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Gene: MCF2 (MCF.2 cell line derived transforming sequence) Homo sapiens
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Symbol: MCF2
Name: MCF.2 cell line derived transforming sequence
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including negative regulation of axonogenesis; positive regulation of apoptotic process; and regulation of small GTPase mediated signal transduction. Predicted to localize to the cytoskeleton and cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARHGEF21; DBL; Oncogene MCF2 (oncogene DBL); proto-oncogene DBL; proto-oncogene MCF-2
Orthologs:
Mus musculus (house mouse) : Mcf2 (mcf.2 transforming sequence)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mcf2 (MCF.2 cell line derived transforming sequence)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcf2 (MCF.2 cell line derived transforming sequence)
Pan paniscus (bonobo/pygmy chimpanzee) : MCF2 (MCF.2 cell line derived transforming sequence)
Canis lupus familiaris (dog) : MCF2 (MCF.2 cell line derived transforming sequence)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcf2 (MCF.2 cell line derived transforming sequence)
Sus scrofa (pig) : MCF2 (MCF.2 cell line derived transforming sequence)
Chlorocebus sabaeus (green monkey) : MCF2 (MCF.2 cell line derived transforming sequence)
Heterocephalus glaber (naked mole-rat) : Mcf2 (MCF.2 cell line derived transforming sequence)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX139,581,770 - 139,708,227 (-)Ensembl
GRCh38X139,581,768 - 139,708,279 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X138,663,930 - 138,790,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X138,491,596 - 138,618,047 (-)NCBINCBI36hg18NCBI36
Build 34X138,389,449 - 138,450,372NCBI
CeleraX139,031,369 - 139,157,817 (-)NCBI
Cytogenetic MapXq27.1NCBI
HuRefX127,931,315 - 128,057,565 (-)NCBIHuRef
CHM1_1X138,574,821 - 138,701,280 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MCF2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1345996
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.