PEG10 (paternally expressed 10) - Rat Genome Database

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Gene: PEG10 (paternally expressed 10) Canis lupus familiaris
Analyze
Symbol: PEG10
Name: paternally expressed 10
RGD ID: 12229143
Description: This gene is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Use of non-AUG (CUG) translation initiation codon has been found for this gene. [provided by RefSeq, Oct 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: retrotransposon-derived protein PEG10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,121,414 - 20,134,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,121,414 - 20,134,133 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1419,680,715 - 19,693,431 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01419,936,876 - 19,949,584 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1419,936,923 - 19,945,475 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,088,550 - 20,101,264 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01419,823,839 - 19,836,542 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,081,203 - 20,093,924 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:17942406   PMID:20084274   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PEG10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,121,414 - 20,134,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,121,414 - 20,134,133 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1419,680,715 - 19,693,431 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01419,936,876 - 19,949,584 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1419,936,923 - 19,945,475 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,088,550 - 20,101,264 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01419,823,839 - 19,836,542 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,081,203 - 20,093,924 (+)NCBIUU_Cfam_GSD_1.0
PEG10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38794,656,325 - 94,669,695 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl794,656,325 - 94,669,695 (+)EnsemblGRCh38hg38GRCh38
GRCh37794,285,637 - 94,299,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,123,573 - 94,136,943 (+)NCBINCBI36Build 36hg18NCBI36
Celera788,983,852 - 88,997,218 (+)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef788,892,971 - 88,906,336 (+)NCBIHuRef
CHM1_1794,215,681 - 94,228,835 (+)NCBICHM1_1
T2T-CHM13v2.0795,892,249 - 95,905,573 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2793,614,786 - 93,628,044 (+)NCBI
Peg10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3964,747,306 - 4,760,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl64,747,306 - 4,760,517 (+)EnsemblGRCm39 Ensembl
GRCm3864,747,306 - 4,760,517 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl64,747,306 - 4,760,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv3764,697,306 - 4,710,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3664,697,380 - 4,710,476 (+)NCBIMGSCv36mm8
Celera64,890,266 - 4,910,398 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.81NCBI
Peg10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8433,809,026 - 33,822,224 (+)NCBIGRCr8
mRatBN7.2432,842,441 - 32,855,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl432,848,493 - 32,852,621 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx437,805,521 - 37,818,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0433,731,648 - 33,744,849 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0432,137,390 - 32,150,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0429,795,524 - 29,804,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0429,704,123 - 29,714,984 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera428,372,489 - 28,385,349 (+)NCBICelera
Cytogenetic Map4q21NCBI
Peg10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,390,847 - 11,391,929 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,383,919 - 11,395,313 (+)NCBIChiLan1.0ChiLan1.0
PEG10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26112,494,034 - 112,507,402 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17160,758,673 - 160,772,041 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0786,606,249 - 86,619,580 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17100,195,741 - 100,208,882 (+)NCBIpanpan1.1PanPan1.1panPan2
Peg10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511833,412,101 - 33,425,479 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365855,441,493 - 5,443,868 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365855,437,807 - 5,451,185 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEG10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl974,474,107 - 74,486,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1974,474,121 - 74,486,983 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2981,643,099 - 81,655,365 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PEG10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12154,371,708 - 54,384,874 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604249,937,815 - 49,951,357 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Peg10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248131,432,049 - 1,450,263 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PEG10
127 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 12 8 2
Low 5 8 5 6 5 5 3 6 6
Below cutoff 5 3 1 1 1 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000044113   ⟹   ENSCAFP00000041426
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1420,121,414 - 20,134,133 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845034061   ⟹   ENSCAFP00845026663
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1419,936,923 - 19,945,475 (+)Ensembl
RefSeq Acc Id: NM_001172543   ⟹   NP_001166014
RefSeq Status: REVIEWED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11420,121,414 - 20,134,133 (+)NCBI
Dog10K_Boxer_Tasha1419,680,715 - 19,693,431 (+)NCBI
ROS_Cfam_1.01419,936,876 - 19,949,584 (+)NCBI
UMICH_Zoey_3.11420,088,550 - 20,101,264 (+)NCBI
UNSW_CanFamBas_1.01419,823,839 - 19,836,542 (+)NCBI
UU_Cfam_GSD_1.01420,081,203 - 20,093,924 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001172544   ⟹   NP_001166015
RefSeq Status: REVIEWED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11420,121,414 - 20,134,133 (+)NCBI
Dog10K_Boxer_Tasha1419,680,715 - 19,693,431 (+)NCBI
ROS_Cfam_1.01419,936,876 - 19,949,584 (+)NCBI
UMICH_Zoey_3.11420,088,550 - 20,101,264 (+)NCBI
UNSW_CanFamBas_1.01419,823,839 - 19,836,542 (+)NCBI
UU_Cfam_GSD_1.01420,081,203 - 20,093,924 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001166014 (Get FASTA)   NCBI Sequence Viewer  
  NP_001166015 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000072000.1
  ENSCAFP00030027450.1
  ENSCAFP00040020899.1
  ENSCAFP00845026663.1
Reference Protein Sequences
RefSeq Acc Id: NP_001166014   ⟸   NM_001172543
- Peptide Label: isoform 1
- UniProtKB: A0A8I3PE59 (UniProtKB/TrEMBL),   A0A8P0PNC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001166015   ⟸   NM_001172544
- Peptide Label: isoform 2
- UniProtKB: A0A8C0SGH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041426   ⟸   ENSCAFT00000044113
RefSeq Acc Id: ENSCAFP00845026663   ⟸   ENSCAFT00845034061
Protein Domains
CCHC-type

Promoters
RGD ID:13685754
Promoter ID:EPDNEW_C3823
Type:single initiation site
Name:PEG10_1
Description:Canis lupus familiaris paternally expressed 10 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11420,121,459 - 20,121,519EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032379 Ensembl
  ENSCAFG00000056109 UniProtKB/TrEMBL
  ENSCAFG00030017055 UniProtKB/TrEMBL
  ENSCAFG00040013027 UniProtKB/TrEMBL
  ENSCAFG00845019307 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000105667.1 UniProtKB/TrEMBL
  ENSCAFT00030031468.1 UniProtKB/TrEMBL
  ENSCAFT00040024058.1 UniProtKB/TrEMBL
  ENSCAFT00845034061.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/TrEMBL
  3.30.70.270 UniProtKB/TrEMBL
  HIV Type 1 Reverse Transcriptase, subunit A, domain 1 UniProtKB/TrEMBL
InterPro DNA/RNA_pol_sf UniProtKB/TrEMBL
  LDOC1-rel UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/TrEMBL
  Retrotrans_gag_dom UniProtKB/TrEMBL
  Rev_trsase/Diguanyl_cyclase UniProtKB/TrEMBL
  Znf_CCHC UniProtKB/TrEMBL
  Znf_CCHC_sf UniProtKB/TrEMBL
NCBI Gene PEG10 ENTREZGENE
PANTHER PTHR15503 UniProtKB/TrEMBL
  RETROTRANSPOSON-DERIVED PROTEIN PEG10 UniProtKB/TrEMBL
Pfam Retrotrans_gag UniProtKB/TrEMBL
PROSITE ZF_CCHC UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/TrEMBL
  SSF56672 UniProtKB/TrEMBL
  SSF57756 UniProtKB/TrEMBL
UniProt A0A8C0SGH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PE59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PNC8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:49685 ENTREZGENE