Peg10 (paternally expressed 10) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Peg10 (paternally expressed 10) Heterocephalus glaber
Analyze
Symbol: Peg10
Name: paternally expressed 10
RGD ID: 18932549
Description: This gene is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: retrotransposon-derived protein PEG10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248131,432,049 - 1,450,263 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:17942406   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Peg10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248131,432,049 - 1,450,263 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PEG10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38794,656,325 - 94,669,695 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl794,656,325 - 94,669,695 (+)EnsemblGRCh38hg38GRCh38
GRCh37794,285,637 - 94,299,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,123,573 - 94,136,943 (+)NCBINCBI36Build 36hg18NCBI36
Celera788,983,852 - 88,997,218 (+)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef788,892,971 - 88,906,336 (+)NCBIHuRef
CHM1_1794,215,681 - 94,228,835 (+)NCBICHM1_1
T2T-CHM13v2.0795,892,249 - 95,905,573 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2793,614,786 - 93,628,044 (+)NCBI
Peg10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3964,747,306 - 4,760,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl64,747,306 - 4,760,517 (+)EnsemblGRCm39 Ensembl
GRCm3864,747,306 - 4,760,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl64,747,306 - 4,760,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv3764,697,306 - 4,710,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3664,697,380 - 4,710,476 (+)NCBIMGSCv36mm8
Celera64,890,266 - 4,910,398 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.81NCBI
Peg10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8433,809,026 - 33,822,224 (+)NCBIGRCr8
mRatBN7.2432,842,441 - 32,855,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl432,848,493 - 32,852,621 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx437,805,521 - 37,818,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0433,731,648 - 33,744,849 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0432,137,390 - 32,150,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0429,795,524 - 29,804,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0429,704,123 - 29,714,984 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera428,372,489 - 28,385,349 (+)NCBICelera
Cytogenetic Map4q21NCBI
Peg10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,390,847 - 11,391,929 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,383,919 - 11,395,313 (+)NCBIChiLan1.0ChiLan1.0
PEG10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26112,494,034 - 112,507,402 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17160,758,673 - 160,772,041 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0786,606,249 - 86,619,580 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17100,195,741 - 100,208,882 (+)NCBIpanpan1.1PanPan1.1panPan2
PEG10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,121,414 - 20,134,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,121,414 - 20,134,133 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1419,680,715 - 19,693,431 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01419,936,876 - 19,949,584 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1419,936,923 - 19,945,475 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,088,550 - 20,101,264 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01419,823,839 - 19,836,542 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,081,203 - 20,093,924 (+)NCBIUU_Cfam_GSD_1.0
Peg10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511833,412,101 - 33,425,479 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365855,441,493 - 5,443,868 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365855,437,807 - 5,451,185 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEG10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl974,474,107 - 74,486,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1974,474,121 - 74,486,983 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2981,643,099 - 81,655,365 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PEG10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12154,371,708 - 54,384,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604249,937,815 - 49,951,357 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NM_001291216   ⟹   NP_001278145
RefSeq Status: REVIEWED
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248131,432,049 - 1,450,263 (+)NCBI
RefSeq Acc Id: NM_001291217   ⟹   NP_001278146
RefSeq Status: REVIEWED
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248131,432,049 - 1,450,263 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001278145 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278146 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001278145   ⟸   NM_001291216
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001278146   ⟸   NM_001291217
- Peptide Label: isoform 2


Additional Information

Database Acc Id Source(s)
NCBI Gene Peg10 ENTREZGENE