Mcf2 (MCF.2 cell line derived transforming sequence) - Rat Genome Database

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Gene: Mcf2 (MCF.2 cell line derived transforming sequence) Heterocephalus glaber
Analyze
Symbol: Mcf2
Name: MCF.2 cell line derived transforming sequence
RGD ID: 18921251
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); dendrite development (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal hemophilia A (ortholog); factor VIII deficiency (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proto-oncogene DBL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248087,009,996 - 7,116,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248087,010,020 - 7,116,752 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mcf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248087,009,996 - 7,116,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248087,010,020 - 7,116,752 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MCF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X139,581,770 - 139,708,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX139,581,770 - 139,708,216 (-)EnsemblGRCh38hg38GRCh38
GRCh37X138,663,929 - 138,790,326 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X138,491,596 - 138,618,047 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X138,389,449 - 138,450,372NCBI
CeleraX139,031,369 - 139,157,817 (-)NCBICelera
Cytogenetic MapXq27.1NCBI
HuRefX127,931,315 - 128,057,565 (-)NCBIHuRef
CHM1_1X138,574,821 - 138,701,280 (-)NCBICHM1_1
T2T-CHM13v2.0X137,890,836 - 138,020,159 (-)NCBIT2T-CHM13v2.0
Mcf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X59,101,316 - 59,224,546 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX59,101,316 - 59,224,449 (-)EnsemblGRCm39 Ensembl
GRCm38X60,055,956 - 60,179,184 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX60,055,956 - 60,179,089 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X57,309,133 - 57,400,820 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X56,402,743 - 56,494,427 (-)NCBIMGSCv36mm8
CeleraX46,495,004 - 46,586,548 (-)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX33.5NCBI
Mcf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X143,444,510 - 143,550,839 (-)NCBIGRCr8
mRatBN7.2X138,414,077 - 138,514,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX138,409,256 - 138,514,446 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X143,159,071 - 143,292,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX143,154,209 - 143,274,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X143,188,541 - 143,236,007 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X145,597,430 - 145,693,790 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX134,485,013 - 134,591,931 (-)NCBICelera
Cytogenetic MapXq36NCBI
Mcf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554895,665,530 - 5,709,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554895,613,310 - 5,715,688 (+)NCBIChiLan1.0ChiLan1.0
MCF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X139,031,267 - 139,143,551 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X139,034,869 - 139,147,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X128,737,271 - 128,848,384 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X138,985,456 - 139,047,015 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX138,984,632 - 139,096,066 (-)Ensemblpanpan1.1panPan2
MCF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X109,543,609 - 109,627,265 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX109,545,245 - 109,627,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX95,370,950 - 95,454,589 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X111,530,138 - 111,601,036 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX111,530,151 - 111,601,032 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X108,664,168 - 108,747,786 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X110,848,683 - 110,932,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X110,528,154 - 110,611,768 (-)NCBIUU_Cfam_GSD_1.0
Mcf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X107,580,518 - 107,707,380 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365137,922,700 - 8,034,793 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365137,950,082 - 8,035,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX114,258,074 - 114,356,156 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X114,258,082 - 114,356,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X130,456,205 - 130,575,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X114,670,397 - 114,795,400 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX114,670,454 - 114,776,957 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606552,394,633 - 52,527,358 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004862313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013078695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021242534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002388656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01074157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01074158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01074159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01074160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01003915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000018546   ⟹   ENSHGLP00000018362
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248087,009,996 - 7,116,804 (+)Ensembl
RefSeq Acc Id: XM_004862313   ⟹   XP_004862370
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,058,164 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_013078695   ⟹   XP_012934149
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,058,164 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242524   ⟹   XP_021098183
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,484 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242525   ⟹   XP_021098184
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,484 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242526   ⟹   XP_021098185
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,484 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242527   ⟹   XP_021098186
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,020 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242528   ⟹   XP_021098187
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,484 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242529   ⟹   XP_021098188
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,483 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242530   ⟹   XP_021098189
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,484 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242531   ⟹   XP_021098190
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,485 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242532   ⟹   XP_021098191
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,485 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242533   ⟹   XP_021098192
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,484 - 7,116,752 (+)NCBI
RefSeq Acc Id: XM_021242534   ⟹   XP_021098193
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,484 - 7,116,752 (+)NCBI
RefSeq Acc Id: XR_002388656
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248087,010,484 - 7,116,752 (+)NCBI
RefSeq Acc Id: XP_021098186   ⟸   XM_021242527
- Peptide Label: isoform X4
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098188   ⟸   XM_021242529
- Peptide Label: isoform X6
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098183   ⟸   XM_021242524
- Peptide Label: isoform X1
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098184   ⟸   XM_021242525
- Peptide Label: isoform X2
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098185   ⟸   XM_021242526
- Peptide Label: isoform X3
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098187   ⟸   XM_021242528
- Peptide Label: isoform X5
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098189   ⟸   XM_021242530
- Peptide Label: isoform X7
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098192   ⟸   XM_021242533
- Peptide Label: isoform X11
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098193   ⟸   XM_021242534
- Peptide Label: isoform X13
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL),   G5BE75 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098191   ⟸   XM_021242532
- Peptide Label: isoform X9
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098190   ⟸   XM_021242531
- Peptide Label: isoform X8
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004862370   ⟸   XM_004862313
- Peptide Label: isoform X10
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012934149   ⟸   XM_013078695
- Peptide Label: isoform X12
- UniProtKB: A0A0N8ETN1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000018362   ⟸   ENSHGLT00000018546


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013161 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000018546 ENTREZGENE
Gene3D-CATH 1.20.58.60 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  RhoGEF_Guanine_NuclExch_SF UniProtKB/TrEMBL
NCBI Gene Mcf2 ENTREZGENE
PANTHER PROTO-ONCOGENE DBL UniProtKB/TrEMBL
  RHO GUANINE EXCHANGE FACTOR-RELATED UniProtKB/TrEMBL
Pfam CRAL_TRIO_2 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PROSITE CRAL_TRIO UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SEC14 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF52087 UniProtKB/TrEMBL
UniProt A0A0N8ETN1 ENTREZGENE, UniProtKB/TrEMBL
  G5BE75 ENTREZGENE, UniProtKB/TrEMBL