157557   ⟸   ENSMUST00000235273
RefSeq Acc Id: ENSMUSP00000158290   ⟸   ENSMUST00000235213
RefSeq Acc Id: ENSMUSP00000093830   ⟸   ENSMUST00000096119
Protein Domains
Ceramidase_alk   Ceramidse_alk_C

Promoters
RGD ID:13679258
Promoter ID:EPDNEW_M23778
Type:initiation region
Name:Asah2_2
Description:Mus musculus N-acylsphingosine amidohydrolase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23779  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381932,061,407 - 32,061,467EPDNEW
RGD ID:13679260
Promoter ID:EPDNEW_M23779
Type:initiation region
Name:Asah2_1
Description:Mus musculus N-acylsphingosine amidohydrolase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23778  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381932,108,193 - 32,108,253EPDNEW
RGD ID:6829839
Promoter ID:MM_KWN:26842
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4
Transcripts:UC008HEX.1,   UC008HEY.1,   UC008HEZ.1,   UC008HFA.1,   UC008HFB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361932,182,409 - 32,182,909 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859310 AgrOrtholog
Ensembl Genes ENSMUSG00000024887 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000093830 UniProtKB/Swiss-Prot
  ENSMUSP00000157392 UniProtKB/TrEMBL
  ENSMUSP00000157424 UniProtKB/Swiss-Prot
  ENSMUSP00000157557 UniProtKB/TrEMBL
  ENSMUSP00000157744 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000158185 UniProtKB/Swiss-Prot
  ENSMUSP00000158290 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000096119 UniProtKB/Swiss-Prot
  ENSMUST00000235213 UniProtKB/TrEMBL
  ENSMUST00000235273 UniProtKB/TrEMBL
  ENSMUST00000236030 UniProtKB/Swiss-Prot
  ENSMUST00000236208 UniProtKB/TrEMBL
  ENSMUST00000236504 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000237104 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ceramidase_alk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCDase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUT/ALK_ceramidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUT/ALK_ceramidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1859310 ENTREZGENE
NCBI Gene 54447 ENTREZGENE
PANTHER PTHR12670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ceramidase_alk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ceramidse_alk_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asah2 PhenoGen
UniProt A0A494B8X7_MOUSE UniProtKB/TrEMBL
  A0A494B9A2_MOUSE UniProtKB/TrEMBL
  ASAH2_MOUSE UniProtKB/Swiss-Prot
  B7ZN55_MOUSE UniProtKB/TrEMBL
  B9EHG7 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHE3 ENTREZGENE
UniProt Secondary Q3UWP9 UniProtKB/Swiss-Prot
  Q8BNP0 UniProtKB/Swiss-Prot
  Q8BQN7 UniProtKB/Swiss-Prot
  Q8R236 UniProtKB/Swiss-Prot