MIR4507 (microRNA 4507) - Rat Genome Database

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Gene: MIR4507 (microRNA 4507) Homo sapiens
Analyze
Symbol: MIR4507
Name: microRNA 4507
RGD ID: 5134850
HGNC Page HGNC:41642
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,858,124 - 105,858,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,858,124 - 105,858,175 (-)EnsemblGRCh38hg38GRCh38
GRCh3714106,324,293 - 106,324,344 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map14q32.33NCBI
HuRef1486,457,226 - 86,457,277 (-)NCBIHuRef
CHM1_114106,195,080 - 106,195,131 (-)NCBICHM1_1
T2T-CHM13v2.014100,129,690 - 100,129,741 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR4507HumanChemical and Drug Induced Liver Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28545106


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR4507Humandecabromodiphenyl ether increases expressionEXP 6480464decabromobiphenyl ether results in increased expression of MIR4507 mRNACTDPMID:34166751
MIR4507Humanparacetamol increases expressionEXP 6480464Acetaminophen results in increased expression of MIR4507 mRNACTDPMID:28545106
MIR4507Humansodium arsenite decreases expressionEXP 6480464sodium arsenite results in decreased expression of MIR4507 mRNACTDPMID:29207610

PMID:16381832   PMID:20733160  



.

1 to 10 of 41 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.33(chr14:104953508-106873666)x1 copy number loss See cases [RCV000135387] Chr14:104953508..106873666 [GRCh38]
Chr14:105419845..107281875 [GRCh37]
Chr14:104490890..106352920 [NCBI36]
Chr14:14q32.33		 uncertain significance
GRCh38/hg38 14q32.33(chr14:105817508-106855263)x1 copy number loss See cases [RCV000135642] Chr14:105817508..106855263 [GRCh38]
Chr14:106283841..107263478 [GRCh37]
Chr14:105354886..106334523 [NCBI36]
Chr14:14q32.33		 likely benign
GRCh38/hg38 14q32.33(chr14:104622881-106678844)x1 copy number loss See cases [RCV000135781] Chr14:104622881..106678844 [GRCh38]
Chr14:105017236..107134861 [GRCh37]
Chr14:104088281..106205906 [NCBI36]
Chr14:14q32.33		 uncertain significance
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.33(chr14:105023396-106850750)x1 copy number loss See cases [RCV000135897] Chr14:105023396..106850750 [GRCh38]
Chr14:105489733..107258965 [GRCh37]
Chr14:104560778..106330010 [NCBI36]
Chr14:14q32.33		 pathogenic
1 to 10 of 41 rows

Predicted Targets
Summary Value
Count of predictions:28846
Count of gene targets:11211
Count of transcripts:21799
Interacting mature miRNAs:hsa-miR-4507
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
3 70 3 7 7 20 58 14 406 5 5 435 395 2 3 13 14 51 9



Ensembl Acc Id: ENST00000581070
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl14105,858,124 - 105,858,175 (-)Ensembl
RefSeq Acc Id: NR_039730
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814105,858,124 - 105,858,175 (-)NCBI
GRCh3714106,324,293 - 106,324,344 (-)ENTREZGENE
HuRef1486,457,226 - 86,457,277 (-)ENTREZGENE
CHM1_114106,195,080 - 106,195,131 (-)NCBI
T2T-CHM13v2.014100,129,690 - 100,129,741 (-)NCBI
Sequence:


1 to 10 of 10 rows
Database
Acc Id
Source(s)
COSMIC MIR4507 COSMIC
Ensembl Genes ENSG00000264024 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000581070 ENTREZGENE
GTEx ENSG00000264024 GTEx
HGNC ID HGNC:41642 ENTREZGENE
Human Proteome Map MIR4507 Human Proteome Map
miRBase MI0016871 ENTREZGENE
NCBI Gene 100616135 ENTREZGENE
RNAcentral URS0000099F48 RNACentral
  URS000075B6FF RNACentral
1 to 10 of 10 rows