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Gene: Galm (galactose mutarotase) Heterocephalus glaber

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Symbol:

Galm

Name:

galactose mutarotase

RGD ID:

18927366

Description:

ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN carbohydrate metabolic process (ortholog); PARTICIPATES IN Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH buphthalmos (ortholog); galactosemia 4 (ortholog); genetic disease (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Aldose 1-epimerase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GALM (galactose mutarotase)	NCBI	Ortholog
Mus musculus (house mouse):	Galm (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Galm (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Galm (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GALM (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GALM (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101967759 (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GALM (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GALM (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	20,163,901 - 20,235,256 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	20,164,179 - 20,236,151 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Galm	Naked Mole-Rat	buphthalmos		ISO	RGD:1350990	8554872	ClinVar Annotator: match by term: Congenital glaucoma	ClinVar	PMID:19234632\|PMID:28492532\|PMID:31251480\|PMID:9097971\|PMID:9497261
Galm	Naked Mole-Rat	galactosemia 4		ISO	RGD:1350990	8554872	ClinVar Annotator: match by term: GALM-related condition \| ClinVar Annotator: match by term: Galactosemia 4	ClinVar	PMID:25741868\|PMID:28492532\|PMID:30451973\|PMID:30910422
Galm	Naked Mole-Rat	genetic disease		ISO	RGD:1350990	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532
Galm	Naked Mole-Rat	Lynch syndrome		ISO	RGD:1350990	8554872	ClinVar Annotator: match by term: Hereditary nonpolyposis colorectal neoplasms	ClinVar	PMID:28492532
Galm	Naked Mole-Rat	RASopathy		ISO	RGD:1350990	8554872	ClinVar Annotator: match by term: RASopathy	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Galm	Naked Mole-Rat	galactosemia 4		ISO	RGD:1350990	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Galm	Naked Mole-Rat	carbohydrate metabolic process	acts_upstream_of_or_within	ISO	RGD:1350990	9068941	PMID:12753898	MGI	PMID:12753898
Galm	Naked Mole-Rat	carbohydrate metabolic process	involved_in	IEA	InterPro:IPR008183\|InterPro:IPR011013	150520179		InterPro	GO_REF:0000002
Galm	Naked Mole-Rat	galactose catabolic process via UDP-galactose, Leloir pathway	involved_in	IEA	PANTHER:PTN001297121	150520179		TreeGrafter	GO_REF:0000118
Galm	Naked Mole-Rat	galactose metabolic process	involved_in	IEA	UniPathway:UPA00214	150520179		UniProt	GO_REF:0000041
Galm	Naked Mole-Rat	glucose metabolic process	involved_in	IEA	PANTHER:PTN001297121	150520179		TreeGrafter	GO_REF:0000118
Galm	Naked Mole-Rat	hexose metabolic process	involved_in	IEA	UniPathway:UPA00242	150520179		UniProt	GO_REF:0000041
Galm	Naked Mole-Rat	hexose metabolic process	involved_in	IEA	InterPro:IPR015443	150520179		InterPro	GO_REF:0000002

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Galm	Naked Mole-Rat	aldose 1-epimerase activity	enables	IEA	PANTHER:PTN001297121	150520179		TreeGrafter	GO_REF:0000118
Galm	Naked Mole-Rat	aldose 1-epimerase activity	enables	IEA	EC:5.1.3.3	150520179		UniProt	GO_REF:0000003
Galm	Naked Mole-Rat	carbohydrate binding	enables	IEA	InterPro:IPR011013\|InterPro:IPR014718	150520179		InterPro	GO_REF:0000002
Galm	Naked Mole-Rat	catalytic activity	enables	IEA	InterPro:IPR011013	150520179		InterPro	GO_REF:0000002
Galm	Naked Mole-Rat	isomerase activity	enables	IEA	UniProtKB-KW:KW-0413	150520179		UniProt	GO_REF:0000043
Galm	Naked Mole-Rat	isomerase activity	enables	IEA	InterPro:IPR008183\|InterPro:IPR015443\|InterPro:IPR047215	150520179		InterPro	GO_REF:0000002
Galm	Naked Mole-Rat	protein homodimerization activity	NOT\|enables	ISO	RGD:1350990	9068941	PMID:12753898	MGI	PMID:12753898

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Galm	Naked Mole-Rat	Fanconi syndrome pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00572
Galm	Naked Mole-Rat	fructose-1,6-bisphosphatase deficiency pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00562
Galm	Naked Mole-Rat	gluconeogenesis pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00128
Galm	Naked Mole-Rat	glycogen storage disease type Ia pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00374\|SMP:00581
Galm	Naked Mole-Rat	glycogen storage disease type Ib pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00573
Galm	Naked Mole-Rat	glycogen storage disease type VII pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00531
Galm	Naked Mole-Rat	glycolysis pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00040
Galm	Naked Mole-Rat	phosphoenolpyruvate carboxykinase deficiency pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00560
Galm	Naked Mole-Rat	triosephosphate isomerase deficiency pathway		ISO	RGD:1350990	9068941		SMPDB	SMP:00563

