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Gene: PEG10 (paternally expressed 10) Sus scrofa
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Symbol: PEG10
Name: paternally expressed 10
Description: This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Different isoforms resulting from alternatively spliced transcript variants, and use of non-AUG (CUG) translation initiation codon have been found for this gene. [provided by RefSeq, Oct 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: retrotransposon-derived protein PEG10
Orthologs:
Homo sapiens (human) : PEG10 (paternally expressed 10)  HGNC  Alliance
Mus musculus (house mouse) : Peg10 (paternally expressed 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Peg10 (paternally expressed 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Peg10 (paternally expressed 10)
Pan paniscus (bonobo/pygmy chimpanzee) : PEG10 (paternally expressed 10)
Canis lupus familiaris (dog) : PEG10 (paternally expressed 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Peg10 (paternally expressed 10)
Chlorocebus sabaeus (African green monkey) : PEG10 (paternally expressed 10)
Heterocephalus glaber (naked mole-rat) : Peg10 (paternally expressed 10)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl974,474,058 - 74,486,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1974,474,121 - 74,486,983 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2981,643,099 - 81,655,365 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene Ontology Annotations
References - uncurated

Genomics

Comparative Map Data

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences

Additional Information

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More on PEG10
NCBI Gene
Ensembl Gene
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 14020890
Created: 2019-01-29
Species: Sus scrofa
Last Modified: 2020-02-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.