Lamtor2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2) - Rat Genome Database

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Gene: Lamtor2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2) Heterocephalus glaber
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Symbol: Lamtor2
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
RGD ID: 18930613
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); fibroblast migration (ortholog); positive regulation of MAPK cascade (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); gastrointestinal stromal tumor (ortholog); immunodeficiency 42 (ortholog); FOUND IN FNIP-folliculin RagC/D GAP (ortholog); late endosome (ortholog); lysosomal membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Mitogen-activated protein-binding protein-interacting protein; ragulator complex protein LAMTOR2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,398,505 - 1,403,789 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,399,235 - 1,403,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Lamtor2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,398,505 - 1,403,789 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,399,235 - 1,403,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
LAMTOR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,054,782 - 156,058,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,054,782 - 156,058,506 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,024,573 - 156,028,297 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,291,229 - 154,294,923 (+)NCBINCBI36Build 36hg18NCBI36
Celera1129,097,578 - 129,101,362 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,387,097 - 127,390,882 (+)NCBIHuRef
CHM1_11157,420,604 - 157,424,391 (+)NCBICHM1_1
T2T-CHM13v2.01155,193,248 - 155,196,972 (+)NCBIT2T-CHM13v2.0
Lamtor2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,457,126 - 88,460,258 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,457,126 - 88,460,381 (-)EnsemblGRCm39 Ensembl
GRCm38388,549,819 - 88,552,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,549,819 - 88,553,074 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,353,741 - 88,356,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,635,746 - 88,638,854 (-)NCBIMGSCv36mm8
Celera388,589,626 - 88,592,744 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.87NCBI
Lamtor2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,306,353 - 176,310,617 (-)NCBIGRCr8
mRatBN7.22174,008,556 - 174,011,950 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,008,548 - 174,013,013 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,152,706 - 181,156,089 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,175,071 - 179,178,454 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,775,155 - 173,778,545 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,911,530 - 187,914,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,911,533 - 187,915,596 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,313,930 - 207,317,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,665,354 - 180,668,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2167,952,942 - 167,956,317 (-)NCBICelera
Cytogenetic Map2q34NCBI
Lamtor2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,236,868 - 2,242,137 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,237,506 - 2,242,070 (+)NCBIChiLan1.0ChiLan1.0
LAMTOR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,787,756 - 93,791,536 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,519,704 - 93,523,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,396,937 - 131,400,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,226,400 - 135,230,167 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,226,400 - 135,230,167 (+)Ensemblpanpan1.1panPan2
LAMTOR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,760,632 - 41,764,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,760,638 - 41,763,299 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,250,160 - 41,252,889 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,627,377 - 41,630,107 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,627,383 - 41,630,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,408,225 - 41,410,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,461,577 - 41,464,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,746,005 - 41,748,735 (-)NCBIUU_Cfam_GSD_1.0
Lamtor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,286,374 - 26,289,979 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,316,616 - 5,322,158 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,316,748 - 5,320,364 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMTOR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,971,871 - 93,976,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,972,112 - 93,975,561 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,714,889 - 102,718,338 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMTOR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,806,509 - 7,810,296 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,806,510 - 7,810,456 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,102,867 - 7,106,653 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000008400   ⟹   ENSHGLP00000008311
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248851,398,505 - 1,403,789 (+)Ensembl
RefSeq Acc Id: XM_004871177   ⟹   XP_004871234
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248851,399,245 - 1,403,669 (+)NCBI
RefSeq Acc Id: XM_013068030   ⟹   XP_012923484
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248851,399,235 - 1,403,669 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004871234 (Get FASTA)   NCBI Sequence Viewer  
  XP_012923484 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA99564 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000008311
GenBank Protein JAN97480 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012923484   ⟸   XM_013068030
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QNR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004871234   ⟸   XM_004871177
- Peptide Label: isoform X2
- UniProtKB: G5ARA4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000008311   ⟸   ENSHGLT00000008400


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006015 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000008400 ENTREZGENE
Gene3D-CATH Dynein light chain 2a, cytoplasmic UniProtKB/TrEMBL
InterPro LAMTOR2-like UniProtKB/TrEMBL
  Roadblock/LAMTOR2_dom UniProtKB/TrEMBL
KEGG Report hgl:101703739 UniProtKB/TrEMBL
NCBI Gene Lamtor2 ENTREZGENE
PANTHER PTHR13323 UniProtKB/TrEMBL
Pfam Robl_LC7 UniProtKB/TrEMBL
SMART Robl_LC7 UniProtKB/TrEMBL
Superfamily-SCOP Roadblock/LC7 domain UniProtKB/TrEMBL
UniProt A0AAX6QNR8 ENTREZGENE, UniProtKB/TrEMBL
  G5ARA4 ENTREZGENE, UniProtKB/TrEMBL