PMID:21993625	PMID:22301074	PMID:30032202

Galm
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	20,163,901 - 20,235,256 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	20,164,179 - 20,236,151 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

GALM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	38,666,114 - 38,734,765 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	38,666,081 - 38,741,237 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	38,893,256 - 38,961,907 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	38,746,743 - 38,815,049 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	38,804,889 - 38,873,176	NCBI
Celera	2	38,734,098 - 38,802,942 (+)	NCBI		Celera
Cytogenetic Map	2	p22.1	NCBI
HuRef	2	38,632,684 - 38,700,744 (+)	NCBI		HuRef
CHM1_1	2	38,823,545 - 38,892,563 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	38,672,993 - 38,743,547 (+)	NCBI		T2T-CHM13v2.0

Galm
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	80,434,886 - 80,492,461 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	80,434,900 - 80,492,530 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	80,127,458 - 80,185,032 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	80,127,471 - 80,185,101 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	80,526,811 - 80,584,372 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	80,035,797 - 80,093,358 (+)	NCBI		MGSCv36	mm8
Celera	17	84,443,907 - 84,501,487 (+)	NCBI		Celera
Cytogenetic Map	17	E3	NCBI
cM Map	17	50.46	NCBI

Galm
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	20,589,775 - 20,641,516 (-)	NCBI		GRCr8
mRatBN7.2	6	14,837,540 - 14,889,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	14,837,548 - 14,889,310 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	15,135,882 - 15,187,744 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	15,458,146 - 15,509,901 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	14,954,424 - 15,006,178 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	2,808,988 - 2,860,742 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	2,808,841 - 2,860,744 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	2,785,889 - 2,837,635 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	3,024,123 - 3,078,720 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	3,024,122 - 3,078,719 (+)	NCBI
Celera	6	14,514,739 - 14,566,190 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

Galm
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	6,330,410 - 6,403,219 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	6,330,520 - 6,399,522 (+)	NCBI	ChiLan1.0	ChiLan1.0

GALM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	87,736,071 - 87,810,064 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	87,739,913 - 87,814,044 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	38,697,338 - 38,770,470 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	39,456,786 - 39,527,119 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	39,456,786 - 39,527,116 (+)	Ensembl	panpan1.1		panPan2

GALM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	30,741,990 - 30,793,456 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	30,742,127 - 30,792,465 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	30,558,189 - 30,609,682 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	31,397,079 - 31,448,378 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	31,397,221 - 31,447,503 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	30,619,873 - 30,671,292 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	30,689,932 - 30,741,032 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	30,902,711 - 30,953,995 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101967759
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	41,066,829 - 41,333,563 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936508	12,495,438 - 12,502,236 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GALM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	101,617,526 - 101,753,125 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	101,617,521 - 101,682,821 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	107,762,128 - 107,827,418 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GALM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	68,647,287 - 68,720,735 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	68,647,297 - 68,720,739 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	43,259,741 - 43,332,630 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_004839318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_004839319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01015991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01015992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GEBF01006971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH174163	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000020399 ⟹ ENSHGLP00000020198

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624738	20,163,901 - 20,235,256 (+)	Ensembl

RefSeq Acc Id:

XM_004839318 ⟹ XP_004839375

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624738	20,164,179 - 20,234,995 (+)	NCBI

RefSeq Acc Id:

XM_004839319 ⟹ XP_004839376

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624738	20,164,180 - 20,236,151 (+)	NCBI


Protein RefSeqs	XP_004839375	(Get FASTA)	NCBI Sequence Viewer
	XP_004839376	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EHB18432	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000020198
GenBank Protein	JAN96661	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_004839375 ⟸ XM_004839318
- Peptide Label:	isoform X1
- UniProtKB:	A0AAX6NXQ8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_004839376 ⟸ XM_004839319
- Peptide Label:	isoform X2
- UniProtKB:	G5CA71 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000020198 ⟸ ENSHGLT00000020399

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000014460	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000020399	ENTREZGENE
Gene3D-CATH	2.70.98.10	UniProtKB/TrEMBL
InterPro	Ald1_epimerase_CS	UniProtKB/TrEMBL
	Aldose_1-epimerase	UniProtKB/TrEMBL
	Aldose_1/G6P_1-epimerase	UniProtKB/TrEMBL
	Gal_mutarotase_sf_dom	UniProtKB/TrEMBL
	Galactose_mutarotase-like	UniProtKB/TrEMBL
	GH-type_carb-bd	UniProtKB/TrEMBL
NCBI Gene	Galm	ENTREZGENE
PANTHER	ALDOSE-1-EPIMERASE	UniProtKB/TrEMBL
	GALACTOSE MUTAROTASE	UniProtKB/TrEMBL
Pfam	Aldose_epim	UniProtKB/TrEMBL
PIRSF	GALM	UniProtKB/TrEMBL
PROSITE	ALDOSE_1_EPIMERASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF74650	UniProtKB/TrEMBL
UniProt	A0AAX6NXQ8	ENTREZGENE, UniProtKB/TrEMBL
	G5CA71	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB