Mier2 (MIER family member 2) - Rat Genome Database

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Gene: Mier2 (MIER family member 2) Heterocephalus glaber
Analyze
Symbol: Mier2
Name: MIER family member 2
RGD ID: 18927935
Description: ENCODES a protein that exhibits histone deacetylase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Salivary Gland Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Mesoderm induction early response protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248288,036,450 - 8,052,151 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248288,030,391 - 8,054,349 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Mier2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248288,036,450 - 8,052,151 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248288,030,391 - 8,054,349 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MIER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819305,573 - 344,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19305,573 - 344,815 (-)EnsemblGRCh38hg38GRCh38
GRCh3719305,573 - 344,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619256,575 - 295,791 (-)NCBINCBI36Build 36hg18NCBI36
Celera19467,724 - 506,032 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef1976,550 - 115,239 (-)NCBIHuRef
CHM1_119303,503 - 344,381 (-)NCBICHM1_1
T2T-CHM13v2.019255,525 - 294,230 (-)NCBIT2T-CHM13v2.0
Mier2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,376,079 - 79,395,229 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,376,079 - 79,391,033 (-)EnsemblGRCm39 Ensembl
GRCm381079,540,245 - 79,557,042 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,540,245 - 79,555,199 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,002,990 - 79,017,836 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361078,943,374 - 78,958,220 (-)NCBIMGSCv36mm8
Celera1080,553,552 - 80,568,412 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Mier2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,804,238 - 10,819,979 (+)NCBIGRCr8
mRatBN7.2710,153,501 - 10,169,381 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,153,649 - 10,169,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,025,706 - 13,041,902 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,903,793 - 14,919,989 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,765,804 - 12,781,867 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0713,039,759 - 13,055,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,039,781 - 13,055,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,203,171 - 13,219,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,671,223 - 11,687,698 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,671,241 - 11,686,518 (+)NCBI
Celera78,319,518 - 8,334,990 (+)NCBICelera
Cytogenetic Map7q11NCBI
Mier2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,279,451 - 7,302,123 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,279,507 - 7,300,202 (+)NCBIChiLan1.0ChiLan1.0
MIER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,604,134 - 4,644,798 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,847,155 - 3,889,553 (-)NCBINHGRI_mPanPan1
PanPan1.119259,565 - 297,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19259,565 - 288,920 (-)Ensemblpanpan1.1panPan2
MIER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12058,063,976 - 58,083,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2058,063,449 - 58,083,083 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,867,332 - 57,886,361 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,807,791 - 58,826,821 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,807,805 - 58,826,821 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,861,617 - 57,880,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,341,528 - 58,360,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,544,998 - 58,564,027 (+)NCBIUU_Cfam_GSD_1.0
Mier2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,788,537 - 217,809,511 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493658825,253 - 46,246 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493658825,272 - 46,226 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,912,761 - 77,938,855 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,912,766 - 77,938,855 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,251,675 - 79,277,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,532 - 70,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660819,036,848 - 9,072,091 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: ENSHGLT00000020047   ⟹   ENSHGLP00000019849
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248288,036,450 - 8,052,151 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000020048   ⟹   ENSHGLP00000019850
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248288,036,491 - 8,052,151 (+)Ensembl
RefSeq Acc Id: XM_004866032   ⟹   XP_004866089
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248288,030,391 - 8,054,349 (+)NCBI
RefSeq Acc Id: XM_021244938   ⟹   XP_021100597
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248288,030,391 - 8,054,349 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004866089 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100597 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB03932 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019850
GenBank Protein JAN98668 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004866089   ⟸   XM_004866032
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J563 (UniProtKB/TrEMBL),   G5B3S1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100597   ⟸   XM_021244938
- Peptide Label: isoform X2
- UniProtKB: G5B3S1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000019850   ⟸   ENSHGLT00000020048
RefSeq Acc Id: ENSHGLP00000019849   ⟸   ENSHGLT00000020047


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014210 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000020048 ENTREZGENE
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro ELM2_dom UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  MIER/MTA UniProtKB/TrEMBL
  SANT/Myb UniProtKB/TrEMBL
  SANT_dom UniProtKB/TrEMBL
KEGG Report hgl:101725247 UniProtKB/TrEMBL
NCBI Gene Mier2 ENTREZGENE
PANTHER MESODERM INDUCTION EARLY RESPONSE PROTEIN 2 UniProtKB/TrEMBL
  PTHR10865 UniProtKB/TrEMBL
Pfam ELM2 UniProtKB/TrEMBL
  Myb_DNA-binding UniProtKB/TrEMBL
PROSITE ELM2 UniProtKB/TrEMBL
  SANT UniProtKB/TrEMBL
SMART ELM2 UniProtKB/TrEMBL
  SANT UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A0P6J563 ENTREZGENE, UniProtKB/TrEMBL
  G5B3S1 ENTREZGENE, UniProtKB/TrEMBL