Gdap1 (ganglioside induced differentiation associated protein 1) - Rat Genome Database

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Gene: Gdap1 (ganglioside induced differentiation associated protein 1) Heterocephalus glaber
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Symbol: Gdap1
Name: ganglioside induced differentiation associated protein 1
RGD ID: 18930624
Description: INVOLVED IN cellular response to vitamin D (ortholog); PARTICIPATES IN mitochondria fission pathway; ASSOCIATED WITH autosomal recessive axonal Charcot-Marie-Tooth disease with vocal cord paresis (ortholog); axonal neuropathy (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN cytosol (inferred); membrane (inferred); mitochondrial outer membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ganglioside-induced differentiation-associated protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474416,859,700 - 16,879,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474416,859,946 - 16,878,723 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease axonal type 2C  ISOGDAP1 (Homo sapiens)9068941DNA:missense mutation:cds:p.G327D (human)RGDPMID:21365284 and REF_RGD_ID:12738395
1 to 19 of 19 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gdap1Naked Mole-Ratautosomal recessive axonal Charcot-Marie-Tooth disease with vocal cord paresis  ISOGDAP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11743579 more ...
Gdap1Naked Mole-Rataxonal neuropathy  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Axonal neuropathyClinVarPMID:14561495 more ...
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease  ISOGDAP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11743580 more ...
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease  ISOGDAP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11743580 more ...
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease axonal type 2K  ISOGDAP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11743579 more ...
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease intermediate type  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth and IntermediateClinVarPMID:25741868 and PMID:28492532
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease recessive intermediate A  ISOGDAP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11743580 more ...
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease type 1  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease and type IClinVarPMID:28492532
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease type 4  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease type 4ClinVarPMID:11743580 more ...
Gdap1Naked Mole-RatCharcot-Marie-Tooth disease type 4A  ISOGDAP1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11743579 more ...
Gdap1Naked Mole-Ratgenetic disease  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:12499475 more ...
Gdap1Naked Mole-Ratisolated elevated serum creatine phosphokinase levels  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: HYPERCKEMIA and IDIOPATHICClinVarPMID:14561495 more ...
Gdap1Naked Mole-Ratmitochondrial complex V (ATP synthase) deficiency nuclear type 2  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Mitochondrial complex V (ATP synthase) deficiency nuclear type 2ClinVarPMID:28492532
Gdap1Naked Mole-Ratneuropathy  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Peripheral neuropathyClinVarPMID:15377708 more ...
Gdap1Naked Mole-Ratperipheral nervous system disease  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Peripheral neuropathyClinVarPMID:15377708 more ...
Gdap1Naked Mole-Ratpolyneuropathy  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: PolyneuropathyClinVarPMID:14561495 more ...
Gdap1Naked Mole-Ratsensory peripheral neuropathy  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Sensory neuropathyClinVarPMID:14561495 more ...
Gdap1Naked Mole-RatSOST-related sclerosing bone dysplasia  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Elevated alkaline phosphataseClinVarPMID:14561495 more ...
Gdap1Naked Mole-RatTalipes Cavus  ISOGDAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pes cavusClinVarPMID:28492532
1 to 19 of 19 rows


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gdap1Naked Mole-Ratcellular response to vitamin D  ISOGdap1 (Rattus norvegicus)9068941 RGDPMID:25449168 and REF_RGD_ID:12738378
Gdap1Naked Mole-Ratmitochondrial fission involved_inIEAUniProtKB:Q8TB36 and ensembl:ENSP00000220822150520179 EnsemblGO_REF:0000107
Gdap1Naked Mole-Ratmitochondrial fission involved_inIEAPANTHER:PTN000136714 and PANTHER:PTN000136715150520179 TreeGrafterGO_REF:0000118
Gdap1Naked Mole-Ratmitochondrial fusion involved_inIEAUniProtKB:Q8TB36 and ensembl:ENSP00000220822150520179 EnsemblGO_REF:0000107
Gdap1Naked Mole-Ratmitochondrial fusion involved_inIEAPANTHER:PTN000136714 and PANTHER:PTN000136715150520179 TreeGrafterGO_REF:0000118
Gdap1Naked Mole-Ratprotein targeting to mitochondrion involved_inIEAUniProtKB:Q8TB36 and ensembl:ENSP00000220822150520179 EnsemblGO_REF:0000107
Gdap1Naked Mole-Ratprotein targeting to mitochondrion involved_inIEAPANTHER:PTN000136714 and PANTHER:PTN000136715150520179 TreeGrafterGO_REF:0000118
Gdap1Naked Mole-Ratresponse to retinoic acid acts_upstream_of_or_withinIEAUniProtKB:O88741 and ensembl:ENSMUSP00000026879150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gdap1Naked Mole-Ratcytosol located_inIEAUniProtKB:Q8TB36 and ensembl:ENSP00000220822150520179 EnsemblGO_REF:0000107
Gdap1Naked Mole-Ratmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
Gdap1Naked Mole-Ratmitochondrial outer membrane located_inIEAUniProtKB:Q8TB36 and ensembl:ENSP00000220822150520179 EnsemblGO_REF:0000107
Gdap1Naked Mole-Ratmitochondrial outer membrane located_inIEAPANTHER:PTN000136714 and PANTHER:PTN000136715150520179 TreeGrafterGO_REF:0000118
Gdap1Naked Mole-Ratmitochondrion located_inIEAUniProtKB:Q8TB36 and ensembl:ENSP00000220822150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gdap1Naked Mole-Ratprotein binding enablesISOUniProtKB:A2RU14 more ...9068941 PMID:32296183IntActPMID:32296183
Gdap1Naked Mole-Ratprotein binding enablesISOUniProtKB:O15392 more ...9068941 PMID:32814053IntActPMID:32814053

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gdap1Naked Mole-Ratmitochondria fission pathway  ISOGDAP1 (Homo sapiens)9068941 RGDPMID:21683788 more ...
PMID:21993625   PMID:30032202  



Gdap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474416,859,700 - 16,879,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474416,859,946 - 16,878,723 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GDAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38874,350,403 - 74,488,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl874,320,613 - 74,518,007 (+)EnsemblGRCh38hg38GRCh38
GRCh37875,262,638 - 75,401,107 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36875,425,173 - 75,441,900 (+)NCBINCBI36Build 36hg18NCBI36
Build 34875,425,251 - 75,439,157NCBI
Celera871,260,475 - 71,277,203 (+)NCBICelera
Cytogenetic Map8q21.11NCBI
HuRef870,753,599 - 70,770,326 (+)NCBIHuRef
CHM1_1875,314,604 - 75,331,330 (+)NCBICHM1_1
T2T-CHM13v2.0874,779,703 - 74,918,431 (+)NCBIT2T-CHM13v2.0
Gdap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,202,028 - 17,234,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,215,586 - 17,234,495 (+)EnsemblGRCm39 Ensembl
GRCm38117,145,373 - 17,164,271 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,145,362 - 17,164,271 (+)EnsemblGRCm38mm10GRCm38
MGSCv37117,135,454 - 17,154,352 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36117,130,611 - 17,149,485 (+)NCBIMGSCv36mm8
Celera117,069,144 - 17,087,736 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.21NCBI
Gdap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr856,715,935 - 6,735,013 (-)NCBIGRCr8
mRatBN7.251,932,613 - 1,951,691 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl51,932,613 - 2,030,061 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx54,048,988 - 4,068,071 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.055,687,862 - 5,706,945 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.055,381,543 - 5,400,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.051,328,963 - 1,347,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl51,328,913 - 1,347,921 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.051,323,590 - 1,342,573 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.451,006,203 - 1,025,281 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.151,008,936 - 1,025,382 (-)NCBI
Celera51,574,343 - 1,593,421 (-)NCBICelera
Cytogenetic Map5q11NCBI
Gdap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554446,051,301 - 6,069,765 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554446,053,422 - 6,069,741 (-)NCBIChiLan1.0ChiLan1.0
GDAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2790,064,000 - 90,109,634 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1865,691,783 - 65,820,188 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0870,854,665 - 70,900,532 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1872,528,869 - 72,545,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl872,528,869 - 72,545,346 (+)Ensemblpanpan1.1panPan2
GDAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12922,805,468 - 22,835,909 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2922,804,965 - 22,833,069 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2923,070,273 - 23,100,798 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02922,916,906 - 22,947,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2922,928,645 - 23,031,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12922,976,040 - 23,006,559 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02923,010,785 - 23,041,610 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02923,361,889 - 23,392,422 (+)NCBIUU_Cfam_GSD_1.0
Gdap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530356,448,982 - 56,466,822 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366482,981,546 - 3,014,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366482,981,802 - 2,999,161 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl461,577,112 - 61,596,049 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1461,577,413 - 61,596,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2467,190,455 - 67,209,140 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1869,948,800 - 69,965,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl869,949,052 - 69,966,421 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603971,407,858 - 71,452,631 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000022552   ⟹   ENSHGLP00000022341
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474416,859,700 - 16,879,057 (-)Ensembl
RefSeq Acc Id: XM_004842041   ⟹   XP_004842098
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474416,859,946 - 16,878,721 (-)NCBI
RefSeq Acc Id: XM_021256011   ⟹   XP_021111670
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474416,859,946 - 16,878,723 (-)NCBI
RefSeq Acc Id: XR_001183275
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474416,859,946 - 16,878,721 (-)NCBI
Protein RefSeqs XP_004842098 (Get FASTA)   NCBI Sequence Viewer  
  XP_021111670 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB14200 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022341
GenBank Protein JAO00436 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021111670   ⟸   XM_021256011
- Peptide Label: isoform X2
- UniProtKB: A0AAX6SUZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842098   ⟸   XM_004842041
- Peptide Label: isoform X1
- UniProtKB: G5BY39 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000022341   ⟸   ENSHGLT00000022552



1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000015931 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000022552 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro GDAP1 UniProtKB/TrEMBL
  Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report hgl:101720956 UniProtKB/TrEMBL
NCBI Gene Gdap1 ENTREZGENE
PANTHER GDAP1, ISOFORM A UniProtKB/TrEMBL
  PTHR44188:SF3 UniProtKB/TrEMBL
Pfam GST_C_2 UniProtKB/TrEMBL
  GST_N_3 UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
  GST_NTER UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
UniProt A0AAX6SUZ3 ENTREZGENE, UniProtKB/TrEMBL
  G5BY39 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows